Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges
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Title
Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges
Authors
Keywords
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Journal
Frontiers in Cell and Developmental Biology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-06-03
DOI
10.3389/fcell.2020.00364
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Note: Only part of the references are listed.- Melatonin suppresses senescence‐derived mitochondrial dysfunction in mesenchymal stem cells via the HSPA1L–mitophagy pathway
- (2020) Jun Hee Lee et al. AGING CELL
- Improved therapeutics of modified mesenchymal stem cells: an update
- (2020) Dickson Kofi Wiredu Ocansey et al. Journal of Translational Medicine
- Alteration of fatty acid oxidation by increased CPT1A on replicative senescence of placenta-derived mesenchymal stem cells
- (2020) Jin Seok et al. Stem Cell Research & Therapy
- AICAR and nicotinamide treatment synergistically augment the proliferation and attenuate senescence-associated changes in mesenchymal stromal cells
- (2020) Mohammadhossein Khorraminejad-Shirazi et al. Stem Cell Research & Therapy
- Senescence-Associated Metabolomic Phenotype in Primary and iPSC-Derived Mesenchymal Stromal Cells
- (2020) Eduardo Fernandez-Rebollo et al. Stem Cell Reports
- OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases
- (2019) Yan Lu et al. Stem Cell Research & Therapy
- Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature
- (2019) Lucas-Sebastian Spitzhorn et al. Stem Cell Research & Therapy
- High doses of synthetic antioxidants induce premature senescence in cultivated mesenchymal stem cells
- (2019) Ju. S. Kornienko et al. Scientific Reports
- Frailty and Rejuvenation with Stem Cells: Therapeutic Opportunities and Clinical Challenges
- (2019) Xue-Lian Sun et al. REJUVENATION RESEARCH
- Sirt1 Promotes Osteogenic Differentiation and Increases Alveolar Bone Mass via Bmi1 Activation in Mice
- (2019) Hua Wang et al. JOURNAL OF BONE AND MINERAL RESEARCH
- HIF1α-mediated AIMP3 suppression delays stem cell aging via the induction of autophagy
- (2019) Chul Kim et al. AGING CELL
- Bone Marrow Mesenchymal Stem Cells-Derived Exosomal MiR-29b-3p Regulates Aging-Associated Insulin Resistance
- (2019) Tian Su et al. ACS Nano
- Identification of senescent cells in multipotent mesenchymal stromal cell cultures: current methods and future directions
- (2019) WEICHAO Zhai et al. CYTOTHERAPY
- FGF21 Mediates Mesenchymal Stem Cell Senescence via Regulation of Mitochondrial Dynamics
- (2019) Xin Li et al. Oxidative Medicine and Cellular Longevity
- Concise Review: Mesenchymal Stem Cells: From Roots to Boost
- (2019) Anna Andrzejewska et al. STEM CELLS
- Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis
- (2019) Lina Fu et al. PLOS BIOLOGY
- Study on the Dynamic Biological Characteristics of Human Bone Marrow Mesenchymal Stem Cell Senescence
- (2019) Xiongbin Chen et al. Stem Cells International
- The Link Between Epigenetic Clocks for Aging and Senescence
- (2019) Wolfgang Wagner Frontiers in Genetics
- p16INK4A-expressing mesenchymal stromal cells restore the senescence–clearance–regeneration sequence that is impaired in chronic muscle inflammation
- (2019) Takako S. Chikenji et al. EBioMedicine
- Nicotinamide phosphoribosyltransferase postpones rat bone marrow mesenchymal stem cell senescence by mediating NAD+–Sirt1 signaling
- (2019) Chenchen Pi et al. Aging-US
- Restoring extracellular matrix synthesis in senescent stem cells
- (2019) Na Rong et al. FASEB JOURNAL
- From discoveries in ageing research to therapeutics for healthy ageing
- (2019) Judith Campisi et al. NATURE
- Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability
- (2019) Daniela Hladik et al. Stem Cell Research & Therapy
- Effect of aging on behaviour of mesenchymal stem cells
- (2019) Juan Antonio Fafián-Labora et al. World Journal of Stem Cells
- Autophagic Control of Skin Aging
- (2019) Leopold Eckhart et al. Frontiers in Cell and Developmental Biology
- Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Abdominal Aortic Aneurysm Exhibit Senescence Phenomena
- (2019) Xiaoran Huang et al. Oxidative Medicine and Cellular Longevity
- Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway
- (2019) Dmitry Kondrikov et al. EXPERIMENTAL GERONTOLOGY
- NANOG Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence by Upregulating PBX1 and Activating AKT Signaling
- (2019) Feilin Liu et al. Oxidative Medicine and Cellular Longevity
- mTORC1 and mTORC2 Differentially Regulate Cell Fate Programs to Coordinate Osteoblastic Differentiation in Mesenchymal Stromal Cells
- (2019) Theres Schaub et al. Scientific Reports
- Short and Long Term Clinical and Immunologic Follow up after Bone Marrow Mesenchymal Stromal Cell Therapy in Progressive Multiple Sclerosis—A Phase I Study
- (2019) Ellen Iacobaeus et al. Journal of Clinical Medicine
- Local delivery of tetramethylpyrazine eliminates the senescent phenotype of bone marrow mesenchymal stromal cells and creates an anti-inflammatory and angiogenic environment in aging mice
- (2018) Bo Gao et al. AGING CELL
- Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of Sirtuin 1
- (2018) Vuong Cat Khanh et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Ascorbic acid inhibits senescence in mesenchymal stem cells through ROS and AKT/mTOR signaling
- (2018) Mengkai Yang et al. CYTOTECHNOLOGY
- Umbilical Cord Mesenchymal Stem Cell Treatment for Crohn's Disease: A Randomized Controlled Clinical Trial
- (2018) Jian Zhang et al. Gut and Liver
- Senescent cells: a therapeutic target for cardiovascular disease
- (2018) Bennett G. Childs et al. JOURNAL OF CLINICAL INVESTIGATION
- Mechanisms and functions of cellular senescence
- (2018) Nicolás Herranz et al. JOURNAL OF CLINICAL INVESTIGATION
- Stem Cell Rejuvenation and the Role of Autophagy in Age Retardation by Caloric Restriction: An Update
- (2018) Shanrong Bi et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Comparison of telomere length measurement methods
- (2018) Tsung-Po Lai et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- miR-10a rejuvenates aged human mesenchymal stem cells and improves heart function after myocardial infarction through KLF4
- (2018) Jun Dong et al. Stem Cell Research & Therapy
- Reactive Oxygen Species, Superoxide Dimutases, and PTEN-p53-AKT-MDM2 Signaling Loop Network in Mesenchymal Stem/Stromal Cells Regulation
- (2018) Satoru Matsuda et al. Cells
- Micro-RNAS Regulate Metabolic Syndrome-induced Senescence in Porcine Adipose Tissue-derived Mesenchymal Stem Cells through the P16/MAPK Pathway
- (2018) Y. Meng et al. CELL TRANSPLANTATION
- Safety and Potential Therapeutic Effect of Two Intracavernous Autologous Bone Marrow Derived Mesenchymal Stem Cells injections in Diabetic Patients with Erectile Dysfunction: An Open Label Phase I Clinical Trial
- (2018) Saddam Al Demour et al. UROLOGIA INTERNATIONALIS
- Interrupted reprogramming into induced pluripotent stem cells does not rejuvenate human mesenchymal stromal cells
- (2018) Carolin Göbel et al. Scientific Reports
- Osteogenesis and aging: lessons from mesenchymal stem cells
- (2018) Arantza Infante et al. Stem Cell Research & Therapy
- Reversibility of irreversible aging
- (2018) Fedor Galkin et al. AGEING RESEARCH REVIEWS
- MiR-217 promotes cell proliferation and osteogenic differentiation of BMSCs by targeting DKK1 in steroid-associated osteonecrosis
- (2018) Zhipeng Dai et al. BIOMEDICINE & PHARMACOTHERAPY
- The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex
- (2018) Rong Wu et al. Cell Metabolism
- Overexpression of ERBB4 rejuvenates aged mesenchymal stem cell and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathway
- (2018) Xiaoting Liang et al. FASEB JOURNAL
- Macrophage migration inhibitory factor rescues mesenchymal stem cells from doxorubicin-induced senescence though the PI3K-Akt signaling pathway
- (2017) Wenzheng Xia et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Senescence of mesenchymal stem cells (Review)
- (2017) Yi Li et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Lactoferrin Protects Human Mesenchymal Stem Cells from Oxidative Stress-Induced Senescence and Apoptosis
- (2017) Soon Yong Park et al. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
- High glucose induces the aging of mesenchymal stem cells via Akt/mTOR signaling
- (2017) Dayong Zhang et al. Molecular Medicine Reports
- Restoring the quantity and quality of elderly human mesenchymal stem cells for autologous cell-based therapies
- (2017) Travis J. Block et al. Stem Cell Research & Therapy
- Overexpression of Insulin-Like Growth Factor 1 Enhanced the Osteogenic Capability of Aging Bone Marrow Mesenchymal Stem Cells
- (2017) Ching-Yun Chen et al. Theranostics
- Microvesicles as Potential Biomarkers for the Identification of Senescence in Human Mesenchymal Stem Cells
- (2017) Qian Lei et al. Theranostics
- Techniques to Induce and Quantify Cellular Senescence
- (2017) Nicole Noren Hooten et al. Jove-Journal of Visualized Experiments
- Role of p16 INK4a and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells
- (2017) Cristina Mas-Bargues et al. Redox Biology
- Senescence-associated DNA methylation is stochastically acquired in subpopulations of mesenchymal stem cells
- (2016) Julia Franzen et al. AGING CELL
- Secreted microvesicular miR-31 inhibits osteogenic differentiation of mesenchymal stem cells
- (2016) Sylvia Weilner et al. AGING CELL
- Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses
- (2016) Servet Özcan et al. Aging-US
- miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53–p21 and p16–pRB pathways
- (2016) Jin Shang et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming
- (2016) Alejandro Ocampo et al. CELL
- Aging impairs osteoblast differentiation of mesenchymal stem cells grown on titanium by favoring adipogenesis
- (2016) Rodrigo Paolo Flores ABUNA et al. Journal of Applied Oral Science
- The effects of the DNA methyltranfserases inhibitor 5-Azacitidine on ageing, oxidative stress and DNA methylation of adipose derived stem cells
- (2016) Katarzyna Kornicka et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Antioxidant effects of Cirsium setidens extract on oxidative stress in human mesenchymal stem cells
- (2016) Jun Hee Lee et al. Molecular Medicine Reports
- Derepression ofhTERTgene expression promotes escape from oncogene-induced cellular senescence
- (2016) Priyanka L. Patel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Restoration of Mitochondrial NAD+Levels Delays Stem Cell Senescence and Facilitates Reprogramming of Aged Somatic Cells
- (2016) Myung Jin Son et al. STEM CELLS
- MiR-211/STAT5A Signaling Modulates Migration of Mesenchymal Stem Cells to Improve its Therapeutic Efficacy
- (2016) Xinyang Hu et al. STEM CELLS
- NANOG Reverses the Myogenic Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF-Dependent Gene Expression
- (2016) Panagiotis Mistriotis et al. STEM CELLS
- Rationale and design of the allogeneiC human mesenchymal stem cells (hMSC) in patients with aging fRAilTy via intravenoUS delivery (CRATUS) study: A phase I/II, randomized, blinded and placebo controlled trial to evaluate the safety and potential efficacy of allogeneic human mesenchymal stem cell infusion in patients with aging frailty
- (2016) Samuel Golpanian et al. Oncotarget
- Is senescence-associated β-galactosidase a marker of neuronal senescence?
- (2016) Malgorzata Piechota et al. Oncotarget
- Self-Assembled Heterojunction Carbon Nanotubes Synergizing with Photoimmobilized IGF-1 Inhibit Cellular Senescence
- (2016) Wu-Ya Chen et al. Advanced Healthcare Materials
- Development of an angiogenesis-promoting microvesicle-alginate-polycaprolactone composite graft for bone tissue engineering applications
- (2016) Hui Xie et al. PeerJ
- Adult Stem Cell Therapy for Stroke: Challenges and Progress
- (2016) Oh Young Bang et al. Journal of Stroke
- Prelamin A accumulation and stress conditions induce impaired Oct-1 activity and autophagy in prematurely aged human mesenchymal stem cell
- (2016) Arantza Infante et al. Aging-US
- Endogenous ROS levels are increased in replicative senescence in human bone marrow mesenchymal stromal cells
- (2015) Sin-Gu Jeong et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in Patients With Acute Myocardial Infarction Based on Individual Patient Data
- (2015) M. Gyongyosi et al. CIRCULATION RESEARCH
- Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues
- (2015) Huijuan Liu et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- ATM, MacroH2A.1, and SASP: The Checks and Balances of Cellular Senescence
- (2015) Marek Kozlowski et al. MOLECULAR CELL
- Abrogation of Age-Induced MicroRNA-195 Rejuvenates the Senescent Mesenchymal Stem Cells by Reactivating Telomerase
- (2015) Motoi Okada et al. STEM CELLS
- Mesenchymal Progenitors Aging Highlights a miR-196 Switch Targeting HOXB7 as Master Regulator of Proliferation and Osteogenesis
- (2015) Olivia Candini et al. STEM CELLS
- Systemic impact molds mesenchymal stromal/stem cell aging
- (2015) Stephan Reitinger et al. TRANSFUSION AND APHERESIS SCIENCE
- Myeloma cells can corrupt senescent mesenchymal stromal cells and impair their anti-tumor activity
- (2015) Umberto Galderisi et al. Oncotarget
- Roles of microRNA-34a targeting SIRT1 in mesenchymal stem cells
- (2015) Fengyun Zhang et al. Stem Cell Research & Therapy
- Noncoding RNA control of cellular senescence
- (2015) Kotb Abdelmohsen et al. Wiley Interdisciplinary Reviews-RNA
- HighOCT4and Lowp16INK4AExpressions DetermineIn VitroLifespan of Mesenchymal Stem Cells
- (2015) Carla A. Piccinato et al. Stem Cells International
- Patient-Specific Age: The Other Side of the Coin in Advanced Mesenchymal Stem Cell Therapy
- (2015) Magdalena M. Schimke et al. Frontiers in Physiology
- MicroRNA-141-3p plays a role in human mesenchymal stem cell aging by directly targeting ZMPSTE24
- (2014) K.-R. Yu et al. JOURNAL OF CELL SCIENCE
- A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods
- (2014) Marialaura Madrigal et al. Journal of Translational Medicine
- Stem cell aging: mechanisms, regulators and therapeutic opportunities
- (2014) Juhyun Oh et al. NATURE MEDICINE
- Telomere Length
- (2014) Alison J. Montpetit et al. NURSING RESEARCH
- A Systematic Review of Preclinical Studies on the Therapeutic Potential of Mesenchymal Stromal Cell-Derived Microvesicles
- (2014) Celine Akyurekli et al. Stem Cell Reviews and Reports
- Inhibition of Akt/mTOR Attenuates Age-Related Changes in Mesenchymal Stem Cells
- (2014) Borzo Gharibi et al. STEM CELLS
- SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin
- (2014) Huiqiang Chen et al. Frontiers in Aging Neuroscience
- Epigenetic Rejuvenation of Mesenchymal Stromal Cells Derived from Induced Pluripotent Stem Cells
- (2014) Joana Frobel et al. Stem Cell Reports
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- I B is a regulator of the senescence-associated secretory phenotype in DNA damage- and oncogene-induced senescence
- (2013) E. Alexander et al. JOURNAL OF CELL SCIENCE
- Mesenchymal Stem Cells from iPS Cells Facilitate Periodontal Regeneration
- (2013) K. Hynes et al. JOURNAL OF DENTAL RESEARCH
- Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells
- (2013) V Severino et al. Cell Death & Disease
- Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease
- (2012) Sudhir H. Ranganath et al. Cell Stem Cell
- Pluripotent stem cells escape from senescence-associated DNA methylation changes
- (2012) C. M. Koch et al. GENOME RESEARCH
- Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through promoting the ROS production
- (2012) Da-yong Zhang et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Monitoring of cellular senescence by DNA-methylation at specific CpG sites
- (2011) Carmen M. Koch et al. AGING CELL
- Lack of autophagy in the hematopoietic system leads to loss of hematopoietic stem cell function and dysregulated myeloid proliferation
- (2011) Monika Mortensen et al. Autophagy
- SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase gene
- (2011) Shuntaro Yamashita et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Inhibition of cellular senescence by developmentally regulated FGF receptors in mesenchymal stem cells
- (2011) D. L. Coutu et al. BLOOD
- Autophagy and Aging
- (2011) David C. Rubinsztein et al. CELL
- Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16ink4a
- (2011) Martin Kosar et al. CELL CYCLE
- Four faces of cellular senescence
- (2011) Francis Rodier et al. JOURNAL OF CELL BIOLOGY
- SIRT1 is required for long-term growth of human mesenchymal stem cells
- (2011) Hong-Feng Yuan et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- DNA Methyltransferase Controls Stem Cell Aging by Regulating BMI1 and EZH2 through MicroRNAs
- (2011) Ah-Young So et al. PLoS One
- The suppressive effect of mesenchymal stromal cells on T cell proliferation is conserved in old age
- (2011) Katja Landgraf et al. TRANSPLANT IMMUNOLOGY
- Gene Expression Profile Associated with Oncogenic Ras-induced Senescence, Cell Death, and Transforming Properties in Human Cells
- (2010) Sophy S. Moumtzi et al. CANCER INVESTIGATION
- Linking functional decline of telomeres, mitochondria and stem cells during ageing
- (2010) Ergün Sahin et al. NATURE
- A Long-Term Follow-Up Study of Intravenous Autologous Mesenchymal Stem Cell Transplantation in Patients With Ischemic Stroke
- (2010) Jin Soo Lee et al. STEM CELLS
- Phenotypical/functional characterization of in vitro-expanded mesenchymal stromal cells from patients with Crohn's disease
- (2009) Maria Ester Bernardo et al. CYTOTHERAPY
- Autophagy mediates the mitotic senescence transition
- (2009) A. R.J. Young et al. GENES & DEVELOPMENT
- A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
- (2009) Rosa M. Marión et al. NATURE
- Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo
- (2009) Florence Debacq-Chainiaux et al. Nature Protocols
- Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapies
- (2007) A. Stolzing et al. MECHANISMS OF AGEING AND DEVELOPMENT
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