Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment
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Title
Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment
Authors
Keywords
Cancer, Hedgehog signaling, Angiogenesis, Microenvironment, Epithelial-mesenchymal transition, Drug resistance, Metastasis, Cancer stem cells
Journal
Molecular Cancer
Volume 15, Issue 1, Pages -
Publisher
Springer Nature
Online
2016-03-19
DOI
10.1186/s12943-016-0509-3
References
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Note: Only part of the references are listed.- Non-canonical GLI1/2 activation by PI3K/AKT signaling in renal cell carcinoma: A novel potential therapeutic target
- (2016) Jiancheng Zhou et al. CANCER LETTERS
- Sonic hedgehog-glioma associated oncogene homolog 1 signaling enhances drug resistance in CD44+/Musashi-1+ gastric cancer stem cells
- (2015) Min Xu et al. CANCER LETTERS
- Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects
- (2015) J. Wellbrock et al. CLINICAL CANCER RESEARCH
- Hedgehog Pathway Inhibitors Promote Adaptive Immune Responses in Basal Cell Carcinoma
- (2015) A. Otsuka et al. CLINICAL CANCER RESEARCH
- Sonidegib: First Global Approval
- (2015) Celeste B. Burness DRUGS
- Modulation of Sonic hedgehog signaling and WW domain containing oxidoreductase WOX1 expression enhances radiosensitivity of human glioblastoma cells
- (2015) Ming-Fu Chiang et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NF B activity
- (2015) A. L. Furmanski et al. JOURNAL OF CELL SCIENCE
- Sonic Hedgehog inhibition as a strategy to augment radiosensitivity of hepatocellular carcinoma
- (2015) Chiao-Ling Tsai et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Inhibition of hedgehog signal pathway by cyclopamine attenuates inflammation and articular cartilage damage in rats with adjuvant-induced arthritis
- (2015) Rong Li et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia
- (2015) D Kern et al. ONCOGENE
- p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling
- (2015) Elisa Maria Memmi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer
- (2015) Murielle Mimeault et al. Oncotarget
- Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level
- (2015) Jessian L. Munoz et al. Oncotarget
- Hedgehog Signaling in the Maintenance of Cancer Stem Cells
- (2015) Catherine Cochrane et al. Cancers
- Proteasome inhibition reverses hedgehog inhibitor and taxane resistance in ovarian cancer
- (2015) Adam D. Steg et al. Oncotarget
- Selective inhibition of IFNG-induced autophagy byMir155- andMir31-responsive WNT5A and SHH signaling
- (2014) Sahana Holla et al. Autophagy
- Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells
- (2014) Xiaoming Hou et al. BIOCHIMIE
- A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance
- (2014) Z. Liu et al. BLOOD
- Inhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cells
- (2014) C D’Amato et al. BRITISH JOURNAL OF CANCER
- Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition
- (2014) Marcel Kool et al. CANCER CELL
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- Network Modeling of TGF Signaling in Hepatocellular Carcinoma Epithelial-to-Mesenchymal Transition Reveals Joint Sonic Hedgehog and Wnt Pathway Activation
- (2014) S. N. Steinway et al. CANCER RESEARCH
- Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer
- (2014) Jillian Brechbiel et al. CANCER TREATMENT REVIEWS
- Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth
- (2014) Laura Di Magno et al. CELL CYCLE
- Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma
- (2014) E. J. Kim et al. CLINICAL CANCER RESEARCH
- CD44 Expression Denotes a Subpopulation of Gastric Cancer Cells in Which Hedgehog Signaling Promotes Chemotherapy Resistance
- (2014) C. Yoon et al. CLINICAL CANCER RESEARCH
- Roles for Hedgehog signaling in adult organ homeostasis and repair
- (2014) R. Petrova et al. DEVELOPMENT
- The Shh Receptor Boc Promotes Progression of Early Medulloblastoma to Advanced Tumors
- (2014) Frédéric Mille et al. DEVELOPMENTAL CELL
- Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors
- (2014) P. Infante et al. EMBO JOURNAL
- Gli1 Protein Regulates the S-phase Checkpoint in Tumor Cells via Bid Protein, and Its Inhibition Sensitizes to DNA Topoisomerase 1 Inhibitors
- (2014) Kaushlendra Tripathi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Sonic Hedgehog Signaling Pathway Maintains the Cancer Stem Cell Self-Renewal of Anaplastic Thyroid Cancer by Inducing Snail Expression
- (2014) Katherine B. Heiden et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Sonic hedgehog signalling proteins are frequently expressed in retinoblastoma and are associated with aggressive clinicopathological features
- (2014) J.-Y. Choe et al. JOURNAL OF CLINICAL PATHOLOGY
- Estrogen promotes stemness and invasiveness of ER-positive breast cancer cells through Gli1 activation
- (2014) Ying Sun et al. Molecular Cancer
- Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition
- (2014) Yujie Tang et al. NATURE MEDICINE
- Stromal response to Hedgehog signaling restrains pancreatic cancer progression
- (2014) J. J. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of theSHHgene in prostate cancer cell resistance to paclitaxel
- (2014) Malgorzata Statkiewicz et al. PROSTATE
- GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis
- (2014) E Pantazi et al. Cell Death & Disease
- Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling
- (2014) Pawel Niewiadomski et al. Cell Reports
- Dosage-Dependent Regulation of Pancreatic Cancer Growth and Angiogenesis by Hedgehog Signaling
- (2014) Esha Mathew et al. Cell Reports
- Protein-bound polysaccharide decreases invasiveness and proliferation in pancreatic cancer by inhibition of hedgehog signaling and HIF-1α pathways under hypoxia
- (2013) Hideya Onishi et al. CANCER LETTERS
- Role of hypoxia-inducible factors in breast cancer metastasis
- (2013) Daniele M Gilkes et al. Future Oncology
- Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells
- (2013) Ying Wang et al. HEPATOLOGY
- Nonclassical hedgehog-gli signaling and its clinical implications
- (2013) Lalita A. Shevde et al. INTERNATIONAL JOURNAL OF CANCER
- Nonclassical Activation of Hedgehog Signaling Enhances Multidrug Resistance and Makes Cancer Cells Refractory to Smoothened-targeting Hedgehog Inhibition
- (2013) Shamik Das et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NOD2-Nitric Oxide-responsive MicroRNA-146a Activates Sonic Hedgehog Signaling to Orchestrate Inflammatory Responses in Murine Model of Inflammatory Bowel Disease
- (2013) Devram Sampat Ghorpade et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs
- (2013) Aamir Ahmad et al. Journal of Hematology & Oncology
- Tissue-Derived Hedgehog Proteins Modulate Th Differentiation and Disease
- (2013) A. L. Furmanski et al. JOURNAL OF IMMUNOLOGY
- Noncanonical Regulation of the Hedgehog Mediator GLI1 by c-MYC in Burkitt Lymphoma
- (2013) Joon Won Yoon et al. MOLECULAR CANCER RESEARCH
- Unraveling the therapeutic potential of the Hedgehog pathway in cancer
- (2013) Dereck Amakye et al. NATURE MEDICINE
- The mechanisms of Hedgehog signalling and its roles in development and disease
- (2013) James Briscoe et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche
- (2013) Guiomar Solanas et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Evasion of p53 and G2/M checkpoints are characteristic of Hh-driven basal cell carcinoma
- (2013) Z J Li et al. ONCOGENE
- Gli1 Deletion Prevents Helicobacter-Induced Gastric Metaplasia and Expansion of Myeloid Cell Subsets
- (2013) Mohamad El-Zaatari et al. PLoS One
- Hedgehog/GLI Signaling Activates Suppressor of Cytokine Signaling 1 (SOCS1) in Epidermal and Neural Tumor Cells
- (2013) Sandra Laner-Plamberger et al. PLoS One
- Vismodegib Suppresses TRAIL-mediated Liver Injury in a Mouse Model of Nonalcoholic Steatohepatitis
- (2013) Petra Hirsova et al. PLoS One
- Hedgehog signaling is active in human prostate cancer stroma and regulates proliferation and differentiation of adjacent epithelium
- (2013) Sarah E. Wilkinson et al. PROSTATE
- Hypoxia and metastasis in an orthotopic cervix cancer xenograft model
- (2013) Naz Chaudary et al. RADIOTHERAPY AND ONCOLOGY
- Hedgehog Signaling Controls T Cell Killing at the Immunological Synapse
- (2013) M. de la Roche et al. SCIENCE
- Hedgehog inhibition reduces angiogenesis by downregulation of tumoral VEGF-A expression in hepatocellular carcinoma
- (2013) Matthias Pinter et al. United European Gastroenterology Journal
- Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma
- (2012) S. Blotta et al. BLOOD
- SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial–mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway
- (2012) Xuqi Li et al. CANCER LETTERS
- Hedgehog Signaling Is a Novel Therapeutic Target in Tamoxifen-Resistant Breast Cancer Aberrantly Activated by PI3K/AKT Pathway
- (2012) B. Ramaswamy et al. CANCER RESEARCH
- Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis
- (2012) L. Ouyang et al. CELL PROLIFERATION
- A Randomized Phase II Trial of Vismodegib versus Placebo with FOLFOX or FOLFIRI and Bevacizumab in Patients with Previously Untreated Metastatic Colorectal Cancer
- (2012) J. Berlin et al. CLINICAL CANCER RESEARCH
- Gastric Sonic Hedgehog Acts as a Macrophage Chemoattractant During the Immune Response to Helicobacter pylori
- (2012) Michael A. Schumacher et al. GASTROENTEROLOGY
- Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growthin vitroandin vivo
- (2012) Malin Wickström et al. INTERNATIONAL JOURNAL OF CANCER
- Inhibition of the Hedgehog Pathway Targets the Tumor-Associated Stroma in Pancreatic Cancer
- (2012) R. F. Hwang et al. MOLECULAR CANCER RESEARCH
- Vismodegib
- (2012) Andrzej Dlugosz et al. NATURE REVIEWS DRUG DISCOVERY
- Hedgehog Signaling and Maintenance of Homeostasis in the Intestinal Epithelium
- (2012) Nikè V. J. A. Büller et al. PHYSIOLOGY
- Sonic Hedgehog Signaling Inhibition Provides Opportunities for Targeted Therapy by Sulforaphane in Regulating Pancreatic Cancer Stem Cell Self-Renewal
- (2012) Mariana Rodova et al. PLoS One
- Gli Proteins in Development and Disease
- (2011) Chi-chung Hui et al. Annual Review of Cell and Developmental Biology
- Natural Innate and Adaptive Immunity to Cancer
- (2011) Matthew D. Vesely et al. Annual Review of Immunology
- Hedgehog-Producing Cancer Cells Respond to and Require Autocrine Hedgehog Activity
- (2011) S. Singh et al. CANCER RESEARCH
- Blocking Hedgehog Survival Signaling at the Level of the GLI Genes Induces DNA Damage and Extensive Cell Death in Human Colon Carcinoma Cells
- (2011) T. Mazumdar et al. CANCER RESEARCH
- Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer
- (2011) Hideya Onishi et al. CANCER SCIENCE
- Tumor Metastasis: Molecular Insights and Evolving Paradigms
- (2011) Scott Valastyan et al. CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Boc and Gas1 Each Form Distinct Shh Receptor Complexes with Ptch1 and Are Required for Shh-Mediated Cell Proliferation
- (2011) Luisa Izzi et al. DEVELOPMENTAL CELL
- Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways
- (2011) Nadine Rohwer et al. DRUG RESISTANCE UPDATES
- Sonic Hedgehog Signaling Protects Human Hepatocellular Carcinoma Cells Against Ionizing Radiation in an Autocrine Manner
- (2011) Yu-Jen Chen et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Hedgehog Signaling: Networking to Nurture a Promalignant Tumor Microenvironment
- (2011) L. G. Harris et al. MOLECULAR CANCER RESEARCH
- Persistent Sonic Hedgehog Signaling in Adult Brain Determines Neural Stem Cell Positional Identity
- (2011) Rebecca A. Ihrie et al. NEURON
- Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61
- (2011) L G Harris et al. ONCOGENE
- Hedgehog signaling update
- (2010) M. Michael Cohen Jr. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- TGF- Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling
- (2010) R. W. Johnson et al. CANCER RESEARCH
- Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways
- (2010) Pilar Chinchilla et al. CELL CYCLE
- Mechanisms of Inactivation of PTCH1 Gene in Nevoid Basal Cell Carcinoma Syndrome: Modification of the Two-Hit Hypothesis
- (2010) S. Pan et al. CLINICAL CANCER RESEARCH
- Overexpression of Smoothened Activates the Sonic Hedgehog Signaling Pathway in Pancreatic Cancer-Associated Fibroblasts
- (2010) K. Walter et al. CLINICAL CANCER RESEARCH
- Review: Targeting the Hedgehog pathway in cancer
- (2010) Sachin Gupta et al. Therapeutic Advances in Medical Oncology
- Hedgehog signalling: Emerging evidence for non-canonical pathways
- (2009) Dagan Jenkins CELLULAR SIGNALLING
- Hedgehog signalling in colon cancer and stem cells
- (2009) Alberto Gulino et al. EMBO Molecular Medicine
- GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
- (2009) O. Nolan-Stevaux et al. GENES & DEVELOPMENT
- The Hedgehog Pathway Transcription Factor GLI1 Promotes Malignant Behavior of Cancer Cells by Up-regulating Osteopontin
- (2009) Shamik Das et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer
- (2009) J M Bailey et al. ONCOGENE
- Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
- (2009) H. Tian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
- (2009) R. L. Yauch et al. SCIENCE
- Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
- (2009) K. P. Olive et al. SCIENCE
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Cancer-related inflammation
- (2008) Alberto Mantovani et al. NATURE
- Rational targeting of Notch signaling in cancer
- (2008) P Rizzo et al. ONCOGENE
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