Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies

Genetic variant of CXCR1 (rs2234671) associates with clinical outcome in perihilar cholangiocarcinoma

(2022) Isabella Lurje et al.   Liver Cancer

Prognostic and Predictive Molecular Markers in Cholangiocarcinoma

(2022) Sandra Pavicevic et al.   Cancers

Interstitial lung diseases

(2022) Marlies Wijsenbeek et al.   LANCET

Biology of lung macrophages in health and disease

(2022) Helena Aegerter et al.   IMMUNITY

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

(2022) Aveline Filliol et al.   NATURE

Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study

(2022) Joshua J Solomon et al.   Lancet Respiratory Medicine

Epithelial–Mesenchymal Plasticity and Endothelial–Mesenchymal Transition in Cutaneous Wound Healing

(2022) Remy Vu et al.   Cold Spring Harbor Perspectives in Biology

Essential immune functions of fibroblasts in innate host defense

(2022) Kellen J. Cavagnero et al.   Frontiers in Immunology

Cenicriviroc for the treatment of COVID-19: first interim results of a randomised, placebo-controlled, investigator-initiated, double-blind phase II trial

(2022) Florian Kurth et al.   Journal of Global Antimicrobial Resistance

Cancer-associated fibroblasts: overview, progress, challenges, and directions

(2021) Qinrong Ping et al.   CANCER GENE THERAPY

A structurally optimized FXR agonist, MET409, reduced liver fat content over 12 weeks in patients with non-alcoholic steatohepatitis

(2021) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Role of liver sinusoidal endothelial cells in liver diseases

(2021) Jordi Gracia-Sancho et al.   Nature Reviews Gastroenterology & Hepatology

PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease

(2021) Maria E. Moreno-Fernandez et al.   Cell Metabolism

Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease

(2021) Hao Zhao et al.   CLINICAL SCIENCE

TGF ‐β as a driver of fibrosis: physiological roles and therapeutic opportunities

(2021) Erine H Budi et al.   JOURNAL OF PATHOLOGY

Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

(2021) Michael Dudek et al.   NATURE

Club cell-specific role of programmed cell death 5 in pulmonary fibrosis

(2021) Soo-Yeon Park et al.   Nature Communications

In Situ Vaccination as a Strategy to Modulate the Immune Microenvironment of Hepatocellular Carcinoma

(2021) Isabella Lurje et al.   Frontiers in Immunology

Hypothermic Oxygenated Machine Perfusion (HOPE) Reduces Early Allograft Injury and Improves Post-Transplant Outcomes in Extended Criteria Donation (ECD) Liver Transplantation from Donation After Brain Death (DBD)

(2021) Zoltan Czigany et al.   ANNALS OF SURGERY

Heart and Brain Pericytes Exhibit a Pro-Fibrotic Response After Vascular Injury

(2021) Thanh T.D. Pham et al.   CIRCULATION RESEARCH

Single‐Cell Transcriptomic Analysis Reveals a Hepatic Stellate Cell–Activation Roadmap and Myofibroblast Origin During Liver Fibrosis in Mice

(2021) Wu Yang et al.   HEPATOLOGY

EBF1 is expressed in pericytes and contributes to pericyte cell commitment

(2021) Francesca Pagani et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Molecular Biomarkers in Idiopathic Pulmonary Fibrosis: State of the Art and Future Directions

(2021) Anna Stainer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

(2021) Aleksandra Deczkowska et al.   NATURE MEDICINE

CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells

(2021) Yuzo Koda et al.   Nature Communications

Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases

(2021) Cheng-Cheng Deng et al.   Nature Communications

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions

(2021) David O. Dias et al.   Nature Communications

The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1

(2021) Yue Xi et al.   Science Advances

Transcriptomic Profiling of the Liver Sinusoidal Endothelium during Cirrhosis Reveals Stage-Specific Secretory Signature

(2021) Nicolò Manicardi et al.   Cancers

Hepatic fibrosis 2022: Unmet needs and a blueprint for the future

(2021) Scott L. Friedman et al.   HEPATOLOGY

Molecular and Cellular Mediators of the Gut-Liver Axis in the Progression of Liver Diseases

(2021) Alix Bruneau et al.   Frontiers in Medicine

Pirfenidone: Molecular Mechanisms and Potential Clinical Applications in Lung Disease

(2020) Saleela M Ruwanpura et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cenicriviroc Treatment for Adults with Nonalcoholic Steatohepatitis and Fibrosis: Final Analysis of the Phase 2b CENTAUR Study

(2020) Vlad Ratziu et al.   HEPATOLOGY

Human Lung Conventional Dendritic Cells Orchestrate Lymphoid Neogenesis During COPD

(2020) Thomas Naessens et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neoplastic fibrocytes play an essential role in bone marrow fibrosis in Jak2V617F-induced primary myelofibrosis mice

