Article
Medicine, General & Internal
Rebecca Panconesi, Mauricio Flores Carvalho, Janina Eden, Marilena Fazi, Fariha Ansari, Leandro Mancina, Nadia Navari, Richard Xavier Sousa Da Silva, Daniele Dondossola, Lucia Bautista Borrego, Matthias Pietzke, Adriano Peris, David Meierhofer, Paolo Muiesan, Alexander Galkin, Fabio Marra, Philipp Dutkowski, Andrea Schlegel
Summary: This study investigated the effects of NRP and HOPE on DCD liver transplantation using an animal model. The results showed that HOPE can reduce mitochondrial injury and inflammation, and improve post-transplant survival.
Article
Surgery
Zoltan Czigany, Johann Pratschke, Jiri Fronek, Markus Guba, Wenzel Schoening, Dimitri Aristotle Raptis, Joachim Andrassy, Matthijs Kramer, Pavel Strnad, Rene Hany Tolba, Wenjia Liu, Theresa Keller, Hannah Miller, Sandra Pavicevic, Deniz Uluk, Matej Kocik, Isabella Lurje, Christian Trautwein, Arianeb Mehrabi, Irinel Popescu, Florian Wolfgang Rudolf Vondran, Cynthia Ju, Frank Tacke, Ulf Peter Neumann, Georg Lurje
Summary: This study demonstrates that HOPE significantly reduces early allograft injury and improves post-transplant outcomes in ECD-DBD liver transplantation compared to SCS.
Article
Biochemistry & Molecular Biology
Anna Radajewska, Jakub Szyller, Anna Krzywonos-Zawadzka, Agnieszka Olejnik, Grzegorz Sawicki, Iwona Bil-Lula
Summary: Transplanted organs are exposed to harmful conditions before and after surgery. Adding the antioxidant MitoQ to the hypothermic machine perfusion system can mitigate kidney injury and improve transplantation success rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Federica Rigo, Nicola De Stefano, Damiano Patrono, Victor De Donato, Ludovico Campi, Diana Turturica, Teresa Doria, Veronica Sciannameo, Paola Berchialla, Francesco Tandoi, Renato Romagnoli
Summary: The study aimed to investigate the impact of dual-hypothermic oxygenated machine perfusion (D-HOPE) on hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). The results showed that D-HOPE did not reduce HCC recurrence but allowed the use of extended criteria donor livers, with comparable postoperative outcomes to static cold storage (SCS).
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Immunology
Laura W. D. Knijff, Cees van Kooten, Rutger J. Ploeg
Summary: Hypothermic machine perfusion (HMP) is the new gold standard for clinical kidney preservation and a promising strategy for higher risk donor livers. HMP has been shown to decrease the risk of delayed graft function (DGF) and improve graft survival in kidney transplantation. HMP prior to liver transplantation may reduce the chance of early allograft dysfunction (EAD) and reduce ischemic damage in the biliary tract.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Njikem Asong-Fontem, Arnau Panisello-Rosello, Mylene Sebagh, Mathilde Gonin, Joan Rosello-Catafau, Rene Adam
Summary: The scarcity of livers for transplantation is a growing concern and researchers are exploring new strategies to expand the donor pool. A study found that IGL-2 preservation solution demonstrated a protective role for fatty livers by preserving endothelial glycocalyx, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Wen Hou, Shuang Yang, Jiansen Lu, Yuan Shi, Jing Chen, Decheng Chen, Fei Wang, Lei Liu
Summary: In this study, a stable intestinal hypothermic machine perfusion (HMP) system was established and it was found that HMP could significantly alleviate intestinal ischemia-reperfusion injury (IRI) and improve the outcome after intestinal transplantation (IT).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Leonie van Leeuwen, Leonie H. Venema, Raphael Heilig, Henri G. D. Leuvenink, Benedikt M. Kessler
Summary: This study investigated the effects of doxycycline on protein degradation and the urinary proteome during hypothermic machine perfusion (HMP). The results showed that doxycycline altered protein degradation during HMP, indicating its protective effects. The study also revealed metabolic and complement coagulation pathway alterations during machine perfusion, which could be targeted to attenuate ischemia-reperfusion injury (IRI).
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Medicine, General & Internal
Fabian Horne, Moritz Drefs, Malte Joachim Schirren, Dominik Thomas Koch, Ganildo Cepele, Severin Johannes Jacobi, Elnaz Payani, Nikolaus Boerner, Jens Werner, Markus Otto Guba, Dionysios Koliogiannis
Summary: The study demonstrates that pre-transplant graft preconditioning with HOPE can reduce the incidence of PRS and EAD in liver transplantation, as well as improve hemodynamic stability. HOPE can also mitigate ES and prevent hyperpotassemic complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Guillaume Rossignol, Xavier Muller, Valerie Hervieu, Sophie Collardeau-Frachon, Antoine Breton, Natacha Boulanger, Mickael Lesurtel, Remi Dubois, Kayvan Mohkam, Jean-Yves Mabrut
Summary: This single-center pilot study presents feasibility and safety data for transplantation of partial liver grafts undergoing ex situ split during HOPE, suggesting improved preservation compared with static ex situ splitting.
LIVER TRANSPLANTATION
(2022)
Article
Biology
Teresa Rampino, Marilena Gregorini, Giuliana Germinario, Eleonora Francesca Pattonieri, Fulvia Erasmi, Maria Antonietta Grignano, Stefano Bruno, Esra Alomari, Stefano Bettati, Annalia Asti, Marina Ramus, Mara De Amici, Giorgia Testa, Stefania Bruno, Gabriele Ceccarelli, Nicoletta Serpieri, Carmelo Libetta, Vincenzo Sepe, Flavia Blasevich, Federica Odaldi, Lorenzo Maroni, Francesco Vasuri, Gaetano La Manna, Matteo Ravaioli
Summary: This study explores the use of hypothermic oxygenated perfusion (HOPE) combined with extracellular vesicles (EV) derived from mesenchymal stromal cells as a new strategy for organ preservation. The results show that EV delivery during HOPE can effectively reduce ischemic damage, prevent reoxygenation-dependent injury, and improve transplant outcomes. This study is significant in increasing the donor pool and improving transplantation success.
Article
Biochemistry & Molecular Biology
Karol Tejchman, Anita Sierocka, Katarzyna Kotfis, Maciej Kotowski, Barbara Dolegowska, Marek Ostrowski, Jerzy Sienko
Summary: Ischemia-reperfusion injury (IRI) after renal transplantation is a complex biochemical process involving numerous enzymes and non-enzymatic compounds in antioxidant defense mechanisms. Two different kidney storage methods were found to lead to distinct biochemical changes, while the correlation with recipient gender, preservation solution, and perfusate pH was inconclusive.
Article
Cell Biology
Wei Zhou, Zibiao Zhong, Danni Lin, Zhongzhong Liu, Qiuyan Zhang, Haoyang Xia, Sheng Peng, Anxiong Liu, Zhongshan Lu, Yanfeng Wang, Shaojun Ye, Qifa Ye
Summary: Ischemia-reperfusion injury (IRI) is a serious issue in donations after heart death (DCD) liver transplantation, and hypothermic oxygenated perfusion (HOPE) has been shown to reduce liver IRI by regulating inflammation. HOPE can protect against DCD liver transplantation-induced-liver IRI by reducing inflammation via HECTD3-mediated TRAF3 K63-linked polyubiquitination.
CELL DEATH & DISEASE
(2021)
Article
Surgery
Rahel K. Wyss, Natalia Mendez Carmona, Maria Arnold, Adrian Segiser, Matteo Mueller, Philipp Dutkowski, Thierry P. Carrel, Sarah L. Longnus
Summary: The study investigated a new method for heart transplants used in DCD, called HOPE, which provides improved cardioprotection by reducing cardiac succinate levels, alleviating graft injury.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Medicine, General & Internal
Jeannette Widmer, Janina Eden, Mauricio Flores Carvalho, Philipp Dutkowski, Andrea Schlegel
Summary: The renaissance of dynamic preservation techniques has brought extended criteria donor (ECD) livers back into the transplantable organ pool. However, there is ongoing debate about the advantages and disadvantages of different perfusion strategies and their best applications for specific categories of marginal livers.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Eva Maria Dobrindt, Robert Oellinger, Anne Floercken, Sven Maerdian, Moritz Schmelzle, Georg Lurje, Johann Pratschke, Wenzel Schoening
ZENTRALBLATT FUR CHIRURGIE
(2023)
Review
Gastroenterology & Hepatology
Daniel Q. Huang, Norah A. Terrault, Frank Tacke, Lise Lotte Gluud, Marco Arrese, Elisabetta Bugianesi, Rohit Loomba
Summary: Cirrhosis is a major cause of morbidity and mortality in people with chronic liver disease globally. The epidemiology and burden of cirrhosis are changing due to factors such as obesity, alcohol consumption, and improved management of viral hepatitis. This review highlights global trends in cirrhosis epidemiology, the contributions of various liver diseases, and suggests ways to tackle the increasing burden of cirrhosis.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Oncology
Jana K. Striefler, Phung T. Binder, Franziska Brandes, Daniel Rau, Silvan Wittenberg, David Kaul, Siyer Roohani, Armin Jarosch, Frederik M. Schaefer, Robert Oellinger, Sven Maerdian, Lars Bullinger, Kai -Uwe Eckardt, Jan Kruse, Anne Floercken
Summary: This study retrospectively analyzed sarcoma patients admitted to the ICU from 2005 to 2022. Sex, tumor localization, therapeutic intention, line of chemotherapy, SAPS II score, and SOFA score significantly impacted overall survival. The study confirms the predictive relevance of established sepsis and performance scores in sarcoma patients.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Christopher Dietz-Fricke, Frank Tacke, Caroline Zollner, Munevver Demir, Hartmut H. Schmidt, Christoph Schramm, Katharina Willuweit, Christian M. Lange, Sabine Weber, Gerald Denk, Christoph P. Berg, Julia M. Grottenthaler, Uta Merle, Alexander Olkus, Stefan Zeuzem, Kathrin Sprinzl, Thomas Berg, Florian van Bommel, Johannes Wiegand, Toni Herta, Thomas Seufferlein, Eugen Zizer, Nektarios Dikopoulos, Robert Thimme, Christoph Neumann-Haefelin, Peter R. Galle, Martin Sprinzl, Ansgar W. Lohse, Julian Schulze zur Wiesch, Jan Kempski, Andreas Geier, Florian P. Reiter, Bernhard Schlevogt, Juliana Goediker, Wolf Peter Hofmann, Peter Buggisch, Julia Kahlhofer, Kerstin Port, Benjamin Maasoumy, Markus Cornberg, Heiner Wedemeyer, Katja Deterding
Summary: This study reported the safety and efficacy of bulevirtide in the treatment of chronic hepatitis D in a real-world setting in Germany. Among the 114 patients included, 87 cases showed virologic response and only a small proportion did not respond after 24 weeks of treatment. The treatment was well tolerated and showed signs of improvement in liver inflammation.
Article
Engineering, Biomedical
Amanda P. C. S. Boteon, Marisa R. D. Lima, Bianca Della Guardia, Mauricio F. Carvalho, Andrea Schlegel, Yuri L. Boteon
Summary: This case report highlights the use of HOPE treatment for an extended criteria donor organ, allowing for successful liver retransplantation in a complex surgical case. Further research is needed, but HOPE may have the potential to expand the donor organ pool and reduce the time constraints of transplantation surgeries.
Review
Biochemistry & Molecular Biology
Isabella Lurje, Nadine T. Gaisa, Ralf Weiskirchen, Frank Tacke
Summary: Fibrosis, a pathological scar tissue formation, can occur in various organs due to different etiologies and contributes to global morbidity and mortality. Common mechanisms involve sustained injury to parenchymal cells triggering a deregulated wound healing response. The transformation of fibroblasts into myofibroblasts with excessive extracellular matrix production is a hallmark of the disease, along with complex cellular interactions involving immune cells, endothelial cells, and parenchymal cells. Mediators such as growth factors, cytokines, and danger-associated molecular patterns play important roles in fibrosis across organs.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Linda Hammerich, Frank Tacke
Summary: This Review provides an extensive overview of the mechanisms of inflammation and fibrosis in the liver, particularly in NAFLD or NASH, and discusses the current advances and therapeutic implications. Chronic liver diseases characterized by persistent inflammation and subsequent liver fibrosis have significant impact on long-term morbidity and mortality. Inflammatory responses involve hepatic cell types and signals related to intrahepatic injury pathways, gut-liver axis, and circulation.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Janine Buettner, Elisabeth Bluethner, Sophie Greif, Anja Kuehl, Sefer Elezkurtaj, Jan Ulrich, Sebastian Maasberg, Christoph Jochum, Frank Tacke, Ulrich-Frank Pape
Summary: This study investigated biomarkers for the regulation mechanisms in the intestinal barrier during adaptive response or treatment with the glucagon-like peptide-2 analog in short bowel syndrome patients. Gene expression analyses and intestinal permeability testing were conducted. The results showed altered gene expression in nutrient transport genes and the usefulness of mannitol recovery in describing gut absorptive capacity.
Article
Gastroenterology & Hepatology
Simon Moosburner, Leke Wiering, Nathalie N. Roschke, Axel Winter, Muenevver Demir, Joseph M. G. V. Gassner, Maximilian Zimmer, Paul Ritschl, Brigitta Globke, Georg Lurje, Frank Tacke, Wenzel Schoening, Johann Pratschke, Robert Oellinger, Igor M. Sauer, Nathanael Raschzok
Summary: This study compared various clinical risk scores for the prediction of liver allograft failure after transplantation and found that the EASE score showed good predictive value for graft and patient survival. It provides significant prognostic value for patients and healthcare professionals in the Eurotransplant region.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Johannes Kolck, Timo Alexander Auer, Thula Walter-Rittel, Clarissa Hosse, Aboelyazid Elkilany, Adrian Alexander Marth, Uwe Pelzer, Raphael Mohr, Felix Krenzien, Georg Lurje, Wenzel Schoening, Bernd Hamm, Dominik Geisel, Uli Fehrenbach
Summary: This study aimed to develop a predictive model for lymph node metastasis (LNM) in patients with intrahepatic cholangiocarcinoma (iCC) using computed tomography (CT) features. The study found that an LN short axis diameter of ≥ 9 mm had the highest predictive power for LNM. Additionally, the presence of intrahepatic metastasis, hilar tumor infiltration, and tumor growth along the liver capsule were identified as significant imaging features in the predictive model.
ABDOMINAL RADIOLOGY
(2023)
Article
Surgery
Sebastian Knitter, Linda Feldbruegge, Nora Nevermann, Brigitta Globke, Santiago Andres Ortiz Galindo, Thomas Winklmann, Felix Krenzien, Philipp K. Haber, Thomas Malinka, Georg Lurje, Wenzel Schoening, Johann Pratschke, Moritz Schmelzle
Summary: The cost-effectiveness of robotic liver surgery (RS), laparoscopic surgery (LS), and open surgery (OS) for major hepatectomies was evaluated in this study. It was found that RS and LS had comparable costs, but were higher than OS, mainly due to higher intraoperative costs. The length of procedure, length of stay, and development of major complications were independently associated with higher costs.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Nutrition & Dietetics
Elisabeth Bluethner, Ulrich-Frank Pape, Frank Tacke, Sophie Greif
Summary: This study aims to analyze the changes in quality of life (QoL) of teduglutide-treated patients with chronic intestinal failure (cIF) and compare them to a non-treated cIF control group. The results show significant improvements in SBS-QoL and SF-36 scores in teduglutide-treated patients compared to the non-treated group in a real-world setting. There are also significant differences in QoL changes between the treated and non-treated patients.
Meeting Abstract
Gastroenterology & Hepatology
Malin Fromme, Carolin V. Schneider, Nurdan Gueldiken, Samira Amzou, Yizhao Luo, Monica Pons, Joan Genesca, Marc Miravitlles, Katrine Thorhauge, Johan Waern, Jan Sperl, Sona Frankova, Marc Bartel, Holger Zimmer, Markus Zorn, Aleksander Krag, Alice Turner, Christian Trautwein, Pavel Strnad
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Igor Spivak, Nurdan Gueldiken, Valentyn Usachov, Lei Fu, Fa-Rong Mo, Gokce Kobazi Ensari, Franziska Hufnagel, Malin Fromme, Christian Preisinger, Pavel Strnad
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Ines Volkert, Malin Fromme, Huan Su, Nurdan Gueldiken, Ramadan Mohamed Mohamed, Cecilia Lindhauer, Pavel Strnad, Christian Trautwein
JOURNAL OF HEPATOLOGY
(2023)