Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation

m6A RNA methylation regulates the fate of endogenous retroviruses

(2021) Tomasz Chelmicki et al.   NATURE

Dnmt1 has de novo activity targeted to transposable elements

(2021) Chuck Haggerty et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Silencing and Transcriptional Regulation of Endogenous Retroviruses: An Overview

(2020) Franziska K. Geis et al.   Viruses-Basel

Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia

(2020) Özgen Deniz et al.   Nature Communications

Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo

(2020) Amanda R. Wasylishen et al.   Science Advances

An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility

(2020) Carmen Navarro et al.   Nature Communications

SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells

(2019) Parysatis Sachs et al.   Nature Communications

Mechanism for autoinhibition and activation of the MORC3 ATPase

(2019) Yi Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transposable elements drive widespread expression of oncogenes in human cancers

(2019) Hyo Sik Jang et al.   NATURE GENETICS

MORC3 Is a Target of the Influenza A Viral Protein NS1

(2019) Yi Zhang et al.   STRUCTURE

A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells

(2018) Kei Fukuda et al.   GENOME RESEARCH

Human Endogenous Retroviruses in Neurological Diseases

(2018) Patrick Küry et al.   TRENDS IN MOLECULAR MEDICINE

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

(2018) Christopher H. Douse et al.   Nature Communications

Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation

(2018) Daniel R Fuentes et al.   eLife

Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators

(2017) Nian Liu et al.   NATURE

On the role of H3.3 in retroviral silencing

(2017) Gernot Wolf et al.   NATURE

Hyperactivation of HUSH complex function by Charcot–Marie–Tooth disease mutation in MORC2

(2017) Iva A Tchasovnikarova et al.   NATURE GENETICS

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

(2017) M Ryan Corces et al.   NATURE METHODS

Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX

(2017) Dominik Hoelper et al.   Nature Communications

Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration

(2016) Vidya Ramesh et al.   GENES & DEVELOPMENT

The Emerging Role of MORC Family Proteins in Cancer Development and Bone Homeostasis

(2016) Guoju Hong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus

(2016) Elizabeth Sloan et al.   JOURNAL OF VIROLOGY

Long Terminal Repeats: From Parasitic Elements to Building Blocks of the Transcriptional Regulatory Repertoire

(2016) Peter J. Thompson et al.   MOLECULAR CELL

Rapid immunoprecipitation mass spectrometry of endogenous proteins (RIME) for analysis of chromatin complexes

(2016) Hisham Mohammed et al.   Nature Protocols

Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin

(2016) Sisi Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory evolution of innate immunity through co-option of endogenous retroviruses

(2016) E. B. Chuong et al.   SCIENCE

H3K9me3-Dependent Heterochromatin: Barrier to Cell Fate Changes

(2016) Justin S. Becker et al.   TRENDS IN GENETICS

Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase

(2016) Forest H. Andrews et al.   Cell Reports

Endogenous retroviral promoter exaptation in human cancer

(2016) Artem Babaian et al.   Mobile DNA

Morc3 mutant mice exhibit reduced cortical area and thickness, accompanied by altered haematopoietic stem cells niche and bone cell differentiation

(2016) Gaurav Jadhav et al.   Scientific Reports

Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells

(2015) Bin Xia Yang et al.   CELL

The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation

(2015) Quanyuan He et al.   Cell Stem Cell

Atrx promotes heterochromatin formation at retrotransposons

(2015) D. Sadic et al.   EMBO REPORTS

Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells

(2015) Simon J. Elsässer et al.   NATURE

Transcriptional landscape of repetitive elements in normal and cancer human cells

(2014) Steven W Criscione et al.   BMC GENOMICS

Widespread contribution of transposable elements to the innovation of gene regulatory networks

(2014) Vasavi Sundaram et al.   GENOME RESEARCH

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

MORC1 represses transposable elements in the mouse male germline

(2014) William A. Pastor et al.   Nature Communications

H3.3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin

(2013) P. Chen et al.   GENES & DEVELOPMENT

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

The Majority of Primate-Specific Regulatory Sequences Are Derived from Transposable Elements

(2013) Pierre-Étienne Jacques et al.   PLoS Genetics

Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome

(2012) Abdenour Soufi et al.   CELL

DNA Methylation and SETDB1/H3K9me3 Regulate Predominantly Distinct Sets of Genes, Retroelements, and Chimeric Transcripts in mESCs

(2011) Mohammad M. Karimi et al.   Cell Stem Cell

Two-step colocalization of MORC3 with PML nuclear bodies

(2010) Y. Mimura et al.   JOURNAL OF CELL SCIENCE

KAP1 controls endogenous retroviruses in embryonic stem cells

(2010) Helen M. Rowe et al.   NATURE

Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET

(2010) Toshiyuki Matsui et al.   NATURE

Transposable elements have rewired the core regulatory network of human embryonic stem cells

(2010) Galih Kunarso et al.   NATURE GENETICS

A rapid micro chromatin immunoprecipitation assay (ChIP)

(2008) John Arne Dahl et al.   Nature Protocols