Mechanisms of fibrosis: therapeutic translation for fibrotic disease

Novel Role of IL-13 in Fibrosis Induced by Nonalcoholic Steatohepatitis and Its Amelioration by IL-13R-Directed Cytotoxin in a Rat Model

(2014) T. Shimamura et al.   JOURNAL OF IMMUNOLOGY

The mechanical memory of lung myofibroblasts

(2012) Jenna L. Balestrini et al.   Integrative Biology

End of an ERA: Lessons from Negative Clinical Trials in Idiopathic Pulmonary Fibrosis

(2011) Paul W. Noble et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutralizing IL-17 Prevents Obliterative Bronchiolitis in Murine Orthotopic Lung Transplantation

(2011) L. Fan et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Therapeutic Potential for HDAC Inhibitors in the Heart

(2011) Timothy A. McKinsey   Annual Review of Pharmacology and Toxicology

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

(2011) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

Plasma CCN2 (connective tissue growth factor; CTGF) is a potential biomarker in idiopathic pulmonary fibrosis (IPF)

(2011) Masato Kono et al.   CLINICA CHIMICA ACTA

IL-17 induces apoptosis of vascular endothelial cells — A potential mechanism for human acute coronary syndrome

(2011) Faliang Zhu et al.   CLINICAL IMMUNOLOGY

Role of IL-13 in systemic sclerosis

(2011) Patrizia Fuschiotti   CYTOKINE

Macitentan: entry-into-humans study with a new endothelin receptor antagonist

(2011) Patricia N. Sidharta et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Accelerated and Progressive and Lethal Liver Fibrosis in Mice That Lack Interleukin (IL)-10, IL-12p40, and IL-13Rα2

(2011) Margaret M. Mentink–Kane et al.   GASTROENTEROLOGY

Mechanical Stretch Induces Epithelial-Mesenchymal Transition in Alveolar Epithelia via Hyaluronan Activation of Innate Immunity

(2011) Rebecca L. Heise et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44

(2011) Yuejuan Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lack of interleukin-1α or interleukin-1β inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice

(2011) Yehuda Kamari et al.   JOURNAL OF HEPATOLOGY

CD4+CD25+Foxp3+ regulatory T cells suppress cardiac fibrosis in the hypertensive heart

(2011) Peter Kanellakis et al.   JOURNAL OF HYPERTENSION

IL-13 Induces Skin Fibrosis in Atopic Dermatitis by Thymic Stromal Lymphopoietin

(2011) M.-H. Oh et al.   JOURNAL OF IMMUNOLOGY

IL-13 Induces Connective Tissue Growth Factor in Rat Hepatic Stellate Cells via TGF- -Independent Smad Signaling

(2011) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

Canonical Wnt/β-catenin signaling mediates transforming growth factor-β1-driven podocyte injury and proteinuria

(2011) Dan Wang et al.   KIDNEY INTERNATIONAL

Asthma Phenotypes and Interleukin-13 — Moving Closer to Personalized Medicine

(2011) Monica Kraft   NEW ENGLAND JOURNAL OF MEDICINE

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of a Tyrosine Kinase Inhibitor in Idiopathic Pulmonary Fibrosis

(2011) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

PPAR-γ Ligands Repress TGFβ-Induced Myofibroblast Differentiation by Targeting the PI3K/Akt Pathway: Implications for Therapy of Fibrosis

(2011) Ajit A. Kulkarni et al.   PLoS One

Activation of WNT / β-Catenin Signaling in Pulmonary Fibroblasts by TGF-β1 Is Increased in Chronic Obstructive Pulmonary Disease

(2011) Hoeke A. Baarsma et al.   PLoS One

IL-1 and IL-23 Mediate Early IL-17A Production in Pulmonary Inflammation Leading to Late Fibrosis

(2011) Paméla Gasse et al.   PLoS One

Pirfenidone in idiopathic pulmonary fibrosis: the CAPACITY program

(2011) Luca Richeldi et al.   Expert Review of Respiratory Medicine

New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2/CCR2 axis

(2010) Lei Sun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inhibition and Role of let-7d in Idiopathic Pulmonary Fibrosis

(2010) Kusum V. Pandit et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

β-Catenin Mediates Mechanically Regulated, Transforming Growth Factor-β1–Induced Myofibroblast Differentiation of Aortic Valve Interstitial Cells

(2010) Jan-Hung Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MicroRNA-29, a key regulator of collagen expression in systemic sclerosis

(2010) Britta Maurer et al.   ARTHRITIS AND RHEUMATISM

Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor

(2010) Tsutomu Fujii et al.   BMC GASTROENTEROLOGY

Interleukin-17–Dependent Autoimmunity to Collagen Type V in Atherosclerosis

(2010) Melanie L. Dart et al.   CIRCULATION RESEARCH

Therapeutic Potential of Janus-activated Kinase-2 Inhibitors for the Management of Myelofibrosis

(2010) S. Verstovsek   CLINICAL CANCER RESEARCH

miR-200a Prevents Renal Fibrogenesis Through Repression of TGF- 2 Expression

(2010) B. Wang et al.   DIABETES

PRM-151 (recombinant human serum amyloid P/pentraxin 2) for the treatment of fibrosis

(2010) J.S. Duffield et al.   DRUG NEWS & PERSPECTIVES

Colitis and Intestinal Inflammation in IL10−/− Mice Results From IL-13Rα2–Mediated Attenuation of IL-13 Activity

(2010) Mark S. Wilson et al.   GASTROENTEROLOGY

Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis

(2010) Christoph Roderburg et al.   HEPATOLOGY

Effectiveness of the PPARγ agonist, GW570, in liver fibrosis

(2010) Liu Yang et al.   INFLAMMATION RESEARCH

Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice

(2010) David M. Patrick et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis

(2010) Gang Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent

(2010) Mark S. Wilson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

miR-192 Mediates TGF- /Smad3-Driven Renal Fibrosis

(2010) A. C. K. Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Repression of IP-10 by Interactions between Histone Deacetylation and Hypermethylation in Idiopathic Pulmonary Fibrosis

(2010) W. R. Coward et al.   MOLECULAR AND CELLULAR BIOLOGY

Methylation determines fibroblast activation and fibrogenesis in the kidney

(2010) Wibke Bechtel et al.   NATURE MEDICINE

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

CD4+CD25+Foxp3+ Regulatory T Cells Depletion May Attenuate the Development of Silica-Induced Lung Fibrosis in Mice

(2010) Fangwei Liu et al.   PLoS One

Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis

(2010) Isabel Nawroth et al.   RADIOTHERAPY AND ONCOLOGY

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

CD3 mAb treatment ameliorated the severity of the cGVHD-induced lupus nephritis in mice by up-regulation of Foxp3+ regulatory T cells in the target tissue: Kidney

(2010) Ji-Lu Zhang et al.   TRANSPLANT IMMUNOLOGY

Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation

(2009) Senthil K. Venugopal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Global Impairment of CD4+CD25+FOXP3+Regulatory T Cells in Idiopathic Pulmonary Fibrosis

(2009) Ioannis Kotsianidis et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Imatinib Treatment for Idiopathic Pulmonary Fibrosis

(2009) Craig E. Daniels et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Critical Role for IL-6 in Hypertrophy and Fibrosis in Chronic Cardiac Allograft Rejection

(2009) J. A. Diaz et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The role of IL-1 in the pathogenesis of heart disease

(2009) Marcin Bujak et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Suppression of type I collagen production by microRNA-29b in cultured human stellate cells

(2009) Tomohiro Ogawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IL-17 induces myocardial fibrosis and enhances RANKL/OPG and MMP/TIMP signaling in isoproterenol-induced heart failure

(2009) Weiwei Feng et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The etiology of liver damage imparts cytokines transforming growth factor β1 or interleukin-13 as driving forces in fibrogenesis

(2009) Hong-Lei Weng et al.   HEPATOLOGY

Cardiac Mast Cells Mediate Left Ventricular Fibrosis in the Hypertensive Rat Heart

(2009) Scott P. Levick et al.   HYPERTENSION

Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-β

(2009) Sylvia A. Vetrone et al.   JOURNAL OF CLINICAL INVESTIGATION

Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis

(2009) Mark A.A. Claassen et al.   JOURNAL OF HEPATOLOGY

Role of T Cell TGF  Signaling and IL-17 in Allograft Acceptance and Fibrosis Associated with Chronic Rejection

(2009) S. M. Faust et al.   JOURNAL OF IMMUNOLOGY

Interleukin-13 and Its Receptors in Idiopathic Interstitial Pneumonia: Clinical Implications for Lung Function

(2009) Sung-Woo Park et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial

(2009) Talmadge E King et al.   LANCET

TGF-β activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN

(2009) Mitsuo Kato et al.   NATURE CELL BIOLOGY

IL-1RI deficiency ameliorates early experimental renal interstitial fibrosis

(2009) Lynelle K. Jones et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Telomere Diseases

(2009) Rodrigo T. Calado et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serum Amyloid P Inhibits Fibrosis Through Fc R-Dependent Monocyte-Macrophage Regulation in Vivo

(2009) A. P. Castano et al.   Science Translational Medicine

Epigenetic Modifications: New Therapeutic Targets in Primary Myelofibrosis

(2009) Kirugaval Hemavathy et al.   Current Stem Cell Research & Therapy

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

(2009) John T. Pesce et al.   PLoS Pathogens

Tissue stiffness, latent TGF-β1 Activation, and mechanical signal transduction: Implications for the pathogenesis and treatment of fibrosis

(2009) Boris Hinz   Current Rheumatology Reports

Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection

(2008) William E. Lawson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lung alveolar integrity is compromised by telomere shortening in telomerase-null mice

(2008) Jooeun Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Epithelial Endoplasmic Reticulum Stress and Apoptosis in Sporadic Idiopathic Pulmonary Fibrosis

(2008) Martina Korfei et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Treatment of Idiopathic Pulmonary Fibrosis with Etanercept

(2008) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Telomere Shortening in Familial and Sporadic Pulmonary Fibrosis

(2008) Jennifer T. Cronkhite et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

In VivoInvestigations on Anti-Fibrotic Potential of Proteasome Inhibition in Lung and Skin Fibrosis

(2008) Serena Fineschi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Thy-1 Promoter Hypermethylation

(2008) Yan Y. Sanders et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets

(2008) Johanna Myllyharju   ANNALS OF MEDICINE

Imatinib mesylate treatment of nephrogenic systemic fibrosis

(2008) Jonathan Kay et al.   ARTHRITIS AND RHEUMATISM

Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention?

(2008) R C Chambers   BRITISH JOURNAL OF PHARMACOLOGY

miR-133 and miR-30 Regulate Connective Tissue Growth Factor

(2008) Rudy F. Duisters et al.   CIRCULATION RESEARCH

Hepatoprotective Effect of Infliximab, an Anti-TNF-α Agent, on Carbon Tetrachloride-Induced Hepatic Fibrosis

(2008) Ibrahim Halil Bahcecioglu et al.   INFLAMMATION

Hyper-responsiveness of IPF/UIP fibroblasts: Interplay between TGFβ1, IL-13 and CCL2

(2008) Lynne A. Murray et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation

(2008) D. D. Shao et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Coagulation status modulates murine hepatic fibrogenesis: implications for the development of novel therapies

(2008) Q. M. ANSTEE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

PPAR-γ agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-β

(2008) Toru Kawai et al.   LABORATORY INVESTIGATION

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE

Short telomeres are a risk factor for idiopathic pulmonary fibrosis

(2008) J. K. Alder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

(2008) E. van Rooij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pioglitazone, a Peroxisome Proliferator-Activated Receptor Gamma Ligand, Suppresses Bleomycin-Induced Acute Lung Injury and Fibrosis

(2008) Yasuhiro Aoki et al.   RESPIRATION

Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease

(2008) Harmeet Malhi et al.   SEMINARS IN LIVER DISEASE

Ultrasound Imaging Accurately Detects Skin Thickening in a Mouse Scleroderma Model

(2008) Jennifer L. Tedstone et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing

(2008) Stephan Barrientos et al.   WOUND REPAIR AND REGENERATION

Baseline BAL Neutrophilia Predicts Early Mortality in Idiopathic Pulmonary Fibrosis

(2007) Brent W. Kinder et al.   CHEST

Abrogation of the Antifibrotic Effects of Natural Killer Cells/Interferon-γ Contributes to Alcohol Acceleration of Liver Fibrosis

(2007) Won–Il Jeong et al.   GASTROENTEROLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY