Dark genome, bright ideas: Recent approaches to harness transposable elements in immunotherapies

PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

(2022) Qin Wu et al.   Nature Chemical Biology

Targeting DDX3X triggers anti-tumor immunity via a dsRNA-mediated tumor-intrinsic type I interferon response

(2021) Hyeongjwa Choi et al.   CANCER RESEARCH

Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes

(2021) Grégory Ehx et al.   IMMUNITY

Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity

(2021) Gabriel K. Griffin et al.   NATURE

The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function

(2021) Lexus R. Johnson et al.   CELL

Transposon-triggered innate immune response confers cancer resistance to the blind mole rat

(2021) Yang Zhao et al.   NATURE IMMUNOLOGY

Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency

(2020) Parinaz Mehdipour et al.   NATURE

Transposable element expression in tumors is associated with immune infiltration and increased antigenicity

(2019) Yu Kong et al.   Nature Communications

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

(2018) Wanqiang Sheng et al.   CELL

Switching roles for DNA and histone methylation depend on evolutionary ages of human endogenous retroviruses

(2018) Hitoshi Ohtani et al.   GENOME RESEARCH

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

(2018) Hanghang Zhang et al.   CELL

Noncoding regions are the main source of targetable tumor-specific antigens

(2018) Céline M. Laumont et al.   Science Translational Medicine