Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities

Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets

(2020) Carsten Deppermann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epidemiology and surveillance for hepatocellular carcinoma: New trends

(2020) Amit G. Singal et al.   JOURNAL OF HEPATOLOGY

Selonsertib for Patients with Bridging Fibrosis or Compensated Cirrhosis Due to NASH: Results from Randomized Ph III STELLAR Trials

(2020) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Targeting of Hepatic Macrophages by Therapeutic Nanoparticles

(2020) Clara I. Colino et al.   Frontiers in Immunology

Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease

(2020) Young-Ri Shim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Intestinal microbiome‐macrophage crosstalk contributes to cholestatic liver disease by promoting intestinal permeability

(2020) Anna Isaacs‐Ten et al.   HEPATOLOGY

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis

(2020) Jason S. Seidman et al.   IMMUNITY

Deciphering human macrophage development at single-cell resolution

(2020) Zhilei Bian et al.   NATURE

Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis

(2020) Prakash Ramachandran et al.   Nature Reviews Gastroenterology & Hepatology

LC3-associated phagocytosis protects against inflammation and liver fibrosis via immunoreceptor inhibitory signaling

(2020) JingHong Wan et al.   Science Translational Medicine

Blocking GSDMD processing in innate immune cells but not in hepatocytes protects hepatic ischemia–reperfusion injury

(2020) Jichang Li et al.   Cell Death & Disease

The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis

(2020) Tobias Puengel et al.   Journal of Clinical Medicine

Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human

(2020) Juanjuan Zhao et al.   Cell Discovery

Current and emerging pharmacotherapeutic interventions for the treatment of liver fibrosis

(2020) Joeri Lambrecht et al.   EXPERT OPINION ON PHARMACOTHERAPY

M2 macrophage‐derived exosomes facilitate hepatocarcinoma metastasis by transferring α M β 2 integrin to tumor cells

(2020) Jindao Wu et al.   HEPATOLOGY

Mice Lacking the Purinergic Receptor P2X5 Exhibit Defective Inflammasome Activation and Early Susceptibility to Listeria monocytogenes

(2020) Yun Hee Jeong et al.   JOURNAL OF IMMUNOLOGY

Modulation of calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation

(2019) Amina A. Negash et al.   PLoS Pathogens

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

(2019) Wenting Yang et al.   Nature Communications

Blocking TREM-1+ Tumor-associated macrophages induced by hypoxia reverses immunosuppression and anti-PD-L1 resistance in liver cancer

(2019) Qinchuan Wu et al.   HEPATOLOGY

MRP14 enhances the ability of macrophage to recruit T cells and promotes obesity-induced insulin resistance

(2019) Chang Xia et al.   INTERNATIONAL JOURNAL OF OBESITY

Bone marrow‐derived macrophage contributes to fibrosing steatohepatitis through activating hepatic stellate cells

(2019) Juqiang Han et al.   JOURNAL OF PATHOLOGY

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

(2019) Mohsen Malehmir et al.   NATURE MEDICINE

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

Unveiling the depletion of Kupffer cells in experimental hepatocarcinogenesis through liver macrophage subtype-specific markers

(2019) Sander Lefere et al.   JOURNAL OF HEPATOLOGY

Macrophages as a Cell-Based Therapy for Liver Disease

(2019) Philip J. Starkey Lewis et al.   SEMINARS IN LIVER DISEASE

The unexpected role of neutrophils for resolving liver inflammation by transmitting microRNA-223 to macrophages

(2019) Adrien Guillot et al.   HEPATOLOGY

Hypoxia‐Inducible Factor (HIF)‐2α Reprograms Liver Macrophages to Protect Against Acute Liver Injury via the Production of Interleukin‐6

(2019) Rachel Y. Gao et al.   HEPATOLOGY

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

(2019) Johnny Bonnardel et al.   IMMUNITY

Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities

(2019) Chen Lu et al.   Molecular Cancer

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

(2019) Xuelian Xiong et al.   MOLECULAR CELL

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

(2019) Mashito Sakai et al.   IMMUNITY

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Safety profile of autologous macrophage therapy for liver cirrhosis

(2019) Francesca Moroni et al.   NATURE MEDICINE

Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

(2019) Bishuang Cai et al.   Cell Metabolism

Effects of Belapectin, an Inhibitor of Galectin-3, in Patients With Nonalcoholic Steatohepatitis With Cirrhosis and Portal Hypertension

(2019) Naga Chalasani et al.   GASTROENTEROLOGY

Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases

(2019) Daphne van der Heide et al.   Frontiers in Immunology

Anti-NASH Drug Development Hitches a Lift on PPAR Agonism

(2019) Joost Boeckmans et al.   Cells

α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis

(2018) Bas G.J. Surewaard et al.   Cell Host & Microbe

Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90

(2018) Banishree Saha et al.   HEPATOLOGY

Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

(2018) Oliver Krenkel et al.   HEPATOLOGY

A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis

(2018) Scott L. Friedman et al.   HEPATOLOGY

Kupffer-derived matrix metalloproteinase-9 contributes to liver fibrosis resolution

(2018) Min Feng et al.   International Journal of Biological Sciences

The role of Kupffer cells in hepatic iron and lipid metabolism

(2018) Charlotte L. Scott et al.   JOURNAL OF HEPATOLOGY

Type I interferon receptor signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis

(2018) Katharina Borst et al.   JOURNAL OF HEPATOLOGY

Neutrophils and neutrophil extracellular traps in the liver and gastrointestinal system

(2018) Masaki Honda et al.   Nature Reviews Gastroenterology & Hepatology

Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages

(2018) Carlota Recio et al.   Frontiers in Immunology

Fatty acid activates NLRP3 inflammasomes in mouse Kupffer cells through mitochondrial DNA release

(2018) Junjiang Pan et al.   CELLULAR IMMUNOLOGY

Pharmacological inhibition of CCR2/5 signaling prevents and reverses alcohol-induced liver damage, steatosis and inflammation in mice

(2018) Aditya Ambade et al.   HEPATOLOGY

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis

(2018) Yongsheng Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Hepatic Inflammation via Macrophage Cell Death

(2018) Zhuan Li et al.   SEMINARS IN LIVER DISEASE

Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation

(2018) Tomohito Izumi et al.   Nature Communications

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

(2018) Sonya A. MacParland et al.   Nature Communications

The Role of Monocytes and Macrophages in Acute and Acute-on-Chronic Liver Failure

(2018) Evangelos Triantafyllou et al.   Frontiers in Immunology

MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure

(2017) Evangelos Triantafyllou et al.   GUT

Hepatitis C virus-induced CCL5 secretion from macrophages activates hepatic stellate cells

(2017) Reina Sasaki et al.   HEPATOLOGY

The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial

(2017) Rohit Loomba et al.   HEPATOLOGY

A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment

(2017) Frederic Sierro et al.   IMMUNITY

Targeting hepatic macrophages to treat liver diseases

(2017) Frank Tacke   JOURNAL OF HEPATOLOGY

HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production

(2017) Xin Yu et al.   JOURNAL OF HEPATOLOGY

Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure

(2017) Benjamin L. Woolbright et al.   JOURNAL OF HEPATOLOGY

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

Prolonged Ischemia Triggers Necrotic Depletion of Tissue-Resident Macrophages To Facilitate Inflammatory Immune Activation in Liver Ischemia Reperfusion Injury

(2017) Shi Yue et al.   JOURNAL OF IMMUNOLOGY

The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury

(2017) Lara Campana et al.   JOURNAL OF IMMUNOLOGY

Spleen-derived lipocalin-2 in the portal vein regulates Kupffer cells activation and attenuates the development of liver fibrosis in mice

(2017) Tomonori Aoyama et al.   LABORATORY INVESTIGATION

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis

(2017) Robert G Bennett et al.   WORLD JOURNAL OF GASTROENTEROLOGY

MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock

(2017) Muhamuda Kader et al.   PLoS Pathogens

Ly6Chi Monocytes and Their Macrophage Descendants Regulate Neutrophil Function and Clearance in Acetaminophen-Induced Liver Injury

(2017) Nadine Graubardt et al.   Frontiers in Immunology

Dynamic plasticity of macrophage functions in diseased liver

(2017) Thomas Ritz et al.   CELLULAR IMMUNOLOGY

The CCR2 Inhibitor Propagermanium Attenuates Diet-Induced Insulin Resistance, Adipose Tissue Inflammation and Non-Alcoholic Steatohepatitis

(2017) Petra Mulder et al.   PLoS One

Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice

(2016) Jihye Han et al.   Autophagy

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

(2016) Tobias Eggert et al.   CANCER CELL

A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair

(2016) Jing Wang et al.   CELL

CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria

(2016) Zhutian Zeng et al.   Cell Host & Microbe

Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies

(2016) Cynthia Ju et al.   Cellular & Molecular Immunology

Liver Fibrosis: From Pathogenesis to Novel Therapies

(2016) Ralf Weiskirchen et al.   DIGESTIVE DISEASES

Transcriptome‐based profiling of yolk sac‐derived macrophages reveals a role for Irf8 in macrophage maturation

(2016) Nora Hagemeyer et al.   EMBO JOURNAL

Galectin-3 regulates inflammasome activation in cholestatic liver injury

(2016) Jijing Tian et al.   FASEB JOURNAL

Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice

(2016) Bruna Araujo David et al.   GASTROENTEROLOGY

Platelets: No longer bystanders in liver disease

(2016) Abhishek Chauhan et al.   HEPATOLOGY

Chemokine (C-C motif) receptor 2-positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury

(2016) Jana C. Mossanen et al.   HEPATOLOGY

A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice

(2016) Mei Yee Koh et al.   HEPATOLOGY

Homegrown Macrophages

(2016) Ki-Wook Kim et al.   IMMUNITY

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions

(2016) Lynette Beattie et al.   JOURNAL OF HEPATOLOGY

IL-6 pathway in the liver: From physiopathology to therapy

(2016) Dirk Schmidt-Arras et al.   JOURNAL OF HEPATOLOGY

Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β

(2016) Ghulam Ilyas et al.   JOURNAL OF HEPATOLOGY

Characterization of the Inflammasome in Human Kupffer Cells in Response to Synthetic Agonists and Pathogens

(2016) Claudia Zannetti et al.   JOURNAL OF IMMUNOLOGY

Monocyte chemoattractant protein-1 is not required for liver regeneration after partial hepatectomy

(2016) Stephanie L. Wyler et al.   Journal of Inflammation-London

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

(2016) Chi Ma et al.   NATURE

On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

(2016) Igor Theurl et al.   NATURE MEDICINE

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells

(2016) E. L. Soucie et al.   SCIENCE

Specification of tissue-resident macrophages during organogenesis

(2016) E. Mass et al.   SCIENCE

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

(2016) Charlotte L. Scott et al.   Nature Communications

Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis

(2016) Zizhen Gong et al.   Oncotarget

Fluorescent cell-traceable dexamethasone-loaded liposomes for the treatment of inflammatory liver diseases

(2015) Matthias Bartneck et al.   BIOMATERIALS

Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer

(2015) Joan Font-Burgada et al.   CELL

Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice

(2015) Magdalena Mazagova et al.   FASEB JOURNAL

CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure

(2015) Benjamin M. Stutchfield et al.   GASTROENTEROLOGY

Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells

(2015) Yanan Wang et al.   HEPATOLOGY

Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration

(2015) Caryn L. Elsegood et al.   HEPATOLOGY

The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice

(2015) Patrice N. Mimche et al.   HEPATOLOGY

CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: Limiting steatohepatitis by maintaining intestinal homeostasis

(2015) Kai Markus Schneider et al.   HEPATOLOGY

Liver inflammation abrogates immunological tolerance induced by Kupffer cells

(2015) Felix Heymann et al.   HEPATOLOGY

Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury

(2015) Hai Huang et al.   HEPATOLOGY

Liver-Resident Macrophage Necroptosis Orchestrates Type 1 Microbicidal Inflammation and Type-2-Mediated Tissue Repair during Bacterial Infection

(2015) Camille Blériot et al.   IMMUNITY

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Defective Initiation of Liver Regeneration in Osteopontin-Deficient Mice after Partial Hepatectomy due to Insufficient Activation of IL-6/Stat3 Pathway

(2015) Yankai Wen et al.   International Journal of Biological Sciences

MicroRNA Cargo of Extracellular Vesicles from Alcohol-exposed Monocytes Signals Naive Monocytes to Differentiate into M2 Macrophages

(2015) Banishree Saha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets

(2015) Jessica R. Hitchcock et al.   JOURNAL OF CLINICAL INVESTIGATION

NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation

(2015) Jun Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+monocytes at a site of sterile injury

(2015) Daniela Dal-Secco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Monocyte-endothelial cell interactions in the regulation of vascular sprouting and liver regeneration in mouse

(2015) Pedro Melgar-Lesmes et al.   JOURNAL OF HEPATOLOGY

Inflammasome activation and function in liver disease

(2015) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

The NLRP3 Inflammasome and IL-1β Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant Hepatitis

(2015) Sheng Guo et al.   PLoS Pathogens

Mouse CD11b+Kupffer Cells Recruited from Bone Marrow Accelerate Liver Regeneration after Partial Hepatectomy

(2015) Kiyoshi Nishiyama et al.   PLoS One

M2 Kupffer Cells Promote Hepatocyte Senescence

(2014) Jinghong Wan et al.   AMERICAN JOURNAL OF PATHOLOGY

The role of neutrophils in the development of liver diseases

(2014) Ruonan Xu et al.   Cellular & Molecular Immunology

The adaptor ASC exacerbates lethalListeria monocytogenesinfection by mediating IL-18 production in an inflammasome-dependent and -independent manner

(2014) Kohsuke Tsuchiya et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion

(2014) Hyo-Yeon Kim et al.   FEBS Journal

Roles for Chemokines in Liver Disease

(2014) Fabio Marra et al.   GASTROENTEROLOGY

CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis

(2014) Josef Ehling et al.   GUT

Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C+macrophage infiltration in mice

(2014) Christer Baeck et al.   HEPATOLOGY

Maraviroc, a CCR5 antagonist, ameliorates the development of hepatic steatosis in a mouse model of non-alcoholic fatty liver disease (NAFLD)

(2014) L. Perez-Martinez et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival

(2014) Emmanuel L. Gautier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

Infiltrating Monocyte-Derived Macrophages and Resident Kupffer Cells Display Different Ontogeny and Functions in Acute Liver Injury

(2014) E. Zigmond et al.   JOURNAL OF IMMUNOLOGY

Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice

(2014) Meng Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Interaction of Kupffer Cells and Platelets Determines the Severity of Ischemia-Reperfusion Injury in Steatosis

(2014) Koichi Ogawa et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Ly6Chi Monocyte Recruitment Is Responsible for Th2 Associated Host-Protective Macrophage Accumulation in Liver Inflammation due to Schistosomiasis

(2014) Marcia Nascimento et al.   PLoS Pathogens

Ly6Chigh Monocytes Become Alternatively Activated Macrophages in Schistosome Granulomas with Help from CD4+ Cells

(2014) Natasha M. Girgis et al.   PLoS Pathogens

Role of hepatic resident and infiltrating macrophages in liver repair after acute injury

(2013) Qiang You et al.   BIOCHEMICAL PHARMACOLOGY

C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice

(2013) Po-sung Chu et al.   HEPATOLOGY

ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury

(2013) Naoko Kamo et al.   HEPATOLOGY

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury

(2013) H. Huang et al.   JOURNAL OF IMMUNOLOGY

Chemokine Receptor CXCR6-Dependent Hepatic NK T Cell Accumulation Promotes Inflammation and Liver Fibrosis

(2013) A. Wehr et al.   JOURNAL OF IMMUNOLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance

(2013) Connie H Y Wong et al.   NATURE IMMUNOLOGY

CLEC4F Is an Inducible C-Type Lectin in F4/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in Liver

(2013) Chih-Ya Yang et al.   PLoS One

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling

(2013) T. G. Bird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beyond Stem Cells: Self-Renewal of Differentiated Macrophages

(2013) M. H. Sieweke et al.   SCIENCE

IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease

(2013) Amina A. Negash et al.   PLoS Pathogens

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

(2012) Kouichi Miura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice

(2012) Rafaz Hoque et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Depletion of Kupffer cells modulates ethanol-induced hepatocyte DNA synthesis in C57Bl/6 mice

(2012) Solomon E. Owumi et al.   ENVIRONMENTAL TOXICOLOGY

CD11b+Gr1+bone marrow cells ameliorate liver fibrosis by producing interleukin-10 in mice

(2012) Yang-Gun Suh et al.   HEPATOLOGY

Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics

(2012) Evaggelia Liaskou et al.   HEPATOLOGY

Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma

(2012) Hang Li et al.   HEPATOLOGY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

(2012) Jan Petrasek et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammasomes in liver diseases

(2012) Gyongyi Szabo et al.   JOURNAL OF HEPATOLOGY

Interaction between Kupffer cells and platelets in the early period of hepatic ischemia–reperfusion injury—An in vivo study

(2012) Takafumi Tamura et al.   JOURNAL OF SURGICAL RESEARCH

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

Oval Cell Response Is Attenuated by Depletion of Liver Resident Macrophages in the 2-AAF/Partial Hepatectomy Rat

(2012) Shuai Xiang et al.   PLoS One

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced Liver Regeneration in IL-10–Deficient Mice after Partial Hepatectomy via Stimulating Inflammatory Response and Activating Hepatocyte STAT3

(2011) Shi Yin et al.   AMERICAN JOURNAL OF PATHOLOGY

Kupffer Cells Influence Parenchymal Invasion and Phenotypic Orientation, but Not the Proliferation, of Liver Progenitor Cells in a Murine Model of Liver Injury

(2011) Noémi Van Hul et al.   AMERICAN JOURNAL OF PATHOLOGY

CCR9+ Macrophages Are Required for Acute Liver Inflammation in Mouse Models of Hepatitis

(2011) Nobuhiro Nakamoto et al.   GASTROENTEROLOGY

Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury

(2011) Christer Baeck et al.   GUT

Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice

(2011) Felix Heymann et al.   HEPATOLOGY

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

(2010) Kouichi Miura et al.   GASTROENTEROLOGY

Galectin-3 ablation protects mice from diet-induced NASH: A major scavenging role for galectin-3 in liver

(2010) Carla Iacobini et al.   JOURNAL OF HEPATOLOGY

Murine Kupffer Cells Are Protective in Total Hepatic Ischemia/Reperfusion Injury with Bowel Congestion through IL-10

(2010) J. D. Ellett et al.   JOURNAL OF IMMUNOLOGY

Forkhead Box M1 Transcription Factor Is Required for Macrophage Recruitment during Liver Repair

(2010) X. Ren et al.   MOLECULAR AND CELLULAR BIOLOGY

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Inhibition of allogeneic T-cell response by Kupffer cells expressing indoleamine 2,3-dioxygenase

(2010) Mao-Lin Yan   WORLD JOURNAL OF GASTROENTEROLOGY

Kupffer Cell Suppression of CD8+ T Cells in Human Hepatocellular Carcinoma Is Mediated by B7-H1/Programmed Death-1 Interactions

(2009) K. Wu et al.   CANCER RESEARCH

Kupffer Cells Mediate Leptin-Induced Liver Fibrosis

(2009) Jianhua Wang et al.   GASTROENTEROLOGY

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

CCR2 promotes hepatic fibrosis in mice

(2009) Ekihiro Seki et al.   HEPATOLOGY

Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice

(2009) Yosuke Osawa et al.   HEPATOLOGY

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE

Mechanism of T cell tolerance induction by murine hepatic Kupffer cells

(2008) Qiang You et al.   HEPATOLOGY

High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection

(2008) Tong Ding et al.   HUMAN PATHOLOGY