In Vitro and In Vivo Modeling of Normal and Leukemic Bone Marrow Niches: Cellular Senescence Contribution to Leukemia Induction and Progression

Dysfunction of metabolic activity of bone marrow mesenchymal stem cells in aged mice

(2022) Xiaoyu Li et al.   CELL PROLIFERATION

Toll-like Receptor 4, Osteoblasts and Leukemogenesis; the Lesson from Acute Myeloid Leukemia

(2022) Øystein Bruserud et al.   MOLECULES

Subversion of serotonin-receptor signaling in osteoblasts by kynurenine drives Acute Myeloid Leukemia

(2022) Marta Galan-Diez et al.   Cancer Discovery

Emilin-2 is a component of bone marrow extracellular matrix regulating mesenchymal stem cell differentiation and hematopoietic progenitors

(2022) Francesco Da Ros et al.   Stem Cell Research & Therapy

Cellular Interaction of Bone Marrow Mesenchymal Stem Cells with Polymer and Hydrogel 3D Microscaffold Templates

(2022) Beatriz N. L. Costa et al.   ACS Applied Materials & Interfaces

Large‐cohort humanized NPI mice reconstituted with CD34 + hematopoietic stem cells are feasible for evaluating preclinical cancer immunotherapy

(2022) Xiongfei Xu et al.   FASEB JOURNAL

Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs

(2022) Natalie Kudlova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activatable senoprobes and senolytics: Novel strategies to detect and target senescent cells

(2022) Samir Morsli et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A Comprehensive Atlas of Immunological Differences Between Humans, Mice, and Non-Human Primates

(2022) Zachary B. Bjornson-Hooper et al.   Frontiers in Immunology

Leukemia’s Next Top Model? Syngeneic Models to Advance Adoptive Cellular Therapy

(2022) Jaquelyn T. Zoine et al.   Frontiers in Immunology

Bone Marrow Aging and the Leukaemia-Induced Senescence of Mesenchymal Stem/Stromal Cells: Exploring Similarities

(2022) Paola Fernanda Ruiz-Aparicio et al.   Journal of Personalized Medicine

Telomere Dysfunction in Chronic Lymphocytic Leukemia

(2021) Billy Michael Chelliah Jebaraj et al.   Frontiers in Oncology

A Two-Photon Probe Based on Naphthalimide-Styrene Fluorophore for the In Vivo Tracking of Cellular Senescence

(2021) Beatriz Lozano-Torres et al.   ANALYTICAL CHEMISTRY

Syngeneic leukemia models using lentiviral transgenics

(2021) Nurit Keinan et al.   Cell Death & Disease

Venetoclax and Navitoclax in Combination with Chemotherapy in Patients with Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma

(2021) Vinod A. Pullarkat et al.   Cancer Discovery

Targeting mesenchymal stromal cells plasticity to reroute acute myeloid leukemia course

(2021) Giulia Borella et al.   BLOOD

Modeling human tumor-immune environments in vivo for the preclinical assessment of immunotherapies

(2021) Bethany Bareham et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The Bone Marrow Niche in B-Cell Acute Lymphoblastic Leukemia: The Role of Microenvironment from Pre-Leukemia to Overt Leukemia

(2021) Erica Dander et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Constitutive Extracellular Protein Release by Acute Myeloid Leukemia Cells—A Proteomic Study of Patient Heterogeneity and Its Modulation by Mesenchymal Stromal Cells

(2021) Elise Aasebø et al.   Cancers

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

(2021) Ruchi Kumari et al.   Frontiers in Cell and Developmental Biology

Alternative Animal Models of Aging Research

(2021) Susanne Holtze et al.   Frontiers in Molecular Biosciences

The age of the bone marrow microenvironment influences B-cell acute lymphoblastic leukemia progression via CXCR5-CXCL13

(2021) Costanza Zanetti et al.   BLOOD

Leukemia-Induced Cellular Senescence and Stemness Alterations in Mesenchymal Stem Cells Are Reversible upon Withdrawal of B-Cell Acute Lymphoblastic Leukemia Cells

(2021) Natalia-Del Pilar Vanegas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sensitization to Drug Treatment in Precursor B-Cell Acute Lymphoblastic Leukemia Is Not Achieved by Stromal NF-κB Inhibition of Cell Adhesion but by Stromal PKC-Dependent Inhibition of ABC Transporters Activity

(2021) Paola Fernanda Ruiz-Aparicio et al.   MOLECULES

Cellular senescence and hematological malignancies: From pathogenesis to therapeutics

(2021) Dingyu Hu et al.   PHARMACOLOGY & THERAPEUTICS

Coculture in vitro with endothelial cells induces cytarabine resistance of acute myeloid leukemia cells in a VEGF-A/VEGFR-2 signaling–independent manner

(2021) Shuichiro Okamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mouse Models of CMML

(2021) Ekaterina Belotserkovskaya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer

(2021) Yi-Xin Chen et al.   PHARMACOLOGICAL RESEARCH

Culturing patient-derived malignant hematopoietic stem cells in engineered and fully humanized 3D niches

(2021) Andrés García-García et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patient-Derived Bone Marrow Spheroids Reveal Leukemia-Initiating Cells Supported by Mesenchymal Hypoxic Niches in Pediatric B-ALL

(2021) Juan Carlos Balandrán et al.   Frontiers in Immunology

Emerging Bone Marrow Microenvironment-Driven Mechanisms of Drug Resistance in Acute Myeloid Leukemia: Tangle or Chance?

(2021) Marilena Ciciarello et al.   Cancers

The Cross-Talk between Myeloid and Mesenchymal Stem Cells of Human Bone Marrow Represents a Biomarker of Aging That Regulates Immune Response and Bone Reabsorption

(2021) Maria Elisa Perico et al.   Cells

Pro‐inflammatory cytokines favor the emergence of ETV6‐RUNX1‐positive pre‐leukemic cells in a model of mesenchymal niche

(2020) Linda Beneforti et al.   BRITISH JOURNAL OF HAEMATOLOGY

Human Mesenchymal Stem Cells-mediated Transcriptomic Regulation of Leukemic Cells in Delivering Anti-tumorigenic Effects

(2020) Vahid Hosseinpour Sarmadi et al.   CELL TRANSPLANTATION

Dissecting the spatial bone marrow microenvironment of hematopoietic stem cells

(2020) Konstantinos D. Kokkaliaris   CURRENT OPINION IN ONCOLOGY

Shp2 activation in bone marrow microenvironment mediates the drug resistance of B-cell acute lymphoblastic leukemia through enhancing the role of VCAM-1/VLA-4

(2020) Kunlin Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment

(2020) Chengxiang Xia et al.   LEUKEMIA

Acute Myeloid Leukaemia in Its Niche: the Bone Marrow Microenvironment in Acute Myeloid Leukaemia

(2020) E. E. Ladikou et al.   Current Oncology Reports

Bone Marrow Senescence and the Microenvironment of Hematological Malignancies

(2020) Charlotte Hellmich et al.   Frontiers in Oncology

Targeting BMP signaling in the bone marrow microenvironment of myeloid leukemia

(2020) Sylvain Lefort et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The bone marrow stromal niche: a therapeutic target of hematological myeloid malignancies

(2020) Lena Behrmann et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Dual Targeting of Stromal Cell Support and Leukemic Cell Growth by a Peptidic PKC Inhibitor Shows Effectiveness against B-ALL

(2020) Paola Fernanda Ruiz-Aparicio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies

(2020) Yonghan He et al.   Journal of Hematology & Oncology

Senolytic drugs: from discovery to translation

(2020) J. L. Kirkland et al.   JOURNAL OF INTERNAL MEDICINE

Janus Kinase mutations in mice lacking PU.1 and Spi-B drive B cell leukemia through reactive oxygen species-induced DNA damage

(2020) Michelle Lim et al.   MOLECULAR AND CELLULAR BIOLOGY

A Senescence-Centric View of Aging: Implications for Longevity and Disease

(2020) M. Borghesan et al.   TRENDS IN CELL BIOLOGY

Senescence-Associated Pro-inflammatory Cytokines and Tumor Cell Plasticity

(2020) Jean Paul Vernot   Frontiers in Molecular Biosciences

Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy

(2020) Dorian Forte et al.   Cell Metabolism

Mesenchymal stem cells promote caspase expression in Molt-4 leukemia cells via GSK-3α/β and ERK1/2 signaling pathways as a therapeutic strategy

