TRPV4-induced Müller cell gliosis and TNF-α elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NF-κB pathway

Krüppel-like factor 7 protects retinal ganglion cells and promotes functional preservation via activating the Akt pathway after retinal ischemia-reperfusion injury

(2021) Zongyuan Li et al.   EXPERIMENTAL EYE RESEARCH

Soluble tumor necrosis factor-alpha-induced hyperexcitability contributes to retinal ganglion cell apoptosis by enhancing Nav1.6 in experimental glaucoma

(2021) Shuo Cheng et al.   Journal of Neuroinflammation

Elevated TRPV4 Levels Contribute to Endothelial Damage and Scarring in Experimental Spinal Cord Injury

(2020) Hemant Kumar et al.   JOURNAL OF NEUROSCIENCE

Group II metabotropic glutamate receptor agonist promotes retinal ganglion cell survival by reducing neuronal excitotoxicity in a rat chronic ocular hypertension model

(2020) Qian li et al.   NEUROPHARMACOLOGY

Transient receptor potential vanilloid four channels modulate inhibitory inputs through differential regulation of GABA and glycine receptors in rat retinal ganglion cells

(2020) Qian Li et al.   FASEB JOURNAL

Inflammation in Glaucoma: From the back to the front of the eye, and beyond

(2020) Christophe Baudouin et al.   PROGRESS IN RETINAL AND EYE RESEARCH

TRPV4 blockade suppresses atrial fibrillation in sterile pericarditis rats

(2020) Jie Liao et al.   JCI Insight

TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI)

(2019) Xing-Liang Yang et al.   Journal of Neuroinflammation

The expression and function of TRPV4 channels in primate retinal ganglion cells and bipolar cells

(2019) Fan Gao et al.   Cell Death & Disease

Volume sensing in the transient receptor potential vanilloid 4 ion channel is cell type–specific and mediated by an N-terminal volume-sensing domain

(2019) Trine L. Toft-Bertelsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piezo channel plays a part in retinal ganglion cell damage

(2019) Wataru Morozumi et al.   EXPERIMENTAL EYE RESEARCH

Stattic inhibits RANKL-mediated osteoclastogenesis by suppressing activation of STAT3 and NF-κB pathways

(2018) Chang-hong Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Neuroimmflammation and microglia in glaucoma: time for a paradigm shift

(2018) Xin Wei et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Manganese exposure facilitates microglial JAK2-STAT3 signaling and consequent secretion of TNF-a and IL-1β to promote neuronal death

(2018) Lifeng Yin et al.   NEUROTOXICOLOGY

Retinal detachment-induced Müller glial cell swelling activates TRPV4 ion channels and triggers photoreceptor death at body temperature

(2018) Hidetaka Matsumoto et al.   JOURNAL OF NEUROSCIENCE

Activation of 5-HT1A receptors promotes retinal ganglion cell function by inhibiting the cAMP-PKA pathway to modulate presynaptic GABA release in chronic glaucoma

(2018) Xujiao Zhou et al.   JOURNAL OF NEUROSCIENCE

EphrinB/EphB forward signaling in Müller cells causes apoptosis of retinal ganglion cells by increasing tumor necrosis factor alpha production in rat experimental glaucomatous model

(2018) Shu-Ting Liu et al.   Acta Neuropathologica Communications

Specific inhibition of TRPV4 enhances retinal ganglion cell survival in adult porcine retinal explants

(2017) Linnéa Taylor et al.   EXPERIMENTAL EYE RESEARCH

When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor

(2017) Trine L. Toft-Bertelsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neuroprotective effect of 5ɑ-androst-3β,5,6β-triol on retinal ganglion cells in a rat chronic ocular hypertension model

(2017) Yan-Qiu Chen et al.   NEUROSCIENCE LETTERS

Fluid-induced lung injury—role of TRPV4 channels

(2017) Shailesh Bihari et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Modulation of the TRPV4 ion channel as a therapeutic target for disease

(2017) Megan S. Grace et al.   PHARMACOLOGY & THERAPEUTICS

BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells

(2017) Margaret E. Maes et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Alpha7 nicotinic acetylcholine receptor agonist promotes retinal ganglion cell function via modulating GABAergic presynaptic activity in a chronic glaucomatous model

(2017) Xujiao Zhou et al.   Scientific Reports

Blockage of transient receptor potential vanilloid 4 alleviates myocardial ischemia/reperfusion injury in mice

(2017) Qian Dong et al.   Scientific Reports

Electroretinography in glaucoma diagnosis

(2016) Laura J. Wilsey et al.   CURRENT OPINION IN OPHTHALMOLOGY

Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) reduces neonatal hypoxic-ischaemic brain damage

(2016) Mariya Hristova et al.   JOURNAL OF NEUROCHEMISTRY

Glia–neuron interactions in the mammalian retina

(2016) Elena Vecino et al.   PROGRESS IN RETINAL AND EYE RESEARCH

TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye

(2016) Daniel A. Ryskamp et al.   Scientific Reports

TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Muller Glia

(2015) A. O. Jo et al.   JOURNAL OF NEUROSCIENCE

Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation

(2015) J. L. Cueva Vargas et al.   JOURNAL OF NEUROSCIENCE

Swelling and Eicosanoid Metabolites Differentially Gate TRPV4 Channels in Retinal Neurons and Glia

(2014) D. A. Ryskamp et al.   JOURNAL OF NEUROSCIENCE

Involvement of TRPV4 channels in Aβ40-induced hippocampal cell death and astrocytic Ca2+ signalling

(2014) Ji-Zhong Bai et al.   NEUROTOXICOLOGY

The Complex Role of Neuroinflammation in Glaucoma

(2014) I. Soto et al.   Cold Spring Harbor Perspectives in Medicine

Glial cell-expressed mechanosensitive channel TRPV4 mediates infrasound-induced neuronal impairment

(2013) Ming Shi et al.   ACTA NEUROPATHOLOGICA

Stimulation of transient receptor potential vanilloid 4 channel suppresses abnormal activation of microglia induced by lipopolysaccharide

(2012) Masakazu Konno et al.   GLIA

Relationship between glial potassium regulation and axon excitability: A role for glial Kir4.1 channels

(2012) Virginia Bay et al.   GLIA

The Polymodal Ion Channel Transient Receptor Potential Vanilloid 4 Modulates Calcium Flux, Spiking Rate, and Apoptosis of Mouse Retinal Ganglion Cells

(2011) D. A. Ryskamp et al.   JOURNAL OF NEUROSCIENCE

Glaucoma

(2011) Harry A Quigley   LANCET

The Molecular and Cellular Identity of Peripheral Osmoreceptors

(2011) Stefan G. Lechner et al.   NEURON

The molecular basis of retinal ganglion cell death in glaucoma

(2011) Mohammadali Almasieh et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The inflammasomes: mechanisms of activation and function

(2010) Eicke Latz   CURRENT OPINION IN IMMUNOLOGY

Wild-type and Brachyolmia-causing Mutant TRPV4 Channels Respond Directly to Stretch Force

(2010) Stephen Loukin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanism of NLRP3 Inflammasome Activation

(2010) Chengcheng Jin et al.   JOURNAL OF CLINICAL IMMUNOLOGY

C-peptide stimulates nitrites generation via the calcium-JAK2/STAT1 pathway in murine macrophage Raw264.7 cells

(2010) Soo Kyung Lee et al.   LIFE SCIENCES

ProNGF induces TNFα-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway

(2010) Frédéric Lebrun-Julien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRP Channels and Pain

(2009) Daniel Cortright et al.   CURRENT PHARMACEUTICAL DESIGN

Excitotoxic Death of Retinal Neurons In Vivo Occurs via a Non-Cell-Autonomous Mechanism

(2009) F. Lebrun-Julien et al.   JOURNAL OF NEUROSCIENCE

Cellular signaling and factors involved in Müller cell gliosis: Neuroprotective and detrimental effects

(2009) Andreas Bringmann et al.   PROGRESS IN RETINAL AND EYE RESEARCH

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

(2008) J. E. Herrmann et al.   JOURNAL OF NEUROSCIENCE

Rodent electroretinography: Methods for extraction and interpretation of rod and cone responses

(2007) A WEYMOUTH et al.   PROGRESS IN RETINAL AND EYE RESEARCH