Diverse biological roles of the tetrathiomolybdate anion

The glutathione/metallothionein system challenges the design of efficient O2-activating Cu-complexes

(2020) Alice Santoro et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein

(2019) Tiantian Fang et al.   Nature Communications

Ammonium tetrathiomolybdate treatment of copper‐associated hepatopathy in dogs

(2019) Daniel K. Langlois et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Ni II ‐ATCUN‐Catalyzed Tyrosine Nitration in the Presence of Nitrite and Sulfite

(2019) Biplab K. Maiti et al.   CHEMISTRY-A EUROPEAN JOURNAL

Lysyl oxidase in cancer inhibition and metastasis

(2018) Kathryn A. Johnston et al.   CANCER LETTERS

Unusual Reduction Mechanism of Copper in Cysteine-Rich Environment

(2018) Biplab K. Maiti et al.   INORGANIC CHEMISTRY

The unique fold and lability of the [2Fe-2S] clusters of NEET proteins mediate their key functions in health and disease

(2018) Ola Karmi et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Animal models of Wilson disease

(2018) Emily Reed et al.   JOURNAL OF NEUROCHEMISTRY

Iron–sulfur cluster biosynthesis and trafficking – impact on human disease conditions

(2018) C. Wachnowsky et al.   Metallomics

Tetrathiomolybdate inhibits the reaction of cisplatin with human copper chaperone Atox1

(2018) Yao Tian et al.   Metallomics

SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α

(2018) Emilia Mira et al.   Nature Communications

commentary on the paper entitled “Bis-choline tetrathiomolybdate in patients with Wilson's disease: an open-label, multicentre, phase II study,”

(2018) Wolfgang Stremmel   HEPATOLOGY

The mice with human tumours: Growing pains for a popular cancer model

(2018) Cassandra Willyard   NATURE

Insights into the Molybdenum/Copper Heterometallic Cluster Assembly in the Orange Protein: Probing Intermolecular Interactions with an Artificial Metal-Binding ATCUN Tag

(2017) Biplab K. Maiti et al.   INORGANIC CHEMISTRY

Protein-Assisted Formation of Molybdenum Heterometallic Clusters: Evidence for the Formation of S2MoS2–M–S2MoS2 Clusters with M = Fe, Co, Ni, Cu, or Cd within the Orange Protein

(2017) Biplab K. Maiti et al.   INORGANIC CHEMISTRY

Copper metallothioneins

(2017) Jenifer Calvo et al.   IUBMB LIFE

Copper signaling in the brain and beyond

(2017) Cheri M. Ackerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the human copper proteome and analysis of its expression variation in cancers

(2017) S. Blockhuys et al.   Metallomics

The small iron-sulfur protein from the ORP operon binds a [2Fe-2S] cluster

(2016) Biplab K. Maiti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders

(2016) Hille Fieten et al.   Disease Models & Mechanisms

Ceruloplasmin and other copper binding components of blood plasma and their functions: an update

(2016) M. C. Linder   Metallomics

Functional analysis and drug response to zinc and D-penicillamine in stableATP7Bmutant hepatic cell lines

(2016) Gursimran Chandhok et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin

(2016) Cristine L. Chisholm et al.   Oncotarget

Pharmacologic evaluation of ammonium tetrathiomolybdate after intravenous and oral administration to healthy dogs

(2015) Christina M. Chan et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

Geographic distribution of ATP7B mutations in Wilson disease

(2015) Amanda Gomes et al.   ANNALS OF HUMAN BIOLOGY

Effects of tetrathiomolybdate and penicillamine on brain hydroxyl radical and free copper levels: A microdialysis study in vivo

(2015) Ji-Wei Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens

(2015) Karrera Y. Djoko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Behind the Link between Copper and Angiogenesis: Established Mechanisms and an Overview on the Role of Vascular Copper Transport Systems

(2015) Emanuela Urso et al.   JOURNAL OF VASCULAR RESEARCH

Wilson's disease and other neurological copper disorders

(2015) Oliver Bandmann et al.   LANCET NEUROLOGY

Targeting copper in cancer therapy: ‘Copper That Cancer’

(2015) Delphine Denoyer et al.   Metallomics

Cancer-Related NEET Proteins Transfer 2Fe-2S Clusters to Anamorsin, a Protein Required for Cytosolic Iron-Sulfur Cluster Biogenesis

(2015) Colin H. Lipper et al.   PLoS One

Tetrathiomolybdate inhibits mitochondrial complex IV and mediates degradation of hypoxia-inducible factor-1α in cancer cells

(2015) Kyu Kwang Kim et al.   Scientific Reports

How copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1

(2014) Helena Öhrvik et al.   Annals of the New York Academy of Sciences

One Electron Reduced Square Planar Bis(benzene-1,2-dithiolato) Copper Dianionic Complex and Redox Switch by O2/HO–

(2014) Biplab K. Maiti et al.   INORGANIC CHEMISTRY

Synthesis and characterization of [S2MoS2Cu(n-SPhF)]2−(n=o, m, p) clusters: Potential 19F-NMR structural probes for Orange Protein

(2014) Biplab K. Maiti et al.   INORGANIC CHEMISTRY COMMUNICATIONS

Mo–Cu metal cluster formation and binding in an orange protein isolated from Desulfovibrio gigas

(2014) Marta S. P. Carepo et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Copper is required for oncogenic BRAF signalling and tumorigenesis

(2014) Donita C. Brady et al.   NATURE

Memo Is a Copper-Dependent Redox Protein with an Essential Role in Migration and Metastasis

(2014) G. MacDonald et al.   Science Signaling

Novel Role of Copper Transport Protein Antioxidant-1 in Neointimal Formation After Vascular Injury

(2013) Takashi Kohno et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bioavailable copper modulates oxidative phosphorylation and growth of tumors

(2013) S. Ishida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rearrangement of Mo-Cu-S Cluster Reflects the Structural ­Instability of Orange Protein Cofactor

(2013) Biplab K. Maiti et al.   ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE

Synthesis of [MoS4]2--M (M = Cu and Cd) Clusters: Potential NMR Spectroscopic Structural Probes for the Orange Protein

(2012) Biplab K. Maiti et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Diverse Functional Properties of Wilson Disease ATP7B Variants

(2012) Dominik Huster et al.   GASTROENTEROLOGY

Advances in the Understanding of Mammalian Copper Transporters

(2012) Yanfang Wang et al.   Advances in Nutrition

Mouse Models of Cancer

(2011) Dong-Joo Cheon et al.   Annual Review of Pathology-Mechanisms of Disease

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Highly reactive oxygen species: detection, formation, and possible functions

(2011) Wolfhardt Freinbichler et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Anaerobe-Specific Orange Protein Complex of Desulfovibrio vulgaris Hildenborough Is Encoded by Two Divergent Operons Coregulated by  54 and a Cognate Transcriptional Regulator

(2011) A. Fievet et al.   JOURNAL OF BACTERIOLOGY

Facile transfer of [2Fe-2S] clusters from the diabetes drug target mitoNEET to an apo-acceptor protein

(2011) John A. Zuris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advances in metal-induced oxidative stress and human disease

(2011) Klaudia Jomova et al.   TOXICOLOGY

Dog models of naturally occurring cancer

(2011) Jennie L. Rowell et al.   TRENDS IN MOLECULAR MEDICINE

A non-comparative randomized phase II study of 2 doses of ATN-224, a copper/zinc superoxide dismutase inhibitor, in patients with biochemically recurrent hormone-naïve prostate cancer

(2011) Jianqing Lin et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Copper Metallochaperones

(2010) Nigel J. Robinson et al.   Annual Review of Biochemistry

Enhancing Tumor-Specific Uptake of the Anticancer Drug Cisplatin with a Copper Chelator

(2010) Seiko Ishida et al.   CANCER CELL

Effect of glutathione depletion on removal of copper from LEC rat livers by tetrathiomolybdate

(2010) Yasumitsu Ogra et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Extracellular SOD-Derived H2O2 Promotes VEGF Signaling in Caveolae/Lipid Rafts and Post-Ischemic Angiogenesis in Mice

(2010) Jin Oshikawa et al.   PLoS One

Crystallization and crystallographic analysis of the apo form of the orange protein (ORP) fromDesulfovibrio gigas

(2009) Shabir Najmudin et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Tracing Copper−Thiomolybdate Complexes in a Prospective Treatment for Wilson’s Disease†

(2009) Limei Zhang et al.   BIOCHEMISTRY

The conquest of Wilson's disease

(2009) J. M. Walshe   BRAIN

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Structural Biology of Copper Trafficking

(2009) Amie K. Boal et al.   CHEMICAL REVIEWS

Antiangiogenic Tetrathiomolybdate Protects against Her2/neu-Induced Breast Carcinoma by Hypoplastic Remodeling of the Mammary Gland

(2009) Q. Pan et al.   CLINICAL CANCER RESEARCH

Coordination complexes incorporating pyrophosphate: Structural overview and exploration of their diverse magnetic, catalytic and biological properties

(2009) Oluwatayo F. Ikotun et al.   COORDINATION CHEMISTRY REVIEWS

Zinc and tetrathiomolybdate for the treatment of Wilson’s disease and the potential efficacy of anticopper therapy in a wide variety of diseases

(2009) George J. Brewer   Metallomics

The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity

(2009) L. Macomber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tetrathiomolybdate Inhibits Copper Trafficking Proteins Through Metal Cluster Formation

(2009) H. M. Alvarez et al.   SCIENCE

Treatment of Wilson's disease with tetrathiomolybdate: V. control of free copper by tetrathiomolybdate and a comparison with trientine

(2009) George J. Brewer et al.   Translational Research

Copper-Associated Hepatitis in Labrador Retrievers

(2009) R. Smedley et al.   VETERINARY PATHOLOGY

SPARC: a matricellular regulator of tumorigenesis

(2009) Shanna A. Arnold et al.   Journal of Cell Communication and Signaling

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

COPPER AND ANGIOGENESIS: UNRAVELLING A RELATIONSHIP KEY TO CANCER PROGRESSION

(2008) Lydia Finney et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Phase I Study of Copper-Binding Agent ATN-224 in Patients with Advanced Solid Tumors

(2008) S. A. Lowndes et al.   CLINICAL CANCER RESEARCH

Plasticity in [(R4–xR1x)4N]4[Cu4{S2C2(CN)2}4] (x = 0–4) is Molded by a Guest Cation on an Elastic Anionic Host

(2008) Biplab K. Maiti et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

The use of copper-lowering therapy with tetrathiomolybdate in medicine

(2008) George J Brewer   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The human tri-peptide GHK and tissue remodeling

(2008) Loren Pickart   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Stability and ATP Binding of the Nucleotide-binding Domain of the Wilson Disease Protein: Effect of the Common H1069Q Mutation

(2008) Agustina Rodriguez-Granillo et al.   JOURNAL OF MOLECULAR BIOLOGY

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Mitochondrial copper(I) transfer from Cox17 to Sco1 is coupled to electron transfer

(2008) L. Banci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo/Ex Vivo and In Situ Assays Used in Cancer Research: A Brief Review

(2008) Beverly A. Teicher   TOXICOLOGIC PATHOLOGY