14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts

Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element

(2017) Peng Huang et al.   GENES & DEVELOPMENT

An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility

(2017) Samuel Lessard et al.   JOURNAL OF CLINICAL INVESTIGATION

An imprinted non-coding genomic cluster at 14q32 defines clinically relevant molecular subtypes in osteosarcoma across multiple independent datasets

(2017) Katherine E. Hill et al.   Journal of Hematology & Oncology

Tough decoy targeting of predominant let-7 miRNA species in adult human hematopoietic cells

(2017) Jaira F. de Vasconcellos et al.   Journal of Translational Medicine

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation

(2017) Xin Liu et al.   NATURE CELL BIOLOGY

Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci

(2017) Matthew C Canver et al.   NATURE GENETICS

UBE2O remodels the proteome during terminal erythroid differentiation

(2017) Anthony T. Nguyen et al.   SCIENCE

Rare coding variants pinpoint genes that control human hematological traits

(2017) Abdou Mousas et al.   PLoS Genetics

Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits

(2016) Nathalie Chami et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

(2016) William J. Astle et al.   CELL

Fetal haemoglobin in sickle-cell disease: from genetic epidemiology to new therapeutic strategies

(2016) Guillaume Lettre et al.   LANCET

Deregulation of small non-coding RNAs at the DLK1-DIO3 imprinted locus predicts lung cancer patient outcome

(2016) Katey S.S. Enfield et al.   Oncotarget

A comprehensive joint analysis of the long and short RNA transcriptomes of human erythrocytes

(2015) Jennifer F. Doss et al.   BMC GENOMICS

Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels

(2015) Fabrice Danjou et al.   NATURE GENETICS

Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors

(2015) Samuel Lessard et al.   Genome Medicine

A double-blind, placebo-controlled phase II study of the efficacy and safety of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease

(2014) Marvin E. Reid et al.   AMERICAN JOURNAL OF HEMATOLOGY

Clinical features associated with copy number variations of the 14q32 imprinted gene cluster

(2014) Jill A. Rosenfeld et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome

(2014) L. Shaham et al.   BLOOD

Global transcriptome analyses of human and murine terminal erythroid differentiation

(2014) X. An et al.   BLOOD

Developmental transcriptome analysis of human erythropoiesis

(2014) L. Shi et al.   HUMAN MOLECULAR GENETICS

The multiMiR R package and database: integration of microRNA–target interactions along with their disease and drug associations

(2014) Yuanbin Ru et al.   NUCLEIC ACIDS RESEARCH

LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo

(2013) Y. T. Lee et al.   BLOOD

Genetic regulation of fetal haemoglobin in inherited bone marrow failure syndromes

(2013) Blanche P. Alter et al.   BRITISH JOURNAL OF HAEMATOLOGY

MicroRNA-486-3p Regulates γ-Globin Expression in Human Erythroid Cells by Directly Modulating BCL11A

(2013) Valentina Lulli et al.   PLoS One

An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level

(2013) D. E. Bauer et al.   SCIENCE

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Reawakening fetal hemoglobin: prospects for new therapies for the  -globin disorders

(2012) D. E. Bauer et al.   BLOOD

Combinatorial Assembly of Developmental Stage-Specific Enhancers Controls Gene Expression Programs during Human Erythropoiesis

(2012) Jian Xu et al.   DEVELOPMENTAL CELL

Epigenetic and molecular profiles of erythroid cells after hydroxyurea treatment in sickle cell anemia

(2011) A. L. Walker et al.   BLOOD

miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades

(2011) Marc R. Friedländer et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-96 Directly Inhibits γ-Globin Expression in Human Erythropoiesis

(2011) Imane Azzouzi et al.   PLoS One

MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13

(2011) V. G. Sankaran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

14q32/miRNA Clusters loss of heterozygosity in acute lymphoblastic leukemia is associated with up-regulation of BCL11a

(2010) Cecilia Agueli et al.   AMERICAN JOURNAL OF HEMATOLOGY

Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation

(2010) Geneviève Galarneau et al.   NATURE GENETICS

Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells

(2010) Song Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Short-chain fatty acid-mediated effects on erythropoiesis in primary definitive erythroid cells

(2009) H. Bhatia et al.   BLOOD

GAGE: generally applicable gene set enrichment for pathway analysis

(2009) Weijun Luo et al.   BMC BIOINFORMATICS

Let-7 microRNAs are developmentally regulated in circulating human erythroid cells

(2009) Seung-Jae Noh et al.   Journal of Translational Medicine

Determinants of MicroRNA Processing Inhibition by the Developmentally Regulated RNA-binding Protein Lin28

(2008) Elena Piskounova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA

(2008) Inha Heo et al.   MOLECULAR CELL

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of  -thalassemia

(2008) M. Uda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA polymorphisms at the BCL11A, HBS1L-MYB, and  -globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease

(2008) G. Lettre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific RepressorBCL11A

(2008) Vijay G. Sankaran et al.   SCIENCE