(2020) Yoshinori Ozono et al.   LEUKEMIA

Kidney dendritic cells: fundamental biology and functional roles in health and disease

(2020) Christian Kurts et al.   Nature Reviews Nephrology

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

(2020) Richard S. Finn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis

(2020) Tatsuya Tsukui et al.   Nature Communications

Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis

(2020) Ping An et al.   Nature Communications

Ischemia-Reperfusion Injury in Marginal Liver Grafts and the Role of Hypothermic Machine Perfusion: Molecular Mechanisms and Clinical Implications

(2020) Zoltan Czigany et al.   Journal of Clinical Medicine

The role of Smad2 and Smad3 in regulating homeostatic functions of fibroblasts in vitro and in adult mice

(2020) Shuaibo Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma

(2020) Min Zhang et al.   JOURNAL OF HEPATOLOGY

Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis

(2020) Susanne Gaul et al.   JOURNAL OF HEPATOLOGY

Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities

(2020) Yankai Wen et al.   Cellular & Molecular Immunology

Dendritic Cell and T Cell Crosstalk in Liver Fibrogenesis and Hepatocarcinogenesis: Implications for Prevention and Therapy of Liver Cancer

(2020) Isabella Lurje et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fibrosis: from mechanisms to medicines

(2020) Neil C. Henderson et al.   NATURE

Impact of Angiogenesis- and Hypoxia-Associated Polymorphisms on Tumor Recurrence in Patients with Hepatocellular Carcinoma Undergoing Surgical Resection

(2020) Hannah Miller et al.   Cancers

Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis

(2020) Tingting Su et al.   Cellular and Molecular Gastroenterology and Hepatology

TGF-β1 decreases CHOP expression and prevents cardiac fibroblast apoptosis induced by endoplasmic reticulum stress

(2020) F. Olivares-Silva et al.   TOXICOLOGY IN VITRO

Dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy

(2019) Shyam S. Bansal et al.   CIRCULATION

Ferroptosis is a type of autophagy-dependent cell death

(2019) Borong Zhou et al.   SEMINARS IN CANCER BIOLOGY

Differential roles of VEGF: Relevance to tissue fibrosis

(2019) Juan Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Treatment Strategies for Hepatocellular Carcinoma – a Multidisciplinary Approach

(2019) Isabella Lurje et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis

(2019) Oliver Krenkel et al.   GUT

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease

(2019) Oliver Distler et al.   NEW ENGLAND JOURNAL OF MEDICINE

The FMS-like tyrosine kinase-3 ligand/lung dendritic cell axis contributes to regulation of pulmonary fibrosis

(2019) Meritxell Tort Tarrés et al.   THORAX

Apoptosis resistance in fibroblasts precedes progressive scarring in pulmonary fibrosis and is partially mediated by Toll-like receptor 4 activation

(2019) Kelly M Hanson et al.   TOXICOLOGICAL SCIENCES

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

(2019) Nona Farbehi et al.   eLife

Hypoxia inducible factor‐1 promotes liver fibrosis in nonalcoholic fatty liver disease by activating PTEN/p65 signaling pathway

(2019) Jie Han et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pericytes and Neurovascular Function in the Healthy and Diseased Brain

(2019) Lachlan S. Brown et al.   Frontiers in Cellular Neuroscience

Nintedanib in Progressive Fibrosing Interstitial Lung Diseases

(2019) Kevin R. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Capillary‐Resident EphA7 + Pericytes Are Multipotent Cells with Anti‐Ischemic Effects Through Capillary Formation

(2019) Yuri Yoshida et al.   Stem Cells Translational Medicine

Pirfenidone in patients with unclassifiable progressive fibrosing interstitial lung disease: a double-blind, randomised, placebo-controlled, phase 2 trial

(2019) Toby M Maher et al.   Lancet Respiratory Medicine

CX3CR1 Mediates the Development of Monocyte-Derived Dendritic Cells during Hepatic Inflammation

(2019) Salvatore Sutti et al.   Cells

Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice

(2019) Zhuzhen Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells

(2019) Tomomi Ichikawa et al.   NATURE IMMUNOLOGY

Shared and distinct mechanisms of fibrosis

(2019) Jörg H. W. Distler et al.   Nature Reviews Rheumatology

Endothelium-mediated contributions to fibrosis

(2019) Xuetao Sun et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

ROS directly activates transforming growth factor β type 1 receptor signalling in human vascular smooth muscle cells

(2019) Raafat Mohamed et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cell death mechanisms in eukaryotes

(2019) J. Grace Nirmala et al.   CELL BIOLOGY AND TOXICOLOGY

Unravelling fibrosis using single-cell transcriptomics

(2019) Ross Dobie et al.   CURRENT OPINION IN PHARMACOLOGY

Morphomolecular motifs of pulmonary neoangiogenesis in interstitial lung diseases

