Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging

Antigen presentation safeguards the integrity of the hematopoietic stem cell pool

(2022) Pablo Hernández-Malmierca et al.   Cell Stem Cell

Adiponectin receptors sustain haematopoietic stem cells throughout adulthood by protecting them from inflammation

(2022) Corbin E. Meacham et al.   NATURE CELL BIOLOGY

Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling

(2021) Daniel Hormaechea-Agulla et al.   Cell Stem Cell

Clonal hematopoiesis associated with epigenetic aging and clinical outcomes

(2021) Daniel Nachun et al.   AGING CELL

Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS

(2021) Jennifer J. Trowbridge et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection

(2021) Francisco Caiado et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Conditionally pathogenic genetic variants of a hematopoietic disease–suppressing enhancer

(2021) Alexandra A. Soukup et al.   Science Advances

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition

(2020) Ashwini Hinge et al.   Cell Stem Cell

Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness

(2020) Hitoshi Takizawa et al.   Cell Stem Cell

Loss of epigenetic polarity is a hallmark of hematopoietic stem cell aging

(2020) Eva Mejia-Ramirez et al.   HUMAN MOLECULAR GENETICS

The global clonal complexity of the murine blood system declines throughout life and after serial transplantation

(2019) Miguel Ganuza et al.   BLOOD

Haematopoietic stem cells in perisinusoidal niches are protected from ageing

(2019) Mehmet Saçma et al.   NATURE CELL BIOLOGY

Environmental influences on clonal hematopoiesis

(2019) Katherine Y. King et al.   EXPERIMENTAL HEMATOLOGY

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

(2018) Steve Horvath et al.   NATURE REVIEWS GENETICS

The integration of inflammaging in age-related diseases

(2018) Tamas Fulop et al.   SEMINARS IN IMMUNOLOGY

A whole lifespan mouse multi-tissue DNA methylation clock

(2018) Margarita V Meer et al.   eLife

OTP: An automatized system for managing and processing NGS data

(2017) Eva Reisinger et al.   JOURNAL OF BIOTECHNOLOGY

SC3: consensus clustering of single-cell RNA-seq data

(2017) Vladimir Yu Kiselev et al.   NATURE METHODS

A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation

(2016) S. Nestorowa et al.   BLOOD

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

(2016) Eric M. Pietras et al.   NATURE CELL BIOLOGY

Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation

(2016) Katie A. Matatall et al.   Cell Reports

Stress and Non-Stress Roles of Inflammatory Signals during HSC Emergence and Maintenance

(2016) Thomas Clapes et al.   Frontiers in Immunology

Characterization of Mouse Models of Mycobacterium avium Complex Infection and Evaluation of Drug Combinations

(2015) Claire Andréjak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

destiny: diffusion maps for large-scale single-cell data in R

(2015) Philipp Angerer et al.   BIOINFORMATICS

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors

(2015) Simon Haas et al.   Cell Stem Cell

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

(2015) Dagmar Walter et al.   NATURE

STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling

(2015) Nadine Haetscher et al.   Nature Communications

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging

(2013) Isabel Beerman et al.   Cell Stem Cell

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Accounting for technical noise in single-cell RNA-seq experiments

(2013) Philip Brennecke et al.   NATURE METHODS

Tagmentation-based whole-genome bisulfite sequencing

(2013) Qi Wang et al.   Nature Protocols

Age- And Sex-Related Variations in Platelet Count in Italy: A Proposal of Reference Ranges Based on 40987 Subjects' Data

(2013) Ginevra Biino et al.   PLoS One

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation

(2011) Hitoshi Takizawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells

(2011) B. L. Esplin et al.   JOURNAL OF IMMUNOLOGY

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

(2010) Megan T. Baldridge et al.   NATURE

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Hematopoietic Cytokines Can Instruct Lineage Choice

(2009) M. A. Rieger et al.   SCIENCE

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

The p47 GTPase Lrg-47 (Irgm1) Links Host Defense and Hematopoietic Stem Cell Proliferation

(2008) Carl G. Feng et al.   Cell Stem Cell