TRPV4 inhibitor HC067047 produces antidepressant-like effect in LPS-induced depression mouse model

Cholinergic transmission from the basal forebrain modulates social memory in male mice

(2021) Ornela Kljakic et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Adult food choices depend on sex and exposure to early-life stress: Underlying brain circuitry, adipose tissue adaptations and metabolic responses

(2021) S.R. Ruigrok et al.   Neurobiology of Stress

FGF21 Attenuated LPS-Induced Depressive-Like Behavior via Inhibiting the Inflammatory Pathway

(2020) Xue Wang et al.   Frontiers in Pharmacology

Characterization of astrocytes throughout life in wildtype and APP/PS1 mice after early-life stress exposure

(2020) Maralinde R. Abbink et al.   Journal of Neuroinflammation

Irradiation increases brain-derived neurotrophic factor precursor signaling in the mouse hippocampus

(2020) Zhen Wang et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+

(2020) Brian M. Woolums et al.   Nature Communications

TRPV4 calcium influx controls sclerostin protein loss independent of purinergic calcium oscillations

(2020) Katrina M. Williams et al.   BONE

Immunoneuropsychiatry — novel perspectives on brain disorders

(2019) Katrin Pape et al.   Nature Reviews Neurology

The selective TRPV4 channel antagonist HC-067047 attenuates mechanical allodynia in diabetic mice

(2019) Fabiana C. Dias et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Augmentation effect of ketamine by guanosine in the novelty-suppressed feeding test is dependent on mTOR signaling pathway

(2019) Anderson Camargo et al.   JOURNAL OF PSYCHIATRIC RESEARCH

MicroRNA-32-5p knockout eliminates lipopolysaccharide-induced depressive-like behavior in mice through inhibition of astrocyte overactivity

(2019) Xiaolin Zhong et al.   BRAIN BEHAVIOR AND IMMUNITY

Kinin Receptors Sensitize TRPV4 Channel and Induce Mechanical Hyperalgesia: Relevance to Paclitaxel-Induced Peripheral Neuropathy in Mice

(2017) Robson Costa et al.   MOLECULAR NEUROBIOLOGY

Activation of Transient Receptor Potential Vanilloid 4 Impairs the Dendritic Arborization of Newborn Neurons in the Hippocampal Dentate Gyrus through the AMPK and Akt Signaling Pathways

(2017) Yujing Tian et al.   Frontiers in Molecular Neuroscience

Pleiotropic function of TRPV4 ion channels in the central nervous system

(2016) Patrick Kanju et al.   EXPERIMENTAL PHYSIOLOGY

Inactivation of BRD7 results in impaired cognitive behavior and reduced synaptic plasticity of the medial prefrontal cortex

(2015) Yang Xu et al.   BEHAVIOURAL BRAIN RESEARCH

Inflammation and clinical response to treatment in depression: A meta-analysis

(2015) R. Strawbridge et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Effects of treadmill running and rutin on lipolytic signaling pathways and TRPV4 protein expression in the adipose tissue of diet-induced obese mice

(2015) Neng Chen et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress

(2015) Yan-Wei Luo et al.   NEUROPHARMACOLOGY

TRPV4 activation at the physiological temperature is a critical determinant of neuronal excitability and behavior

(2015) Koji Shibasaki et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A Novel Subtype of Astrocytes Expressing TRPV4 (Transient Receptor Potential Vanilloid 4) Regulates Neuronal Excitability via Release of Gliotransmitters

(2014) Koji Shibasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-related changes in the distribution of transient receptor potential vanilloid 4 channel (TRPV4) in the central nervous system of rats

(2014) Jae Chul Lee et al.   JOURNAL OF MOLECULAR HISTOLOGY

Molecular and cellular neuroinflammatory status of mouse brain after systemic lipopolysaccharide challenge: importance of CCR2/CCL2 signaling

(2014) Julie Cazareth et al.   Journal of Neuroinflammation

Activation of Transient Receptor Potential Vanilloid 4 is Involved in Neuronal Injury in Middle Cerebral Artery Occlusion in Mice

(2014) Pinghui Jie et al.   MOLECULAR NEUROBIOLOGY

Involvement of TRPV4 channels in Aβ40-induced hippocampal cell death and astrocytic Ca2+ signalling

(2014) Ji-Zhong Bai et al.   NEUROTOXICOLOGY

Glial cell-expressed mechanosensitive channel TRPV4 mediates infrasound-induced neuronal impairment

(2013) Ming Shi et al.   ACTA NEUROPATHOLOGICA

The puzzle of TRPV4 channelopathies

(2013) Bernd Nilius et al.   EMBO REPORTS

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion

(2013) Helena W Morrison et al.   Journal of Neuroinflammation

Activation of Transient Receptor Potential Vanilloid 4 Increases NMDA-Activated Current in Hippocampal Pyramidal Neurons

(2013) Lin Li et al.   Frontiers in Cellular Neuroscience

The Increased Activity of TRPV4 Channel in the Astrocytes of the Adult Rat Hippocampus after Cerebral Hypoxia/Ischemia

(2012) Olena Butenko et al.   PLoS One

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression

(2012) Charles L. Raison et al.   JAMA Psychiatry

Depressive-like behavior induced by tumor necrosis factor-α in mice

(2011) Manuella P. Kaster et al.   NEUROPHARMACOLOGY

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

(2010) W. Everaerts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

(2008) Hui-Ming Gao et al.   TRENDS IN IMMUNOLOGY