Bone marrow characterization in sickle cell disease: inflammation and stress erythropoiesis lead to suboptimal CD34 recovery

Safety and efficacy of plerixafor dose escalation for the mobilization of CD34 + hematopoietic progenitor cells in patients with sickle cell disease: interim results

(2018) Farid Boulad et al.   HAEMATOLOGICA

Plerixafor enables safe, rapid, efficient mobilization of hematopoietic stem cells in sickle cell disease patients after exchange transfusion

(2018) Chantal Lagresle-Peyrou et al.   HAEMATOLOGICA

Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia

(2018) Alexis A. Thompson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and efficacy of plerixafor dose escalation for the mobilization of CD34 + hematopoietic progenitor cells in patients with sickle cell disease: interim results

(2018) Farid Boulad et al.   HAEMATOLOGICA

Plerixafor enables safe, rapid, efficient mobilization of hematopoietic stem cells in sickle cell disease patients after exchange transfusion

(2018) Chantal Lagresle-Peyrou et al.   HAEMATOLOGICA

Improving Gene Therapy Efficiency through the Enrichment of Human Hematopoietic Stem Cells

(2017) Katelyn E. Masiuk et al.   MOLECULAR THERAPY

RNA Trans-Splicing Targeting Endogenous β-Globin Pre-Messenger RNA in Human Erythroid Cells

(2017) Naoya Uchida et al.   Human Gene Therapy Methods

Efficient Ex Vivo Engineering and Expansion of Highly Purified Human Hematopoietic Stem and Progenitor Cell Populations for Gene Therapy

(2017) Erika Zonari et al.   Stem Cell Reports

Bone Marrow as a Hematopoietic Stem Cell Source for Gene Therapy in Sickle Cell Disease: Evidence from Rhesus and SCD Patients

(2017) Naoya Uchida et al.   Human Gene Therapy Clinical Development

Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers

(2016) L. Breda et al.   BLOOD

Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology

(2016) D. Zhang et al.   BLOOD

CRISPR/Cas9-Mediated Correction of the Sickle Mutation in Human CD34+ cells

(2016) Megan D Hoban et al.   MOLECULAR THERAPY

CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells

(2016) Daniel P. Dever et al.   NATURE

Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and β-thalassemia

(2016) Lin Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy

(2016) Akanksha Chhabra et al.   Science Translational Medicine

Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells

(2016) M. A. DeWitt et al.   Science Translational Medicine

Optimal conditions for the performance of a monocyte monolayer assay

(2016) Tik Nga Tong et al.   TRANSFUSION

Human and Murine Hematopoietic Stem Cell Aging Is Associated with Functional Impairments and Intrinsic Megakaryocytic/Erythroid Bias

(2016) Alexandra Rundberg Nilsson et al.   PLoS One

Hematopoietic stem cells: concepts, definitions, and the new reality

(2015) C. J. Eaves   BLOOD

Anemia: progress in molecular mechanisms and therapies

(2015) Vijay G Sankaran et al.   NATURE MEDICINE

Nonmyeloablative HLA-Matched Sibling Allogeneic Hematopoietic Stem Cell Transplantation for Severe Sickle Cell Phenotype

(2014) Matthew M. Hsieh et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Endothelial activation and inflammation biomarkers in children and adolescents with sickle cell disease

(2013) Emmanuil S. Hatzipantelis et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Platelet Activation and Inhibition iN Sickle cell disease (PAINS) study

(2013) Andrew L. Frelinger et al.   PLATELETS

Hematopoietic stem cell expansion: challenges and opportunities

(2012) Marta A. Walasek et al.   Annals of the New York Academy of Sciences

Monocytes from sickle cell disease patients induce differential pulmonary endothelial gene expression via activation of NF-κB signaling pathway

(2012) Surinder Safaya et al.   MOLECULAR IMMUNOLOGY

Role of oxidative stress in the pathogenesis of sickle cell disease

(2011) Erica N. Chirico et al.   IUBMB LIFE

P-Selectin–Mediated Platelet-Neutrophil Aggregate Formation Activates Neutrophils in Mouse and Human Sickle Cell Disease

(2010) Renata Polanowska-Grabowska et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet and leucocyte activation in childhood sickle cell disease: association with nocturnal hypoxaemia

(2010) David P. Inwald et al.   BRITISH JOURNAL OF HAEMATOLOGY

Aggregation of mononuclear and red blood cells through an  4 1-Lu/basal cell adhesion molecule interaction in sickle cell disease

(2010) V. Chaar et al.   HAEMATOLOGICA

Increased levels of the inflammatory biomarker C-reactive protein at baseline are associated with childhood sickle cell vasocclusive crises

(2009) Suba Krishnan et al.   BRITISH JOURNAL OF HAEMATOLOGY

Granulocyte colony-stimulating factor (G-CSF) administration in individuals with sickle cell disease: time for a moratorium?

(2009) Courtney D. Fitzhugh et al.   CYTOTHERAPY

Delayed processing of blood increases the frequency of activated CD11b+ CD15+ granulocytes which inhibit T cell function

(2008) Kyle C. McKenna et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapy

(2008) C. Lanaro et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Sickle Red Cell–Endothelium Interactions

(2008) Dhananjay K. Kaul et al.   MICROCIRCULATION