(2020) Ezzatollah Fathi et al.   CURRENT GENE THERAPY

Ex vivo cultures and drug testing of primary acute myeloid leukemia samples: Current techniques and implications for experimental design and outcome

(2020) D.G.J. Cucchi et al.   DRUG RESISTANCE UPDATES

Safety and efficacy of navitoclax, a BCL-2 and BCL-XL inhibitor, in patients with relapsed or refractory lymphoid malignancies: results from a phase 2a study

(2020) Sven de Vos et al.   LEUKEMIA & LYMPHOMA

Senescent bone marrow microenvironment promotes Nras-mutant leukemia

(2020) Peiqing Zhou et al.   Journal of Molecular Cell Biology

Merger of dynamic two-photon and phosphorescence lifetime microscopy reveals dependence of lymphocyte motility on oxygen in solid and hematological tumors

(2019) Mateusz Rytelewski et al.   Journal for ImmunoTherapy of Cancer

Bone Marrow Mesenchymal Stromal Cell-Derived Periostin Promotes B-ALL Progression by Modulating CCL2 in Leukemia Cells

(2019) Zhenling Ma et al.   Cell Reports

Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence

(2019) Jie-Yu Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activin A contributes to the definition of a pro-oncogenic bone marrow microenvironment in t(12;21) preleukemia

(2019) Federica Portale et al.   EXPERIMENTAL HEMATOLOGY

Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells

(2019) Puneet Agarwal et al.   Cell Stem Cell

Relationship between senescence in macaques and bone marrow mesenchymal stem cells and the molecular mechanism

(2019) Xing-hua Pan et al.   Aging-US

Reciprocal modulation of cell functions upon direct interaction of adipose mesenchymal stromal and activated immune cells

(2019) Polina Bobyleva et al.   CELL BIOCHEMISTRY AND FUNCTION

Normal and leukemic stem cell niche interactions

(2019) Il-Hoan Oh et al.   CURRENT OPINION IN HEMATOLOGY

Cellular Senescence: Aging, Cancer, and Injury

(2019) Arianna Calcinotto et al.   PHYSIOLOGICAL REVIEWS

Losing Sense of Self and Surroundings: Hematopoietic Stem Cell Aging and Leukemic Transformation

(2019) Evgenia V. Verovskaya et al.   TRENDS IN MOLECULAR MEDICINE

Mesenchymal stem cells targeting PI3K/AKT pathway in leukemic model

(2019) Esraa S A Ahmed et al.   TUMOR BIOLOGY

Acute Leukemia Induces Senescence and Impaired Osteogenic Differentiation in Mesenchymal Stem Cells Endowing Leukemic Cells with Functional Advantages

(2019) Ximena Bonilla et al.   Stem Cells International

Effects of telomere length on leukemogenesis

(2019) Shihui Ma et al.   Science China-Life Sciences

Tunneling Nanotubes Mediate the Expression of Senescence Markers in Mesenchymal Stem/Stromal Cell Spheroids

(2019) Jacklyn Whitehead et al.   STEM CELLS

Fluorescence Imaging of Actin Turnover Parses Early Stem Cell Lineage Divergence and Senescence

(2019) Prakhar Mishra et al.   Scientific Reports

Moving Myeloid Leukemia Drug Discovery Into the Third Dimension

(2019) Donna M. Cartledge Wolf et al.   Frontiers in Pediatrics

Bone marrow mesenchymal stromal cells from acute myelogenous leukemia patients demonstrate adipogenic differentiation propensity with implications for leukemia cell support

(2019) Mitra Azadniv et al.   LEUKEMIA

A Critical Review of Animal Models Used in Acute Myeloid Leukemia Pathophysiology

(2019) Skayneh et al.   Genes

Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells

(2019) Farah Kouzi et al.   ONCOGENE

Mice with hyper-long telomeres show less metabolic aging and longer lifespans

(2019) Miguel A. Muñoz-Lorente et al.   Nature Communications

Microenvironmental contributions to hematopoietic stem cell aging

(2019) Ya-Hsuan Ho et al.   HAEMATOLOGICA

Senescence chips for ultrahigh-throughput isolation and removal of senescent cells

(2018) Yuchao Chen et al.   AGING CELL

The interplay of leukemia cells and the bone marrow microenvironment

(2018) Delfim Duarte et al.   BLOOD

Senescent cells re-engineered to express soluble programmed death receptor-1 for inhibiting programmed death receptor-1/programmed death ligand-1 as a vaccination approach against breast cancer

(2018) Zehong Chen et al.   CANCER SCIENCE

Aging- and Senescence-associated Changes of Mesenchymal Stromal Cells in Myelodysplastic Syndromes

(2018) Domenico Mattiucci et al.   CELL TRANSPLANTATION

Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side

(2018) Rodrigo Prieto-Bermejo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Escape from senescence boosts tumour growth

(2018) Jan Paul Medema   NATURE

Engineering a multicellular vascular niche to model hematopoietic cell trafficking

(2018) Surya S. Kotha et al.   Stem Cell Research & Therapy

3D models of the bone marrow in health and disease: yesterday, today, and tomorrow

(2018) Annamarija Raic et al.   MRS Communications

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress

(2018) Jia Fang et al.   Aging-US

Acute myeloid leukemia induces pro-tumoral p16INK4a driven senescence in the bone marrow microenvironment

(2018) Amina M Abdul-Aziz et al.   BLOOD

Abnormal Morphological and Functional Nature of Bone Marrow Stromal Cells Provides Preferential Support for Survival of Acute Myeloid Leukemia Cells

(2018) Shlomit Yehudai‐Resheff et al.   INTERNATIONAL JOURNAL OF CANCER

Mouse Models for Cancer Immunotherapy Research

(2018) Brian Olson et al.   Cancer Discovery

Mesenchymal stromal cells from myelodysplastic and acute myeloid leukemia patients display in vitro reduced proliferative potential and similar capacity to support leukemia cell survival

(2018) Giulia Corradi et al.   Stem Cell Research & Therapy

The polyphenol quercetin induces cell death in leukemia by targeting epigenetic regulators of pro-apoptotic genes

(2018) Marisa Claudia Alvarez et al.   Clinical Epigenetics

Development of solvent-casting particulate leaching (SCPL) polymer scaffolds as improved three-dimensional supports to mimic the bone marrow niche

(2018) Antonella Sola et al.   Materials Science & Engineering C-Materials for Biological Applications

A three-dimensional ex vivo tri-culture model mimics cell-cell interactions between acute myeloid leukemia and the vascular niche

(2017) Laura J. Bray et al.   HAEMATOLOGICA

Microenvironmental stromal cells abrogate NF-κB inhibitor-induced apoptosis in chronic lymphocytic leukemia

(2017) Carl Philipp Simon-Gabriel et al.   HAEMATOLOGICA

Phenotypic and Functional Alterations of Hematopoietic Stem and Progenitor Cells in an In Vitro Leukemia-Induced Microenvironment

(2017) Jean-Paul Vernot et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging

(2017) Hanjun Li et al.   JOURNAL OF CLINICAL INVESTIGATION

An OFF–ON Two-Photon Fluorescent Probe for Tracking Cell Senescence in Vivo

(2017) Beatriz Lozano-Torres et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion

(2017) B Kumar et al.   LEUKEMIA

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Mimicking the Acute Myeloid Leukemia Niche for Molecular Study and Drug Screening

(2017) Mohammad Houshmand et al.   TISSUE ENGINEERING PART C-METHODS

HSC Niche Biology and HSC Expansion Ex Vivo

(2017) Sachin Kumar et al.   TRENDS IN MOLECULAR MEDICINE

3D models of the hematopoietic stem cell niche under steady-state and active conditions

(2017) Lisa Rödling et al.   Scientific Reports

The Bone Marrow Microenvironment in Health and Myeloid Malignancy

(2017) Marta Galán-Díez et al.   Cold Spring Harbor Perspectives in Medicine

A three-dimensional ex vivo tri-culture model mimics cell-cell interactions between acute myeloid leukemia and the vascular niche

(2017) Laura J. Bray et al.   HAEMATOLOGICA

Microenvironmental stromal cells abrogate NF-κB inhibitor-induced apoptosis in chronic lymphocytic leukemia

(2017) Carl Philipp Simon-Gabriel et al.   HAEMATOLOGICA

Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence

(2017) Nicola Alessio et al.   NEOPLASIA

Overview of the Use of Murine Models in Leukemia and Lymphoma Research

(2017) Rebecca Kohnken et al.   Frontiers in Oncology

The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy

(2017) Markus Schosserer et al.   Frontiers in Oncology

Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1

(2017) Cao Ma et al.   PLoS One

Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy

(2016) R. Moschoi et al.   BLOOD

Humanized Mouse Xenograft Models: Narrowing the Tumor–Microenvironment Gap

(2016) J. Jason Morton et al.   CANCER RESEARCH

Differential regulation of senescence andin vitrodifferentiation by 17β-estradiol between mesenchymal stem cells derived from male and female mini-pigs

(2016) Won-Jae Lee et al.   Journal of Veterinary Science

Long-term in vitro maintenance of clonal abundance and leukaemia-initiating potential in acute lymphoblastic leukaemia

(2016) D Pal et al.   LEUKEMIA

Modeling the chronic lymphocytic leukemia microenvironment in vitro

(2016) Kyle Crassini et al.   LEUKEMIA & LYMPHOMA

Bone Marrow Microenvironment Niche Regulates miR-221/222 in Acute Lymphoblastic Leukemia

(2016) B. S. Moses et al.   MOLECULAR CANCER RESEARCH

Pathology of Mouse Models of Accelerated Aging

(2016) L. Harkema et al.   VETERINARY PATHOLOGY

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Senescent stromal cell-induced divergence and therapeutic resistance in T cell acute lymphoblastic leukemia/lymphoma

(2016) David M. Habiel et al.   Oncotarget

Characterization and Expression of Senescence Marker in Prolonged Passages of Rat Bone Marrow-Derived Mesenchymal Stem Cells

(2016) Noridzzaida Ridzuan et al.   Stem Cells International

Improved Human Bone Marrow Mesenchymal Stem Cell Osteogenesis in 3D Bioprinted Tissue Scaffolds with Low Intensity Pulsed Ultrasound Stimulation

(2016) Xuan Zhou et al.   Scientific Reports

Engineering the hematopoietic stem cell niche: Frontiers in biomaterial science

(2015) Ji Sun Choi et al.   Biotechnology Journal

Characterization of bone marrow-derived mesenchymal stem cells in aging

(2015) Natasha Baker et al.   BONE

Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities

(2015) Koen Schepers et al.   Cell Stem Cell

Altered mesenchymal niche cells impede generation of normal hematopoietic progenitor cells in leukemic bone marrow

(2015) M Lim et al.   LEUKEMIA

Mesenchymal stromal cells from patients with acute myeloid leukemia have altered capacity to expand differentiated hematopoietic progenitors

(2015) Priya Chandran et al.   LEUKEMIA RESEARCH

An overview of chronic myeloid leukemia and its animal models

(2015) WeiXu Ma et al.   Science China-Life Sciences

Long term maintenance of myeloid leukemic stem cells cultured with unrelated human mesenchymal stromal cells

(2015) Sawa Ito et al.   Stem Cell Research

Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival

(2015) Valentina Trimarco et al.   Oncotarget

Animal Models of Aging Research: Implications for Human Aging and Age-Related Diseases

(2015) Sarah J. Mitchell et al.   Annual Review of Animal Biosciences

Engineering the hematopoietic stem cell niche: Frontiers in biomaterial science

(2015) Ji Sun Choi et al.   Biotechnology Journal

Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice

(2015) Aparna Raval et al.   PLoS One

Three-Dimensional Microfluidic Tri-Culture Model of the Bone Marrow Microenvironment for Study of Acute Lymphoblastic Leukemia

(2015) Allison Bruce et al.   PLoS One

Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support

(2015) Jeannette Boutter et al.   Oncotarget

Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge

(2014) Kahn Rhrissorrakrai et al.   BIOINFORMATICS

Nice Neighborhood: Emerging Concepts of the Stem Cell Niche

(2014) David T. Scadden   CELL

Telomerase Inhibition Effectively Targets Mouse and Human AML Stem Cells and Delays Relapse following Chemotherapy

(2014) Claudia Bruedigam et al.   Cell Stem Cell

Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche

(2014) Maher Hanoun et al.   Cell Stem Cell

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

(2014) Yu-suke Torisawa et al.   NATURE METHODS

Identification of small molecules that support human leukemia stem cell activity ex vivo

(2014) Caroline Pabst et al.   NATURE METHODS

Mesenchymal Stem Cells from Rats with Chronic Kidney Disease Exhibit Premature Senescence and Loss of Regenerative Potential

(2014) Barbara Mara Klinkhammer et al.   PLoS One

Mesenchymal Stromal Cells Derived from the Bone Marrow of Acute Lymphoblastic Leukemia Patients Show Altered BMP4 Production: Correlations with the Course of Disease

(2014) Ángeles Vicente López et al.   PLoS One

Murine Models of Acute Leukemia: Important Tools in Current Pediatric Leukemia Research

(2014) Elad Jacoby et al.   Frontiers in Oncology

Biomimetic macroporous PEG hydrogels as 3D scaffolds for the multiplication of human hematopoietic stem and progenitor cells

(2013) Annamarija Raic et al.   BIOMATERIALS

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

(2013) Christin E. Burd et al.   CELL

A novel three-dimensional stromal-based model forin vitrochemotherapy sensitivity testing of leukemia cells

(2013) Omar S. Aljitawi et al.   LEUKEMIA & LYMPHOMA

How animal models of leukaemias have already benefited patients

(2013) Julien Ablain et al.   Molecular Oncology

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

(2013) Kimberly A Hartwell et al.   Nature Chemical Biology

Evidences of Early Senescence in Multiple Myeloma Bone Marrow Mesenchymal Stromal Cells

(2013) Thibaud André et al.   PLoS One

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomere Dynamics in Mice and Humans

(2013) Rodrigo T. Calado et al.   SEMINARS IN HEMATOLOGY

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma

(2012) R. W. J. Groen et al.   BLOOD

Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment

(2012) Y. Chen et al.   BLOOD

Animal models of leukemia: any closer to the real thing?

(2012) Guerry J. Cook et al.   CANCER AND METASTASIS REVIEWS

The sorafenib plus nutlin-3 combination promotes synergistic cytotoxicity in acute myeloid leukemic cells irrespectively of FLT3 and p53 status

(2012) G. Zauli et al.   HAEMATOLOGICA

Automated analysis of single stem cells in microfluidic traps

(2012) Stefan A. Kobel et al.   LAB ON A CHIP

Contribution of an Aged Microenvironment to Aging-Associated Myeloproliferative Disease

(2012) Virag Vas et al.   PLoS One

Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells

(2012) E. Taniguchi Ishikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rate of Increase of Short Telomeres Predicts Longevity in Mammals

(2012) Elsa Vera et al.   Cell Reports

Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination

(2011) Nuno M. V. Gomes et al.   AGING CELL

3D co-culture of hematopoietic stem and progenitor cells and mesenchymal stem cells in collagen scaffolds as a model of the hematopoietic niche

(2011) Isabelle Leisten et al.   BIOMATERIALS

Mimicking the functional hematopoietic stem cell niche in vitro: recapitulation of marrow physiology by hydrogel-based three-dimensional cultures of mesenchymal stromal cells

(2011) M. B. Sharma et al.   HAEMATOLOGICA

Importance of serum source for the in vitro replicative senescence of human bone marrow derived mesenchymal stem cells

(2011) Shivali Duggal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Leukemia Stem Cells and Microenvironment: Biology and Therapeutic Targeting

(2011) Marina Y. Konopleva et al.   JOURNAL OF CLINICAL ONCOLOGY

Critical features of FAK-expressing AML bone marrow microenvironment through leukemia stem cell hijacking of mesenchymal stromal cells

(2011) M Despeaux et al.   LEUKEMIA

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Cellular senescence: A link between cancer and age-related degenerative disease?

(2011) Judith Campisi et al.   SEMINARS IN CANCER BIOLOGY

Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

(2009) A. V. Kurtova et al.   BLOOD

Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones

(2009) A. Kohler et al.   BLOOD

Long-term culture of leukemic bone marrow primary cells in biomimetic osteoblast niche

(2009) Li Hou et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Real-time in vivo imaging of p16Ink4areveals cross talk with p53

(2009) Kimi Yamakoshi et al.   JOURNAL OF CELL BIOLOGY

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

Resistance to FLT3 inhibition in an in vitro model of primary AML cells with a stem cell phenotype in a defined microenvironment

(2008) U Mony et al.   LEUKEMIA