Dissecting copper biology and cancer treatment: ‘Activating Cuproptosis or suppressing Cuproplasia’

FDX1-dependent and independent mechanisms of elesclomol-mediated intracellular copper delivery

(2023) Mohammad Zulkifli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations

(2023) Hong Yan et al.   Redox Biology

Structure–Activity Relationships of 8-Hydroxyquinoline-Derived Mannich Bases with Tertiary Amines Targeting Multidrug-Resistant Cancer

(2022) Veronika F. S. Pape et al.   JOURNAL OF MEDICINAL CHEMISTRY

Copper induces cell death by targeting lipoylated TCA cycle proteins

(2022) Peter Tsvetkov et al.   SCIENCE

Selective Targeting of Cancer Cells by Copper Ionophores: An Overview

(2022) Valentina Oliveri   Frontiers in Molecular Biosciences

A yeast suppressor screen links Coa4 to the mitochondrial copper delivery pathway for cytochrome c oxidase

(2022) Abhinav B Swaminathan et al.   GENETICS

Dynamic regulation of HIF-1 signaling in the rhesus monkey heart after ischemic injury

(2022) Tao Wang et al.   BMC Cardiovascular Disorders

Proteomics revealed the crosstalk between copper stress and cuproptosis, and explored the feasibility of curcumin as anticancer copper ionophore

(2022) Ying Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial copper in human genetic disorders

(2022) Natalie M. Garza et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Extracellular Cu2+ pools and their detection: From current knowledge to next-generation probes

(2021) Enrico Falcone et al.   COORDINATION CHEMISTRY REVIEWS

Copper biology

(2021) Tiffany Tsang et al.   CURRENT BIOLOGY

Development of lactobionic acid conjugated-copper chelators as anticancer candidates for hepatocellular carcinoma

(2021) Xueke Zhao et al.   Arabian Journal of Chemistry

Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis

(2021) Divya Ramchandani et al.   Nature Communications

Copper promotion of myocardial regeneration

(2020) Ying Xiao et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma

(2020) Tiffany Tsang et al.   NATURE CELL BIOLOGY

Dithiocarbamate prodrugs activated by prostate specific antigen to target prostate cancer

(2020) Subha Bakthavatsalam et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nanoscale Copper(II)–Diethyldithiocarbamate Coordination Polymer as a Drug Self-Delivery System for Highly Robust and Specific Cancer Therapy

(2020) Ying Peng et al.   MOLECULAR PHARMACEUTICS

Mitochondrial copper depletion suppresses triple-negative breast cancer in mice

(2020) Liyang Cui et al.   NATURE BIOTECHNOLOGY

Getting out what you put in: Copper in mitochondria and its impacts on human disease

(2020) Paul A. Cobine et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Diverse biological roles of the tetrathiomolybdate anion

(2020) Biplab K. Maiti et al.   COORDINATION CHEMISTRY REVIEWS

Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein

(2019) Tiantian Fang et al.   Nature Communications

ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis

(2019) Vinit Shanbhag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial metabolism promotes adaptation to proteotoxic stress

(2019) Peter Tsvetkov et al.   Nature Chemical Biology

A new function of copper zinc superoxide dismutase: as a regulatory DNA-binding protein in gene expression in response to intracellular hydrogen peroxide

(2019) Xiang Li et al.   NUCLEIC ACIDS RESEARCH

Highly Stable, Coordinated Polymeric Nanoparticles Loading Copper(II) Diethyldithiocarbamate for Combinational Chemo/Chemodynamic Therapy of Cancer

(2019) Xinyu Peng et al.   BIOMACROMOLECULES

Clinical manifestations of Wilson disease in organs other than the liver and brain

(2019) Karolina Dzieżyc-Jaworska et al.   Annals of Translational Medicine

Activity-based ratiometric FRET probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism

(2019) Clive Yik-Sham Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic analysis of concentrations of 52 elements in tumor and counterpart normal tissues of patients with non‐small cell lung cancer

(2019) Xin Cheng et al.   Cancer Medicine

A hydrogen peroxide-activated Cu(II) pro-ionophore strategy for modifying naphthazarin as a promising anticancer agent with high selectivity for generating ROS in HepG2 cells over in L02 cells

(2019) Xia-Zhen Bao et al.   FREE RADICAL BIOLOGY AND MEDICINE

COA6 Is Structurally Tuned to Function as a Thiol-Disulfide Oxidoreductase in Copper Delivery to Mitochondrial Cytochrome c Oxidase

(2019) Shivatheja Soma et al.   Cell Reports

Leveraging gamma-glutamyl transferase to direct cytotoxicity of copper dithiocarbamates against prostate cancer cells

(2018) Subha Bakthavatsalam et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metallothionein is elevated in liver and duodenum of Atp7b(−/−) mice

(2018) Chengcheng Christine Zhang et al.   BIOMETALS

Protein lipoylation: an evolutionarily conserved metabolic regulator of health and disease

(2018) Elizabeth A Rowland et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Targeting redox vulnerability of cancer cells by prooxidative intervention of a glutathione-activated Cu(II) pro-ionophore: Hitting three birds with one stone

(2018) Xia-Zhen Bao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Keto-enol-based modification on piperlongumine to generate a potent Cu(II) ionophore that triggers redox imbalance and death of HepG2 cells

(2018) Fang Dai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Flavonoids-induced redox cycling of copper ions leads to generation of reactive oxygen species: A potential role in cancer chemoprevention

(2018) Hussain Arif et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Water soluble glucose derivative of thiocarbohydrazone acts as ionophore with cytotoxic effects on tumor cells

(2018) Carmela Bonaccorso et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer

(2018) Felipe Paredes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox-Dependent Copper Carrier Promotes Cellular Copper Uptake and Oxidative Stress-Mediated Apoptosis of Cancer Cells

(2018) Junmin Zhang et al.   ACS Applied Materials & Interfaces

Designing salicylaldehyde isonicotinoyl hydrazones as Cu(II) ionophores with tunable chelation and release of copper for hitting redox Achilles heel of cancer cells

(2018) Yuan Ji et al.   FREE RADICAL BIOLOGY AND MEDICINE

Copper levels affect targeting of hypoxia-inducible factor 1α to the promoters of hypoxia-regulated genes

(2018) Xiaojuan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wilson disease

(2018) Anna Członkowska et al.   Nature Reviews Disease Primers

Activation of autophagy, observed in liver tissues from patients with Wilson disease and from Atp7b-deficient animals, protects hepatocytes from copper-induced apoptosis

(2018) Elena V. Polishchuk et al.   GASTROENTEROLOGY

A phase II evaluation of elesclomol sodium and weekly paclitaxel in the treatment of recurrent or persistent platinum-resistant ovarian, fallopian tube or primary peritoneal cancer: An NRG oncology/gynecologic oncology group study

(2018) Bradley J. Monk et al.   GYNECOLOGIC ONCOLOGY

A Modular Ionophore Platform for Liver-Directed Copper Supplementation in Cells and Animals

(2018) Timothy A. Su et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of 8-hydroxyquinoline glycoconjugates and preliminary assay of their β1,4-GalT inhibitory and anti-cancer properties

(2018) Monika Krawczyk et al.   BIOORGANIC CHEMISTRY

Structural basis, chemical driving forces and biological implications of flavones as Cu(II) ionophores

(2017) Fang Dai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipoic acid metabolism and mitochondrial redox regulation

(2017) Ashley Solmonson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents

(2017) Valentina Oliveri et al.   Metallomics

Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2

(2017) Bing Xu et al.   Cell Death & Disease

Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases

(2016) Nancy Chan et al.   CLINICAL CANCER RESEARCH

The Activity of Menkes Disease Protein ATP7A Is Essential for Redox Balance in Mitochondria

(2016) Ashima Bhattacharjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper transporters and chaperones: Their function on angiogenesis and cellular signalling

(2016) S R Bharathi Devi et al.   JOURNAL OF BIOSCIENCES

Methanobactin reverses acute liver failure in a rat model of Wilson disease

(2016) Josef Lichtmannegger et al.   JOURNAL OF CLINICAL INVESTIGATION

The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms

(2016) Zhu-Ling Guo et al.   Journal of Hematology & Oncology

Ceruloplasmin and other copper binding components of blood plasma and their functions: an update

(2016) M. C. Linder   Metallomics

Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study

(2016) Anna Maria Santoro et al.   Scientific Reports

Improved cytotoxicity of pyridyl-substituted thiosemicarbazones against MCF-7 when used as metal ionophores

(2015) Fady N. Akladios et al.   BIOMETALS

Synthetic fluorescent probes for studying copper in biological systems

(2015) Joseph A. Cotruvo et al.   CHEMICAL SOCIETY REVIEWS

Mitochondrial disease genesCOA6,COX6BandSCO2have overlapping roles in COX2 biogenesis

(2015) Alok Ghosh et al.   HUMAN MOLECULAR GENETICS

The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways

(2015) Zaklina Kovacevic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asialoglycoprotein receptor mediated hepatocyte targeting — Strategies and applications

(2015) Anisha A. D'Souza et al.   JOURNAL OF CONTROLLED RELEASE

New 8-hydroxyquinoline galactosides. The role of the sugar in the antiproliferative activity of copper(II) ionophores

(2015) Valentina Oliveri et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization

(2015) Christian Stefani et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Copper mediated neurological disorder: Visions into amyotrophic lateral sclerosis, Alzheimer and Menkes disease

(2015) Anami Ahuja et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Wilson's disease and other neurological copper disorders

(2015) Oliver Bandmann et al.   LANCET NEUROLOGY

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Searching for harmony in transition-metal signaling

(2015) Christopher J Chang   Nature Chemical Biology

Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation

(2015) Jing Wang et al.   Nature Chemistry

Synthesis and Cellular Uptake of Folic Acid-Conjugated Cellulose Nanocrystals for Cancer Targeting

(2014) Shuping Dong et al.   BIOMACROMOLECULES

The many “faces” of copper in medicine and treatment

(2014) Anna Hordyjewska et al.   BIOMETALS

Copper Signaling Axis as a Target for Prostate Cancer Therapeutics

(2014) R. Safi et al.   CANCER RESEARCH

Synthesis and biological activities of dithiocarbamates containing 1,2,3-triazoles group

(2014) Qing-Han Li et al.   CHINESE CHEMICAL LETTERS

Copper-dependent and -independent hypoxia-inducible factor-1 regulation of gene expression

(2014) Zhen Zhang et al.   Metallomics

Copper is required for oncogenic BRAF signalling and tumorigenesis

(2014) Donita C. Brady et al.   NATURE

Disulfiram Eradicates Tumor-Initiating Hepatocellular Carcinoma Cells in ROS-p38 MAPK Pathway-Dependent and -Independent Manners

(2014) Tetsuhiro Chiba et al.   PLoS One

Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance

(2014) Chi Kwan Tsang et al.   Nature Communications

Increasing Intracellular Bioavailable Copper Selectively Targets Prostate Cancer Cells

(2013) Michael A. Cater et al.   ACS Chemical Biology

Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse

(2013) S. Jain et al.   ANNALS OF ONCOLOGY

Mouse divalent metal transporter 1 is a copper transporter in HEK293 cells

(2013) Miguel Arredondo et al.   BIOMETALS

Advances in Copper Complexes as Anticancer Agents

(2013) Carlo Santini et al.   CHEMICAL REVIEWS

Golgi in copper homeostasis: a view from the membrane trafficking field

(2013) Roman Polishchuk et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Final Results of Phase III SYMMETRY Study: Randomized, Double-Blind Trial of Elesclomol Plus Paclitaxel Versus Paclitaxel Alone As Treatment for Chemotherapy-Naive Patients With Advanced Melanoma

(2013) Steven J. O'Day et al.   JOURNAL OF CLINICAL ONCOLOGY

In Vitro and in Vivo Anticancer Activity of Copper Bis(thiosemicarbazone) Complexes

(2013) Duraippandi Palanimuthu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mammalian MT1 and MT2 metallothioneins differ in their metal binding abilities

(2013) Ester Artells et al.   Metallomics

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

(2013) Peng Jiang et al.   NATURE

CTR1 Silencing Inhibits Angiogenesis by Limiting Copper Entry into Endothelial Cells

(2013) Gomathy Narayanan et al.   PLoS One

Bioavailable copper modulates oxidative phosphorylation and growth of tumors

(2013) S. Ishida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Curcumin-From Molecule to Biological Function

(2012) Tuba Esatbeyoglu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gluconjugates of 8-hydroxyquinolines as potential anti-cancer prodrugs

(2012) Valentina Oliveri et al.   DALTON TRANSACTIONS

Glycosylated copper(ii) ionophores as prodrugs for β-glucosidase activation in targeted cancer therapy

(2012) Valentina Oliveri et al.   DALTON TRANSACTIONS

Breast cancers with compromised DNA repair exhibit selective sensitivity to elesclomol

(2012) Elizabeth Alli et al.   DNA REPAIR

Copper levels in patients with hematological malignancies

(2012) Georgia D. Kaiafa et al.   European Journal of Internal Medicine

Copper-Dependent Cytotoxicity of 8-Hydroxyquinoline Derivatives Correlates with Their Hydrophobicity and Does Not Require Caspase Activation

(2012) Saverio Tardito et al.   JOURNAL OF MEDICINAL CHEMISTRY

Diethyldithiocarbamate complex with copper: the mechanism of action in cancer cells

(2012) Zdenek Skrott et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling

(2012) M. L. Turski et al.   MOLECULAR AND CELLULAR BIOLOGY

Diethyldithiocarbamate induces apoptosis in neuroblastoma cells by raising the intracellular copper level, triggering cytochrome c release and caspase activation

(2012) Andreza C. Matias et al.   TOXICOLOGY IN VITRO

Advances in the Understanding of Mammalian Copper Transporters

(2012) Yanfang Wang et al.   Advances in Nutrition

Clioquinol induces cytoplasmic clearance of the X-linked inhibitor of apoptosis protein (XIAP): therapeutic indication for prostate cancer

(2011) Michael A. Cater et al.   BIOCHEMICAL JOURNAL

Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy

(2011) Y Yu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nitroxoline (8-hydroxy-5-nitroquinoline) is more a potent anti-cancer agent than clioquinol (5-chloro-7-iodo-8-quinoline)

(2011) Hongchao Jiang et al.   CANCER LETTERS

Unification of the Copper(I) Binding Affinities of the Metallo-chaperones Atx1, Atox1, and Related Proteins

(2011) Zhiguang Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper Binding Agents Acting as Copper Ionophores Lead to Caspase Inhibition and Paraptotic Cell Death in Human Cancer Cells

(2011) Saverio Tardito et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel Thiosemicarbazone Iron Chelators Induce Up-Regulation and Phosphorylation of the Metastasis Suppressor N-myc Down-Stream Regulated Gene 1: A New Strategy for the Treatment of Pancreatic Cancer

(2011) Z. Kovacevic et al.   MOLECULAR PHARMACOLOGY

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

Import, Maturation, and Function of SOD1 and Its Copper Chaperone CCS in the Mitochondrial Intermembrane Space

(2010) Hibiki Kawamata et al.   ANTIOXIDANTS & REDOX SIGNALING

A novel dithiocarbamate analogue with potentially decreased ALDH inhibition has copper-dependent proteasome-inhibitory and apoptosis-inducing activity in human breast cancer cells

(2010) Fei Wang et al.   CANCER LETTERS

Novel Thiosemicarbazones of the ApT and DpT Series and Their Copper Complexes: Identification of Pronounced Redox Activity and Characterization of Their Antitumor Activity

(2010) Patric J. Jansson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2

(2009) Z X Chen et al.   CELL DEATH AND DIFFERENTIATION

Menkes disease

(2009) Zeynep Tümer et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Copper-dependent Recycling of hCTR1, the Human High Affinity Copper Transporter

(2009) Shannon A. Molloy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells

(2009) Shumei Zhai et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Phase II, Randomized, Controlled, Double-Blinded Trial of Weekly Elesclomol Plus Paclitaxel Versus Paclitaxel Alone for Stage IV Metastatic Melanoma

(2009) Steven O'Day et al.   JOURNAL OF CLINICAL ONCOLOGY

Tetrathiomolybdate Inhibits Copper Trafficking Proteins Through Metal Cluster Formation

(2009) H. M. Alvarez et al.   SCIENCE

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

COPPER AND ANGIOGENESIS: UNRAVELLING A RELATIONSHIP KEY TO CANCER PROGRESSION

(2008) Lydia Finney et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Involvement of activating transcription factors JNK, NF-κB, and AP-1 in apoptosis induced by pyrrolidine dithiocarbamate/Cu complex

(2008) Sung-Ho Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Elesclomol induces cancer cell apoptosis through oxidative stress

(2008) J. R. Kirshner et al.   MOLECULAR CANCER THERAPEUTICS

Mechanisms for copper acquisition, distribution and regulation

(2008) Byung-Eun Kim et al.   Nature Chemical Biology

Mitochondrial copper(I) transfer from Cox17 to Sco1 is coupled to electron transfer

(2008) L. Banci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyrrolidine dithiocarbamate-zinc(II) and -copper(II) complexes induce apoptosis in tumor cells by inhibiting the proteasomal activity

(2008) Vesna Milacic et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY