Immune evasion mechanisms in acute myeloid leukemia: A focus on immune checkpoint pathways

Therapeutic Targeting of the Macrophage Immune Checkpoint CD47 in Myeloid Malignancies

(2020) Mark P. Chao et al.   Frontiers in Oncology

The Role of Immune Checkpoints after Cellular Therapy

(2020) Friederike Schmitz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dysregulated Expression of Tim-3 and NKp30 Receptors on NK Cells of Patients with Chronic Lymphocytic Leukemia

(2019) Leila Hadadi et al.   Oncology Research and Treatment

Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT

(2019) Maddalena Noviello et al.   Nature Communications

Immune Checkpoint Inhibitors in Acute Myeloid Leukemia: Novel Combinations and Therapeutic Targets

(2019) Maximilian Stahl et al.   Current Oncology Reports

Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

(2019) Yosuke Togashi et al.   Nature Reviews Clinical Oncology

Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation

(2019) Cristina Toffalori et al.   NATURE MEDICINE

Presence of innate lymphoid cells in pleural effusions of primary and metastatic tumors: Functional analysis and expression of PD‐1 receptor

(2019) Nicola Tumino et al.   INTERNATIONAL JOURNAL OF CANCER

NK cell expression of Tim-3: First impressions matter

(2019) Edward C. So et al.   IMMUNOBIOLOGY

Immune checkpoint-based therapy in myeloid malignancies: a promise yet to be fulfilled

(2019) Jan Philipp Bewersdorf et al.   Expert Review of Anticancer Therapy

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

(2019) Peter van Galen et al.   CELL

PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

(2019) Takahiro Kamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Immune Signaling Checkpoints in Acute Myeloid Leukemia

(2019) Krzysztof Giannopoulos   Journal of Clinical Medicine

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

(2019) Anna M. Paczulla et al.   NATURE

The M2 macrophage marker CD206: a novel prognostic indicator for acute myeloid leukemia

(2019) Zi-Jun Xu et al.   OncoImmunology

The Graft-Versus-Leukemia Effect in AML

(2019) Connor Sweeney et al.   Frontiers in Oncology

Immune Escape after Hematopoietic Stem Cell Transplantation (HSCT): From Mechanisms to Novel Therapies

(2019) Paolo Bernasconi et al.   Cancers

Increased Coexpression of PD-1, TIGIT, and KLRG-1 on Tumor-Reactive CD8 + T Cells During Relapse after Allogeneic Stem Cell Transplantation

(2018) Tim J.A. Hutten et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Immune checkpoint molecules in acute myeloid leukaemia: managing the double-edged sword

(2018) Willemijn Hobo et al.   BRITISH JOURNAL OF HAEMATOLOGY

Targeting myeloid-derived suppressor cells for cancer immunotherapy

(2018) Yijun Liu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Biochemical mechanisms implemented by human acute myeloid leukemia cells to suppress host immune surveillance

(2018) Inna M. Yasinska et al.   Cellular & Molecular Immunology

Novel approaches to acute myeloid leukemia immunotherapy

(2018) Ofrat Beyar-Katz et al.   CLINICAL CANCER RESEARCH

CD8 + T cells expressing both PD-1 and TIGIT but not CD226 are dysfunctional in acute myeloid leukemia (AML) patients

(2018) Mengjie Wang et al.   CLINICAL IMMUNOLOGY

Advances in immunotherapy for acute myeloid leukemia

(2018) Amanda Przespolewski et al.   Future Oncology

Immune checkpoint blockade therapy for cancer: An overview of FDA-approved immune checkpoint inhibitors

(2018) Kristian M. Hargadon et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Coexpression profile of leukemic stem cell markers for combinatorial targeted therapy in AML

(2018) S. Haubner et al.   LEUKEMIA

The Immune Checkpoint Modulator OX40 and Its Ligand OX40L in NK-Cell Immunosurveillance and Acute Myeloid Leukemia

(2018) Tina Nuebling et al.   Cancer Immunology Research

Targeting the Immune Microenvironment in Acute Myeloid Leukemia: A Focus on T Cell Immunity

(2018) Adam J. Lamble et al.   Frontiers in Oncology

Post-remission strategies for the prevention of relapse following allogeneic hematopoietic cell transplantation for high-risk acute myeloid leukemia: expert review from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

(2018) Catherine J. Lee et al.   BONE MARROW TRANSPLANTATION

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade

(2018) Joy Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

Interaction of PVR/PVRL2 with TIGIT/DNAM-1 as a novel immune checkpoint axis and therapeutic target in cancer

(2018) Hauke Stamm et al.   MAMMALIAN GENOME

Targeting Checkpoint Receptors and Molecules for Therapeutic Modulation of Natural Killer Cells

(2018) Nayoung Kim et al.   Frontiers in Immunology

Mechanisms of immune escape after allogeneic hematopoietic cell transplantation

(2018) Robert Zeiser et al.   BLOOD

The distribution of T-cell subsets and the expression of immune checkpoint receptors and ligands in patients with newly diagnosed and relapsed acute myeloid leukemia

(2018) Patrick Williams et al.   CANCER

CD33/CD3-bispecific T-cell engaging (BiTE®) antibody construct targets monocytic AML myeloid-derived suppressor cells

(2018) Regina Jitschin et al.   Journal for ImmunoTherapy of Cancer

Novel Agents for Acute Myeloid Leukemia

(2018) Mario Luppi et al.   Cancers

Frequency and functional characterization of exhausted CD8+ T cells in chronic lymphocytic leukemia

(2017) Saeid Taghiloo et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Tumor-associated macrophage infiltration is highly associated with PD-L1 expression in gastric adenocarcinoma

(2017) Kazuto Harada et al.   Gastric Cancer

Tumor-associated macrophage expression of PD-L1 in implants of high grade serous ovarian carcinoma: A comparison of matched primary and metastatic tumors

(2017) Chelsea E. Gottlieb et al.   GYNECOLOGIC ONCOLOGY

Oral squamous cell carcinoma suppressed antitumor immunity through induction of PD-L1 expression on tumor-associated macrophages

(2017) Canhua Jiang et al.   IMMUNOBIOLOGY

TIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy

(2017) William C. Dougall et al.   IMMUNOLOGICAL REVIEWS

Immune checkpoint inhibitors in cancer therapy: a focus on T-regulatory cells

(2017) Varun Sasidharan Nair et al.   IMMUNOLOGY AND CELL BIOLOGY

Expression of checkpoint molecules on myeloid-derived suppressor cells

(2017) Marlene Ballbach et al.   IMMUNOLOGY LETTERS

The emerging role of immune checkpoint based approaches in AML and MDS

(2017) Prajwal Boddu et al.   LEUKEMIA & LYMPHOMA

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

A distinct innate lymphoid cell population regulates tumor-associated T cells

(2017) Sarah Q Crome et al.   NATURE MEDICINE

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Checkpoint inhibition in pediatric hematologic malignancies

(2017) Kara L. Davis et al.   PEDIATRIC HEMATOLOGY AND ONCOLOGY

In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy

(2017) Sean P. Arlauckas et al.   Science Translational Medicine

Mechanisms of Immune Tolerance in Leukemia and Lymphoma

(2017) Emily K. Curran et al.   TRENDS IN IMMUNOLOGY

Increased BTLA and HVEM in gastric cancer are associated with progression and poor prognosis

(2017) Xiuwen Lan et al.   OncoTargets and Therapy

Preferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment

(2017) Azharuddin Sajid Syed Khaja et al.   Oncotarget

Intratumoral FoxP3+Helios+ Regulatory T Cells Upregulating Immunosuppressive Molecules Are Expanded in Human Colorectal Cancer

(2017) Azharuddin Sajid Syed Khaja et al.   Frontiers in Immunology

NK Cell Exhaustion

(2017) Jiacheng Bi et al.   Frontiers in Immunology

T-cell defect in diffuse large B-cell lymphomas involves expansion of myeloid-derived suppressor cells

(2016) I. Azzaoui et al.   BLOOD

PD-1 checkpoint blockade in patients with relapsed AML after allogeneic stem cell transplantation

(2016) J C Albring et al.   BONE MARROW TRANSPLANTATION

Selective Targeting of Myeloid-Derived Suppressor Cells in Cancer Patients Using DS-8273a, an Agonistic TRAIL-R2 Antibody

(2016) George A. Dominguez et al.   CLINICAL CANCER RESEARCH

T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8+ T-Cell Exhaustion and Poor Clinical Outcome in AML Patients

(2016) Y. Kong et al.   CLINICAL CANCER RESEARCH

PD-L1 expression in cancer patients receiving anti PD-1/PD-L1 antibodies: A systematic review and meta-analysis

(2016) Sara Gandini et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Harnessing the immune system in acute myeloid leukaemia

(2016) Rebecca Austin et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Immunotherapy and Novel Combinations in Oncology: Current Landscape, Challenges, and Opportunities

(2016) KM Morrissey et al.   CTS-Clinical and Translational Science

Innate lymphoid cells are expanded and functionally altered in chronic lymphocytic leukemia

(2016) Iris de Weerdt et al.   HAEMATOLOGICA

The PD-1 Axis Enforces an Anatomical Segregation of CTL Activity that Creates Tumor Niches after Allogeneic Hematopoietic Stem Cell Transplantation

(2016) David Michonneau et al.   IMMUNITY

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation

(2016) Ana C. Anderson et al.   IMMUNITY

Nivolumab in Combination With Platinum‐Based Doublet Chemotherapy for First-Line Treatment of Advanced Non–Small-Cell Lung Cancer

(2016) Naiyer A. Rizvi et al.   JOURNAL OF CLINICAL ONCOLOGY

Ipilimumab for Patients with Relapse after Allogeneic Transplantation

(2016) Matthew S. Davids et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acute myeloid leukemia stem cell markers in prognosis and targeted therapy: potential impact of BMI-1, TIM-3 and CLL-1

(2016) Noureldien H.E. Darwish et al.   Oncotarget

PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma

(2016) Asma Beldi-Ferchiou et al.   Oncotarget

Innate lymphoid cells are expanded and functionally altered in chronic lymphocytic leukemia

(2016) Iris de Weerdt et al.   HAEMATOLOGICA

The immune receptor Tim-3 acts as a trafficker in a Tim-3/galectin-9 autocrine loop in human myeloid leukemia cells

(2016) Isabel Gonçalves Silva et al.   OncoImmunology

Acute Myeloid Leukemia: A Concise Review

(2016) Jennifer Saultz et al.   Journal of Clinical Medicine

A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression

(2015) Yoshikane Kikushige et al.   Cell Stem Cell

CD127+ innate lymphoid cells are dysregulated in treatment naive acute myeloid leukemia patients at diagnosis

(2015) S. Trabanelli et al.   HAEMATOLOGICA

Increase in myeloid-derived suppressor cells (MDSCs) associated with minimal residual disease (MRD) detection in adult acute myeloid leukemia

(2015) Hui Sun et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

TIGIT and PD-1 impair tumor antigen–specific CD8+ T cells in melanoma patients

(2015) Joe-Marc Chauvin et al.   JOURNAL OF CLINICAL INVESTIGATION

Immune Checkpoint Blockade in Cancer Therapy

(2015) Michael A. Postow et al.   JOURNAL OF CLINICAL ONCOLOGY

CD47 blockade triggers T cell–mediated destruction of immunogenic tumors

(2015) Xiaojuan Liu et al.   NATURE MEDICINE

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

T-cell exhaustion in the tumor microenvironment

(2015) Y Jiang et al.   Cell Death & Disease

PD-1hiTIM-3+ T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation

(2015) Y Kong et al.   Blood Cancer Journal

Differential expression and biochemical activity of the immune receptor Tim-3 in healthy and malignant human myeloid cells

(2015) Isabel Gonçalves Silva et al.   Oncotarget

CD127+ innate lymphoid cells are dysregulated in treatment naive acute myeloid leukemia patients at diagnosis

(2015) S. Trabanelli et al.   HAEMATOLOGICA

CTLA-4 and PD-1 Pathway Blockade: Combinations in the Clinic

(2015) Margaret K. Callahan et al.   Frontiers in Oncology

Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential

(2015) Jie Liu et al.   PLoS One

Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma

(2015) Valentina Bevelacqua et al.   Oncotarget

Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia

(2015) Valentina Folgiero et al.   Oncotarget

Immune evasion by oncogenic proteins of acute myeloid leukemia

(2014) S. Elias et al.   BLOOD

Hypothesis: Tim-3/Galectin-9, A New Pathway for Leukemia Stem Cells Survival by Promoting Expansion of Myeloid-Derived Suppressor Cells and Differentiating into Tumor-Associated Macrophages

(2014) Lei Gao et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Allogeneic transplantation as anticancer immunotherapy

(2014) Simrit Parmar et al.   CURRENT OPINION IN IMMUNOLOGY

Complexity and challenges in defining myeloid-derived suppressor cells

(2014) Vera Damuzzo et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

(2013) Eric O. Long et al.   Annual Review of Immunology

Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment

(2013) F. Mussai et al.   BLOOD

PD-1 and Tim-3 Regulate the Expansion of Tumor Antigen-Specific CD8+ T Cells Induced by Melanoma Vaccines

(2013) J. Fourcade et al.   CANCER RESEARCH

Interferon-induced programmed death-ligand 1 (PD-L1/B7-H1) expression increases on human acute myeloid leukemia blast cells during treatment

(2013) Holger Krönig et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

TIM-3 as a novel therapeutic target for eradicating acute myelogenous leukemia stem cells

(2013) Yoshikane Kikushige et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response

(2013) D. Tseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune evasion in acute myeloid leukemia: current concepts and future directions

(2013) Ryan M Teague et al.   Journal for ImmunoTherapy of Cancer

Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9

(2012) M. K. Gleason et al.   BLOOD

Immunosuppressive activity of CD14+ HLA-DR− cells in squamous cell carcinoma of the head and neck

(2012) Kazuaki Chikamatsu et al.   CANCER SCIENCE

CD200R signaling in tumor tolerance and inflammation: A tricky balance

(2012) Tomasz P Rygiel et al.   CURRENT OPINION IN IMMUNOLOGY

Natural killer cell immune escape in acute myeloid leukemia

(2012) E Lion et al.   LEUKEMIA

Expression of CD200 on AML blasts directly suppresses memory T-cell function

(2012) S J Coles et al.   LEUKEMIA

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

(2011) Q. Zhou et al.   BLOOD

Human NK cells in acute myeloid leukaemia patients: analysis of NK cell-activating receptors and their ligands

(2011) Beatriz Sanchez-Correa et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia

(2011) S J Coles et al.   LEUKEMIA

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Prospective separation of normal and leukemic stem cells based on differential expression of TIM3, a human acute myeloid leukemia stem cell marker

(2011) M. Jan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells

(2010) W. Koestner et al.   BLOOD

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia

(2010) Q. Zhou et al.   BLOOD

Clinical significance of B7-H1（PD-L1）expression in human acute leukemia

(2010) Xiangli Chen et al.   CANCER BIOLOGY & THERAPY

In acute myeloid leukemia, B7-H1 (PD-L1) protection of blasts from cytotoxic T cells is induced by TLR ligands and interferon-gamma and can be reversed using MEK inhibitors

(2010) Céline Berthon et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma

(2010) Reiko Nakai et al.   CANCER SCIENCE

Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma

(2010) Mark P. Chao et al.   CELL

TIM-3 Is a Promising Target to Selectively Kill Acute Myeloid Leukemia Stem Cells

(2010) Yoshikane Kikushige et al.   Cell Stem Cell

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

T-cell exhaustion: characteristics, causes and conversion

(2010) John S. Yi et al.   IMMUNOLOGY

Elevated frequencies of CD4+CD25+CD127lo regulatory T cells is associated to poor prognosis in patients with acute myeloid leukemia

(2010) Zhang Shenghui et al.   INTERNATIONAL JOURNAL OF CANCER

Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice

(2010) Shoji Asakura et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

(2010) Kaori Sakuishi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophages as mediators of tumor immunosurveillance

(2010) Siddhartha Jaiswal et al.   TRENDS IN IMMUNOLOGY

PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model

(2009) L. Zhang et al.   BLOOD

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

(2009) Siddhartha Jaiswal et al.   CELL

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

(2009) Ravindra Majeti et al.   CELL

Increased Frequency and Suppression by Regulatory T Cells in Patients with Acute Myelogenous Leukemia

(2009) M. J. Szczepanski et al.   CLINICAL CANCER RESEARCH

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

(2009) Karl S. Peggs et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells

(2009) K. S. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation

(2008) A. Bashey et al.   BLOOD

The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages

(2008) Paola Allavena et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Anti–Cytotoxic T-Lymphocyte Antigen-4 Antibody: The First in an Emerging Class of Immunomodulatory Antibodies for Cancer Treatment

(2008) Lawrence Fong et al.   JOURNAL OF CLINICAL ONCOLOGY