The 4-Aminopyridine Model of Acute Seizures in vitro Elucidates Efficacy of New Antiepileptic Drugs

Initiation and slow propagation of epileptiform activity from ventral to dorsal medial entorhinal cortex is constrained by an inhibitory gradient

(2018) Thomas Ridler et al.   JOURNAL OF PHYSIOLOGY-LONDON

Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs

(2018) Zhibin Chen et al.   JAMA Neurology

Recurrent epileptiform discharges in the medial entorhinal cortex of kainate-treated rats are differentially sensitive to antiseizure drugs

(2018) Peter J. West et al.   EPILEPSIA

Comparison of lacosamide concentrations in cerebrospinal fluid and serum in patients with epilepsy

(2015) Theodor W. May et al.   EPILEPSIA

Lacosamide modulates interictal spiking and high-frequency oscillations in a model of mesial temporal lobe epilepsy

(2015) Charles Behr et al.   EPILEPSY RESEARCH

Current understanding of the mechanism of action of the antiepileptic drug lacosamide

(2015) Michael A. Rogawski et al.   EPILEPSY RESEARCH

Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice

(2015) Sabine Klein et al.   NEUROPHARMACOLOGY

Subiculum–entorhinal cortex interactions during in vitro ictogenesis

(2015) Rochelle Herrington et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

The anti-ictogenic effects of levetiracetam are mirrored by interictal spiking and high-frequency oscillation changes in a model of temporal lobe epilepsy

(2015) Maxime Lévesque et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

ILAE Official Report: A practical clinical definition of epilepsy

(2014) Robert S. Fisher et al.   EPILEPSIA

Hilar Somatostatin Interneurons Contribute to Synchronized GABA Activity in an In Vitro Epilepsy Model

(2014) Sabine Grosser et al.   PLoS One

Modern antiepileptic drug development has failed to deliver: Ways out of the current dilemma

(2011) Wolfgang Löscher et al.   EPILEPSIA

Status epilepticus induces increasing neuronal excitability and hypersynchrony as revealed by optical imaging

(2011) M. Holtkamp et al.   NEUROBIOLOGY OF DISEASE

Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs

(2011) Wolfgang Löscher   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Cotrafficking of SV2 and Synaptotagmin at the Synapse

(2010) J. Yao et al.   JOURNAL OF NEUROSCIENCE

Cortico-hippocampal hyperexcitability in synapsin I/II/III knockout mice: age-dependency and response to the antiepileptic drug levetiracetam

(2010) D. Boido et al.   NEUROSCIENCE

High-frequency electroencephalographic oscillations correlate with outcome of epilepsy surgery

(2009) Julia Jacobs et al.   ANNALS OF NEUROLOGY

Antiepileptic drugs abolish ictal but not interictal epileptiform discharges in vitro

(2009) Margherita D’Antuono et al.   EPILEPSIA

Rapid plasticity at inhibitory and excitatory synapses in the hippocampus induced by ictal epileptiform discharges

(2009) Valeri Lopantsev et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Standard antiepileptic drugs fail to block epileptiform activity in rat organotypic hippocampal slice cultures

(2008) K Albus et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antiepileptic activity of zonisamide on hippocampal CA3 neurons does not depend on carbonic anhydrase inhibition

(2008) Jan Thöne et al.   EPILEPSY RESEARCH

K+-Channel Openers Suppress Epileptiform Activities Induced by 4-Aminopyridine in Cultured Rat Hippocampal Neurons

(2008) Kiyoaki Kobayashi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Intracranial EEG findings in patients with lesional lateral temporal lobe epilepsy

(2007) Naotaka Usui et al.   EPILEPSY RESEARCH