Targeting H3K9 methyltransferase G9a and its related molecule GLP as a potential therapeutic strategy for cancer

ERK-mediated TIMELESS expression suppresses G2/M arrest in colon cancer cells

(2019) Beth K. Neilsen et al.   PLoS One

Stem cells: past, present, and future

(2019) Wojciech Zakrzewski et al.   Stem Cell Research & Therapy

SUMOylation of G9a regulates its function as an activator of myoblast proliferation

(2019) Shruti Srinivasan et al.   Cell Death & Disease

Cyclin D1 integrates G9a-mediated histone methylation

(2019) Zhiping Li et al.   ONCOGENE

Global, regional, and national burden of brain and other CNS cancer, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Anoop P Patel et al.   LANCET NEUROLOGY

Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

(2019) Strowitzki et al.   Cells

Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress

(2019) Hiroki Akiyama et al.   CANCER LETTERS

Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression

(2019) Cristina Segovia et al.   NATURE MEDICINE

Roles and regulation of histone methylation in animal development

(2019) Ashwini Jambhekar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The roles of DNA, RNA and histone methylation in ageing and cancer

(2019) Ewa M. Michalak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TBX2 interacts with heterochromatin protein 1 to recruit a novel repression complex to EGR1-targeted promoters to drive the proliferation of breast cancer cells

(2019) N. T. Crawford et al.   ONCOGENE

Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy

(2018) Maura Knapp et al.   ACTA PHARMACOLOGICA SINICA

Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II)

(2018) Danny C. Lenstra et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dual targeting of histone methyltransferase G9a and DNA-methyltransferase 1 for the treatment of experimental hepatocellular carcinoma

(2018) Marina Bárcena-Varela et al.   HEPATOLOGY

Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities

(2018) Manuela Porru et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer

(2018) Ying Zhang et al.   Molecular Cancer

G9A promotes gastric cancer metastasis by upregulating ITGB3 in a SET domain-independent manner

(2018) Lei Hu et al.   Cell Death & Disease

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in skin tumours

(2018) Alexandra Avgustinova et al.   NATURE CELL BIOLOGY

Increasing G9a automethylation sensitizes B acute lymphoblastic leukemia cells to glucocorticoid-induced death

(2018) Coralie Poulard et al.   Cell Death & Disease

Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends

(2017) Sebastien Antoni et al.   EUROPEAN UROLOGY

Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3

(2017) Lai Wei et al.   JOURNAL OF HEPATOLOGY

Regulation of USP37 Expression by REST-Associated G9a-Dependent Histone Methylation

(2017) Tara H.W. Dobson et al.   MOLECULAR CANCER RESEARCH

G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis

(2017) Francesco Casciello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G9a governs colon cancer stem cell phenotype and chemoradioresistance through PP2A-RPA axis-mediated DNA damage response

(2017) Chi-Wen Luo et al.   RADIOTHERAPY AND ONCOLOGY

G9A promotes tumor cell growth and invasion by silencing CASP1 in non-small-cell lung cancer cells

(2017) Tianhao Huang et al.   Cell Death & Disease

In situ click chemistry generation of cyclooxygenase-2 inhibitors

(2017) Atul Bhardwaj et al.   Nature Communications

Methyltransferase G9a promotes cervical cancer angiogenesis and decreases patient survival

(2017) Ruey-Jien Chen et al.   Oncotarget

Protein-lysine methyltransferases G9a and GLP1 promote responses to DNA damage

(2017) Vasudeva Ginjala et al.   Scientific Reports

Incidence and Mortality and Epidemiology of Breast Cancer in the World

(2016) Mahshid Ghoncheh et al.   Asian Pacific Journal of Cancer Prevention

Discovery of novel small molecule inhibitors of lysine methyltransferase G9a and their mechanism in leukemia cell lines

(2016) Shukkoor M. Kondengaden et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mechanism of G9a inhibitor BIX-01294 acting on U251 glioma cells

(2016) Ai-Shun Guo et al.   Molecular Medicine Reports

G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway

(2016) Shih-Ting Cha et al.   NATURE CELL BIOLOGY

Depletion of G9a gene induces cell apoptosis in human gastric carcinoma

(2016) XIAOLEI LIN et al.   ONCOLOGY REPORTS

BIX01294, an inhibitor of histone methyltransferase, induces autophagy-dependent differentiation of glioma stem-like cells

(2016) Iwona Anna Ciechomska et al.   Scientific Reports

EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells

(2015) Jing Cui et al.   Cancer Cell International

Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II)

(2015) Madura K.P. Jayatunga et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinoma

(2015) Shuli Liu et al.   Oncotarget

Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation

(2015) Jie Zhang et al.   Oncotarget

Functional Role of G9a Histone Methyltransferase in Cancer

(2015) Francesco Casciello et al.   Frontiers in Immunology

The Selective Activation of p53 Target Genes Regulated by SMYD2 in BIX-01294 Induced Autophagy-Related Cell Death

(2015) Jia-Dong Fan et al.   PLoS One

The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia

(2015) William N. Pappano et al.   PLoS One

Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase

(2014) Anna M. Rydzik et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation

(2014) M. Morales et al.   EMBO Molecular Medicine

Novel types and sites of histone modifications emerge as players in the transcriptional regulation contest

(2014) Adam F. Kebede et al.   FEBS Journal

MicroRNA expressions associated with progression of prostate cancer cells to antiandrogen therapy resistance

(2014) Richard Ottman et al.   Molecular Cancer

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of H3K9 Methyltransferase G9a Repressed Cell Proliferation and Induced Autophagy in Neuroblastoma Cells

(2014) Xiao-Xue Ke et al.   PLoS One

Discrepant NOXA (PMAIP1) transcript and NOXA protein levels: a potential Achilles’ heel in mantle cell lymphoma

(2014) M A Dengler et al.   Cell Death & Disease

Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a

(2014) Ramzi F. Sweis et al.   ACS Medicinal Chemistry Letters

Deregulation of Wnt/β-catenin signaling through genetic or epigenetic alterations in human neuroendocrine tumors

(2013) Ji Tae Kim et al.   CARCINOGENESIS

The Histone H3 Methyltransferase G9A Epigenetically Activates the Serine-Glycine Synthesis Pathway to Sustain Cancer Cell Survival and Proliferation

(2013) Jane Ding et al.   Cell Metabolism

Introduction to Stem Cell Therapy

(2013) Jesse K. Biehl et al.   Journal of Cardiovascular Nursing

Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP

(2013) Feng Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Labile Zn Sites in Drug-Target Proteins

(2013) Yu-Ming Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G9a, a multipotent regulator of gene expression

(2012) Shilpa Rani Shankar et al.   Epigenetics

Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription

(2012) Daniel J. Purcell et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study

(2012) Qiujin Shen et al.   LANCET ONCOLOGY

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation

(2012) C M Das et al.   ONCOGENE

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Epigenetic modifications in cancer

(2011) R Kanwal et al.   CLINICAL GENETICS

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

(2011) Masoud Vedadi et al.   Nature Chemical Biology

H3K9 Histone Methyltransferase G9a Promotes Lung Cancer Invasion and Metastasis by Silencing the Cell Adhesion Molecule Ep-CAM

(2010) M.-W. Chen et al.   CANCER RESEARCH

EpCAM in carcinogenesis: the good, the bad or the ugly

(2010) B. T. F. van der Gun et al.   CARCINOGENESIS

Mcl-1; the molecular regulation of protein function

(2010) Luke W. Thomas et al.   FEBS LETTERS

G9a and Glp Methylate Lysine 373 in the Tumor Suppressor p53

(2010) Jing Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ferroportin1 and hephaestin overexpression attenuate iron-induced oxidative stress in MES23.5 dopaminergic cells

(2010) Ning Song et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases

(2010) Yanqi Chang et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Biology of Human H3K9 Methyltransferases

(2010) Hong Wu et al.   PLoS One

Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis

(2010) Z. K. Pinnix et al.   Science Translational Medicine

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

(2009) Yanqi Chang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells

(2008) S H Lee et al.   ONCOGENE