Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

Endothelial to Mesenchymal Transition in Cardiovascular Disease

(2019) Jason C. Kovacic et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Single-Cell Transcriptome Analyses Reveal Endothelial Cell Heterogeneity in Tumors and Changes following Antiangiogenic Treatment

(2018) Qi Zhao et al.   CANCER RESEARCH

Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration

(2018) Tamer M.A. Mohamed et al.   CELL

Single-Cell Sequencing of the Healthy and Diseased Heart Reveals Cytoskeleton-Associated Protein 4 as a New Modulator of Fibroblasts Activation

(2018) Monika M. Gladka et al.   CIRCULATION

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

(2018) Xing Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Resident fibroblast expansion during cardiac growth and remodeling

(2018) Malina J. Ivey et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Multi-ethnic genome-wide association study for atrial fibrillation

(2018) Carolina Roselli et al.   NATURE GENETICS

The human heart contains distinct macrophage subsets with divergent origins and functions

(2018) Geetika Bajpai et al.   NATURE MEDICINE

Iterative random forests to discover predictive and stable high-order interactions

(2018) Sumanta Basu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDGFRα+pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo

(2018) Gediminas Greicius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart

(2018) Daniel A. Skelly et al.   Cell Reports

Single-nucleus transcriptomic survey of cell diversity and functional maturation in postnatal mammalian hearts

(2018) Peng Hu et al.   GENES & DEVELOPMENT

Erythro-myeloid progenitors contribute endothelial cells to blood vessels

(2018) Alice Plein et al.   NATURE

The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration

(2018) Jun Wang et al.   Nature Reviews Cardiology

The Macrophage in Cardiac Homeostasis and Disease

(2018) Kory J. Lavine et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Macrophage Biology, Classification, and Phenotype in Cardiovascular Disease

(2018) Jesse W. Williams et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction

(2018) Sarah A. Dick et al.   NATURE IMMUNOLOGY

Preexisting endothelial cells mediate cardiac neovascularization after injury

(2017) Lingjuan He et al.   JOURNAL OF CLINICAL INVESTIGATION

C1q: A fresh look upon an old molecule

(2017) Nicole M. Thielens et al.   MOLECULAR IMMUNOLOGY

IL11 is a crucial determinant of cardiovascular fibrosis

(2017) Sebastian Schafer et al.   NATURE

Scaling single-cell genomics from phenomenology to mechanism

(2017) Amos Tanay et al.   NATURE

Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration

(2017) Michaela Patterson et al.   NATURE GENETICS

IRF3 and type I interferons fuel a fatal response to myocardial infarction

(2017) Kevin R King et al.   NATURE MEDICINE

Redefining the identity of cardiac fibroblasts

(2017) Michelle D. Tallquist et al.   Nature Reviews Cardiology

WNT Signaling in Cardiac and Vascular Disease

(2017) Sébastien Foulquier et al.   PHARMACOLOGICAL REVIEWS

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

On the value of therapeutic interventions targeting the complement system in acute myocardial infarction

(2017) Reindert W. Emmens et al.   Translational Research

Massively parallel digital transcriptional profiling of single cells

(2017) Grace X. Y. Zheng et al.   Nature Communications

Reciprocal analyses in zebrafish and medaka reveal that harnessing the immune response promotes cardiac regeneration

(2017) Shih-Lei Lai et al.   eLife

Loss of Macrophage Wnt Secretion Improves Remodeling and Function After Myocardial Infarction in Mice

(2017) Dahlia Palevski et al.   Journal of the American Heart Association

The transcription factor scleraxis is a critical regulator of cardiac fibroblast phenotype

(2016) Rushita A. Bagchi et al.   BMC BIOLOGY

In Vivo Cellular Reprogramming: The Next Generation

(2016) Deepak Srivastava et al.   CELL

Defining the Cardiac Fibroblast

(2016) Malina J. Ivey et al.   CIRCULATION JOURNAL

Abandoning M1/M2 for a Network Model of Macrophage Function

(2016) Matthias Nahrendorf et al.   CIRCULATION RESEARCH

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

Primitive Embryonic Macrophages are Required for Coronary Development and MaturationNovelty and Significance

(2016) Jamison Leid et al.   CIRCULATION RESEARCH

Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis

(2016) Dongtak Jeong et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease

(2016) Robert G. Gourdie et al.   NATURE REVIEWS DRUG DISCOVERY

PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements

(2016) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Genetic lineage tracing defines myofibroblast origin and function in the injured heart

(2016) Onur Kanisicak et al.   Nature Communications

Monocyte and Macrophage Plasticity in Tissue Repair and Regeneration

(2015) Amitava Das et al.   AMERICAN JOURNAL OF PATHOLOGY

destiny: diffusion maps for large-scale single-cell data in R

(2015) Philipp Angerer et al.   BIOINFORMATICS

Mesenchymal Cell Contributions to the Stem Cell Niche

(2015) Youmna Kfoury et al.   Cell Stem Cell

Revisiting Cardiac Cellular CompositionNovelty and Significance

(2015) Alexander R. Pinto et al.   CIRCULATION RESEARCH

Loss of Secreted Frizzled-Related Protein-1 Leads to Deterioration of Cardiac Function in Mice and Plays a Role in Human Cardiomyopathy

(2015) P. Sklepkiewicz et al.   Circulation-Heart Failure

Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration

(2015) Ahmed I. Mahmoud et al.   DEVELOPMENTAL CELL

ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

(2015) Gabriele D’Uva et al.   NATURE CELL BIOLOGY

Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth

(2015) Sherine Ensan et al.   NATURE IMMUNOLOGY

A draft network of ligand–receptor-mediated multicellular signalling in human

(2015) Jordan A. Ramilowski et al.   Nature Communications

PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium

(2015) Michela Noseda et al.   Nature Communications

Novel Markers to Delineate Murine M1 and M2 Macrophages

(2015) Kyle A. Jablonski et al.   PLoS One

WIF1 can effectively co-regulate pro-apoptotic activity through the combination with DKK1

(2014) Young Bok Ko et al.   CELLULAR SIGNALLING

Ly-6C high Monocytes Depend on Nr4a1 to Balance Both Inflammatory and Reparative Phases in the Infarcted Myocardium

(2014) Ingo Hilgendorf et al.   CIRCULATION RESEARCH

Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction

(2014) Timo Heidt et al.   CIRCULATION RESEARCH

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Macrophages are required for neonatal heart regeneration

(2014) Arin B. Aurora et al.   JOURNAL OF CLINICAL INVESTIGATION

Resident fibroblast lineages mediate pressure overload–induced cardiac fibrosis

(2014) Thomas Moore-Morris et al.   JOURNAL OF CLINICAL INVESTIGATION

Progressive replacement of embryo-derived cardiac macrophages with age

(2014) Kaaweh Molawi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mesenchymal–endothelial transition contributes to cardiac neovascularization

(2014) Eric Ubil et al.   NATURE

LocTree3 prediction of localization

(2014) Tatyana Goldberg et al.   NUCLEIC ACIDS RESEARCH

Fibromodulin-Deficiency Alters Temporospatial Expression Patterns of Transforming Growth Factor-β Ligands and Receptors during Adult Mouse Skin Wound Healing

(2014) Zhong Zheng et al.   PLoS One

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart

(2014) Kory J. Lavine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Connective tissue cells, but not muscle cells, are involved in establishing the proximo-distal outcome of limb regeneration in the axolotl

(2013) E. Nacu et al.   DEVELOPMENT

Interferon Induced IFIT Family Genes in Host Antiviral Defense

(2013) Xiang Zhou et al.   International Journal of Biological Sciences

Circulating and tissue resident endothelial progenitor cells

(2013) David P. Basile et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Fibroblasts in myocardial infarction: A role in inflammation and repair

(2013) Arti V. Shinde et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Clonal precursor of bone, cartilage, and hematopoietic niche stromal cells

(2013) C. K. F. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WIF1 causes dysfunction of heart in transgenic mice

(2013) Dan Lu et al.   TRANSGENIC RESEARCH

Data exploration, quality control and testing in single-cell qPCR-based gene expression experiments

(2012) Andrew McDavid et al.   BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Thrombospondin-4 regulates fibrosis and remodeling of the myocardium in response to pressure overload

(2012) Ella G. Frolova et al.   FASEB JOURNAL

Characterization of a Wnt-binding site of the WIF-domain of Wnt inhibitory factor-1

(2012) László Bányai et al.   FEBS LETTERS

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin

(2011) James J.H. Chong et al.   Cell Stem Cell

The Wnt antagonist Wif-1 interacts with CTGF and inhibits CTGF activity

(2011) Cordula Surmann-Schmitt et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Adult mouse epicardium modulates myocardial injury by secreting paracrine factors

(2011) Bin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Revealing New Mouse Epicardial Cell Markers through Transcriptomics

(2010) Lars Bochmann et al.   PLoS One

Blockade of Wnt Signaling Inhibits Angiogenesis and Tumor Growth in Hepatocellular Carcinoma

(2009) J. Hu et al.   CANCER RESEARCH

Neurovascular Congruence during Cerebral Cortical Development

(2009) Daniel Stubbs et al.   CEREBRAL CORTEX