Arsenic trioxide and all-trans-retinoic acid selectively exert synergistic cytotoxicity against FLT3-ITD AML cells via co-inhibition of FLT3 signaling pathways

Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells

(2015) M. P. Martelli et al.   BLOOD

Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells

(2015) H. El Hajj et al.   BLOOD

Perturbation of cellular oxidative state induced by dichloroacetate and arsenic trioxide for treatment of acute myeloid leukemia

(2015) Ashkan Emadi et al.   LEUKEMIA RESEARCH

FLT3-ITD in acute promyelocytic leukemia: Clinical distinct profile but still controversial prognosis

(2015) Matteo Molica et al.   LEUKEMIA RESEARCH

An Activating Transcription Factor 5-Mediated Survival Pathway as a Target for Cancer Therapy?

(2015)   Oncotarget

Targeting CDC25C, PLK1 and CHEK1 to overcome Docetaxel resistance induced by loss of LZTS1 in prostate cancer

(2015) Nader Al Nakouzi et al.   Oncotarget

Internal tandem duplication of the FLT3 gene confers poor overall survival in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukemia study

(2014) Antonio R. Lucena-Araujo et al.   ANNALS OF HEMATOLOGY

Regulation of Trib2 by an E2F1-C/EBP  feedback loop in AML cell proliferation

(2014) L. Rishi et al.   BLOOD

High GINS2 transcript level predicts poor prognosis and correlates with high histological grade and endocrine therapy resistance through mammary cancer stem cells in breast cancer patients

(2014) Ming Zheng et al.   BREAST CANCER RESEARCH AND TREATMENT

Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis

(2014) Ying-Hua Wang et al.   CELL

Incorporation of arsenic trioxide in induction therapy improves survival of patients with newly diagnosed acute promyelocytic leukaemia

(2014) Xianmin Song et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Epidermal Growth Factor-Like Domain-Containing Protein 7 (EGFL7) Enhances EGF Receptor−AKT Signaling, Epithelial−Mesenchymal Transition, and Metastasis of Gastric Cancer Cells

(2014) Bai-Hua Luo et al.   PLoS One

The Biology and Targeting of FLT3 in Pediatric Leukemia

(2014) Colleen E. Annesley et al.   Frontiers in Oncology

FLT3-ITD confers poor prognosis in patients with acute promyelocytic leukemia treated with AIDA protocols: long-term follow-up analysis

(2013) M. Breccia et al.   HAEMATOLOGICA

FLT3 inhibitors for acute myeloid leukemia: a review of their efficacy and mechanisms of resistance

(2013) Michael R. Grunwald et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Arsenic trioxide in front-line therapy of acute promyelocytic leukemia (C9710): prognostic significance ofFLT3mutations and complex karyotype

(2013) Xavier Poiré et al.   LEUKEMIA & LYMPHOMA

Epidemiology of childhood acute myeloid leukemia

(2013) Susan E. Puumala et al.   PEDIATRIC BLOOD & CANCER

All-trans-retinoic acid, idarubicin, and IV arsenic trioxide as initial therapy in acute promyelocytic leukemia (APML4)

(2012) H. J. Iland et al.   BLOOD

Adult Acute Leukemia

(2012) Robert Frank Cornell et al.   DM DISEASE-A-MONTH

ATF5 Is Overexpressed in Epithelial Ovarian Carcinomas and Interference With Its Function Increases Apoptosis Through the Downregulation of Bcl-2 in SKOV-3 Cells

(2012) Aiping Chen et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY

BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription

(2011) Z. Sheng et al.   BLOOD

Prognostic value of FLT3 mutations in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline monochemotherapy

(2011) E. Barragan et al.   HAEMATOLOGICA

Results of the APML3 trial incorporating all-trans-retinoic acid and idarubicin in both induction and consolidation as initial therapy for patients with acute promyelocytic leukemia

(2011) H. Iland et al.   HAEMATOLOGICA

Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications

(2011) Shinichiro Takahashi   Journal of Hematology & Oncology

Nfe2l3 (Nrf3) deficiency predisposes mice to T-cell lymphoblastic lymphoma

(2010) G. Chevillard et al.   BLOOD

FLT3 internal tandem duplication is associated with a high relapse rate and central nervous system involvement in acute promyelocytic leukemia cases: single institutional analysis

(2010) Haruko Tashiro et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia

(2009) J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Re-Expression of Transcription Factor ATF5 in Hepatocellular Carcinoma Induces G2-M Arrest

(2008) J. W-M. Gho et al.   CANCER RESEARCH