TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI)

Ion Channels and Receptors as Determinants of Microglial Function

(2019) Pablo Izquierdo et al.   TRENDS IN NEUROSCIENCES

Systemic infusions of anti-interleukin-1β neutralizing antibodies reduce short-term brain injury after cerebral ischemia in the ovine fetus

(2018) Xiaodi Chen et al.   BRAIN BEHAVIOR AND IMMUNITY

Hippocampal interleukin-1 mediates stress-enhanced fear learning: A potential role for astrocyte-derived interleukin-1β

(2018) Meghan E. Jones et al.   BRAIN BEHAVIOR AND IMMUNITY

Stattic inhibits RANKL-mediated osteoclastogenesis by suppressing activation of STAT3 and NF-κB pathways

(2018) Chang-hong Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ginkgolide B ameliorates NLRP3 inflammasome activation after hypoxic-ischemic brain injury in the neonatal male rat

(2018) Aiming Chen et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic–ischemic brain injury in rats

(2018) Di Chen et al.   Journal of Neuroinflammation

Vitexin reduces epilepsy after hypoxic ischemia in the neonatal brain via inhibition of NKCC1

(2018) Wen-di Luo et al.   Journal of Neuroinflammation

Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation

(2018) Mithilesh Kumar Jha et al.   NEUROSCIENTIST

Manganese exposure facilitates microglial JAK2-STAT3 signaling and consequent secretion of TNF-a and IL-1β to promote neuronal death

(2018) Lifeng Yin et al.   NEUROTOXICOLOGY

SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through activation of SRC/ERK/c-MYC/PFKFB2 pathway

(2018) Shu-Jie Zhao et al.   Cell Death & Disease

Attenuation of Retinal Vascular Development in Neonatal Mice Subjected to Hypoxic-Ischemic Encephalopathy

(2018) Ismail S. Zaitoun et al.   Scientific Reports

Cinobufacini protects against paclitaxel-induced peripheral neuropathic pain and suppresses TRPV1 up-regulation and spinal astrocyte activation in rats

(2018) Xiyuan Ba et al.   BIOMEDICINE & PHARMACOTHERAPY

Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes

(2018) Matthew Neal et al.   GLIA

Myeloid cell IRF4 signaling protects neonatal brains from hypoxic ischemic encephalopathy

(2018) Abdullah Al Mamun et al.   NEUROCHEMISTRY INTERNATIONAL

Neonatal hypoxia-ischemia caused mild motor dysfunction, recovered by acrobatic training, without affecting morphological structures involved in motor control in rats

(2018) Heloísa Deola Confortim et al.   BRAIN RESEARCH

NLRP3 Inflammasome Activation in a Transgenic Amyotrophic Lateral Sclerosis Model

(2017) Agnese Gugliandolo et al.   INFLAMMATION

A Review on Potential Involvement of TRPV1 Channels in Ischemia–Reperfusion Injury

(2017) Puneet Kaur Randhawa et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes

(2017) Leslie Freeman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat

(2017) Keren Zhou et al.   STROKE

Selective NLRP3 (Pyrin Domain–Containing Protein 3) Inflammasome Inhibitor Reduces Brain Injury After Intracerebral Hemorrhage

(2017) Honglei Ren et al.   STROKE

Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin

(2017) Yikun Yao et al.   Nature Communications

NLRP3 Is Involved in Ischemia/Reperfusion Injury

(2016) Zhiliang Guo et al.   CNS & Neurological Disorders-Drug Targets

Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) reduces neonatal hypoxic-ischaemic brain damage

(2016) Mariya Hristova et al.   JOURNAL OF NEUROCHEMISTRY

Not everything is scary about a glial scar

(2016) Shane A. Liddelow et al.   NATURE

Glucose and Intermediary Metabolism and Astrocyte–Neuron Interactions Following Neonatal Hypoxia–Ischemia in Rat

(2016) Eva Brekke et al.   NEUROCHEMICAL RESEARCH

Astrocyte GGTI-mediated Rac1 prenylation upregulates NF-κB expression and promotes neuronal apoptosis following hypoxia/ischemia

(2016) Shangfeng Gao et al.   NEUROPHARMACOLOGY

Perspectives of TRPV1 Function on the Neurogenesis and Neural Plasticity

(2016) R. Ramírez-Barrantes et al.   NEURAL PLASTICITY

TRPV1 is crucial for proinflammatory STAT3 signaling and thermoregulation-associated pathways in the brain during inflammation

(2016) Ayaka Yoshida et al.   Scientific Reports

Astrocytes: a central element in neurological diseases

(2015) Milos Pekny et al.   ACTA NEUROPATHOLOGICA

A pathophysiological role of TRPV1 in ischemic injury after transient focal cerebral ischemia in mice

(2015) Jun Miyanohara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRPV1 promotes repetitive febrile seizures by pro-inflammatory cytokines in immature brain

(2015) Wen-Xian Huang et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling

(2015) Samia Habbas et al.   CELL

Activation of mitochondrial transient receptor potential vanilloid 1 channel contributes to microglial migration

(2015) Takahito Miyake et al.   GLIA

Inhibition of connexin43 improves functional recovery after ischemic brain injury in neonatal rats

(2015) Xiaojing Li et al.   GLIA

Astrocyte reactivity after brain injury-: The role of galectins 1 and 3

(2015) Swetlana Sirko et al.   GLIA

Atrial natriuretic peptide down-regulates LPS/ATP-mediated IL-1β release by inhibiting NF-kB, NLRP3 inflammasome and caspase-1 activation in THP-1 cells

(2015) Letizia Mezzasoma et al.   IMMUNOLOGIC RESEARCH

New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling

(2015) M. L. Olsen et al.   JOURNAL OF NEUROSCIENCE

Binding of Capsaicin to the TRPV1 Ion Channel

(2015) Leonardo Darré et al.   MOLECULAR PHARMACEUTICS

Neutralizing anti-interleukin-1β antibodies modulate fetal blood–brain barrier function after ischemia

(2015) Xiaodi Chen et al.   NEUROBIOLOGY OF DISEASE

Vitexin reduces hypoxia–ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model

(2015) Jia-Wei Min et al.   NEUROPHARMACOLOGY

Histidine provides long-term neuroprotection after cerebral ischemia through promoting astrocyte migration

(2015) Ru-jia Liao et al.   Scientific Reports

The pain receptor TRPV1 displays agonist-dependent activation stoichiometry

(2015) Adina Hazan et al.   Scientific Reports

Astrocyte matricellular proteins that control excitatory synaptogenesis are regulated by inflammatory cytokines and correlate with paralysis severity during experimental autoimmune encephalomyelitis

(2015) Pennelope K. Blakely et al.   Frontiers in Neuroscience

The dual face of connexin-based astroglial Ca2+ communication: A key player in brain physiology and a prime target in pathology

(2014) Marijke De Bock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Selenium Reduces Oxidative Stress and Calcium Entry Through TRPV1 Channels in the Neutrophils of Patients with Polycystic Ovary Syndrome

(2014) Seyit Ali Köse et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Activation of the TRPV1 cation channel contributes to stress-induced astrocyte migration

(2014) Karen W. Ho et al.   GLIA

Brain transient receptor potential channels and stroke

(2014) Eric Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

“Hotheaded”: The role OF TRPV1 in brain functions

(2014) D. Martins et al.   NEUROPHARMACOLOGY

Expression of TRPV1 in the C57BL/6 mice brain hippocampus and cortex during development

(2014) Wen-xian Huang et al.   NEUROREPORT

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

(2014) Milos Pekny et al.   PHYSIOLOGICAL REVIEWS

Inflammatory responses in hypoxic ischemic encephalopathy

(2013) Fudong Liu et al.   ACTA PHARMACOLOGICA SINICA

Mechanisms of Neuroprotection from Hypoxia-Ischemia (HI) Brain Injury by Up-regulation of Cytoglobin (CYGB) in a Neonatal Rat Model

(2013) Shu-Feng Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ionic Transporter Activity in Astrocytes, Microglia, and Oligodendrocytes During Brain Ischemia

(2013) Lucio Annunziato et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral inflammation and mobilization of the peripheral immune system following global hypoxia-ischemia in preterm sheep

(2013) Reint K Jellema et al.   Journal of Neuroinflammation

Acute and subacute IL-1β administrations differentially modulate neuroimmune and neurotrophic systems: possible implications for neuroprotection and neurodegeneration

(2013) Cai Song et al.   Journal of Neuroinflammation

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion

(2013) Helena W Morrison et al.   Journal of Neuroinflammation

Hyperbaric oxygenation reduces long-term brain injury and ameliorates behavioral function by suppression of apoptosis in a rat model of neonatal hypoxia–ischemia

(2013) Xiao-Hong Liu et al.   NEUROCHEMISTRY INTERNATIONAL

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Effects of pre- and postnatal protein malnutrition in hypoxic–ischemic rats

(2011) Eduardo Farias Sanches et al.   BRAIN RESEARCH

TRPV1-Dependent and -Independent Alterations in the Limbic Cortex of Neuropathic Mice: Impact on Glial Caspases and Pain Perception

(2011) Catia Giordano et al.   CEREBRAL CORTEX

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

A “Cute” Desensitization of TRPV1

(2010) Filip Touska et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Stimulus-dependent requirement of ion channels for microglial NADPH oxidase-mediated production of reactive oxygen species

(2010) Tom Schilling et al.   JOURNAL OF NEUROIMMUNOLOGY

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

IL-1/IL-1ra balance in the brain revisited – Evidence from transgenic mouse models

(2009) S. Spulber et al.   BRAIN BEHAVIOR AND IMMUNITY

Importance of the non-selective cation channel TRPV1 for microglial reactive oxygen species generation

(2009) Tom Schilling et al.   JOURNAL OF NEUROIMMUNOLOGY

Increased Umbilical Cord Plasma Interleukin-1  Levels was Correlated with Adverse Outcomes of Neonatal Hypoxic-ischemic Encephalopathy

(2009) J. Liu et al.   JOURNAL OF TROPICAL PEDIATRICS

STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria

(2009) Lobelia Samavati et al.   MOLECULAR IMMUNOLOGY

Inflammatory Cytokines in Acute Ischemic Stroke

(2008) Antonino Tuttolomondo et al.   CURRENT PHARMACEUTICAL DESIGN

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

(2008) J. E. Herrmann et al.   JOURNAL OF NEUROSCIENCE

Capsaicin pretreatment attenuates LPS-induced hypothermia through TRPV1-independent mechanisms in chicken

(2008) Hideki Nikami et al.   LIFE SCIENCES

Astrocyte Responses after Neonatal Ischemia: The Yin and the Yang

(2008) Sonia Villapol et al.   NEUROSCIENTIST