Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells

Transcription factor competition at the γ-globin promoters controls hemoglobin switching

(2021) Nan Liu et al.   NATURE GENETICS

Twelve years of SAMtools and BCFtools

(2021) Petr Danecek et al.   GigaScience

Deconvolution of Complex DNA Repair (DECODR): Establishing a Novel Deconvolution Algorithm for Comprehensive Analysis of CRISPR-Edited Sanger Sequencing Data

(2021) Kevin Bloh et al.   CRISPR Journal

ZNF410 represses fetal globin by singular control of CHD4

(2021) Divya S. Vinjamur et al.   NATURE GENETICS

CUT&RUNTools 2.0: A pipeline for single-cell and bulk-level CUT&RUN and CUT&Tag data analysis

(2021) Fulong Yu et al.   BIOINFORMATICS

Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin

(2021) Phillip A. Doerfler et al.   NATURE GENETICS

HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

(2020) Peng Huang et al.   BLOOD

Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts

(2020) Eugene Khandros et al.   BLOOD

High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening

(2020) Rodrigo A. Gier et al.   Nature Communications

NFIA differentially controls adipogenic and myogenic gene program through distinct pathways to ensure brown and beige adipocyte differentiation

(2020) Yuta Hiraike et al.   PLoS Genetics

HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation

(2020) Scott A. Peslak et al.   Blood Advances

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

(2020) Xianjiang Lan et al.   MOLECULAR CELL

Chromatin accessibility and the regulatory epigenome

(2019) Sandy L. Klemm et al.   NATURE REVIEWS GENETICS

Hit and Run Transcriptional Repressors Are Difficult to Catch in the Act

(2019) Manan Shah et al.   BIOESSAYS

Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis

(2019) Falak Sher et al.   NATURE GENETICS

Improved CUT&RUN chromatin profiling tools

(2019) Michael P Meers et al.   eLife

Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch

(2018) Nan Liu et al.   CELL

SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice

(2018) Kunhua Qin et al.   DIABETOLOGIA

14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts

(2018) Samuel Lessard et al.   HUMAN MOLECULAR GENETICS

Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding

(2018) Gabriella E. Martyn et al.   NATURE GENETICS

A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors

(2018) Anand Venkataraman et al.   NATURE METHODS

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells

(2018) Jeremy D. Grevet et al.   SCIENCE

Nfix Promotes Survival of Immature Hematopoietic Cells via Regulation of c-Mpl

(2018) Trent Hall et al.   STEM CELLS

Comparison of gene expression profiles between human erythroid cells derived from fetal liver and adult peripheral blood

(2018) Amornrat Tangprasittipap et al.   PeerJ

Nuclear Factor One X in Development and Disease

(2018) Michael Piper et al.   TRENDS IN CELL BIOLOGY

Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element

(2017) Peng Huang et al.   GENES & DEVELOPMENT

The Encyclopedia of DNA elements (ENCODE): data portal update

(2017) Carrie A Davis et al.   NUCLEIC ACIDS RESEARCH

An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites

(2017) Peter J Skene et al.   eLife

Chromatin looping as a target for altering erythroid gene expression

(2016) Ivan Krivega et al.   Annals of the New York Academy of Sciences

Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis

(2016) Jialiang Huang et al.   DEVELOPMENTAL CELL

Analyzing CRISPR genome-editing experiments with CRISPResso

(2016) Luca Pinello et al.   NATURE BIOTECHNOLOGY

deepTools2: a next generation web server for deep-sequencing data analysis

(2016) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

(2016) T. Masuda et al.   SCIENCE

Nfix Induces a Switch in Sox6 Transcriptional Activity to Regulate MyHC-I Expression in Fetal Muscle

(2016) Valentina Taglietti et al.   Cell Reports

EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression

(2015) A. Renneville et al.   BLOOD

Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels

(2015) Fabrice Danjou et al.   NATURE GENETICS

Nonirradiated NOD,B6.SCID Il2rγ−/− KitW41/W41 (NBSGW) Mice Support Multilineage Engraftment of Human Hematopoietic Cells

(2015) Brian E. McIntosh et al.   Stem Cell Reports

Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival

(2013) P. Holmfeldt et al.   BLOOD

Establishment of Immortalized Human Erythroid Progenitor Cell Lines Able to Produce Enucleated Red Blood Cells

(2013) Ryo Kurita et al.   PLoS One

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A

(2013) J. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level

(2013) D. E. Bauer et al.   SCIENCE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway

(2011) E. R. Macari et al.   BLOOD

Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing

(2011) J. Xu et al.   SCIENCE

Binding patterns of BCL11A in the globin and GATA1 loci and characterization of the BCL11A fetal hemoglobin locus

(2010) Kiran Jawaid et al.   BLOOD CELLS MOLECULES AND DISEASES

Nfix Regulates Fetal-Specific Transcription in Developing Skeletal Muscle

(2010) Graziella Messina et al.   CELL

Transcriptional silencing of  -globin by BCL11A involves long-range interactions and cooperation with SOX6

(2010) J. Xu et al.   GENES & DEVELOPMENT

KLF1 regulates BCL11A expression and γ- to β-globin gene switching

(2010) Dewang Zhou et al.   NATURE GENETICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls  -globin and G-CSF receptor expression

(2009) L. M. Starnes et al.   BLOOD

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of  -thalassemia

(2008) M. Uda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific RepressorBCL11A

(2008) Vijay G. Sankaran et al.   SCIENCE