C2H2 zinc finger transcription factors associated with hemoglobinopathies
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
C2H2 zinc finger transcription factors associated with hemoglobinopathies
Authors
Keywords
-
Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume -, Issue -, Pages 168343
Publisher
Elsevier BV
Online
2023-11-03
DOI
10.1016/j.jmb.2023.168343
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Allosteric autoregulation of DNA binding via a DNA-mimicking protein domain: a biophysical study of ZNF410–DNA interaction using small angle X-ray scattering
- (2023) Gundeep Kaur et al. NUCLEIC ACIDS RESEARCH
- A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression
- (2023) Shohei Takase et al. Nature Communications
- Prevalence and prognostic significance of IKZF1 deletion in paediatric acute lymphoblastic leukemia: A systematic review and meta-analysis
- (2023) Shyam Srinivasan et al. ANNALS OF HEMATOLOGY
- DNA methyltransferase inhibitor exposure–response: Challenges and opportunities
- (2023) Amanda B. Kagan et al. CTS-Clinical and Translational Science
- Discovery of new Lenalidomide derivatives as potent and selective GSPT1 degraders
- (2023) Yiying Wei et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Gene Therapy and Gene Editing for β-Thalassemia
- (2023) Georgios E. Christakopoulos et al. HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
- Precision Editing as a Therapeutic Approach for β-Hemoglobinopathies
- (2023) Kiriaki Paschoudi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Structure-Based Design and Characterization of the Highly Potent and Selective Covalent Inhibitors Targeting the Lysine Methyltransferases G9a/GLP
- (2023) Zongbo Feng et al. Journal of Medicinal Chemistry
- MBD2a–NuRD binds to the methylated γ-globin gene promoter and uniquely forms a complex required for silencing of HbF expression
- (2023) Shengzhe Shang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Development of DNA Aptamer-Based PROTACs That Degrade the Estrogen Receptor
- (2023) Haruna Tsujimura et al. ACS Medicinal Chemistry Letters
- Inheritance of epigenetic transcriptional memory through read–write replication of a histone modification
- (2023) Jason H. Brickner ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
- Recent advances in the development of peptide-based inhibitors targeting epigenetic readers of histone lysine acetylation and methylation marks
- (2023) Sha Liu et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Potent and uniform fetal hemoglobin induction via base editing
- (2023) Thiyagaraj Mayuranathan et al. NATURE GENETICS
- Structures of CTCF–DNA complexes including all 11 zinc fingers
- (2023) Jie Yang et al. NUCLEIC ACIDS RESEARCH
- Analysis of the complex between MBD2 and the histone deacetylase core of NuRD reveals key interactions critical for gene silencing
- (2023) Gage O. Leighton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts
- (2022) Steven Heshusius et al. Scientific Reports
- Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells
- (2022) Kunhua Qin et al. NATURE GENETICS
- Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance
- (2022) Jan Padeken et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- (2022) Dongxu Li et al. ONCOGENE
- Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors
- (2022) John R. Horton et al. STRUCTURE
- Lifetime medical costs attributable to sickle cell disease among nonelderly individuals with commercial insurance
- (2022) Kate M Johnson et al. Blood Advances
- LRF Promotes Indirectly Advantageous Chromatin Conformation via BGLT3-lncRNA Expression and Switch from Fetal to Adult Hemoglobin
- (2022) Vasiliki Chondrou et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Discovery of the First-in-Class G9a/GLP Covalent Inhibitors
- (2022) Kwang-Su Park et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos
- (2022) Fanye Meng et al. JOURNAL OF MEDICINAL CHEMISTRY
- HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription
- (2022) Peng Huang et al. NATURE GENETICS
- A NuRD for all seasons
- (2022) Xavier J. Reid et al. TRENDS IN BIOCHEMICAL SCIENCES
- Integrating transcription and splicing into cell fate: Transcription factors on the block
- (2022) Panagiotis Boumpas et al. Wiley Interdisciplinary Reviews-RNA
- Pharmacological Induction of Fetal Hemoglobin in β-Thalassemia and Sickle Cell Disease: An Updated Perspective
- (2022) Rayan Bou-Fakhredin et al. Pharmaceuticals
- Molecular glue CELMoD compounds are regulators of cereblon conformation
- (2022) Edmond R. Watson et al. SCIENCE
- Design, synthesis and biological evaluation of novel quinazolinone derivatives as CRBN E3 ligase modulators
- (2022) Linyi Liu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Epigenetic inactivation of ERF reactivates γ-globin expression in β-thalassemia
- (2021) Xiuqin Bao et al. AMERICAN JOURNAL OF HUMAN GENETICS
- How structural biology transformed studies of transcription regulation
- (2021) Cynthia Wolberger JOURNAL OF BIOLOGICAL CHEMISTRY
- ZNF410 represses fetal globin by singular control of CHD4
- (2021) Divya S. Vinjamur et al. NATURE GENETICS
- Drugging the ‘undruggable’. Therapeutic targeting of protein–DNA interactions with the use of computer-aided drug discovery methods
- (2021) Mariia Radaeva et al. DRUG DISCOVERY TODAY
- TF-PROTACs Enable Targeted Degradation of Transcription Factors
- (2021) Jing Liu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin
- (2021) Phillip A. Doerfler et al. NATURE GENETICS
- Sequence-specific dynamics of DNA response elements and their flanking sites regulate the recognition by AP-1 transcription factors
- (2021) Johanna Hörberg et al. NUCLEIC ACIDS RESEARCH
- Molecular and cellular mechanisms that regulate human erythropoiesis
- (2021) Alexis Leon Caulier et al. BLOOD
- Mechanistic similarities in recognition of histone tails and DNA by epigenetic readers
- (2021) Kendra R. Vann et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Structural insights into the interaction between transcription factors and the nucleosome
- (2021) Ekaterina Morgunova et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Pathogenic BCL11A variants provide insights into the mechanisms of human fetal hemoglobin silencing
- (2021) Yong Shen et al. PLoS Genetics
- The Expanding Constellation of Histone Post-Translational Modifications in the Epigenetic Landscape
- (2021) Vincenzo Cavalieri Genes
- HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression
- (2020) Peng Huang et al. BLOOD
- Origin of complexity in haemoglobin evolution
- (2020) Arvind S. Pillai et al. NATURE
- Fetal hemoglobin quantification per red blood cell allows to determine protective thresholds in sickle cell disease
- (2020) Nicolas Hebert et al. AMERICAN JOURNAL OF HEMATOLOGY
- UNC0638 induces high levels of fetal hemoglobin expression in β-thalassemia/HbE erythroid progenitor cells
- (2020) Tiwaporn Nualkaew et al. ANNALS OF HEMATOLOGY
- Emerging role of ZBTB7A as an oncogenic driver and transcriptional repressor
- (2020) Sanjay Gupta et al. CANCER LETTERS
- In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor
- (2020) Aidan G. Gilmartin et al. HAEMATOLOGICA
- The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
- (2020) Mikołaj Słabicki et al. NATURE
- Prospecting for molecular glues
- (2020) Willem den Besten et al. Nature Chemical Biology
- Targeting H3K9 methyltransferase G9a and its related molecule GLP as a potential therapeutic strategy for cancer
- (2020) Ziaur Rahman et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- DNA methylation patterns of β-globin cluster in β-thalassemia patients
- (2020) Xiuqin Bao et al. Clinical Epigenetics
- A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site
- (2019) Gabriella E. Martyn et al. BLOOD
- Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure
- (2019) Ciro Milite et al. JOURNAL OF MEDICINAL CHEMISTRY
- Insights for the design of protein lysine methyltransferase G9a inhibitors
- (2019) Mariasoosai Ramya Chandar Charles et al. Future Medicinal Chemistry
- Disruption of the MBD2-NuRD complex but not MBD3-NuRD induces high level HbF expression in human erythroid cells
- (2019) Xiaofei Yu et al. HAEMATOLOGICA
- Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis
- (2019) Falak Sher et al. NATURE GENETICS
- Ikaros Zinc Finger Transcription Factors: Regulators of Cytokine Signaling Pathways and CD4+ T Helper Cell Differentiation
- (2019) Michael D. Powell et al. Frontiers in Immunology
- Structural insights into the recognition of γ-globin gene promoter by BCL11A
- (2019) Yang Yang et al. CELL RESEARCH
- The NuRD complex and macrocephaly associated neurodevelopmental disorders
- (2019) Tyler Mark Pierson et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
- Recent progress in histone methyltransferase (G9a) inhibitors as anticancer agents
- (2019) Hao Cao et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Detection of DNA Modifications by Sequence-Specific Transcription Factors
- (2019) Jie Yang et al. JOURNAL OF MOLECULAR BIOLOGY
- DNA Modification Readers and Writers and Their Interplay
- (2019) Cathia Rausch et al. JOURNAL OF MOLECULAR BIOLOGY
- The timeline of epigenetic drug discovery: from reality to dreams
- (2019) A. Ganesan et al. Clinical Epigenetics
- Evolution of hemoglobin loci and their regulatory elements
- (2018) Sjaak Philipsen et al. BLOOD CELLS MOLECULES AND DISEASES
- Molecular basis of β thalassemia and potential therapeutic targets
- (2018) Swee Lay Thein BLOOD CELLS MOLECULES AND DISEASES
- The many faces of IKZF1 in B-cell precursor acute lymphoblastic leukemia
- (2018) René Marke et al. HAEMATOLOGICA
- 14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts
- (2018) Samuel Lessard et al. HUMAN MOLECULAR GENETICS
- Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA
- (2018) Ke Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding
- (2018) Gabriella E. Martyn et al. NATURE GENETICS
- The many faces of IKZF1 in B-cell precursor acute lymphoblastic leukemia
- (2018) René Marke et al. HAEMATOLOGICA
- Fetal γ-globin genes are regulated by the BGLT3 long non-coding RNA locus
- (2018) Maria Soledad Ivaldi et al. BLOOD
- Organizational principles of 3D genome architecture
- (2018) M. Jordan Rowley et al. NATURE REVIEWS GENETICS
- Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN
- (2018) Quinlan L. Sievers et al. SCIENCE
- Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies
- (2018) Beeke Wienert et al. TRENDS IN GENETICS
- Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element
- (2017) Peng Huang et al. GENES & DEVELOPMENT
- Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase
- (2017) Yan Xiong et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Encyclopedia of DNA elements (ENCODE): data portal update
- (2017) Carrie A Davis et al. NUCLEIC ACIDS RESEARCH
- Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein
- (2017) Yong Lei et al. Nature Communications
- Convergent evolution of hemoglobin switching in jawed and jawless vertebrates
- (2016) Kim Rohlfing et al. BMC EVOLUTIONARY BIOLOGY
- Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase
- (2016) Georg Petzold et al. NATURE
- Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and β-thalassemia
- (2016) Lin Ye et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin
- (2016) T. Masuda et al. SCIENCE
- The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice
- (2015) S. Cui et al. BLOOD
- Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/ -globin looping
- (2015) I. Krivega et al. BLOOD
- EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression
- (2015) A. Renneville et al. BLOOD
- CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function
- (2015) Ya Guo et al. CELL
- Nucleosome Stability Distinguishes Two Different Promoter Types at All Protein-Coding Genes in Yeast
- (2015) Slawomir Kubik et al. MOLECULAR CELL
- The origin and early phylogenetic history of jawed vertebrates
- (2015) Martin D. Brazeau et al. NATURE
- Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS
- (2015) Jan Krönke et al. NATURE
- An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex
- (2015) Megha A. Desai et al. NUCLEIC ACIDS RESEARCH
- Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin
- (2015) Beeke Wienert et al. Nature Communications
- ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis
- (2014) Xue-Song Liu et al. GENES & DEVELOPMENT
- CTCF: an architectural protein bridging genome topology and function
- (2014) Chin-Tong Ong et al. NATURE REVIEWS GENETICS
- Mi2 -mediated silencing of the fetal -globin gene in adult erythroid cells
- (2013) M. Amaya et al. BLOOD
- Fetal hemoglobin in sickle cell anemia: a glass half full?
- (2013) M. H. Steinberg et al. BLOOD
- Sequence-Specific Transcription Factor NF-Y Displays Histone-like DNA Binding and H2B-like Ubiquitination
- (2013) Marco Nardini et al. CELL
- MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma
- (2013) Carol Y Ying et al. NATURE IMMUNOLOGY
- Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
- (2013) J. Kronke et al. SCIENCE
- The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
- (2013) G. Lu et al. SCIENCE
- A common mode of recognition for methylated CpG
- (2013) Yiwei Liu et al. TRENDS IN BIOCHEMICAL SCIENCES
- Ldb1 complexes: the new master regulators of erythroid gene transcription
- (2013) Paul E. Love et al. TRENDS IN GENETICS
- Evolution of Hemoglobin and Its Genes
- (2013) R. C. Hardison Cold Spring Harbor Perspectives in Medicine
- The Molecular Basis of -Thalassemia
- (2013) S. L. Thein Cold Spring Harbor Perspectives in Medicine
- NuRD and Pluripotency: A Complex Balancing Act
- (2012) Guang Hu et al. Cell Stem Cell
- Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation
- (2012) Hideharu Hashimoto et al. NUCLEIC ACIDS RESEARCH
- The role of CTCF in coordinating the expression of single gene loci
- (2011) Austin E Gillen et al. Biochemistry and Cell Biology
- Distinct Ldb1/NLI complexes orchestrate -globin repression and reactivation through ETO2 in human adult erythroid cells
- (2011) C. M. Kiefer et al. BLOOD
- Pomalidomide augments fetal hemoglobin production without the myelosuppressive effects of hydroxyurea in transgenic sickle cell mice
- (2011) S. E. Meiler et al. BLOOD
- The challenge of haemoglobinopathies in resource-poor countries
- (2011) David J. Weatherall BRITISH JOURNAL OF HAEMATOLOGY
- H3K9 methyltransferase G9a and the related molecule GLP
- (2011) Y. Shinkai et al. GENES & DEVELOPMENT
- Compound heterozygosity for KLF1 mutations associated with remarkable increase of fetal hemoglobin and red cell protoporphyrin
- (2011) S. Satta et al. HAEMATOLOGICA
- Erythroid phenotypes associated with KLF1 mutations
- (2011) J. Borg et al. HAEMATOLOGICA
- A Functional Element Necessary for Fetal Hemoglobin Silencing
- (2011) Vijay G. Sankaran et al. NEW ENGLAND JOURNAL OF MEDICINE
- Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1
- (2011) L. Wilkinson-White et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- p66 -MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex
- (2011) M. N. Gnanapragasam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Coordinated Chromatin Control: Structural and Functional Linkage of DNA and Histone Methylation
- (2010) Xiaodong Cheng et al. BIOCHEMISTRY
- The inherited diseases of hemoglobin are an emerging global health burden
- (2010) D. J. Weatherall BLOOD
- Advances in the understanding of haemoglobin switching
- (2010) Vijay G. Sankaran et al. BRITISH JOURNAL OF HAEMATOLOGY
- pRB and E2F4 play distinct cell-intrinsic roles in fetal erythropoiesis
- (2010) Jing Zhang et al. CELL CYCLE
- Decitabine increases fetal hemoglobin in Papio anubis by increasing γ-globin gene transcription
- (2010) Imo Akpan et al. EXPERIMENTAL HEMATOLOGY
- Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin
- (2010) Joseph Borg et al. NATURE GENETICS
- KLF1 regulates BCL11A expression and γ- to β-globin gene switching
- (2010) Dewang Zhou et al. NATURE GENETICS
- A case study in cross-talk: the histone lysine methyltransferases G9a and GLP
- (2010) Robert Collins et al. NUCLEIC ACIDS RESEARCH
- Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease
- (2010) James E. Bradner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sickle Cell Disease at 100 Years
- (2010) S. H. Orkin et al. SCIENCE
- Malaria in patients with sickle cell anemia: burden, risk factors, and outcome at the outpatient clinic and during hospitalization
- (2009) J. Makani et al. BLOOD
- CTCF: Master Weaver of the Genome
- (2009) Jennifer E. Phillips et al. CELL
- LRF Is an Essential Downstream Target of GATA1 in Erythroid Development and Regulates BIM-Dependent Apoptosis
- (2009) Takahiro Maeda et al. DEVELOPMENTAL CELL
- EKLF/KLF1 Controls Cell Cycle Entry via Direct Regulation of E2f2
- (2009) Michael R. Tallack et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells
- (2009) C Flotho et al. LEUKEMIA
- A census of human transcription factors: function, expression and evolution
- (2009) Juan M. Vaquerizas et al. NATURE REVIEWS GENETICS
- Hemoglobin research and the origins of molecular medicine
- (2008) A. N. Schechter BLOOD
- Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells
- (2008) Laure A. Moutouh-de Parseval et al. JOURNAL OF CLINICAL INVESTIGATION
- Hydroxyurea for the Treatment of Sickle Cell Anemia
- (2008) Orah S. Platt NEW ENGLAND JOURNAL OF MEDICINE
- Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific RepressorBCL11A
- (2008) Vijay G. Sankaran et al. SCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started