Inverse Agonism of Cannabinoid Receptor Type 2 Confers Anti-inflammatory and Neuroprotective Effects Following Status Epileptics

Targeting prostaglandin receptor EP2 for adjunctive treatment of status epilepticus

(2020) Marwa M. Nagib et al.   PHARMACOLOGY & THERAPEUTICS

Small‐molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase‐associated malignant glioma growth

(2019) Jiange Qiu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Amelioration of visual deficits and visual system pathology after mild TBI with the cannabinoid type-2 receptor inverse agonist SMM-189

(2019) Natalie M. Guley et al.   EXPERIMENTAL EYE RESEARCH

Suppressing pro-inflammatory prostaglandin signaling attenuates excitotoxicity-associated neuronal inflammation and injury

(2019) Jianxiong Jiang et al.   NEUROPHARMACOLOGY

The Outcome of Status Epilepticus and Long-Term Follow-Up

(2019) László Horváth et al.   Frontiers in Neurology

Underdosing of Benzodiazepines in Patients With Status Epilepticus Enrolled in Established Status Epilepticus Treatment Trial

(2019) Abhishek G. Sathe et al.   ACADEMIC EMERGENCY MEDICINE

Endocannabinoid and Prostanoid Crosstalk in Pain

(2019) Baptiste Buisseret et al.   TRENDS IN MOLECULAR MEDICINE

G protein-coupled receptors in acquired epilepsy: Druggability and translatability

(2019) Ying Yu et al.   PROGRESS IN NEUROBIOLOGY

Reduced cannabinoid 2 receptor activity increases susceptibility to induced seizures in mice

(2019) Lindsey Shapiro et al.   EPILEPSIA

Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2

(2018) Jianxiong Jiang et al.   ACS Chemical Neuroscience

Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB 1 and CB 2 receptors and relevance for Alzheimer’s disease and levodopa-induced dyskinesia

(2018) Gemma Navarro et al.   BRAIN BEHAVIOR AND IMMUNITY

Status epilepticus triggers long-lasting activation of complement C1q-C3 signaling in the hippocampus that correlates with seizure frequency in experimental epilepsy

(2018) Nicole D. Schartz et al.   NEUROBIOLOGY OF DISEASE

The spatiotemporal expression changes of CB2R in the hippocampus of rats following pilocarpine-induced status epilepticus

(2018) Qiong Wu et al.   EPILEPSY RESEARCH

Anticonvulsant effect of cannabinoid receptor agonists in models of seizures in developing rats

(2017) Megan N. Huizenga et al.   EPILEPSIA

Cannabinoid receptor 1/2 double-knockout mice develop epilepsy

(2017) Shane Rowley et al.   EPILEPSIA

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

(2017) Pavel Klein et al.   EPILEPSIA

Neuroinflammatory targets and treatments for epilepsy validated in experimental models

(2017) Eleonora Aronica et al.   EPILEPSIA

Alleviation of Neuropathology by Inhibition of Monoacylglycerol Lipase in APP Transgenic Mice Lacking CB2 Receptors

(2017) Jian Zhang et al.   MOLECULAR NEUROBIOLOGY

Animal Models of Seizures and Epilepsy: Past, Present, and Future Role for the Discovery of Antiseizure Drugs

(2017) Wolfgang Löscher   NEUROCHEMICAL RESEARCH

Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype

(2017) Xu Kang et al.   Scientific Reports

Defining the therapeutic time window for suppressing the inflammatory prostaglandin E2 signaling after status epilepticus

(2016) Yifeng Du et al.   Expert Review of Neurotherapeutics

The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting

(2016) Christopher S. von Bartheld et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Microglia activation states and cannabinoid system: Therapeutic implications

(2016) M. Mecha et al.   PHARMACOLOGY & THERAPEUTICS

Anti-Inflammatory Small Molecules To Treat Seizures and Epilepsy: From Bench to Bedside

(2016) Avijit Dey et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Defining the therapeutic time window for suppressing the inflammatory prostaglandin E2 signaling after status epilepticus

(2016) Yifeng Du et al.   Expert Review of Neurotherapeutics

Mild Traumatic Brain Injury Produces Neuron Loss That Can Be Rescued by Modulating Microglial Activation Using a CB2 Receptor Inverse Agonist

(2016) Wei Bu et al.   Frontiers in Neuroscience

Candidate Drug Targets for Prevention or Modification of Epilepsy

(2015) Nicholas H. Varvel et al.   Annual Review of Pharmacology and Toxicology

Synthesis and biological evaluation of (3′,5′-dichloro-2,6-dihydroxy-biphenyl-4-yl)-aryl/alkyl-methanone selective CB2 inverse agonist

(2015) Chaela S. Presley et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pharmacotherapy for Status Epilepticus

(2015) Eugen Trinka et al.   DRUGS

A definition and classification of status epilepticus - Report of the ILAE Task Force on Classification of Status Epilepticus

(2015) Eugen Trinka et al.   EPILEPSIA

Status epilepticus in adults

(2015) John P Betjemann et al.   LANCET NEUROLOGY

Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy

(2015) Ivan Soltesz et al.   NATURE REVIEWS NEUROSCIENCE

Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus

(2015) Jianxiong Jiang et al.   NEUROBIOLOGY OF DISEASE

Time from convulsive status epilepticus onset to anticonvulsant administration in children

(2015) I. Sanchez Fernandez et al.   NEUROLOGY

Cannabinoids in the Treatment of Epilepsy

(2015) Daniel Friedman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alternatively activated microglia and macrophages in the central nervous system

(2015) Rafael Franco et al.   PROGRESS IN NEUROBIOLOGY

Mechanisms Responsible for Cognitive Impairment in Epilepsy

(2015) Pierre-Pascal Lenck-Santini et al.   Cold Spring Harbor Perspectives in Medicine

Motor, Visual and Emotional Deficits in Mice after Closed-Head Mild Traumatic Brain Injury Are Alleviated by the Novel CB2 Inverse Agonist SMM-189

(2014) Anton Reiner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation

(2014) Daniel J. Hermanson et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

COX-2-derived endocannabinoid metabolites as novel inflammatory mediators

(2014) Mireille Alhouayek et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cyclooxygenase-2 in epilepsy

(2013) Asheebo Rojas et al.   EPILEPSIA

Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms

(2013) Jeannie Chin et al.   EPILEPSY & BEHAVIOR

Behavioral impairments in rats with chronic epilepsy suggest comorbidity between epilepsy and attention deficit/hyperactivity disorder

(2013) Eduardo Pineda et al.   EPILEPSY & BEHAVIOR

Experimental Models of Status Epilepticus and Neuronal Injury for Evaluation of Therapeutic Interventions

(2013) Doodipala Reddy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

EP2 Receptor Signaling Pathways Regulate Classical Activation of Microglia

(2013) Yi Quan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antibody testing for brain immunohistochemistry: Brain immunolabeling for the cannabinoid CB2 receptor

(2013) Jean-Ha Baek et al.   JOURNAL OF NEUROSCIENCE METHODS

New avenues for anti-epileptic drug discovery and development

(2013) Wolfgang Löscher et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation

(2013) Jianxiong Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glia and epilepsy: excitability and inflammation

(2013) Orrin Devinsky et al.   TRENDS IN NEUROSCIENCES

Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection

(2013) Jianxiong Jiang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Insights into the regulation of protein abundance from proteomic and transcriptomic analyses

(2012) Christine Vogel et al.   NATURE REVIEWS GENETICS

The role of inflammation in epileptogenesis

(2012) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2

(2012) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Management of refractory status epilepticus in adults: still more questions than answers

(2011) Andrea O Rossetti et al.   LANCET NEUROLOGY

Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans

(2010) Zsófia Maglóczky et al.   EPILEPSIA

Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas

(2010) Nephi Stella   GLIA

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor

(2010) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal characterization of changes in hippocampal cannabinoid CB 1 receptor expression following pilocarpine-induced status epilepticus

(2009) Katherine W. Falenski et al.   BRAIN RESEARCH

Factors predictive of outcome in patients with de novo status epilepticus

(2008) M.-H. Tsai et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

CB2receptors in the brain: role in central immune function

(2007) G A Cabral et al.   BRITISH JOURNAL OF PHARMACOLOGY