Macrophages Orchestrate Hematopoietic Programs and Regulate HSC Function During Inflammatory Stress

The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Their Inflammatory Properties

(2020) Natallia Salei et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Restricted Hematopoietic Progenitors and Erythropoiesis Require SCF from Leptin Receptor+ Niche Cells in the Bone Marrow

(2019) Stefano Comazzetto et al.   Cell Stem Cell

MERTK tyrosine kinase receptor together with TIM4 phosphatidylserine receptor mediates distinct signal transduction pathways for efferocytosis and cell proliferation

(2019) Chihiro Nishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin

(2019) Laura C. Burzynski et al.   IMMUNITY

The mesenchymal niche in MDS

(2019) Eline Pronk et al.   BLOOD

Identification and transcriptome analysis of erythroblastic island macrophages

(2019) Wei Li et al.   BLOOD

Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology

(2019) Sho Morioka et al.   IMMUNITY

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging

(2019) Ya-Hsuan Ho et al.   Cell Stem Cell

Pro-inflammatory Aorta-Associated Macrophages Are Involved in Embryonic Development of Hematopoietic Stem Cells

(2019) Samanta Antonella Mariani et al.   IMMUNITY

Platelets Promote Macrophage Polarization toward Pro-inflammatory Phenotype and Increase Survival of Septic Mice

(2019) Agostina Carestia et al.   Cell Reports

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

(2019) Marco Orecchioni et al.   Frontiers in Immunology

Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells

(2019) Zhaoyuan Liu et al.   CELL

The Role of Interferon, Inflammation and Infection in Aplastic Anemia

(2019) Katherine C. MacNamara   BLOOD

Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes

(2019) Yasunobu Nagata et al.   Nature Communications

Understanding intrinsic hematopoietic stem cell aging

(2019) Eva Mejia-Ramirez et al.   HAEMATOLOGICA

Microenvironmental contributions to hematopoietic stem cell aging

(2019) Ya-Hsuan Ho et al.   HAEMATOLOGICA

Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment

(2018) Simranpreet Kaur et al.   BLOOD

Hematopoietic stem cell loss and hematopoietic failure in severe aplastic anemia is driven by macrophages and aberrant podoplanin expression

(2018) Amanda McCabe et al.   HAEMATOLOGICA

Bone marrow drives central nervous system regeneration after radiation injury

(2018) Jorg Dietrich et al.   JOURNAL OF CLINICAL INVESTIGATION

Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia

(2018) A.H. Cull et al.   LEUKEMIA RESEARCH

IFNγ inhibits G-CSF induced neutrophil expansion and invasion of the CNS to prevent viral encephalitis

(2018) Chandran Ramakrishna et al.   PLoS Pathogens

Hematopoietic stem cell loss and hematopoietic failure in severe aplastic anemia is driven by macrophages and aberrant podoplanin expression

(2018) Amanda McCabe et al.   HAEMATOLOGICA

Type I IFNs drive hematopoietic stem and progenitor cell collapse via impaired proliferation and increased RIPK1-dependent cell death during shock-like ehrlichial infection

(2018) Julianne N. P. Smith et al.   PLoS Pathogens

Macrophage TNF-α licenses donor T cells in murine bone marrow failure and can be implicated in human aplastic anemia

(2018) Wanling Sun et al.   BLOOD

Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes

(2018) Zhen Ping et al.   LEUKEMIA

Aplastic Anemia

(2018) Neal S. Young   NEW ENGLAND JOURNAL OF MEDICINE

Tet2 restrains inflammatory gene expression in macrophages

(2017) Alyssa H. Cull et al.   EXPERIMENTAL HEMATOLOGY

CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis

(2017) Amanda C. Doran et al.   JOURNAL OF CLINICAL INVESTIGATION

Phagocytosis imprints heterogeneity in tissue-resident macrophages

(2017) Noelia A-Gonzalez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses

(2017) Michael R. Elliott et al.   JOURNAL OF IMMUNOLOGY

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

(2017) Emma Lefrançais et al.   NATURE

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

(2017) José J. Fuster et al.   SCIENCE

Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches

(2017) Simranpreet Kaur et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Unraveling Macrophage Heterogeneity in Erythroblastic Islands

(2017) Katie Giger Seu et al.   Frontiers in Immunology

Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients

(2016) T. A. M. Claushuis et al.   BLOOD

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

(2016) A. A. Basiorka et al.   BLOOD

CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages

(2016) Jin Hur et al.   Cell Stem Cell

Macrophages: Key regulators of steady-state and demand-adapted hematopoiesis

(2016) Amanda McCabe et al.   EXPERIMENTAL HEMATOLOGY

Hematopoietic (stem) cell development - how divergent are the roads taken?

(2016) Mari-Liis Kauts et al.   FEBS LETTERS

Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance

(2016) Bangwei Luo et al.   IMMUNITY

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging

(2016) Kira Young et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Platelets Mediate Host Defense againstStaphylococcus aureusthrough Direct Bactericidal Activity and by Enhancing Macrophage Activities

(2016) Ramadan A. Ali et al.   JOURNAL OF IMMUNOLOGY

Elie Metchnikoff, the Man and the Myth

(2016) Siamon Gordon   Journal of Innate Immunity

Fetal liver endothelium regulates the seeding of tissue-resident macrophages

(2016) Pia Rantakari et al.   NATURE

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

(2016) Eric M. Pietras et al.   NATURE CELL BIOLOGY

MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation

(2016) Bishuang Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specification of tissue-resident macrophages during organogenesis

(2016) E. Mass et al.   SCIENCE

Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution

(2016) Bangwei Luo et al.   Nature Communications

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

(2016) Charlotte L. Scott et al.   Nature Communications

Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation

(2016) Katie A. Matatall et al.   Cell Reports

Monocyte-Derived Macrophages Are Impaired in Myelodysplastic Syndrome

(2016) Yu Han et al.   Journal of Immunology Research

How Mouse Macrophages Sense What Is Going On

(2016) Klaus Ley et al.   Frontiers in Immunology

The Macrophage-depleting Agent Clodronate Promotes Durable Hematopoietic Chimerism and Donor-specific Skin Allograft Tolerance in Mice

(2016) Zhanzhuo Li et al.   Scientific Reports

The hematopoietic stem cell niche in homeostasis and disease

(2015) L. M. Calvi et al.   BLOOD

CCL5 derived from platelets increases megakaryocyte proplatelet formation

(2015) K. R. Machlus et al.   BLOOD

IFN- -mediated hematopoietic cell destruction in murine models of immune-mediated bone marrow failure

(2015) J. Chen et al.   BLOOD

Myocardial Infarction Activates CCR2+ Hematopoietic Stem and Progenitor Cells

(2015) Partha Dutta et al.   Cell Stem Cell

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions

(2015) Eric M. Pietras et al.   Cell Stem Cell

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors

(2015) Simon Haas et al.   Cell Stem Cell

Myeloid Cell-Derived Reactive Oxygen Species Externally Regulate the Proliferation of Myeloid Progenitors in Emergency Granulopoiesis

(2015) Hyun-Jeong Kwak et al.   IMMUNITY

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs

(2015) Satoshi Nishimura et al.   JOURNAL OF CELL BIOLOGY

CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow

(2015) Ayako Nakamura-Ishizu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophages retain hematopoietic stem cells in the spleen via VCAM-1

(2015) Partha Dutta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Early hematopoiesis and macrophage development

(2015) Kathleen E. McGrath et al.   SEMINARS IN IMMUNOLOGY

Macrophage-Lineage Cells Negatively Regulate the Hematopoietic Stem Cell Pool in Response to Interferon Gamma at Steady State and During Infection

(2015) Amanda McCabe et al.   STEM CELLS

Primitive macrophages control HSPC mobilization and definitive haematopoiesis

(2015) Jana Travnickova et al.   Nature Communications

Reduced Expression of Osteonectin and Increased Natural Killer Cells May Contribute to the Pathophysiology of Aplastic Anemia

(2015) Meerim Park et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Phylogenetic and Ontogenetic View of Erythroblastic Islands

(2015) Katie M. Giger et al.   Biomed Research International

MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme

(2015) Kristina H. Knubel et al.   Oncotarget

Thrombocytopenia impairs host defense in gram-negative pneumonia-derived sepsis in mice

(2014) S. F. de Stoppelaar et al.   BLOOD

Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages

(2014) Malay Haldar et al.   CELL

Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction

(2014) Timo Heidt et al.   CIRCULATION RESEARCH

G-CSF: From granulopoietic stimulant to bone marrow stem cell mobilizing agent

(2014) Linda J. Bendall et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Mobilization with granulocyte colony-stimulating factor blocks medullar erythropoiesis by depleting F4/80+VCAM1+CD169+ER-HR3+Ly6G+ erythroid island macrophages in the mouse

(2014) Rebecca N. Jacobsen et al.   EXPERIMENTAL HEMATOLOGY

Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production

(2014) Yan Li et al.   GENES & DEVELOPMENT

IFN- -Induced TNF-  Expression Is Regulated by Interferon Regulatory Factors 1 and 8 in Mouse Macrophages

(2014) V. Vila-del Sol et al.   JOURNAL OF IMMUNOLOGY

Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo

(2014) M. K. Chang et al.   JOURNAL OF IMMUNOLOGY

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Clonal dynamics of native haematopoiesis

(2014) Jianlong Sun et al.   NATURE

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

(2014) Christoph Schneider et al.   NATURE IMMUNOLOGY

Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells

(2014) Meng Zhao et al.   NATURE MEDICINE

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion

(2014) Ingmar Bruns et al.   NATURE MEDICINE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Type II Interferon Promotes Differentiation of Myeloid-Biased Hematopoietic Stem Cells

(2014) Katie A. Matatall et al.   STEM CELLS

p62 Is Required for Stem Cell/Progenitor Retention through Inhibition of IKK/NF-κB/Ccl4 Signaling at the Bone Marrow Macrophage-Osteoblast Niche

(2014) Kyung Hee Chang et al.   Cell Reports

Biology of BM failure syndromes: role of microenvironment and niches

(2014) S. R. Balderman et al.   Hematology-American Society of Hematology Education Program

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

(2013) María Casanova-Acebes et al.   CELL

TLRs control hematopoiesis during infection

(2013) Alberto Yáñez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

MyD88 Signaling in CD4 T Cells Promotes IFN-  Production and Hematopoietic Progenitor Cell Expansion in Response to Intracellular Bacterial Infection

(2013) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

(2013) C. L. Cunningham et al.   JOURNAL OF NEUROSCIENCE

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy

(2013) Alejandra Sanjuan-Pla et al.   NATURE

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance

(2013) Connie H Y Wong et al.   NATURE IMMUNOLOGY

Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer

(2013) L. Bosurgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Demand-adapted regulation of early hematopoiesis in infection and inflammation

(2012) H. Takizawa et al.   BLOOD

How I treat acquired aplastic anemia

(2012) P. Scheinberg et al.   BLOOD

Hematopoietic Stem Cell Subtypes Expand Differentially during Development and Display Distinct Lymphopoietic Programs

(2012) Claudia Benz et al.   Cell Stem Cell

The Diaphragms of Fenestrated Endothelia: Gatekeepers of Vascular Permeability and Blood Composition

(2012) Radu V. Stan et al.   DEVELOPMENTAL CELL

Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells

(2012) S. Boettcher et al.   JOURNAL OF IMMUNOLOGY

Expansion of bone marrow neutrophils following G-CSF administration in mice results in osteolineage cell apoptosis and mobilization of hematopoietic stem and progenitor cells

(2012) P Singh et al.   LEUKEMIA

Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation

(2012) I G Winkler et al.   LEUKEMIA

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow

(2012) Aya Ludin et al.   NATURE IMMUNOLOGY

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

IFN  induces monopoiesis and inhibits neutrophil development during inflammation

(2011) A. M. de Bruin et al.   BLOOD

Erythropoietin Contrastingly Affects Bacterial Infection and Experimental Colitis by Inhibiting Nuclear Factor-κB-Inducible Immune Pathways

(2011) Manfred Nairz et al.   IMMUNITY

Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation

(2011) Daigo Hashimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice

(2011) Matthew J. Christopher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow CD169+macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

(2011) Andrew Chow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2

(2011) A. M. KERRIGAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Inflammation Triggers Emergency Granulopoiesis through a Density-Dependent Feedback Mechanism

(2011) Derek W. Cain et al.   PLoS One

Shared and Distinct Functions of the Transcription Factors IRF4 and IRF8 in Myeloid Cell Development

(2011) Michio Yamamoto et al.   PLoS One

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Concise Review: Anemia Caused by Viruses

(2011) Frédéric Morinet et al.   STEM CELLS

CD81 Is Essential for the Re-entry of Hematopoietic Stem Cells to Quiescence following Stress-Induced Proliferation Via Deactivation of the Akt Pathway

(2011) Kuanyin K. Lin et al.   PLOS BIOLOGY

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

(2010) I. G. Winkler et al.   BLOOD

Macrophages as novel target cells for erythropoietin

(2010) L. Lifshitz et al.   HAEMATOLOGICA

Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration

(2010) Kristin N. Kornerup et al.   JOURNAL OF APPLIED PHYSIOLOGY

Infection-Induced Myelopoiesis during Intracellular Bacterial Infection Is Critically Dependent upon IFN-  Signaling

(2010) K. C. MacNamara et al.   JOURNAL OF IMMUNOLOGY

Macrophage pro-inflammatory cytokine secretion is enhanced following interaction with autologous platelets

(2010) Christopher M Scull et al.   Journal of Inflammation-London

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

(2010) Megan T. Baldridge et al.   NATURE

Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation

(2009) J. Hoggatt et al.   BLOOD

Orchestration of macrophage polarization

(2009) A. Mantovani et al.   BLOOD

Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones

(2009) A. Kohler et al.   BLOOD

CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions

(2009) Kyle J. Eash et al.   BLOOD

Selective Expansion of the Monocytic Lineage Directed by Bacterial Infection

(2009) N. V. Serbina et al.   JOURNAL OF IMMUNOLOGY

IL-1R Type I-Dependent Hemopoietic Stem Cell Proliferation Is Necessary for Inflammatory Granulopoiesis and Reactive Neutrophilia

(2009) Yoshihiro Ueda et al.   JOURNAL OF IMMUNOLOGY

Mer tyrosine kinase (MerTK) promotes macrophage survival following exposure to oxidative stress

(2009) Adil Anwar et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Myelodysplastic Syndromes

(2009) Ayalew Tefferi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Erythroblastic islands: niches for erythropoiesis

(2008) J. A. Chasis et al.   BLOOD

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse

(2008) Rebecca C. Furze et al.   FASEB JOURNAL

CXCR4 is required for the quiescence of primitive hematopoietic cells

(2008) Yuchun Nie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Haematopoietic stem cell release is regulated by circadian oscillations

(2008) Simón Méndez-Ferrer et al.   NATURE

Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin

(2008) M. Brines et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA