Analysis of the complex between MBD2 and the histone deacetylase core of NuRD reveals key interactions critical for gene silencing

Protein Dynamics to Define and Refine Disordered Protein Ensembles

(2022) Pavithra M. Naullage et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Benchmarking AlphaFold for protein complex modeling reveals accuracy determinants

(2022) Rui Yin et al.   PROTEIN SCIENCE

A NuRD for all seasons

(2022) Xavier J. Reid et al.   TRENDS IN BIOCHEMICAL SCIENCES

Densely methylated DNA traps Methyl-CpG–binding domain protein 2 but permits free diffusion by Methyl-CpG–binding domain protein 3

(2022) Gage O. Leighton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular architecture of nucleosome remodeling and deacetylase sub‐complexes by integrative structure determination

(2022) Shreyas Arvindekar et al.   PROTEIN SCIENCE

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations

(2020) Lucas Farnung et al.   eLife

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

The topology of chromatin-binding domains in the NuRD deacetylase complex

(2020) Christopher J Millard et al.   NUCLEIC ACIDS RESEARCH

The Nucleosome Remodeling and Deacetylase Complex Has an Asymmetric, Dynamic, and Modular Architecture

(2020) Jason K.K. Low et al.   Cell Reports

Disruption of the MBD2-NuRD complex but not MBD3-NuRD induces high level HbF expression in human erythroid cells

(2019) Xiaofei Yu et al.   HAEMATOLOGICA

Readers of DNA methylation, the MBD family as potential therapeutic targets

(2018) Gordon D. Ginder et al.   PHARMACOLOGY & THERAPEUTICS

Conformational Ensemble of Disordered Proteins Probed by Solvent Paramagnetic Relaxation Enhancement (sPRE)

(2018) Hamed Kooshapur et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Insights into the activation mechanism of class I HDAC complexes by inositol phosphates

(2016) Peter J. Watson et al.   Nature Communications

The structure of the core NuRD repression complex provides insights into its interaction with chromatin

(2016) Christopher J Millard et al.   eLife

DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells

(2016) Sarah J Hainer et al.   eLife

NanoBRET—A Novel BRET Platform for the Analysis of Protein–Protein Interactions

(2015) Thomas Machleidt et al.   ACS Chemical Biology

Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation

(2015) J. Sperlazza et al.   BLOOD

An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex

(2015) Megha A. Desai et al.   NUCLEIC ACIDS RESEARCH

Towards an understanding of the structure and function of MTA1

(2014) Christopher J. Millard et al.   CANCER AND METASTASIS REVIEWS

Towards elucidating the stability, dynamics and architecture of the nucleosome remodeling and deacetylase complex by using quantitative interaction proteomics

(2014) Susan L. Kloet et al.   FEBS Journal

Insight into the Architecture of the NuRD Complex

(2014) Saad S. M. Alqarni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Promoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain

(2014) Tomoko Yamada et al.   NEURON

Probing the Dynamic Distribution of Bound States for Methylcytosine-binding Domains on DNA

(2013) Jason M. Cramer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates

(2013) Christopher J. Millard et al.   MOLECULAR CELL

Structural Characterization of Intrinsically Disordered Proteins by NMR Spectroscopy

(2013) Simone Kosol et al.   MOLECULES

The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes

(2013) Y Cai et al.   ONCOGENE

Unique Features of the Anti-parallel, Heterodimeric Coiled-coil Interaction between Methyl-cytosine Binding Domain 2 (MBD2) Homologues and GATA Zinc Finger Domain Containing 2A (GATAD2A/p66α)

(2012) Ninad M. Walavalkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stoichiometry of chromatin-associated protein complexes revealed by label-free quantitative mass spectrometry-based proteomics

(2012) Arne H. Smits et al.   NUCLEIC ACIDS RESEARCH

Plant Homeodomain (PHD) Fingers of CHD4 Are Histone H3-binding Modules with Preference for Unmodified H3K4 and Methylated H3K9

(2011) Robyn E. Mansfield et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methyl-Binding Domain Protein 2-Dependent Proliferation and Survival of Breast Cancer Cells

(2011) O. Y. Mian et al.   MOLECULAR CANCER RESEARCH

Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequence

(2011) J. Neel Scarsdale et al.   NUCLEIC ACIDS RESEARCH

p66 -MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex

(2011) M. N. Gnanapragasam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMR Characterization of Long-Range Order in Intrinsically Disordered Proteins

(2010) Loïc Salmon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biopython: freely available Python tools for computational molecular biology and bioinformatics

(2009) P. J. A. Cock et al.   BIOINFORMATICS