(2019) Maximilian Ackermann et al.   EUROPEAN RESPIRATORY JOURNAL

Classical Dendritic Cells Mediate Hypertension by Promoting Renal Oxidative Stress and Fluid Retention

(2019) Xiaohan Lu et al.   HYPERTENSION

Skin barrier immunity and ageing

(2019) Emma S. Chambers et al.   IMMUNOLOGY

Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

(2018) Oliver Krenkel et al.   HEPATOLOGY

A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis

(2018) Scott L. Friedman et al.   HEPATOLOGY

Extracellular matrix remodeling and cardiac fibrosis

(2018) Li Li et al.   MATRIX BIOLOGY

Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications

(2018) Ralf Weiskirchen et al.   MOLECULAR ASPECTS OF MEDICINE

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Effects of pirfenidone in acute and sub-chronic liver fibrosis, and an initiation-promotion cancer model in the mouse

(2018) Oleksii Seniutkin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Machine perfusion for liver transplantation in the era of marginal organs-New kids on the block

(2018) Zoltan Czigany et al.   LIVER INTERNATIONAL

A randomized trial of normothermic preservation in liver transplantation

(2018) David Nasralla et al.   NATURE

Myocardial fibrosis: biomedical research from bench to bedside

(2017) Mariann Gyöngyösi et al.   EUROPEAN JOURNAL OF HEART FAILURE

Th1 effector T cells selectively orchestrate cardiac fibrosis in nonischemic heart failure

(2017) Tania Nevers et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antioxidants and NOX1/NOX4 inhibition blocks TGFβ1-induced CCN2 and α-SMA expression in dermal and gingival fibroblasts

(2017) Hannah Murphy-Marshman et al.   PLoS One

Regeneration of fat cells from myofibroblasts during wound healing

(2017) Maksim V. Plikus et al.   SCIENCE

A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis

(2017) Jaclyn N. Taroni et al.   Genome Medicine

Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance

(2017) Giang T. Nguyen et al.   Frontiers in Cellular and Infection Microbiology

TGF-β Tumor Suppression through a Lethal EMT

(2016) Charles J. David et al.   CELL

Epithelial-mesenchymal transition in tissue repair and fibrosis

(2016) Rivka C. Stone et al.   CELL AND TISSUE RESEARCH

The origin of renal fibroblasts/myofibroblasts and the signals that trigger fibrosis

(2016) Yu Bo Yang Sun et al.   DIFFERENTIATION

Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis

(2016) Richard L. Gieseck et al.   IMMUNITY

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

Persistence of cirrhosis is maintained by intrahepatic regulatory T cells that inhibit fibrosis resolution by regulating the balance of tissue inhibitors of metalloproteinases and matrix metalloproteinases

(2016) Xiaohui Zhang et al.   Translational Research

Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis

(2016) Eric Lefebvre et al.   PLoS One

A Pneumocyte–Macrophage Paracrine Lipid Axis Drives the Lung toward Fibrosis

(2015) Freddy Romero et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Immunosurveillance of the Liver by Intravascular Effector CD8 + T Cells

(2015) Luca G. Guidotti et al.   CELL

A Hypoxia-Induced Vascular Endothelial-to-Mesenchymal Transition in Development of Radiation-Induced Pulmonary Fibrosis

(2015) S.-H. Choi et al.   CLINICAL CANCER RESEARCH

CX3CR1-expressing inflammatory dendritic cells contribute to the progression of steatohepatitis

(2015) Salvatore Sutti et al.   CLINICAL SCIENCE

Liver sinusoidal endothelial cells in hepatic fibrosis

(2015) Laurie D. DeLeve   HEPATOLOGY

Progenitor Cells, Bone Marrow–Derived Fibrocytes and Endothelial-to-Mesenchymal Transition

(2015) Francisco J. Rios et al.   HYPERTENSION

Reversibility of liver fibrosis

(2015) Mengxi Sun et al.   Clinics and Research in Hepatology and Gastroenterology

The Fibroblast Growth Factor signaling pathway

(2015) David M. Ornitz et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Myofibroblasts in Murine Cutaneous Fibrosis Originate From Adiponectin-Positive Intradermal Progenitors

(2015) Roberta Goncalves Marangoni et al.   Arthritis & Rheumatology

Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis

(2015) Rui-Ming Liu et al.   Redox Biology

Hypoxia-induced Deoxycytidine Kinase Contributes to Epithelial Proliferation in Pulmonary Fibrosis

(2014) Tingting Weng et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Treatment with pirfenidone for two years decreases fibrosis, cytokine levels and enhances CB2 gene expression in patients with chronic hepatitis C

(2014) Lucia Flores-Contreras et al.   BMC GASTROENTEROLOGY

Endothelial dysfunction in systemic sclerosis

(2014) Nezam Altorok et al.   CURRENT OPINION IN RHEUMATOLOGY

Vascular Endothelial Growth Factor Promotes Fibrosis Resolution and Repair in Mice

(2014) Liu Yang et al.   GASTROENTEROLOGY

CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis

(2014) Josef Ehling et al.   GUT

Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C+macrophage infiltration in mice

(2014) Christer Baeck et al.   HEPATOLOGY

Curtailing Endothelial TGF-  Signaling Is Sufficient to Reduce Endothelial-Mesenchymal Transition and Fibrosis in CKD

(2014) S. Xavier et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

(2014) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

TGF-  Signaling Mediates Endothelial-to-Mesenchymal Transition (EndMT) During Vein Graft Remodeling

(2014) B. C. Cooley et al.   Science Translational Medicine

Vascular endothelial growth factor aggravates fibrosis and vasculopathy in experimental models of systemic sclerosis

(2013) Britta Maurer et al.   ANNALS OF THE RHEUMATIC DISEASES

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease

(2013) Tingting Weng et al.   FASEB JOURNAL

Apoptosis and angiogenesis: an evolving mechanism for fibrosis

(2013) Ariel Johnson et al.   FASEB JOURNAL

BMP-7 counteracting TGF-beta1 activities in organ fibrosis

(2013) Ralf Weiskirchen   Frontiers in Bioscience-Landmark

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype

(2013) Chris J. Watson et al.   HUMAN MOLECULAR GENETICS

Inactivation of tumor-specific CD8+ CTLs by tumor-infiltrating tolerogenic dendritic cells

(2013) Hirotomo Harimoto et al.   IMMUNOLOGY AND CELL BIOLOGY

MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis

(2013) S. A. Gharib et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury

(2013) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immature, Semi-Mature, and Fully Mature Dendritic Cells: Toward a DC-Cancer Cells Interface That Augments Anticancer Immunity

(2013) Aleksandra M. Dudek et al.   Frontiers in Immunology

Differential expression of junctional adhesion molecules in different stages of systemic sclerosis

(2012) Mirko Manetti et al.   ARTHRITIS AND RHEUMATISM

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

(2012) Fanli Meng et al.   GASTROENTEROLOGY

CD11b+Gr1+bone marrow cells ameliorate liver fibrosis by producing interleukin-10 in mice

(2012) Yang-Gun Suh et al.   HEPATOLOGY

Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion

(2012) Shrikant R. Mulay et al.   JOURNAL OF CLINICAL INVESTIGATION

Dendritic Cell-Specific Disruption of TGF-  Receptor II Leads to Altered Regulatory T Cell Phenotype and Spontaneous Multiorgan Autoimmunity

(2012) R. Ramalingam et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Significance of the Balance between Regulatory T (Treg) and T Helper 17 (Th17) Cells during Hepatitis B Virus Related Liver Fibrosis

(2012) Jing Li et al.   PLoS One

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Differentiation of Liver Sinusoidal Endothelial Cells in Progression and Regression of Hepatic Fibrosis in Rats

(2011) Guanhua Xie et al.   GASTROENTEROLOGY

Diverse roles of TGF-β receptor II in renal fibrosis and inflammation in vivo and in vitro

(2011) Xiao-Ming Meng et al.   JOURNAL OF PATHOLOGY

Kidney Dendritic Cells Induce Innate Immunity against Bacterial Pyelonephritis

(2011) A. P. Tittel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Analysis of machine perfusion benefits in kidney grafts: a preclinical study

(2011) Nader Vaziri et al.   Journal of Translational Medicine

Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials

(2011) Paul W Noble et al.   LANCET

A CommonMUC5BPromoter Polymorphism and Pulmonary Fibrosis

(2011) Max A. Seibold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pirfenidone mitigates left ventricular fibrosis and dysfunction after myocardial infarction and reduces arrhythmias

(2010) Duy T. Nguyen et al.   HEART RHYTHM

Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype

(2010) Susan K Mathai et al.   LABORATORY INVESTIGATION

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Endothelin-1 and Transforming Growth Factor-β1 Independently Induce Fibroblast Resistance to Apoptosis via AKT Activation

(2009) Priya Kulasekaran et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

Platelet-Derived Growth Factor Signaling Through Ephrin-B2 Regulates Hepatic Vascular Structure and Function

(2008) David Semela et al.   GASTROENTEROLOGY

Clinical Significance of Serum HMGB-1 and sRAGE Levels in Systemic Sclerosis: Association with Disease Severity

(2008) Ayumi Yoshizaki et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation

(2008) D. D. Shao et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation

(2007) Anna R. Hemnes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY