Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance

Endocytosis is required for exocytosis and priming of respiratory burst activity in human neutrophils

(2017) T. Michael Creed et al.   INFLAMMATION RESEARCH

Skap2 is required for β 2 integrin–mediated neutrophil recruitment and functions

(2017) Mark Boras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Frontline Science: Tumor necrosis factor-α stimulation and priming of human neutrophil granule exocytosis

(2017) Kenneth R. McLeish et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Role of Reactive Oxygen Species in Antibiotic-Mediated Killing of Bacteria

(2017) Heleen Van Acker et al.   TRENDS IN MICROBIOLOGY

T3SS effector VopL inhibits the host ROS response, promoting the intracellular survival of Vibrio parahaemolyticus

(2017) Marcela de Souza Santos et al.   PLoS Pathogens

Lack of OxyR and KatG Results in Extreme Susceptibility of Francisella tularensis LVS to Oxidative Stress and Marked Attenuation In vivo

(2017) Marie Honn et al.   Frontiers in Cellular and Infection Microbiology

Multiple Phenotypic Changes Define Neutrophil Priming

(2017) Irina Miralda et al.   Frontiers in Cellular and Infection Microbiology

Chronic granulomatous disease: Clinical, functional, molecular, and genetic studies. The Israeli experience with 84 patients

(2016) Baruch Wolach et al.   AMERICAN JOURNAL OF HEMATOLOGY

Reactive Oxygen Species and Neutrophil Function

(2016) Christine C. Winterbourn et al.   Annual Review of Biochemistry

How did life survive Earth's great oxygenation?

(2016) Woodward W Fischer et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation

(2016) Stephanie Volmering et al.   IMMUNITY

Priming of the neutrophil respiratory burst: role in host defense and inflammation

(2016) Jamel El-Benna et al.   IMMUNOLOGICAL REVIEWS

Clinical, Immunological, and Molecular Findings of Patients with p47phox Defect Chronic Granulomatous Disease (CGD) in Indian Families

(2016) Manasi Kulkarni et al.   JOURNAL OF CLINICAL IMMUNOLOGY

cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity

(2016) Ondrej Cerny et al.   JOURNAL OF IMMUNOLOGY

PI(3)P-p40 phox binding regulates NADPH oxidase activation in mouse macrophages and magnitude of inflammatory responses in vivo

(2016) Juhi Bagaitkar et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Regulating Rho GTPases and their regulators

(2016) Richard G. Hodge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells

(2016) Daniel M. Houslay et al.   Science Signaling

Fis Is Essential for Yersinia pseudotuberculosis Virulence and Protects against Reactive Oxygen Species Produced by Phagocytic Cells during Infection

(2016) Erin R. Green et al.   PLoS Pathogens

Primary immune deficiencies with defects in neutrophil function

(2016) M. C. Dinauer   Hematology-American Society of Hematology Education Program

Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells

(2016) Daniel M. Houslay et al.   Science Signaling

Community Behavior and Spatial Regulation within a Bacterial Microcolony in Deep Tissue Sites Serves to Protect against Host Attack

(2015) Kimberly M. Davis et al.   Cell Host & Microbe

ROS-dependent signal transduction

(2015) Colleen R Reczek et al.   CURRENT OPINION IN CELL BIOLOGY

TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils

(2015) Karama Makni-Maalej et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Methodological advances: the unsung heroes of the GPCR structural revolution

(2015) Eshan Ghosh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

(2015) Philipp Kruger et al.   PLoS Pathogens

Streptolysin O Rapidly Impairs Neutrophil Oxidative Burst and Antibacterial Responses to Group A Streptococcus

(2015) Satoshi Uchiyama et al.   Frontiers in Immunology

Genetic disorders coupled to ROS deficiency

(2015) Sharon O’Neill et al.   Redox Biology

Calcium and ROS: A mutual interplay

(2015) Agnes Görlach et al.   Redox Biology

Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival

(2014) Juliana Navarro-Yepes et al.   ANTIOXIDANTS & REDOX SIGNALING

Assembly of phagocyte NADPH oxidase: A concerted binding process?

(2014) Gilda Karimi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Disparate Impact of Oxidative Host Defenses Determines the Fate of Salmonella during Systemic Infection in Mice

(2014) Neil A. Burton et al.   Cell Host & Microbe

NADPH oxidases: an overview from structure to innate immunity-associated pathologies

(2014) Arvind Panday et al.   Cellular & Molecular Immunology

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Decanucleotide insertion polymorphism of F7 significantly influences the risk of thrombosis in patients with essential thrombocythemia

(2014) Veronika Buxhofer-Ausch et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

The Iron-Sensing Fur Regulator Controls Expression Timing and Levels of Salmonella Pathogenicity Island 2 Genes in the Course of Environmental Acidification

(2014) E. Choi et al.   INFECTION AND IMMUNITY

AMPylation of Rho GTPases Subverts Multiple Host Signaling Processes

(2014) Andrew R. Woolery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Insights of p47phoxPhosphorylation Dynamics in the Regulation of NADPH Oxidase Activation and Superoxide Production

(2014) Daniel N. Meijles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils

(2014) G. Damoulakis et al.   JOURNAL OF CELL SCIENCE

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

(2014) Miklós Kovács et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DOCK2 and DOCK5 Act Additively in Neutrophils To Regulate Chemotaxis, Superoxide Production, and Extracellular Trap Formation

(2014) Mayuki Watanabe et al.   JOURNAL OF IMMUNOLOGY

Haplotypes of Fc RIIa and Fc RIIIb Polymorphic Variants Influence IgG-Mediated Responses in Neutrophils

(2014) J. van der Heijden et al.   JOURNAL OF IMMUNOLOGY

Enemy attraction: bacterial agonists for leukocyte chemotaxis receptors

(2014) Dominik Alexander Bloes et al.   NATURE REVIEWS MICROBIOLOGY

The integrin adhesome: from genes and proteins to human disease

(2014) Sabina E. Winograd-Katz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Direct measurement of oxidative and nitrosative stress dynamics inSalmonellainside macrophages

(2014) Joris van der Heijden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Granule Protein Processing and Regulated Secretion in Neutrophils

(2014) Avinash Sheshachalam et al.   Frontiers in Immunology

Are Reactive Oxygen Species Always Detrimental to Pathogens?

(2013) Claudia N. Paiva et al.   ANTIOXIDANTS & REDOX SIGNALING

Identifying Yersinia YopH-Targeted Signal Transduction Pathways that Impair Neutrophil Responses during In Vivo Murine Infection

(2013) Hortensia G. Rolán et al.   Cell Host & Microbe

Assembly of NADPH Oxidase in Human Neutrophils Is Modulated by the Opacity-Associated Protein Expression State of Neisseria gonorrhoeae

(2013) Asya Smirnov et al.   INFECTION AND IMMUNITY

Neutrophil cell surface receptors and their intracellular signal transduction pathways

(2013) Krisztina Futosi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Protein Kinase A-dependent Phosphorylation of Rap1 Regulates Its Membrane Localization and Cell Migration

(2013) Maho Takahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverse novel functions of neutrophils in immunity, inflammation, and beyond

(2013) Attila Mócsai   JOURNAL OF EXPERIMENTAL MEDICINE

Class I Phosphoinositide-3-Kinases and Src Kinases Play a Nonredundant Role in Regulation of Adhesion-Independent and -Dependent Neutrophil Reactive Oxygen Species Generation

(2013) L. Fumagalli et al.   JOURNAL OF IMMUNOLOGY

ROS production in phagocytes: why, when, and where?

(2013) Sophie Dupré-Crochet et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Regulation Of The NADPH Oxidase And Associated Ion Fluxes During Phagocytosis

(2013) Paula Nunes et al.   TRAFFIC

Transcriptional regulation by Ferric Uptake Regulator (Fur) in pathogenic bacteria

(2013) Bryan Troxell et al.   Frontiers in Cellular and Infection Microbiology

Structure-Function of the G Protein–Coupled Receptor Superfamily

(2012) Vsevolod Katritch et al.   Annual Review of Pharmacology and Toxicology

Activation of neutrophil respiratory burst by fungal particles requires phosphatidylinositol 3-phosphate binding to p40phox in humans but not in mice

(2012) J. Bagaitkar et al.   BLOOD

Properties of mouse and human IgG receptors and their contribution to disease models

(2012) P. Bruhns   BLOOD

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Chronic Granulomatous Disease

(2012) Steven M. Holland   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

MUNC13-4 Protein Regulates the Oxidative Response and Is Essential for Phagosomal Maturation and Bacterial Killing in Neutrophils

(2012) Jlenia Monfregola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement

(2012) Francis J. Alenghat et al.   JOURNAL OF CELL SCIENCE

Phosphoinositide 3-OH Kinase Regulates Integrin-Dependent Processes in Neutrophils by Signaling through Its Effector ARAP3

(2012) L. Gambardella et al.   JOURNAL OF IMMUNOLOGY

p40phox Expression Regulates Neutrophil Recruitment and Function during the Resolution Phase of Intestinal Inflammation

(2012) K. L. Conway et al.   JOURNAL OF IMMUNOLOGY

The TLR7/8 Agonist CL097 Primes N -Formyl-Methionyl-Leucyl-Phenylalanine–Stimulated NADPH Oxidase Activation in Human Neutrophils: Critical Role of p47phox Phosphorylation and the Proline Isomerase Pin1

(2012) Karama Makni-Maalej et al.   JOURNAL OF IMMUNOLOGY

Myeloperoxidase: a front-line defender against phagocytosed microorganisms

(2012) S. J. Klebanoff et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The NADPH oxidase cytosolic component p67phox is constitutively phosphorylated in human neutrophils: Regulation by a protein tyrosine kinase, MEK1/2 and phosphatases 1/2A

(2011) Pham My-Chan Dang et al.   BIOCHEMICAL PHARMACOLOGY

Listeriolysin O Suppresses Phospholipase C-Mediated Activation of the Microbicidal NADPH Oxidase to Promote Listeria monocytogenes Infection

(2011) Grace Y. Lam et al.   Cell Host & Microbe

Mitochondrial reactive oxygen species drive proinflammatory cytokine production: Figure 1.

(2011) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Granule Exocytosis Contributes to Priming and Activation of the Human Neutrophil Respiratory Burst

(2011) S. M. Uriarte et al.   JOURNAL OF IMMUNOLOGY

Salmonella detoxifying enzymes are sufficient to cope with the host oxidative burst

(2011) Laurent Aussel et al.   MOLECULAR MICROBIOLOGY

Regulation of reactive oxygen species generation in cell signaling

(2011) Yun Soo Bae et al.   MOLECULES AND CELLS

PI3K  Plays a Critical Role in Neutrophil Activation by Immune Complexes

(2011) S. Kulkarni et al.   Science Signaling

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils

(2010) K. E. Anderson et al.   BLOOD

The prolyl isomerase Pin1 acts as a novel molecular switch for TNF- -induced priming of the NADPH oxidase in human neutrophils

(2010) T. Boussetta et al.   BLOOD

Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase

(2010) T. A. M. Chessa et al.   BLOOD

ROS-inhibitory activity of YopE is required for full virulence of Yersinia in mice

(2010) Warangkhana Songsungthong et al.   CELLULAR MICROBIOLOGY

Coxiella burnetiiAcid Phosphatase Inhibits the Release of Reactive Oxygen Intermediates in Polymorphonuclear Leukocytes

(2010) J. Hill et al.   INFECTION AND IMMUNITY

p47phoxMolecular Activation for Assembly of the Neutrophil NADPH Oxidase Complex

(2010) Julien Marcoux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p47phoxPhox Homology Domain Regulates Plasma Membrane but Not Phagosome Neutrophil NADPH Oxidase Activation

(2010) Xing Jun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Conserved Region between the TPR and Activation Domains of p67phoxParticipates in Activation of the Phagocyte NADPH Oxidase

(2010) Yuichi Maehara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P-Rex1 and Vav1 Cooperate in the Regulation of Formyl-Methionyl-Leucyl-Phenylalanine-Dependent Neutrophil Responses

(2010) C. D. Lawson et al.   JOURNAL OF IMMUNOLOGY

Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis

(2010) Ramona L. McCaffrey et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hydrogen peroxide inactivates the Escherichia coli Isc iron-sulphur assembly system, and OxyR induces the Suf system to compensate

(2010) Soojin Jang et al.   MOLECULAR MICROBIOLOGY

HPK1 Associates with SKAP-HOM to Negatively Regulate Rap1-Mediated B-Lymphocyte Adhesion

(2010) Sebastian Königsberger et al.   PLoS One

ITAM-mediated Signaling by the T-Cell Antigen Receptor

(2010) P. E. Love et al.   Cold Spring Harbor Perspectives in Biology

Src-family and Syk Kinases in Activating and Inhibitory Pathways in Innate Immune Cells: Signaling Cross Talk

(2010) C. A. Lowell   Cold Spring Harbor Perspectives in Biology

Neutrophil Extracellular Traps: How to Generate and Visualize Them

(2010) Volker Brinkmann et al.   Jove-Journal of Visualized Experiments

The Ins and Outs of Leukocyte Integrin Signaling

(2009) Clare L. Abram et al.   Annual Review of Immunology

Emerging Evidence for the Importance of Phosphorylation in the Regulation of NADPH Oxidases

(2009) Gary M. Bokoch et al.   ANTIOXIDANTS & REDOX SIGNALING

A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40phox and selective defects in neutrophil NADPH oxidase activity

(2009) J. D. Matute et al.   BLOOD

p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases

(2009) Jamel El-Benna et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Redundant Hydrogen Peroxide Scavengers Contribute to Salmonella Virulence and Oxidative Stress Resistance

(2009) M. Hebrard et al.   JOURNAL OF BACTERIOLOGY

Phosphorylation of p22phoxon Threonine 147 Enhances NADPH Oxidase Activity by Promoting p47phoxBinding

(2009) Eric M. Lewis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin signalling at a glance

(2009) D. S. Harburger et al.   JOURNAL OF CELL SCIENCE

Critical role of phospholipase Cγ2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis

(2009) Zoltán Jakus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Neutrophils Kill Streptococcus pneumoniae via Serine Proteases

(2009) A. J. Standish et al.   JOURNAL OF IMMUNOLOGY

Inhibition of the human neutrophil NADPH oxidase by Coxiella burnetii

(2009) Daniel W. Siemsen et al.   MICROBES AND INFECTION

Cross-regulation of signaling by ITAM-associated receptors

(2009) Lionel B Ivashkiv   NATURE IMMUNOLOGY

Chronic Granulomatous Disease: The European Experience

(2009) J. Merlijn van den Berg et al.   PLoS One

Rab27a and Rab27b Regulate Neutrophil Azurophilic Granule Exocytosis and NADPH oxidase Activity by Independent Mechanisms

(2009) Jennifer L. Johnson et al.   TRAFFIC

Cellular Defenses against Superoxide and Hydrogen Peroxide

(2008) James A. Imlay   Annual Review of Biochemistry

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

Vav/Phospholipase Cγ2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis

(2008) Viviana Cremasco et al.   ARTHRITIS AND RHEUMATISM

Neisseria gonorrhoeaesuppresses the oxidative burst of human polymorphonuclear leukocytes

(2008) Alison K. Criss et al.   CELLULAR MICROBIOLOGY

Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox

(2008) Houssam Raad et al.   FASEB JOURNAL

Reactive oxygen species in phagocytic leukocytes

(2008) John M. Robinson   HISTOCHEMISTRY AND CELL BIOLOGY

Yersinia pestis Type III Secretion System-Dependent Inhibition of Human Polymorphonuclear Leukocyte Function

(2008) J. L. Spinner et al.   INFECTION AND IMMUNITY

Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase

(2008) Robert Paul et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane

(2008) Jamel El-Benna et al.   Seminars in Immunopathology