Microenvironment in acute myeloid leukemia: focus on senescence mechanisms, therapeutic interactions, and future directions

Mesenchymal stromal cell senescence in haematological malignancies

(2023) Natalya Plakhova et al.   CANCER AND METASTASIS REVIEWS

Tumor Microenvironment in Acute Myeloid Leukemia: Adjusting Niches

(2022) Thomas Menter et al.   Frontiers in Immunology

Venetoclax combined with FLAG‐IDA induction and consolidation in newly diagnosed acute myeloid leukemia

(2022) Courtney D. DiNardo et al.   AMERICAN JOURNAL OF HEMATOLOGY

Indications for haematopoietic cell transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2022

(2022) John A. Snowden et al.   BONE MARROW TRANSPLANTATION

Cancer stem cells: The adventurous journey from hematopoietic to leukemic stem cells

(2022) Andreas Trumpp et al.   CELL

Atypical Rearrangements in APL-Like Acute Myeloid Leukemias: Molecular Characterization and Prognosis

(2022) Luca Guarnera et al.   Frontiers in Oncology

Bone Marrow Aging and the Leukaemia-Induced Senescence of Mesenchymal Stem/Stromal Cells: Exploring Similarities

(2022) Paola Fernanda Ruiz-Aparicio et al.   Journal of Personalized Medicine

Diagnosis and Management of AML in Adults: 2022 ELN Recommendations from an International Expert Panel

(2022) Hartmut Döhner et al.   BLOOD

In Vitro and In Vivo Modeling of Normal and Leukemic Bone Marrow Niches: Cellular Senescence Contribution to Leukemia Induction and Progression

(2022) Myriam Salazar-Terreros et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cellular senescence: the good, the bad and the unknown

(2022) Weijun Huang et al.   Nature Reviews Nephrology

Lymphocyte Exhaustion in AML Patients and Impacts of HMA/Venetoclax or Intensive Chemotherapy on Their Biology

(2022) Dmitry Zhigarev et al.   Cancers

A senescence stress secretome is a hallmark of therapy-related myeloid neoplasm stromal tissue occurring soon after cytotoxic exposure

(2022) Monika M. Kutyna et al.   LEUKEMIA

Impairment of FOXM1 expression in mesenchymal cells from patients with myeloid neoplasms, de novo and therapy-related, may compromise their ability to support hematopoiesis

(2022) Giulia Falconi et al.   Scientific Reports

Venetoclax treatment in cancer patients has limited impact on circulating T and NK cells

(2022) Charis E Teh et al.   Blood Advances

Reactive Oxygen Species Rewires Metabolic Activity in Acute Myeloid Leukemia

(2021) Andrew J. Robinson et al.   Frontiers in Oncology

Venetoclax enhances T cell-mediated anti-leukemic activity by increasing ROS production

(2021) JongBok Lee et al.   BLOOD

De novo acute myeloid leukemia: A population‐ based study of outcome in the United States based on the Surveillance, Epidemiology, and End Results (SEER) database, 1980 to 2017

(2021) Koji Sasaki et al.   CANCER

Acute Myeloid Leukemia: Historical Perspective and Progress in Research and Therapy Over 5 Decades

(2021) Hagop M. Kantarjian et al.   Clinical Lymphoma Myeloma & Leukemia

Cascade of Inflammatory, Fibrotic Processes, and Stress-Induced Senescence in Chronic GVHD-Related Dry Eye Disease

(2021) Yoko Ogawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Catch me if you can: how AML and its niche escape immunotherapy

(2021) Sarah Tettamanti et al.   LEUKEMIA

Dynamic Changes of the Bone Marrow Niche: Mesenchymal Stromal Cells and Their Progeny During Aging and Leukemia

(2021) Kevin Woods et al.   Frontiers in Cell and Developmental Biology

Macrophages in Acute Myeloid Leukaemia: Significant Players in Therapy Resistance and Patient Outcomes

(2021) Katerina E. Miari et al.   Frontiers in Cell and Developmental Biology

Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development

(2021) Yiyi Yao et al.   Experimental Hematology & Oncology

Adhesion Molecules Involved in Stem Cell Niche Retention During Normal Haematopoiesis and in Acute Myeloid Leukaemia

(2021) Julien M. P. Grenier et al.   Frontiers in Immunology

Leukemic Stem Cells: From Leukemic Niche Biology to Treatment Opportunities

(2021) Tony Marchand et al.   Frontiers in Immunology

TIM-3 in Leukemia; Immune Response and Beyond

(2021) Mahnaz Rezaei et al.   Frontiers in Oncology

Live-animal imaging of native haematopoietic stem and progenitor cells

(2020) Constantina Christodoulou et al.   NATURE

Comparative efficacy of 20 graft-versus-host disease prophylaxis therapies for patients after hematopoietic stem-cell transplantation: A multiple-treatments network meta-analysis

(2020) Xin Lv et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Senescence‐associated secretory phenotype promotes chronic ocular graft‐vs‐host disease in mice and humans

(2020) Mio Yamane et al.   FASEB JOURNAL

Sorafenib Maintenance After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia With FLT3–Internal Tandem Duplication Mutation (SORMAIN)

(2020) Andreas Burchert et al.   JOURNAL OF CLINICAL ONCOLOGY

Arsenic trioxide and all-trans retinoic acid suppress the expression of FLT3-ITD

(2020) Cong Liang et al.   LEUKEMIA & LYMPHOMA

Role of PML SUMOylation in arsenic trioxide-induced fibrosis in HSCs

(2020) Jingyuan Dai et al.   LIFE SCIENCES

Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia

(2020) Courtney D. DiNardo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges

(2020) Xueke Zhou et al.   Frontiers in Cell and Developmental Biology

Senescence-Associated Pro-inflammatory Cytokines and Tumor Cell Plasticity

(2020) Jean Paul Vernot   Frontiers in Molecular Biosciences

10-day decitabine with venetoclax for newly diagnosed intensive chemotherapy ineligible, and relapsed or refractory acute myeloid leukaemia: a single-centre, phase 2 trial

(2020) Courtney D DiNardo et al.   Lancet Haematology

Relapse of acute myeloid leukemia after allogeneic hematopoietic cell transplantation: clinical features and outcomes

(2020) Masamitsu Yanada et al.   BONE MARROW TRANSPLANTATION

Immune evasion mechanisms in acute myeloid leukemia: A focus on immune checkpoint pathways

(2020) Saeid Taghiloo et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Relapse of Acute Myeloid Leukemia after Allogeneic Stem Cell Transplantation: Prevention, Detection, and Treatment

(2019) Christina Rautenberg et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting FLT3 mutations in AML: review of current knowledge and evidence

(2019) Naval Daver et al.   LEUKEMIA

N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells

(2019) Meng Zhao et al.   Cell Reports

High doses of synthetic antioxidants induce premature senescence in cultivated mesenchymal stem cells

(2019) Ju. S. Kornienko et al.   Scientific Reports

Haematopoietic stem cell activity and interactions with the niche

(2019) Sandra Pinho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neural cell adhesion molecule 1 (NCAM1; CD56) promotes leukemogenesis and confers drug resistance in AML

(2019) Daniel Sasca et al.   BLOOD

A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia

(2019) Ninib Baryawno et al.   CELL

Quizartinib versus salvage chemotherapy in relapsed or refractory FLT3-ITD acute myeloid leukaemia (QuANTUM-R): a multicentre, randomised, controlled, open-label, phase 3 trial

(2019) Jorge E Cortes et al.   LANCET ONCOLOGY

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

(2019) Anna M. Paczulla et al.   NATURE

The “ultimate” haploidentical transplantation for the elderly with high-risk acute myeloid leukemia

(2019) Antonio Pierini et al.   BONE MARROW TRANSPLANTATION

Long-term results of all-trans retinoic acid and arsenic trioxide in non-high-risk acute promyelocytic leukemia: update of the APL0406 Italian-German randomized trial

(2019) Laura Cicconi et al.   LEUKEMIA

Gilteritinib or Chemotherapy for Relapsed or Refractory FLT3-Mutated AML

(2019) Alexander E. Perl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dysfunctional Bone Marrow Mesenchymal Stem Cells in Patients with Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation

(2018) Yang Song et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation

(2018) Rizwan Romee et al.   BLOOD

An unbalanced monocyte macrophage polarization in the bone marrow microenvironment of patients with poor graft function after allogeneic haematopoietic stem cell transplantation

(2018) Hong-Yan Zhao et al.   BRITISH JOURNAL OF HAEMATOLOGY

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML

(2018) Delfim Duarte et al.   Cell Stem Cell

The crosstalk between hematopoietic stem cells and their niches

(2018) Charles Durand et al.   CURRENT OPINION IN HEMATOLOGY

Inhibition of Vascular Adhesion Protein-1 for Treatment of Graft-Versus-Host Disease in Mice

(2018) Shin Mukai et al.   FASEB JOURNAL

Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow

(2018) Katharina Helene Susek et al.   MATRIX BIOLOGY

Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence

(2018) Adam Kuba et al.   MEDIATORS OF INFLAMMATION

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

(2018) Nimitha R Mathew et al.   NATURE MEDICINE

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence

(2018) Joana Catarina Macedo et al.   Nature Communications

Significant Risk of Graft-versus-Host Disease with Exposure to Checkpoint Inhibitors Before and After Allogeneic transplantation

(2018) Awais Ijaz et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Poor graft function after allogeneic hematopoietic stem cell transplantation—an old complication with new insights☆

(2018) Yuan Kong   SEMINARS IN HEMATOLOGY

Midostaurin reduces Regulatory T cells markers in Acute Myeloid Leukemia

(2018) Lucas Gutierrez et al.   Scientific Reports

Arsenic trioxide and all-trans-retinoic acid selectively exert synergistic cytotoxicity against FLT3-ITD AML cells via co-inhibition of FLT3 signaling pathways

(2017) Li-Na Wang et al.   LEUKEMIA & LYMPHOMA

Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche

(2017) Allison L. Boyd et al.   NATURE CELL BIOLOGY

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

(2017) Richard M. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alteration Analysis of Bone Marrow Mesenchymal Stromal Cells from De Novo Acute Myeloid Leukemia Patients at Diagnosis

(2017) Laura Desbourdes et al.   STEM CELLS AND DEVELOPMENT

Novel Treatment of Chronic Graft-Versus-Host Disease in Mice Using the ER Stress Reducer 4-Phenylbutyric Acid

(2017) Shin Mukai et al.   Scientific Reports

Increased Type 1 Immune Response in the Bone Marrow Immune Microenvironment of Patients with Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation

(2016) Yu-Tong Wang et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy

(2016) R. Moschoi et al.   BLOOD

TCR-alpha/beta and CD19 depletion and treosulfan-based conditioning regimen in unrelated and haploidentical transplantation in children with acute myeloid leukemia

(2016) M Maschan et al.   BONE MARROW TRANSPLANTATION

PD-1 checkpoint blockade in patients with relapsed AML after allogeneic stem cell transplantation

(2016) J C Albring et al.   BONE MARROW TRANSPLANTATION

Incidence and risk factors of poor graft function after allogeneic stem cell transplantation for myelofibrosis

(2016) H Alchalby et al.   BONE MARROW TRANSPLANTATION

Arsenic trioxide induces ROS activity and DNA damage, leading to G0/G1 extension in skin fibroblasts through the ATM-ATR-associated Chk pathway

(2016) Jutapon Chayapong et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Impairment of PI3K/AKT and WNT/β-catenin pathways in bone marrow mesenchymal stem cells isolated from patients with myelodysplastic syndromes

(2016) Giulia Falconi et al.   EXPERIMENTAL HEMATOLOGY

Indoleamine 2,3-dioxygenase and regulatory T cells in acute myeloid leukemia

(2016) Iman Mansour et al.   Hematology

Biomarker Panel for Chronic Graft-Versus-Host Disease

(2016) Jeffrey Yu et al.   JOURNAL OF CLINICAL ONCOLOGY

Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment

(2016) Lei Dong et al.   NATURE

Ipilimumab for Patients with Relapse after Allogeneic Transplantation

(2016) Matthew S. Davids et al.   NEW ENGLAND JOURNAL OF MEDICINE

The incidence, risk factors, and outcomes of primary poor graft function after unmanipulated haploidentical stem cell transplantation

(2015) Yu-Qian Sun et al.   ANNALS OF HEMATOLOGY

Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells

(2015) M. P. Martelli et al.   BLOOD

Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells

(2015) H. El Hajj et al.   BLOOD

Making sense of hematopoietic stem cell niches

(2015) P. E. Boulais et al.   BLOOD

The hematopoietic stem cell niche in homeostasis and disease

(2015) L. M. Calvi et al.   BLOOD

The bone marrow microenvironment is similarly impaired in allogeneic hematopoietic stem cell transplantation patients with early and late poor graft function

(2015) Y Kong et al.   BONE MARROW TRANSPLANTATION

Improved immune recovery after transplantation of TCRαβ/CD19-depleted allografts from haploidentical donors in pediatric patients

(2015) P Lang et al.   BONE MARROW TRANSPLANTATION

Skeletal stem cells

(2015) P. Bianco et al.   DEVELOPMENT

Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues

(2015) Huijuan Liu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia in all risk groups (AML17): results of a randomised, controlled, phase 3 trial

(2015) Alan K Burnett et al.   LANCET ONCOLOGY

Primary graft failure after myeloablative allogeneic hematopoietic cell transplantation for hematologic malignancies

(2015) R F Olsson et al.   LEUKEMIA

HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse

(2014) M. F. Martelli et al.   BLOOD

Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche

(2014) Maher Hanoun et al.   Cell Stem Cell

Effects of Arsenic on Osteoblast Differentiation in Vitro and on Bone Mineral Density and Microstructure in Rats

(2014) Cheng-Tien Wu et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Clinically relevant doses of FLT3-kinase inhibitors quizartinib and midostaurin do not impair T-cell reactivity and function

(2014) D. Wolleschak et al.   HAEMATOLOGICA

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Prognosis and monitoring of core-binding factor acute myeloid leukemia: current and emerging factors

(2014) Nicolas Duployez et al.   Expert Review of Hematology

Association of an Impaired Bone Marrow Microenvironment with Secondary Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation

(2013) Yuan Kong et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

CXCR4-SERINE339 regulates cellular adhesion, retention and mobilization and is a marker for poor prognosis in acute myeloid leukemia

(2013) L Brault et al.   LEUKEMIA

Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche

(2012) Fumio Arai et al.   Annals of the New York Academy of Sciences

Graft failure in the modern era of allogeneic hematopoietic SCT

(2012) R Olsson et al.   BONE MARROW TRANSPLANTATION

Arsenic Trioxide Exerts Antitumor Activity through Regulatory T Cell Depletion Mediated by Oxidative Stress in a Murine Model of Colon Cancer

(2012) A. Thomas-Schoemann et al.   JOURNAL OF IMMUNOLOGY

Outcome of relapse after allogeneic stem cell transplant in patients with acute myeloid leukemia

(2012) Raynier Devillier et al.   LEUKEMIA & LYMPHOMA

The Increased Expression of Integrin α6 (ITGA6) Enhances Drug Resistance in EVI1high Leukemia

(2012) Norio Yamakawa et al.   PLoS One

Arsenic trioxide promotes senescence and regulates the balance of adipogenic and osteogenic differentiation in human mesenchymal stem cells

(2011) H. Cheng et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Alkylating chemotherapeutic agents cyclophosphamide and melphalan cause functional injury to human bone marrow-derived mesenchymal stem cells

(2011) Kevin Kemp et al.   ANNALS OF HEMATOLOGY

FOXM1: From cancer initiation to progression and treatment

(2011) Chuay-Yeng Koo et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1

(2011) R. Balusu et al.   BLOOD

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16ink4a

(2011) Martin Kosar et al.   CELL CYCLE

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

NF-κB–inducing kinase plays an essential T cell–intrinsic role in graft-versus-host disease and lethal autoimmunity in mice

(2011) Susan E. Murray et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating Interleukin (IL)-8, IL-2R, IL-12, and IL-15 Levels Are Independently Prognostic in Primary Myelofibrosis: A Comprehensive Cytokine Profiling Study

(2011) Ayalew Tefferi et al.   JOURNAL OF CLINICAL ONCOLOGY

In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche

(2011) Joji Fujisaki et al.   NATURE

Donor Cell Leukemia: A Review

(2010) Daniel H. Wiseman   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Effects of high-dose chemotherapy on bone marrow multipotent mesenchymal stromal cells isolated from lymphoma patients

(2010) Karen de Lima Prata et al.   EXPERIMENTAL HEMATOLOGY

Nilotinib hampers the proliferation and function of CD8+ T lymphocytes through inhibition of T cell receptor signalling

(2010) J. Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Ex vivoInhibition of NF-κB Signaling in Alloreactive T-cells Prevents Graft-Versus-Host Disease

(2009) M. J. O'Shaughnessy et al.   AMERICAN JOURNAL OF TRANSPLANTATION

PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model

(2009) L. Zhang et al.   BLOOD

Graft-versus-host disease

(2009) James LM Ferrara et al.   LANCET

Toll-like receptor 2–dependent induction of vitamin A–metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity

(2009) Santhakumar Manicassamy et al.   NATURE MEDICINE

Arsenic induces cell apoptosis in cultured osteoblasts through endoplasmic reticulum stress

(2009) Chih-Hsin Tang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Dasatinib exerts an immunosuppressive effect on CD8+ T cells specific for viral and leukemia antigens

(2008) Fei Fei et al.   EXPERIMENTAL HEMATOLOGY

Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B

(2008) R. F. Schlenk et al.   HAEMATOLOGICA

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

(2008) Cristina Lo Celso et al.   NATURE

Haematopoietic stem cell release is regulated by circadian oscillations

(2008) Simón Méndez-Ferrer et al.   NATURE

Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process

(2008) Wolfgang Wagner et al.   PLoS One

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY