Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity

Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) Mitigates Seizures

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Antiepilepticus Effects of Tetrahedral Framework Nucleic Acid via Inhibition of Gliosis-Induced Downregulation of Glutamine Synthetase and Increased AMPAR Internalization in the Postsynaptic Membrane

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Astrocyte immunometabolic regulation of the tumour microenvironment drives glioblastoma pathogenicity

(2022) Rita Perelroizen et al.   BRAIN

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Inhibition of connexin hemichannels alleviates neuroinflammation and hyperexcitability in temporal lobe epilepsy

(2022) Anni Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase

(2022) Junli Zhao et al.   Nature Communications

Silencing of circIgf1r plays a protective role in neuronal injury via regulating astrocyte polarization during epilepsy

(2021) Lin Shao et al.   FASEB JOURNAL

Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4

(2021) Tengfei Huang et al.   Autophagy

Reactive astrocyte nomenclature, definitions, and future directions

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Diversity and Function of Glial Cell Types in Multiple Sclerosis

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Absence of RNA‐binding protein FXR2P prevents prolonged phase of kainate‐induced seizures

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Neuronal circuits overcome imbalance in excitation and inhibition by adjusting connection numbers

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TRPV4 Regulates Soman-Induced Status Epilepticus and Secondary Brain Injury via NMDA Receptor and NLRP3 Inflammasome

(2021) Shuai Wang et al.   Neuroscience Bulletin

Microglia provide structural resolution to injured dendrites after severe seizures

(2021) Ukpong B. Eyo et al.   Cell Reports

Inhibiting with-no-lysine kinases enhances K+/Cl− cotransporter 2 activity and limits status epilepticus

(2021) Kathryn L Lee et al.   BRAIN

TRPV4-induced Müller cell gliosis and TNF-α elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NF-κB pathway

(2021) Qian Li et al.   Journal of Neuroinflammation

TRPV4 inhibitor HC067047 produces antidepressant-like effect in LPS-induced depression mouse model

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Inverse Agonism of Cannabinoid Receptor Type 2 Confers Anti-inflammatory and Neuroprotective Effects Following Status Epileptics

(2020) Ying Yu et al.   MOLECULAR NEUROBIOLOGY

Reactive Glia Inflammatory Signaling Pathways and Epilepsy

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Repetitive Diffuse Mild Traumatic Brain Injury Causes an Atypical Astrocyte Response and Spontaneous Recurrent Seizures

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NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells

(2019) Jason Tchieu et al.   NATURE BIOTECHNOLOGY

Epilepsy in adults

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Region-specific differences and areal interactions underlying transitions in epileptiform activity

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TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI)

(2019) Xing-Liang Yang et al.   Journal of Neuroinflammation

TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice

(2019) Zhouqing Wang et al.   Cell Death & Disease

Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury

(2019) Dylan Laug et al.   JOURNAL OF CLINICAL INVESTIGATION

The 4-Aminopyridine Model of Acute Seizures in vitro Elucidates Efficacy of New Antiepileptic Drugs

(2019) Hanno Heuzeroth et al.   Frontiers in Neuroscience

Endothelial Cdk5 deficit leads to the development of spontaneous epilepsy through CXCL1/CXCR2-mediated reactive astrogliosis

(2019) Xiu-xiu Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NFAT5 and HIF-1α Coordinate to Regulate NKCC1 Expression in Hippocampal Neurons After Hypoxia-Ischemia

(2019) Xing-Liang Yang et al.   Frontiers in Cell and Developmental Biology

TRPV4: a Sensor for Homeostasis and Pathological Events in the CNS

(2018) Hemant Kumar et al.   MOLECULAR NEUROBIOLOGY

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

(2018) Neibla Priego et al.   NATURE MEDICINE

Glial cell-expressed mechanosensitive channel TRPV4 mediates infrasound-induced neuronal impairment

(2013) Ming Shi et al.   ACTA NEUROPATHOLOGICA

Imbalance between Excitation and Inhibition in the Somatosensory Cortex Produces Postadaptation Facilitation

(2013) K. Cohen-Kashi Malina et al.   JOURNAL OF NEUROSCIENCE

Glia and epilepsy: excitability and inflammation

(2013) Orrin Devinsky et al.   TRENDS IN NEUROSCIENCES

Sox9 and NFIA Coordinate a Transcriptional Regulatory Cascade during the Initiation of Gliogenesis

(2012) Peng Kang et al.   NEURON

Reduced Astrocytic Contribution to the Turnover of Glutamate, Glutamine, and GABA Characterizes the Latent Phase in the Kainate Model of Temporal Lobe Epilepsy

(2011) Silje Alvestad et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Response of transcription factor NFATc3 to excitotoxic and traumatic brain insults: Identification of a subpopulation of reactive astrocytes

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Nuclear factor I gene expression in the developing forebrain

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A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

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