Haematopoietic stem cell health in sickle cell disease and its implications for stem cell therapies and secondary haematological disorders

Secondary Neoplasms After Hematopoietic Cell Transplant for Sickle Cell Disease

(2023) Mary Eapen et al.   JOURNAL OF CLINICAL ONCOLOGY

Sickle cell disease as an accelerated aging syndrome

(2022) Ibrahim M Idris et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Inflammation Regulates Haematopoietic Stem Cells and Their Niche

(2022) Nicole Pui-Yu Ho et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

‘ Cell‐ebrating ’ diversity in the bone marrow niche: Classic and novel strategies to uncover niche composition

(2022) Raúl Sánchez‐Lanzas et al.   BRITISH JOURNAL OF HAEMATOLOGY

Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging

(2022) Ruzhica Bogeska et al.   Cell Stem Cell

Melatonin finely tunes proliferation and senescence in hematopoietic stem cells

(2022) Sara Cruciani et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Recent advances in “sickle and niche” research - Tribute to Dr. Paul S Frenette -

(2022) Lidiane S. Torres et al.   Stem Cell Reports

Absence of hydroxyurea‐induced mutational effects supports higher utilisation for the treatment of sickle cell anaemia

(2021) Russell E. Ware et al.   BRITISH JOURNAL OF HAEMATOLOGY

A comprehensive review of hydroxyurea for β-haemoglobinopathies: the role revisited during COVID-19 pandemic

(2021) Nirmani Yasara et al.   Orphanet Journal of Rare Diseases

Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling

(2021) Daniel Hormaechea-Agulla et al.   Cell Stem Cell

A pause in gene therapy: Reflecting on the unique challenges of sickle cell disease

(2021) Alexis Leonard et al.   MOLECULAR THERAPY

Disease severity impacts plerixafor-mobilized stem cell collection in patients with sickle cell disease

(2021) Alexis Leonard et al.   Blood Advances

Clonal hematopoiesis in sickle cell disease

(2021) Thomas Pincez et al.   BLOOD

Inflammation and Aging of Hematopoietic Stem Cells in Their Niche

(2021) Daozheng Yang et al.   Cells

The Hematopoietic Bone Marrow Niche Ecosystem

(2021) Julia Fröbel et al.   Frontiers in Cell and Developmental Biology

Biologic and Clinical Efficacy of LentiGlobin for Sickle Cell Disease

(2021) Julie Kanter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acute Myeloid Leukemia Case after Gene Therapy for Sickle Cell Disease

(2021) Sunita Goyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme

(2021) Elisa Jentho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of RBC Oxidative Stress in Sickle Cell Disease: From the Molecular Basis to Pathologic Implications

(2021) Qinhong Wang et al.   Antioxidants

Sickle Cell Hemoglobin Impairs Lysosomal Processing in Macrophages Leading to Inflammasome Activation and Inflammation

(2020) Marina Jerebtsova et al.   BLOOD

Pathologic angiogenesis in the bone marrow of humanized sickle cell mice is reversible by blood transfusion

(2020) Shin-Young Park et al.   BLOOD

Tracking hematopoietic stem cells and their progeny using whole-genome sequencing

(2020) Henry Lee-Six et al.   EXPERIMENTAL HEMATOLOGY

Safety and Feasibility of Hematopoietic Progenitor Stem Cell Collection by Mobilization with Plerixafor Followed by Apheresis vs Bone Marrow Harvest in Patients with Sickle Cell Disease in the Multi‐center HGB ‐206 Trial

(2020) John F. Tisdale et al.   AMERICAN JOURNAL OF HEMATOLOGY

Haematopoietic stem cell self-renewal in vivo and ex vivo

(2020) Adam C. Wilkinson et al.   NATURE REVIEWS GENETICS

Macrophages Orchestrate Hematopoietic Programs and Regulate HSC Function During Inflammatory Stress

(2020) Allison N. Seyfried et al.   Frontiers in Immunology

Characterization of Hematopoiesis in Sickle Cell Disease by Prospective Isolation of Stem and Progenitor Cells

(2020) Seda S. Tolu et al.   Cells

Nociceptive nerves regulate haematopoietic stem cell mobilization

(2020) Xin Gao et al.   NATURE

CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia

(2020) Haydar Frangoul et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bone marrow characterization in sickle cell disease: inflammation and stress erythropoiesis lead to suboptimal CD34 recovery

(2019) Alexis Leonard et al.   BRITISH JOURNAL OF HAEMATOLOGY

Circadian period 2: a missing beneficial factor in sickle cell disease by lowering pulmonary inflammation, iron overload, and mortality

(2019) Morayo G. Adebiyi et al.   FASEB JOURNAL

Single-cell analysis of bone marrow–derived CD34+ cells from children with sickle cell disease and thalassemia

(2019) Peng Hua et al.   BLOOD

Inflammation in sickle cell disease

(2018) Nicola Conran et al.   CLINICAL HEMORHEOLOGY AND MICROCIRCULATION

An inflammatory environment containing TNFα favors Tet2 -mutant clonal hematopoiesis

(2018) Samuel O. Abegunde et al.   EXPERIMENTAL HEMATOLOGY

Safety and efficacy of plerixafor dose escalation for the mobilization of CD34 + hematopoietic progenitor cells in patients with sickle cell disease: interim results

(2018) Farid Boulad et al.   HAEMATOLOGICA

Safety and efficacy of plerixafor dose escalation for the mobilization of CD34 + hematopoietic progenitor cells in patients with sickle cell disease: interim results

(2018) Farid Boulad et al.   HAEMATOLOGICA

Pathophysiology of Sickle Cell Disease

(2018) Prithu Sundd et al.   Annual Review of Pathology-Mechanisms of Disease

Is chronic use of hydroxyurea safe for patients with sickle cell anemia? An account of genotoxicity and mutagenicity

(2018) Pedro Aurio Maia Filho et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa

(2018) Léon Tshilolo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gene Therapy in a Patient with Sickle Cell Disease

(2017) Jean-Antoine Ribeil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bone Marrow as a Hematopoietic Stem Cell Source for Gene Therapy in Sickle Cell Disease: Evidence from Rhesus and SCD Patients

(2017) Naoya Uchida et al.   Human Gene Therapy Clinical Development

Hyperinflammation in patients with chronic granulomatous disease leads to impairment of hematopoietic stem cell functions

(2016) Maren Weisser et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Risk of individual malignant neoplasms in patients with sickle cell disease: English national record linkage study

(2016) Olena O Seminog et al.   JOURNAL OF THE ROYAL SOCIETY OF MEDICINE

Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia—TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial

(2016) Russell E Ware et al.   LANCET

Neutrophil ageing is regulated by the microbiome

(2015) Dachuan Zhang et al.   NATURE

Hydroxycarbamide treatment in sickle cell disease: estimates of possible leukaemia risk and of hospitalization survival benefit

(2014) Oswaldo Castro et al.   BRITISH JOURNAL OF HAEMATOLOGY

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

(2014) I. Fares et al.   SCIENCE

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

(2013) María Casanova-Acebes et al.   CELL

Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow

(2012) Aya Ludin et al.   NATURE IMMUNOLOGY

Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management

(2011) Erfan Nur et al.   AMERICAN JOURNAL OF HEMATOLOGY

Role of oxidative stress in the pathogenesis of sickle cell disease

(2011) Erica N. Chirico et al.   IUBMB LIFE

Bone marrow CD169+macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

(2011) Andrew Chow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)

(2011) Winfred C Wang et al.   LANCET

Genotoxicity associated with hydroxyurea exposure in infants with sickle cell anemia: Results from the BABY-HUG phase III clinical trial

(2011) Patrick T. McGann et al.   PEDIATRIC BLOOD & CANCER

Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment

(2011) F. Notta et al.   SCIENCE

The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up

(2010) Martin H. Steinberg et al.   AMERICAN JOURNAL OF HEMATOLOGY

Serum melatonin level and oxidative stress in sickle cell anemia

(2010) Eliana Litsuko Tomimatsu Shimauti et al.   BLOOD CELLS MOLECULES AND DISEASES

Primitive haematopoietic progenitors in the blood of patients with sickle cell disease appear to be endogenously mobilized

(2010) H. Croizat et al.   BRITISH JOURNAL OF HAEMATOLOGY

Granulocyte colony-stimulating factor (G-CSF) administration in individuals with sickle cell disease: time for a moratorium?

(2009) Courtney D. Fitzhugh et al.   CYTOTHERAPY