Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

(2013) Kenta Masui et al.   Cell Metabolism

Unraveling the therapeutic potential of the Hedgehog pathway in cancer

(2013) Dereck Amakye et al.   NATURE MEDICINE

Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy

(2013) Sonia Coni et al.   PLoS One

Hedgehog-mediated regulation of PPARγ controls metabolic patterns in neural precursors and shh-driven medulloblastoma

(2012) Bobby Bhatia et al.   ACTA NEUROPATHOLOGICA

Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat

(2012) Raffaele Teperino et al.   CELL

Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation

(2012) Ajay Kumar et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Hedgehog Secretion and Signal Transduction in Vertebrates

(2012) Kaitlyn E. Ryan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hedgehog-GLI Pathway in Medulloblastoma

(2012) Tenley C. Archer et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular subgroups of medulloblastoma: the current consensus

(2011) Michael D. Taylor et al.   ACTA NEUROPATHOLOGICA

Itraconazole Side Chain Analogues: Structure–Activity Relationship Studies for Inhibition of Endothelial Cell Proliferation, Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Glycosylation, and Hedgehog Signaling

(2011) Wei Shi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells

(2010) B M Madhok et al.   BRITISH JOURNAL OF CANCER

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway

(2010) Elspeth M. Beauchamp et al.   JOURNAL OF CLINICAL INVESTIGATION

Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

(2010) Gianluca Canettieri et al.   NATURE CELL BIOLOGY

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

(2010) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

(2009) Ramon C. Sun et al.   BREAST CANCER RESEARCH AND TREATMENT

Mitochondrial Mutations Contribute to HIF1  Accumulation via Increased Reactive Oxygen Species and Up-regulated Pyruvate Dehydrogenease Kinase 2 in Head and Neck Squamous Cell Carcinoma

(2009) W. Sun et al.   CLINICAL CANCER RESEARCH

The coactivator CRTC1 promotes cell proliferation and transformation via AP-1

(2009) G. Canettieri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The Origins of Medulloblastoma Subtypes

(2008) Richard J. Gilbertson et al.   Annual Review of Pathology-Mechanisms of Disease

Simultaneous clinical monitoring of lactic acid, pyruvic acid and ketone bodies in plasma as methoxime/tert-butyldimethylsilyl derivatives by gas chromatography–mass spectrometry in selected ion monitoring mode

(2008) Man-Jeong Paik et al.   BIOMEDICAL CHROMATOGRAPHY

Acquisition of Granule Neuron Precursor Identity Is a Critical Determinant of Progenitor Cell Competence to Form Shh-Induced Medulloblastoma

(2008) Ulrich Schüller et al.   CANCER CELL

Medulloblastoma Can Be Initiated by Deletion of Patched in Lineage-Restricted Progenitors or Stem Cells

(2008) Zeng-Jie Yang et al.   CANCER CELL

Dichloroacetate (DCA) sensitizes both wild‐type and over expressingBcl‐2prostate cancer cells in vitro to radiation

(2008) Wengang Cao et al.   PROSTATE