Role of hypoxia-inducible factors in breast cancer metastasis

Transcriptional Regulation of Urokinase-type Plasminogen Activator Receptor by Hypoxia-Inducible Factor 1 Is Crucial for Invasion of Pancreatic and Liver Cancer

(2015) Peter Büchler et al.   NEOPLASIA

Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis

(2013) D. M. Gilkes et al.   CANCER RESEARCH

Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by InducingP4HA1, P4HA2,andPLOD2Expression in Fibroblasts

(2013) Daniele M. Gilkes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis

(2013) Pallavi Chaturvedi et al.   JOURNAL OF CLINICAL INVESTIGATION

Advances in cancer biology and therapy

(2013) Gregg L. Semenza   JOURNAL OF MOLECULAR MEDICINE-JMM

Procollagen Lysyl Hydroxylase 2 Is Essential for Hypoxia-Induced Breast Cancer Metastasis

(2013) Daniele M. Gilkes et al.   MOLECULAR CANCER RESEARCH

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche

(2012) Jaclyn Sceneay et al.   CANCER RESEARCH

CD24 Is an Effector of HIF-1-Driven Primary Tumor Growth and Metastasis

(2012) S. Thomas et al.   CANCER RESEARCH

Low expression of RECK indicates a shorter survival for patients with invasive breast cancer

(2012) Yue Zhang et al.   CANCER SCIENCE

Chemokine C-C motif receptor 5 and C-C motif ligand 5 promote cancer cell migration under hypoxia

(2012) Sensen Lin et al.   CANCER SCIENCE

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

HIF1  is a central regulator of collagen hydroxylation and secretion under hypoxia during bone development

(2012) L. Bentovim et al.   DEVELOPMENT

Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis

(2012) Carmen Chak-Lui Wong et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

New Insight into the SDF-1/CXCR4 Axis in a Breast Carcinoma Model: Hypoxia-Induced Endothelial SDF-1 and Tumor Cell CXCR4 Are Required for Tumor Cell Intravasation

(2012) F. Jin et al.   MOLECULAR CANCER RESEARCH

Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells

(2012) L. Schito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression

(2012) W. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

(2012) Gregg L. Semenza   TRENDS IN MOLECULAR MEDICINE

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters

(2011) R.-L. Huang et al.   BLOOD

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

A CD44−/CD24+ phenotype is a poor prognostic marker in early invasive breast cancer

(2011) Mohamed A. H. Ahmed et al.   BREAST CANCER RESEARCH AND TREATMENT

EMT: A new vision of hypoxia promoting cancer progression

(2011) Jian Jiang et al.   CANCER BIOLOGY & THERAPY

Multihistology, Target-Driven Pilot Trial of Oral Topotecan as an Inhibitor of Hypoxia-Inducible Factor-1  in Advanced Solid Tumors

(2011) S. Kummar et al.   CLINICAL CANCER RESEARCH

Validation of an immunohistochemical signature predictive of 8-year outcome for patients with breast carcinoma

(2011) Colette Charpin et al.   INTERNATIONAL JOURNAL OF CANCER

Microtubule disruption targets HIF-1α mRNA to cytoplasmic P-bodies for translational repression

(2011) Marisa Carbonaro et al.   JOURNAL OF CELL BIOLOGY

Mouse Snail Is a Target Gene for HIF

(2011) D. Luo et al.   MOLECULAR CANCER RESEARCH

Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells

(2011) F Xing et al.   ONCOGENE

HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

(2011) H Zhang et al.   ONCOGENE

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

(2011) C. C.-L. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo Dynamics and Distinct Functions of Hypoxia in Primary Tumor Growth and Organotropic Metastasis of Breast Cancer

(2010) X. Lu et al.   CANCER RESEARCH

Up-regulation of pro-inflammatory genes as adaptation to hypoxia in MCF-7 cells and in human mammary invasive carcinoma microenvironment

(2010) Marco Tafani et al.   CANCER SCIENCE

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype

(2010) Gianluca Storci et al.   JOURNAL OF CELLULAR PHYSIOLOGY

HIF-1 and HIF-2 transcription factors — Similar but not identical

(2010) Agnieszka Loboda et al.   MOLECULES AND CELLS

Hypoxia and RAS-signaling pathways converge on and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs

(2010) F Loayza-Puch et al.   ONCOGENE

Hypoxia, Snail and incomplete epithelial–mesenchymal transition in breast cancer

(2009) K Lundgren et al.   BRITISH JOURNAL OF CANCER

Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion

(2009) J Chen et al.   BRITISH JOURNAL OF CANCER

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

Chemokine C–X–C motif receptor 6 contributes to cell migration during hypoxia

(2009) Sensen Lin et al.   CANCER LETTERS

Phosphoglucose Isomerase/Autocrine Motility Factor Mediates Epithelial and Mesenchymal Phenotype Conversions in Breast Cancer

(2009) Tatsuyoshi Funasaka et al.   CANCER RESEARCH

Pulmonary Vascular Destabilization in the Premetastatic Phase Facilitates Lung Metastasis

(2009) Y. Huang et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Mechanisms of bone metastases of breast cancer

(2009) Larry J Suva et al.   ENDOCRINE-RELATED CANCER

The Lysyl Oxidases LOX and LOXL2 Are Necessary and Sufficient to Repress E-cadherin in Hypoxia

(2009) Ruth Schietke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells

(2009) Jun Wan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Hypoxia and TGF-β Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment

(2009) Lauren K. Dunn et al.   PLoS One

Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

(2009) X. Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lymphatic and angiogenic characteristics in breast cancer: morphometric analysis and prognostic implications

(2008) Rabab A. A. Mohammed et al.   BREAST CANCER RESEARCH AND TREATMENT

Hypoxia-Inducible Factor-2  Correlates to Distant Recurrence and Poor Outcome in Invasive Breast Cancer

(2008) K. Helczynska et al.   CANCER RESEARCH

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

A signature predictive of disease outcome in breast carcinomas, identified by quantitative immunocytochemical assays

(2008) Colette Charpin et al.   INTERNATIONAL JOURNAL OF CANCER

Hypoxia-inducible Transcription Factor-2α in Endothelial Cells Regulates Tumor Neovascularization through Activation of Ephrin A1

(2008) Toshiharu Yamashita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1

(2008) Marie-Pierre Simon et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA