Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development

Exosomes from BM-MSCs promote acute myeloid leukemia cell proliferation, invasion and chemoresistance via upregulation of S100A4

(2021) Tianxin Lyu et al.   Experimental Hematology & Oncology

Live-animal imaging of native haematopoietic stem and progenitor cells

(2020) Constantina Christodoulou et al.   NATURE

Integrin α7 and Extracellular Matrix Laminin 211 Interaction Promotes Proliferation of Acute Myeloid Leukemia Cells and Is Associated with Granulocytic Sarcoma

(2020) Nobuhiko Kobayashi et al.   Cancers

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

(2020) Valerie Barbier et al.   Nature Communications

Phase 1 Study of combinatorial sorafenib, G‐CSF , and plerixafor treatment in relapsed/refractory, FLT3‐ITD ‐mutated acute myelogenous leukemia patients

(2020) Gautam Borthakur et al.   AMERICAN JOURNAL OF HEMATOLOGY

Adult blood stem cell localization reflects the abundance of reported bone marrow niche cell types and their combinations

(2020) Konstantinos Kokkaliaris et al.   BLOOD

Intravital Imaging Reveals Motility of Adult Hematopoietic Stem Cells in the Bone Marrow Niche

(2020) Samik Upadhaya et al.   Cell Stem Cell

The global burden and attributable risk factor analysis of acute myeloid leukemia in 195 countries and territories from 1990 to 2017: estimates based on the global burden of disease study 2017

(2020) Ming Yi et al.   Journal of Hematology & Oncology

Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia

(2020) Myriam L. R. Haltalli et al.   Nature Communications

Blockade of VLA4 sensitizes leukemic and myeloma tumor cells to CD3 redirection in the bone marrow microenvironment

(2020) Priyanka Nair-Gupta et al.   Blood Cancer Journal

Leukemia incidence trends at the global, regional, and national level between 1990 and 2017

(2020) Ying Dong et al.   Experimental Hematology & Oncology

BL‐8040 CXCR4 antagonist is safe and demonstrates antileukemic activity in combination with cytarabine for the treatment of relapsed/refractory acute myelogenous leukemia: An open‐label safety and efficacy phase 2a study

(2020) Gautam Borthakur et al.   CANCER

Cryo-shocked cancer cells for targeted drug delivery and vaccination

(2020) Tianyuan Ci et al.   Science Advances

The Bcl-2 inhibitor venetoclax inhibits Nrf2 antioxidant pathway activation induced by hypomethylating agents in AML

(2019) Le Xuan Truong Nguyen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hematopoietic niche drives FLT3-ITD acute myeloid leukemia resistance to quizartinib via STAT5- and hypoxia- dependent up-regulation of AXL

(2019) Pierre-Yves Dumas et al.   HAEMATOLOGICA

FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

(2019) Nathalie Javidi-Sharifi et al.   eLife

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

(2019) Irène Baccelli et al.   CANCER CELL

VLA-4 phosphorylation during tumor and immune cell migration relies on its coupling to VEGFR2 and CXCR4 by syndecan-1

(2019) Oisun Jung et al.   JOURNAL OF CELL SCIENCE

Inhibition of Slug effectively targets leukemia stem cells via the Slc13a3/ROS signaling pathway

(2019) Zhonghui Zhang et al.   LEUKEMIA

Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles

(2019) Kyong-Su Park et al.   Stem Cell Research & Therapy

RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia

(2019) Rabindranath Bera et al.   Journal of Hematology & Oncology

Leukemia cells remodel marrow adipocytes via TRPV4-dependent lipolysis

(2019) Shaoxin Yang et al.   HAEMATOLOGICA

A Phase 1B Clinical Study of Combretastatin A1 Diphosphate (OXi4503) and Cytarabine (ARA-C) in Combination (OXA) for Patients with Relapsed or Refractory Acute Myeloid Leukemia

(2019) Fatih M. Uckun et al.   Cancers

The future of mesenchymal stem cell-based therapeutic approaches for cancer – From cells to ghosts

(2018) Andrea Mohr et al.   CANCER LETTERS

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML

(2018) Delfim Duarte et al.   Cell Stem Cell

Stem cell niche-specific Ebf3 maintains the bone marrow cavity

(2018) Masanari Seike et al.   GENES & DEVELOPMENT

STAT3 and apoptosis challenges in cancer

(2018) Nazanin Fathi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Growth differentiation factor 15 contributes to marrow adipocyte remodeling in response to the growth of leukemic cells

(2018) Wei Lu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PGC-1α driven mitochondrial biogenesis in stromal cells underpins mitochondrial trafficking to leukemic blasts

(2018) Christopher R. Marlein et al.   LEUKEMIA

Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow

(2018) Katharina Helene Susek et al.   MATRIX BIOLOGY

HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia

(2018) Amina M. Abdul-Aziz et al.   ONCOGENE

Continuous high dosing of lenalidomide in relapsed, refractory or older newly diagnosed acute myeloid leukemia patients not suitable for other treatment options - results from a phase I study

(2018) Marie Luise Hütter-Krönke et al.   HAEMATOLOGICA

Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes

(2018) Andrés García-García et al.   BLOOD

Small bone marrow adipocytes predict poor prognosis in acute myeloid leukemia

(2017) Wei Lu et al.   HAEMATOLOGICA

TGF-β1 and CXCL12 modulate proliferation and chemotherapy sensitivity of acute myeloid leukemia cells co-cultured with multipotent mesenchymal stromal cells

(2017) Roland Christian Schelker et al.   Hematology

Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia

(2017) Jolieke G. van Oosterwijk et al.   JOURNAL OF CLINICAL INVESTIGATION

The CXCR4 inhibitor BL-8040 induces the apoptosis of AML blasts by downregulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression

(2017) M Abraham et al.   LEUKEMIA

Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion

(2017) B Kumar et al.   LEUKEMIA

Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche

(2017) Allison L. Boyd et al.   NATURE CELL BIOLOGY

Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF

(2017) Bo O. Zhou et al.   NATURE CELL BIOLOGY

A phase 1/2 study of chemosensitization with plerixafor plus G-CSF in relapsed or refractory acute myeloid leukemia

(2017) G L Uy et al.   Blood Cancer Journal

Small bone marrow adipocytes predict poor prognosis in acute myeloid leukemia

(2017) Wei Lu et al.   HAEMATOLOGICA

Phase I study of evofosfamide, an investigational hypoxia-activated prodrug, in patients with advanced leukemia

(2016) Talha Badar et al.   AMERICAN JOURNAL OF HEMATOLOGY

Adult hematopoietic stem cells lacking Hif-1  self-renew normally

(2016) M. Vukovic et al.   BLOOD

Evolution of acute myelogenous leukemia stem cell properties after treatment and progression

(2016) T.-C. Ho et al.   BLOOD

Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy

(2016) R. Moschoi et al.   BLOOD

A phase 2 trial of high dose lenalidomide in patients with relapsed/refractory higher-risk myelodysplastic syndromes and acute myeloid leukaemia with trilineage dysplasia

(2016) Amer M. Zeidan et al.   BRITISH JOURNAL OF HAEMATOLOGY

Distinct bone marrow blood vessels differentially regulate haematopoiesis

(2016) Tomer Itkin et al.   NATURE

Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment

(2016) Lei Dong et al.   NATURE

Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation

(2015) Alexander Scholz et al.   Annals of the New York Academy of Sciences

Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression

(2015) L. Wang et al.   BLOOD

TGF-  signaling in the control of hematopoietic stem cells

(2015) U. Blank et al.   BLOOD

A phase I/II study of sunitinib and intensive chemotherapy in patients over 60 years of age with acute myeloid leukaemia and activatingFLT3mutations

(2015) Walter Fiedler et al.   BRITISH JOURNAL OF HAEMATOLOGY

Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities

(2015) Koen Schepers et al.   Cell Stem Cell

Hypoxia-Activated Prodrug TH-302 Targets Hypoxic Bone Marrow Niches in Preclinical Leukemia Models

(2015) J. Benito et al.   CLINICAL CANCER RESEARCH

Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia

(2015) M. Konopleva et al.   HAEMATOLOGICA

Randomized Phase II Trial of Gemcitabine Plus TH-302 Versus Gemcitabine in Patients With Advanced Pancreatic Cancer

(2015) Mitesh J. Borad et al.   JOURNAL OF CLINICAL ONCOLOGY

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance

(2015) Milica Vukovic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia regulates proliferation of acute myeloid leukemia and sensitivity against chemotherapy

(2015) Heidrun Drolle et al.   LEUKEMIA RESEARCH

Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal

(2015) Melih Acar et al.   NATURE

Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia

(2015) M. Konopleva et al.   HAEMATOLOGICA

Reactive Oxygen Species Regulate Hematopoietic Stem Cell Self-Renewal, Migration and Development, As Well As Their Bone Marrow Microenvironment

(2014) Aya Ludin et al.   ANTIOXIDANTS & REDOX SIGNALING

HIF-1  can act as a tumor suppressor gene in murine acute myeloid leukemia

(2014) T. Velasco-Hernandez et al.   BLOOD

Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF- B mediates chemoresistance

(2014) R. Jacamo et al.   BLOOD

Redox Modulation of Adjacent Thiols in VLA-4 by AS101 Converts Myeloid Leukemia Cells from a Drug-Resistant to Drug-Sensitive State

(2014) A. Layani-Bazar et al.   CANCER RESEARCH

Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche

(2014) Maher Hanoun et al.   Cell Stem Cell

NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism

(2014) K Chrysovergis et al.   INTERNATIONAL JOURNAL OF OBESITY

Phase II Study of the Safety and Antitumor Activity of the Hypoxia-Activated Prodrug TH-302 in Combination With Doxorubicin in Patients With Advanced Soft Tissue Sarcoma

(2014) Sant P. Chawla et al.   JOURNAL OF CLINICAL ONCOLOGY

Direct measurement of local oxygen concentration in the bone marrow of live animals

(2014) Joel A. Spencer et al.   NATURE

Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms

(2014) Lorena Arranz et al.   NATURE

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation

(2014) Yoshiki Omatsu et al.   NATURE

Hif-2  is not essential for cell-autonomous hematopoietic stem cell maintenance

(2013) A. V. Guitart et al.   BLOOD

HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress

(2013) Kevin Rouault-Pierre et al.   Cell Stem Cell

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

Activity of the Hypoxia-Activated Prodrug, TH-302, in Preclinical Human Acute Myeloid Leukemia Models

(2013) S. Portwood et al.   CLINICAL CANCER RESEARCH

Physiologic corticosterone oscillations regulate murine hematopoietic stem/progenitor cell proliferation and CXCL12 expression by bone marrow stromal progenitors

(2013) O Kollet et al.   LEUKEMIA

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Addition of bevacizumab to chemotherapy in acute myeloid leukemia at older age: a randomized phase 2 trial of the Dutch-Belgian Cooperative Trial Group for Hemato-Oncology (HOVON) and the Swiss Group for Clinical Cancer Research (SAKK)

(2012) G. J. Ossenkoppele et al.   BLOOD

A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia

(2012) G. L. Uy et al.   BLOOD

HIF-1α downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation

(2012) M He et al.   CELL DEATH AND DIFFERENTIATION

BMS-936564/MDX-1338: A Fully Human Anti-CXCR4 Antibody Induces Apoptosis In Vitro and Shows Antitumor Activity In Vivo in Hematologic Malignancies

(2012) M. R. Kuhne et al.   CLINICAL CANCER RESEARCH

Serial monitoring of human systemic and xenograft models of leukemia using a novel vascular disrupting agent

(2012) M Benezra et al.   LEUKEMIA

Risk of Natalizumab-Associated Progressive Multifocal Leukoencephalopathy

(2012) Gary Bloomgren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor

(2011) M. S. Redell et al.   BLOOD

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

(2011) Satoshi Yamazaki et al.   CELL

Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies

(2011) Yin Wang et al.   Cell Stem Cell

The vascular niche: home for normal and malignant hematopoietic stem cells

(2011) P L Doan et al.   LEUKEMIA

Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy

(2011) L S Steelman et al.   LEUKEMIA

Cooperation of β2- and β3-adrenergic receptors in hematopoietic progenitor cell mobilization

(2010) Simón Méndez-Ferrer et al.   Annals of the New York Academy of Sciences

Leukemia regression by vascular disruption and antiangiogenic therapy

(2010) G. J. Madlambayan et al.   BLOOD

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

Impact of maturational status on the ability of osteoblasts to enhance the hematopoietic function of stem and progenitor cells

(2010) Ying-Hua Cheng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

High Expression of the Very Late Antigen-4 Integrin Independently Predicts Reduced Risk of Relapse and Improved Outcome in Pediatric Acute Myeloid Leukemia: A Report From the Children's Oncology Group

(2010) Roland B. Walter et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia

(2010) Celine Callens et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Physiological hypoxia promotes lipid raft and PI3K-dependent activation of MAPK 42/44 in leukemia cells

(2010) M Fiegl et al.   LEUKEMIA

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

(2009) H. Dohner et al.   BLOOD

Dissection of PIM serine/threonine kinases in FLT3-ITD–induced leukemogenesis reveals PIM1 as regulator of CXCL12–CXCR4-mediated homing and migration

(2009) Rebekka Grundler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

(2009) Olaia Naveiras et al.   NATURE

Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia

(2008) P. S. Becker et al.   BLOOD

Increased numbers of circulating hematopoietic stem/progenitor cells are chronically maintained in patients treated with the CD49d blocking antibody natalizumab

(2008) H. Bonig et al.   BLOOD

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML

(2008) Z. Zeng et al.   BLOOD

Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100

(2008) B. Nervi et al.   BLOOD

The Bone Marrow Microenvironment as a Tumor Sanctuary and Contributor to Drug Resistance

(2008) M. B. Meads et al.   CLINICAL CANCER RESEARCH

The role of VEGF and a functional link between VEGF and p27Kip1 in acute myeloid leukemia

(2008) B Wegiel et al.   LEUKEMIA

Increased bone marrow microvascular density in haematological malignancies is associated with differential regulation of angiogenic factors

(2008) H F S Negaard et al.   LEUKEMIA

Prognostic value of CXCR4 and FAK expression in acute myelogenous leukemia

(2008) Emmanuelle Tavernier-Tardy et al.   LEUKEMIA RESEARCH

Haematopoietic stem cell release is regulated by circadian oscillations

(2008) Simón Méndez-Ferrer et al.   NATURE