NF-κB–inducing kinase plays an essential T cell–intrinsic role in graft-versus-host disease and lethal autoimmunity in mice

Activation of NF- B1 by OX40 Contributes to Antigen-Driven T Cell Expansion and Survival

(2014) J. Song et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cells Require the NF- B2 Pathway for Cross-Presentation of Soluble Antigens

(2014) E. F. Lind et al.   JOURNAL OF IMMUNOLOGY

The kinase NIK as a therapeutic target in multiple myeloma

(2011) Sandra Gardam et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses

(2011) Janin Hofmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of Negative Feedback Control of Nuclear Factor-κB2 Activity in Lymphocytes Leads to Fatal Lung Inflammation

(2010) Liqun Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Control of Immunity by the TNFR-Related Molecule OX40 (CD134)

(2010) Michael Croft   Annual Review of Immunology

Non-canonical NF-κB signaling pathway

(2010) Shao-Cong Sun   CELL RESEARCH

OX40 is required for regulatory T cell–mediated control of colitis

(2010) Thibault Griseri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TNF Activates a NF- B-Regulated Cellular Program in Human CD45RA- Regulatory T Cells that Modulates Their Suppressive Function

(2010) M. Nagar et al.   JOURNAL OF IMMUNOLOGY

CD44 expression positively correlates with Foxp3 expression and suppressive function of CD4+ Treg cells

(2009) Tie Liu et al.   Biology Direct

Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK

(2009) W. Jin et al.   BLOOD

Acute graft-versus-host disease: from the bench to the bedside

(2009) G. Socie et al.   BLOOD

Membrane Tumor Necrosis Factor (TNF) Induces p100 Processing via TNF Receptor-2 (TNFR2)

(2009) Hilka Rauert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: OX40 Agonists Can Drive Regulatory T Cell Expansion if the Cytokine Milieu Is Right

(2009) C. E. Ruby et al.   JOURNAL OF IMMUNOLOGY

The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance

(2008) Taishin Akiyama et al.   IMMUNITY

Constitutive Production of NF-κB2 p52 Is Not Tumorigenic but Predisposes Mice to Inflammatory Autoimmune Disease by Repressing Bim Expression

(2008) Zhe Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dicer-dependent microRNA pathway safeguards regulatory T cell function

(2008) Adrian Liston et al.   JOURNAL OF EXPERIMENTAL MEDICINE

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

(2008) Silvia Piconese et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

(2008) Sivakumar Vallabhapurapu et al.   NATURE IMMUNOLOGY

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

(2008) Brian J Zarnegar et al.   NATURE IMMUNOLOGY

NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells

(2008) Y. Sasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA