Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) Mitigates Seizures

Silencing of circIgf1r plays a protective role in neuronal injury via regulating astrocyte polarization during epilepsy

(2021) Lin Shao et al.   FASEB JOURNAL

The effect of dipeptidyl peptidase IV on disease-associated microglia phenotypic transformation in epilepsy

(2021) Zhicheng Zheng et al.   Journal of Neuroinflammation

Astrocytic YAP promotes the formation of glia scars and neural regeneration after spinal cord injury

(2020) Changnan Xie et al.   JOURNAL OF NEUROSCIENCE

Deletion of Voltage-Gated Calcium Channels in Astrocytes during Demyelination Reduces Brain Inflammation and Promotes Myelin Regeneration in Mice

(2020) Norma N. Zamora et al.   JOURNAL OF NEUROSCIENCE

Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype

(2020) Baohua Hou et al.   Cell Death & Disease

Transient receptor potential vanilloid 4 activation inhibits the delayed rectifier potassium channels in hippocampal pyramidal neurons: An implication in pathological changes following pilocarpine‐induced status epilepticus

(2020) Li Zhou et al.   JOURNAL OF NEUROSCIENCE RESEARCH

TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice

(2019) Zhouqing Wang et al.   Cell Death & Disease

Detrimental Effects of HMGB-1 Require Microglial-Astroglial Interaction: Implications for the Status Epilepticus -Induced Neuroinflammation

(2019) Gerardo Rosciszewski et al.   Frontiers in Cellular Neuroscience

Temperature elevation in epileptogenic foci exacerbates epileptic discharge through TRPV4 activation

(2019) Koji Shibasaki et al.   LABORATORY INVESTIGATION

Activation of TRPV1 Contributes to Recurrent Febrile Seizures via Inhibiting the Microglial M2 Phenotype in the Immature Brain

(2019) Weilin Kong et al.   Frontiers in Cellular Neuroscience

The Hippo pathway as a drug target in gastric cancer

(2018) Yiting Qiao et al.   CANCER LETTERS

A connexin43/YAP axis regulates astroglial-mesenchymal transition in hemoglobin induced astrocyte activation

(2018) Yong Yang et al.   CELL DEATH AND DIFFERENTIATION

GPER/Hippo-YAP signal is involved in Bisphenol S induced migration of triple negative breast cancer (TNBC) cells

(2018) Qianqian Deng et al.   JOURNAL OF HAZARDOUS MATERIALS

TRPV4 is functionally expressed in oligodendrocyte precursor cells and increases their proliferation

(2018) Kana Ohashi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The Hippo pathway in normal development and cancer

(2018) Marcello Maugeri-Saccà et al.   PHARMACOLOGY & THERAPEUTICS

The Hippo Pathway: Immunity and Cancer

(2018) Zaid Taha et al.   Cancers

TRPV4 regulates matrix stiffness and TGFβ1-induced epithelial-mesenchymal transition

(2018) Shweta Sharma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The paroxysmal depolarization shift in epilepsy research

(2018) Matej Hotka et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Transient receptor potential vanilloid type 4 channels mediate Na-K-Cl-co-transporter-induced brain edema after traumatic brain injury

(2017) Kwok-Tung Lu et al.   JOURNAL OF NEUROCHEMISTRY

The Epigenetics of Epilepsy and Its Progression

(2017) Rebecca M. Hauser et al.   NEUROSCIENTIST

Expression and cellular distribution of transient receptor potential vanilloid 4 in cortical tubers of the tuberous sclerosis complex

(2016) Xin Chen et al.   BRAIN RESEARCH

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Recent advances in status epilepticus

(2016) Eugen Trinka et al.   CURRENT OPINION IN NEUROLOGY

YAP stabilizes SMAD1 and promotes BMP2-induced neocortical astrocytic differentiation

(2016) Zhihui Huang et al.   DEVELOPMENT

TRPV4: Molecular Conductor of a Diverse Orchestra

(2016) John P. M. White et al.   PHYSIOLOGICAL REVIEWS

Transient Receptor Potential Vanilloid 4 Inhibits γ-Aminobutyric Acid-Activated Current in Hippocampal Pyramidal Neurons

(2016) Zhiwen Hong et al.   Frontiers in Molecular Neuroscience

Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice

(2016) Thomas Dalsgaard et al.   Scientific Reports

Hippocampal neuronal maturation triggers post-synaptic clustering of brain temperature-sensor TRPV4

(2015) Koji Shibasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

YAP Is a Critical Inducer of SOCS3, Preventing Reactive Astrogliosis

(2015) Zhihui Huang et al.   CEREBRAL CORTEX

Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K/Akt and upregulating p38 MAPK signaling pathways

(2015) P Jie et al.   Cell Death & Disease

Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis

(2014) A. N. Lau et al.   EMBO JOURNAL

Activation of Transient Receptor Potential Vanilloid 4 is Involved in Neuronal Injury in Middle Cerebral Artery Occlusion in Mice

(2014) Pinghui Jie et al.   MOLECULAR NEUROBIOLOGY

Involvement of TRPV4 channels in Aβ40-induced hippocampal cell death and astrocytic Ca2+ signalling

(2014) Ji-Zhong Bai et al.   NEUROTOXICOLOGY

Glial cell-expressed mechanosensitive channel TRPV4 mediates infrasound-induced neuronal impairment

(2013) Ming Shi et al.   ACTA NEUROPATHOLOGICA

Analysis of responses to the TRPV4 agonist GSK1016790A in the pulmonary vascular bed of the intact-chest rat

(2013) Edward A. Pankey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Transient Receptor Potential Vanilloid 4 Mediates Hypotonicity-Induced Enhancement of Synaptic Transmission in Hippocampal Slices

(2013) Lin Li et al.   CNS Neuroscience & Therapeutics

Role of TRPV1 in susceptibility to PTZ-induced seizure following repeated hyperthermia challenges in neonatal mice

(2013) Wei-Lin Kong et al.   EPILEPSY & BEHAVIOR

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

(2013) Randy Johnson et al.   NATURE REVIEWS DRUG DISCOVERY

TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses

(2013) K. M. Dunn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel zebrafish model of hyperthermia-induced seizures reveals a role for TRPV4 channels and NMDA-type glutamate receptors

(2012) Robert F. Hunt et al.   EXPERIMENTAL NEUROLOGY

Stimulation of transient receptor potential vanilloid 4 channel suppresses abnormal activation of microglia induced by lipopolysaccharide

(2012) Masakazu Konno et al.   GLIA

Allopregnanolone Potentiates the Glutamate-Mediated Seizures Induced by 4-Aminopyridine in Rat Hippocampus in vivo

(2011) Patricia Salazar et al.   NEUROCHEMICAL RESEARCH

A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation

(2010) N Vergnolle et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

(2010) J. Cai et al.   GENES & DEVELOPMENT

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

(2010) B. Zhao et al.   GENES & DEVELOPMENT

The potential role of mitochondrial dysfunction in seizure-associated cell death in the hippocampus and epileptogenesis

(2010) Shang-Der Chen et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Astrocytes in the Epileptic Brain

(2008) Jonathon Wetherington et al.   NEURON