Haematopoietic stem cell activity and interactions with the niche

Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment

(2018) Ryo Yamamoto et al.   Cell Stem Cell

CD150 high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine

(2018) Yuichi Hirata et al.   Cell Stem Cell

In Vivo Labeling by CD73 Marks Multipotent Stromal Cells and Highlights Endothelial Heterogeneity in the Bone Marrow Niche

(2018) Martin Breitbach et al.   Cell Stem Cell

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML

(2018) Delfim Duarte et al.   Cell Stem Cell

Causes and Consequences of Hematopoietic Stem Cell Heterogeneity

(2018) Simon Haas et al.   Cell Stem Cell

The hematopoietic stem cell niche: from embryo to adult

(2018) Xin Gao et al.   DEVELOPMENT

Lineage-Biased Hematopoietic Stem Cells Are Regulated by Distinct Niches

(2018) Sandra Pinho et al.   DEVELOPMENTAL CELL

Hematopoietic stem cell fate through metabolic control

(2018) Kyoko Ito et al.   EXPERIMENTAL HEMATOLOGY

Stem cell niche-specific Ebf3 maintains the bone marrow cavity

(2018) Masanari Seike et al.   GENES & DEVELOPMENT

Niches for Hematopoietic Stem Cells and Their Progeny

(2018) Qiaozhi Wei et al.   IMMUNITY

SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-β signaling

(2018) Linjia Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clonal analysis of lineage fate in native haematopoiesis

(2018) Alejo E. Rodriguez-Fraticelli et al.   NATURE

Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche

(2018) Maria Maryanovich et al.   NATURE MEDICINE

Hepatic thrombopoietin is required for bone marrow hematopoietic stem cell maintenance

(2018) Matthew Decker et al.   SCIENCE

Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin

(2018) Oriane Duchamp de Lageneste et al.   Nature Communications

Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow

(2018) Chunliang Xu et al.   Nature Communications

Neural Regulation of Bone and Bone Marrow

(2018) Maria Maryanovich et al.   Cold Spring Harbor Perspectives in Medicine

Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration

(2018) Heather A. Himburg et al.   Cell Stem Cell

Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells

(2018) Joana Carrelha et al.   NATURE

The Majority of CD45– Ter119– CD31– Bone Marrow Cell Fraction Is of Hematopoietic Origin and Contains Erythroid and Lymphoid Progenitors

(2018) Philip E. Boulais et al.   IMMUNITY

Complexity of bone marrow hematopoietic stem cell niche

(2017) Noboru Asada et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression

(2017) Peipei Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial transplantation rejuvenates aged hematopoietic stem cell function

(2017) Michael G. Poulos et al.   JOURNAL OF CLINICAL INVESTIGATION

Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis

(2017) Aurélie Hérault et al.   NATURE

Leptin-receptor-expressing bone marrow stromal cells are myofibroblasts in primary myelofibrosis

(2017) Matthew Decker et al.   NATURE CELL BIOLOGY

Cell–matrix signals specify bone endothelial cells during developmental osteogenesis

(2017) Urs H. Langen et al.   NATURE CELL BIOLOGY

Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche

(2017) Allison L. Boyd et al.   NATURE CELL BIOLOGY

Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF

(2017) Bo O. Zhou et al.   NATURE CELL BIOLOGY

Differential cytokine contributions of perivascular haematopoietic stem cell niches

(2017) Noboru Asada et al.   NATURE CELL BIOLOGY

Granulocyte-derived TNFα promotes vascular and hematopoietic regeneration in the bone marrow

(2017) Emily Bowers et al.   NATURE MEDICINE

Adrenergic nerves activate an angio-metabolic switch in prostate cancer

(2017) Ali H. Zahalka et al.   SCIENCE

Continuous cell supply from Krt7-expressing hematopoietic stem cells during native hematopoiesis revealed by targeted in vivo gene transfer method

(2017) Yoko Tajima et al.   Scientific Reports

Biology of Bone: The Vasculature of the Skeletal System

(2017) Emma C. Watson et al.   Cold Spring Harbor Perspectives in Medicine

Niche heterogeneity in the bone marrow

(2016) Alexander Birbrair et al.   Annals of the New York Academy of Sciences

Regulation of Hematopoiesis and Osteogenesis by Blood Vessel–Derived Signals

(2016) Saravana K. Ramasamy et al.   Annual Review of Cell and Developmental Biology

G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2

(2016) Yuko Kawano et al.   BLOOD

Aging alters bone-fat reciprocity by shifting in vivo mesenchymal precursor cell fate towards an adipogenic lineage

(2016) Lakshman Singh et al.   BONE

Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function

(2016) Weihuan Wang et al.   CANCER RESEARCH

Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow

(2016) Rui Yue et al.   Cell Stem Cell

CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages

(2016) Jin Hur et al.   Cell Stem Cell

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia

(2016) Noemi A. Zambetti et al.   Cell Stem Cell

Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators

(2016) Lev Silberstein et al.   Cell Stem Cell

Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation

(2016) Ana Cordeiro Gomes et al.   IMMUNITY

Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals

(2016) Catherine M. Sawai et al.   IMMUNITY

T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments

(2016) Edwin D. Hawkins et al.   NATURE

Distinct bone marrow blood vessels differentially regulate haematopoiesis

(2016) Tomer Itkin et al.   NATURE

Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche

(2016) James Y. Chen et al.   NATURE

Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment

(2016) Lei Dong et al.   NATURE

Age-dependent modulation of vascular niches for haematopoietic stem cells

(2016) Anjali P. Kusumbe et al.   NATURE

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance

(2016) K. Ito et al.   SCIENCE

High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo

(2016) Claire S. Koechlein et al.   Nature Communications

Blood flow controls bone vascular function and osteogenesis

(2016) Saravana K. Ramasamy et al.   Nature Communications

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

(2016) Amit Grover et al.   Nature Communications

CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance

(2015) Lauren A. Pitt et al.   CANCER CELL

Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential

(2015) Daniel L. Worthley et al.   CELL

Clarifying Tissue Clearing

(2015) Douglas S. Richardson et al.   CELL

Identification and Specification of the Mouse Skeletal Stem Cell

(2015) Charles K.F. Chan et al.   CELL

Bone Marrow Macrophages Contribute to Diabetic Stem Cell Mobilopathy by Producing Oncostatin M

(2015) Mattia Albiero et al.   DIABETES

Neuropeptide Y regulates the hematopoietic stem cell microenvironment and prevents nerve injury in the bone marrow

(2015) M. H. Park et al.   EMBO JOURNAL

A High Fat Diet Increases Bone Marrow Adipose Tissue (MAT) But Does Not Alter Trabecular or Cortical Bone Mass in C57BL/6J Mice

(2015) Casey R. Doucette et al.   JOURNAL OF CELLULAR PHYSIOLOGY

CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow

(2015) Ayako Nakamura-Ishizu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophages retain hematopoietic stem cells in the spleen via VCAM-1

(2015) Partha Dutta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow

(2015) Vionnie W.C. Yu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal

(2015) Melih Acar et al.   NATURE

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo

(2015) Katrin Busch et al.   NATURE

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

(2015) Dagmar Walter et al.   NATURE

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

(2015) F. Notta et al.   SCIENCE

Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1

(2015) Bo O Zhou et al.   eLife

Megakaryocytes are essential for HSC quiescence through the production of thrombopoietin

(2014) Ayako Nakamura-Ishizu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Notch-Dependent Repression of miR-155 in the Bone Marrow Niche Regulates Hematopoiesis in an NF-κB-Dependent Manner

(2014) Lin Wang et al.   Cell Stem Cell

Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow

(2014) Bo O. Zhou et al.   Cell Stem Cell

Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche

(2014) Maher Hanoun et al.   Cell Stem Cell

Vasculature-Associated Cells Expressing Nestin in Developing Bones Encompass Early Cells in the Osteoblast and Endothelial Lineage

(2014) Noriaki Ono et al.   DEVELOPMENTAL CELL

Osterix Marks Distinct Waves of Primitive and Definitive Stromal Progenitors during Bone Marrow Development

(2014) Toshihide Mizoguchi et al.   DEVELOPMENTAL CELL

Epigenetic regulation of hematopoietic stem cell aging

(2014) Isabel Beerman et al.   EXPERIMENTAL CELL RESEARCH

Aging of the hematopoietic stem cells niche

(2014) Ayako Nakamura-Ishizu et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Niche displacement of human leukemic stem cells uniquely allows their competitive replacement with healthy HSPCs

(2014) Allison L. Boyd et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fgd5identifies hematopoietic stem cells in the murine bone marrow

(2014) Roi Gazit et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms

(2014) Lorena Arranz et al.   NATURE

Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts

(2014) Aruna Kode et al.   NATURE

Clonal dynamics of native haematopoiesis

(2014) Jianlong Sun et al.   NATURE

Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation

(2014) Yoshiki Omatsu et al.   NATURE

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

(2014) Anjali P. Kusumbe et al.   NATURE

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

(2014) Saravana K. Ramasamy et al.   NATURE

Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells

(2014) Meng Zhao et al.   NATURE MEDICINE

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion

(2014) Ingmar Bruns et al.   NATURE MEDICINE

High Fat Diet Rapidly Suppresses B Lymphopoiesis by Disrupting the Supportive Capacity of the Bone Marrow Niche

(2014) Benjamin J. Adler et al.   PLoS One

The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem cell niche function

(2014) Joan Isern et al.   eLife

Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine

(2013) Paul S. Frenette et al.   Annual Review of Immunology

Characterization of the TGF- 1 signaling abnormalities in the Gata1low mouse model of myelofibrosis

(2013) M. Zingariello et al.   BLOOD

Megakaryocytes promote murine osteoblastic HSC niche expansion and stem cell engraftment after radioablative conditioning

(2013) T. S. Olson et al.   BLOOD

Clonal Analysis Unveils Self-Renewing Lineage-Restricted Progenitors Generated Directly from Hematopoietic Stem Cells

(2013) Ryo Yamamoto et al.   CELL

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

(2013) María Casanova-Acebes et al.   CELL

Regional Localization within the Bone Marrow Influences the Functional Capacity of Human HSCs

(2013) Borhane Guezguez et al.   Cell Stem Cell

Matrix-Embedded Osteocytes Regulate Mobilization of Hematopoietic Stem/Progenitor Cells

(2013) Noboru Asada et al.   Cell Stem Cell

Deciphering Hematopoietic Stem Cells in Their Niches: A Critical Appraisal of Genetic Models, Lineage Tracing, and Imaging Strategies

(2013) Chacko Joseph et al.   Cell Stem Cell

Myeloproliferative Neoplasia Remodels the Endosteal Bone Marrow Niche into a Self-Reinforcing Leukemic Niche

(2013) Koen Schepers et al.   Cell Stem Cell

Hematopoiesis

(2013) M. Jagannathan-Bogdan et al.   DEVELOPMENT

PDGFRα and CD51 mark human Nestin+sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion

(2013) Sandra Pinho et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy

(2013) Alejandra Sanjuan-Pla et al.   NATURE

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

(2013) César Nombela-Arrieta et al.   NATURE CELL BIOLOGY

Differential regulation of myeloid leukemias by the bone marrow microenvironment

(2013) Daniela S Krause et al.   NATURE MEDICINE

Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration

(2013) Daniel Lucas et al.   NATURE MEDICINE

Autonomic Nerve Development Contributes to Prostate Cancer Progression

(2013) C. Magnon et al.   SCIENCE

Endothelial Jagged-1 Is Necessary for Homeostatic and Regenerative Hematopoiesis

(2013) Michael G. Poulos et al.   Cell Reports

A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia

(2012) G. L. Uy et al.   BLOOD

Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing

(2012) A. V. Ergen et al.   BLOOD

N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells

(2012) A. M. Greenbaum et al.   BLOOD

Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells

(2012) O. Bromberg et al.   BLOOD

Noncanonical Wnt Signaling Maintains Hematopoietic Stem Cells in the Niche

(2012) Ryohichi Sugimura et al.   CELL

Cdc42 Activity Regulates Hematopoietic Stem Cell Aging and Rejuvenation

(2012) Maria Carolina Florian et al.   Cell Stem Cell

Hematopoietic Stem Cell Subtypes Expand Differentially during Development and Display Distinct Lymphopoietic Programs

(2012) Claudia Benz et al.   Cell Stem Cell

Hematopoietic recovery following chemotherapy is improved by BADGE-induced inhibition of adipogenesis

(2012) Rong-Jia Zhu et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow

(2012) Aya Ludin et al.   NATURE IMMUNOLOGY

Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance

(2012) Ingrid G Winkler et al.   NATURE MEDICINE

Skeletal parasympathetic innervation communicates central IL-1 signals regulating bone mass accrual

(2012) A. Bajayo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tie2+Bone Marrow Endothelial Cells Regulate Hematopoietic Stem Cell Regeneration Following Radiation Injury

(2012) Phuong L. Doan et al.   STEM CELLS

Hoxb4-YFP reporter mouse model: a novel tool for tracking HSC development and studying the role of Hoxb4 in hematopoiesis

(2011) D. Hills et al.   BLOOD

The relationship between bone, hemopoietic stem cells, and vasculature

(2011) S. L. Ellis et al.   BLOOD

Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia

(2011) B. J. Frisch et al.   BLOOD

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

(2011) Satoshi Yamazaki et al.   CELL

Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow

(2011) Yusuke Shiozawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

(2011) Brad Dykstra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice

(2011) Matthew J. Christopher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity

(2011) Keisuke Kataoka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow CD169+macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

(2011) Andrew Chow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche

(2011) Joji Fujisaki et al.   NATURE

Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment

(2011) F. Notta et al.   SCIENCE

Donor Cell Leukemia: A Review

(2010) Daniel H. Wiseman   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Hematopoiesis in 3 dimensions: human and murine bone marrow architecture visualized by confocal microscopy

(2010) T. Takaku et al.   BLOOD

Phenotypically identical hemopoietic stem cells isolated from different regions of bone marrow have different biologic potential

(2010) J. Grassinger et al.   BLOOD

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

(2010) I. G. Winkler et al.   BLOOD

Intermediate-Term Hematopoietic Stem Cells with Extended but Time-Limited Reconstitution Potential

(2010) Patricia Benveniste et al.   Cell Stem Cell

Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-β1

(2010) Grant A. Challen et al.   Cell Stem Cell

Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells

(2010) Jason M. Butler et al.   Cell Stem Cell

The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche

(2010) Yoshiki Omatsu et al.   IMMUNITY

Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation

(2010) Keizo Nishikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment

(2010) Yohei Morita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

(2010) Megan T. Baldridge et al.   NATURE

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells

(2010) Hideki Kobayashi et al.   NATURE CELL BIOLOGY

Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells

(2010) Heather A Himburg et al.   NATURE MEDICINE

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

(2010) I. Beerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation

(2009) M. Dominici et al.   BLOOD

Hematopoietic Stem Cells Do Not Depend on N-Cadherin to Regulate Their Maintenance

(2009) Mark J. Kiel et al.   Cell Stem Cell

Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow

(2009) Satoru Morikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

(2009) Olaia Naveiras et al.   NATURE

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Defective Notch activation in microenvironment leads to myeloproliferative disease

(2008) Y.-W. Kim et al.   BLOOD

A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells

(2008) R. H. Cho et al.   BLOOD

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML

(2008) Z. Zeng et al.   BLOOD

Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100

(2008) B. Nervi et al.   BLOOD

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

Mobilized Hematopoietic Stem Cell Yield Depends on Species-Specific Circadian Timing

(2008) Daniel Lucas et al.   Cell Stem Cell

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

(2008) Cristina Lo Celso et al.   NATURE

Detection of functional haematopoietic stem cell niche using real-time imaging

(2008) Yucai Xie et al.   NATURE

Endochondral ossification is required for haematopoietic stem-cell niche formation

(2008) Charles K. F. Chan et al.   NATURE

Haematopoietic stem cell release is regulated by circadian oscillations

(2008) Simón Méndez-Ferrer et al.   NATURE

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

(2008) Adlen Foudi et al.   NATURE BIOTECHNOLOGY

Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche

(2007) Yoshiaki Kubota et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS