Article
Hematology
Yunfeng Liu, Mouli Pal, Weili Bao, Patricia A. Shi, Cheryl A. Lobo, Xiuli An, Deepa Manwani, Hui Zhong, Karina Yazdanbakhsh
Summary: Patients with sickle cell disease exhibit intravascular hemolysis-associated vascular injury and tissue damage. Classical monocytes in these patients show upregulation of interferon-alpha, which is correlated with total plasma heme levels. This hemolysis-induced response may lead to enhanced numbers of monocytes and macrophages, as well as increased expression of Fc receptor CD64, ultimately contributing to alloantibody-mediated erythrophagocytosis in SCD.
Article
Multidisciplinary Sciences
Hiroyasu Tsutsuki, Tianli Zhang, Kinnosuke Yahiro, Katsuhiko Ono, Yukio Fujiwara, Sunao Iyoda, Fan-Yan Wei, Kazuaki Monde, Kazuko Seto, Makoto Ohnishi, Hiroyuki Oshiumi, Takaaki Akaike, Tomohiro Sawa
Summary: SubAB inhibits the activation of the NLRP3 inflammasome and the production of interleukins in murine macrophages through ER stress signaling, which may be associated with the survival and pathogenicity of STEC strains in hosts.
Article
Fisheries
Zhendong Qin, V. Sarath Babu, Yanan Li, Fei Shi, Fanbin Zhan, Chun Liu, Jun Li, Li Lin
Summary: This study reveals that hemorrhagic venereal infection or tissue injury can result in the release of hemoglobin, which induces oxidative stress and inflammation in head-kidney macrophages. The oxidative activity of hemoglobin upregulates proinflammatory cytokine expression and induces apoptosis in macrophages.
Article
Cardiac & Cardiovascular Systems
Mingming Liu, Meng Yan, Jinlong He, Huizhen Lv, Zhipeng Chen, Liyuan Peng, Wenbin Cai, Fang Yao, Chen Chen, Lei Shi, Kai Zhang, Xu Zhang, Dao-Wen Wang, Li Wang, Yi Zhu, Ding Ai
Summary: Inhibition of MST1/2 exacerbates cardiac dysfunction post-MI by affecting macrophage subtype distribution and LTB4 production.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Marco Buscetta, Marta Cristaldi, Maura Cimino, Agnese La Mensa, Paola Dino, Fabio Bucchieri, Francesca Rappa, Santina Amato, Tommaso Silvano Aronica, Elisabetta Pace, Alessandro Bertani, Chiara Cipollina
Summary: The mechanisms and consequences of GSDMD activation in cigarette smoke-associated inflammation and lung disease are not well understood. This study shows that cigarette smoke extract (CSE) can activate caspase-1 and induce GSDMD cleavage and increased cell permeability. The activation of caspase-4 and caspase-8 by CSE further promotes GSDMD cleavage. These findings suggest that ASC-independent activation of caspase-1, -4, and -8 and subsequent GSDMD cleavage may contribute to macrophage dysfunction and chronic inflammation in the lungs of smokers.
Article
Medicine, General & Internal
Julie Kanter, Mark C. Walters, Lakshmanan Krishnamurti, Markus Y. Mapara, Janet L. Kwiatkowski, Stacey Rifkin-Zenenberg, Banu Aygun, Kimberly A. Kasow, Francis J. Pierciey, Melissa Bonner, Alex Miller, Xinyan Zhang, Jessie Lynch, Dennis Kim, Jean-Antoine Ribeil, Mohammed Asmal, Sunita Goyal, Alexis A. Thompson, John F. Tisdale
Summary: The LentiGlobin gene therapy for sickle cell disease showed promising results, with significant improvements in hemoglobin levels and complete resolution of severe vaso-occlusive events in 35 patients. Adverse events related to treatment were minimal and no cases of hematologic cancer were observed during the follow-up period. Preliminary findings suggest the potential therapeutic efficacy of this treatment.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, Research & Experimental
Yunfeng Liu, Shan Su, Sarah Shayo, Weili Bao, Mouli Pal, Kai Dou, Patricia A. Shi, Banu Aygun, Sally Campbell-Lee, Cheryl A. Lobo, Avital Mendelson, Xiuli An, Deepa Manwani, Hui Zhong, Karina Yazdanbakhsh
Summary: This study identifies the mechanisms governing monocyte/macrophage differentiation in sickle cell disease (SCD). Hemolysis stimulates CSF-1 production, promoting differentiation into blood patrolling monocytes (PMo), while also upregulating CCL-2, inducing differentiation into tissue monocyte-derived macrophages. The balance between these factors is clinically significant, and targeting the CSF-1/CCL-2 ratio may have diagnostic and therapeutic implications in SCD.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Nutrition & Dietetics
Elek Gergo Kovacs, Ahmad Alatshan, Marietta Margit Budai, Zsolt Czimmerer, Eduard Biro, Szilvia Benko
Summary: In addition to its well-known psychoactive effects, caffeine has a wide range of actions that can regulate physiological mechanisms and modulate immune responses. This study showed that caffeine affects the secretion of inflammatory cytokines and signaling pathways in different subpopulations of human monocyte-derived macrophages, with a potential modulatory role in the upregulation of NLRP3 inflammasome-mediated IL-1 beta secretion.
Review
Biochemistry & Molecular Biology
Wenjing Ren, Patrizia Rubini, Yong Tang, Tobias Engel, Peter Illes
Summary: Macrophages are mononuclear phagocytes that can be derived from blood-borne monocytes or exist as resident macrophages in peripheral and central tissues. They have M1 and M2 phenotypes and possess P2X7 receptors that respond to ATP and induce inflammatory responses and diseases. Therefore, P2X7 receptors on macrophages may be important targets for maintaining immune homeostasis and treating inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Sergio D. Catz
Summary: S100A8 and S100A9, cytosolic alarmins with autocrine functions, are shown to be secreted in response to E-selectin through rapid and transient gasdermin-D pore formation, without inducing pyroptosis.
Review
Immunology
Qun Yu, Maojuan Guo, Wenyun Zeng, Miao Zeng, Xiaolu Zhang, Yue Zhang, Wenlan Zhang, Xijuan Jiang, Bin Yu
Summary: The focus is on the interaction between NLRP3 inflammasome activation and glycolysis in macrophages, as well as the mechanism of small molecule compounds regulating glycolysis to influence the activation of NLRP3 inflammasomes. The results of the study may contribute to the development of new drugs for NLRP3 inflammasome-related diseases.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Pharmacology & Pharmacy
Dilpreet Kour, Mehboob Ali, Parul Khajuria, Kuhu Sharma, Palash Ghosh, Sukhleen Kaur, Surbhi Mahajan, P. Ramajayan, Sonali S. Bharate, Subhash Bhardwaj, Sanghapal D. Sawant, D. Srinivasa Reddy, Ajay Kumar
Summary: Sickle cell disease (SCD) is characterized by complications arising from the sickling of erythrocytes due to a point mutation in the beta-globin chain of hemoglobin. Flurbiprofen, a COX-2 inhibitor, was found to be a potent inhibitor of heme-induced NLRP3 inflammasome, providing potential for pain management and disease modification in SCD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shi Yu, Jack Green, Rose Wellens, Gloria Lopez-Castejon, David Brough
Summary: The inhibition of V-ATPase has been shown to exacerbate LPS-induced NLRP3 inflammasome activation in primary human monocytes, leading to an alternative pathway characterized by NLRP3-dependent, K+ efflux-independent, ASC oligomerization and caspase-1 activation. This suggests that V-ATPases play additional roles during NLRP3 inflammasome activation in primary human monocytes.
Article
Hematology
Slimane Allali, Rachel Rignault-Bricard, Mariane de Montalembert, Melissa Taylor, Tahar Bouceba, Olivier Hermine, Thiago Trovati Maciel
Summary: Monocyte activation and systemic inflammation in sickle cell disease (SCD) are associated with the interaction between hemoglobin S (HbS) and Toll-like receptor 4 (TLR4), resulting in the expression of proinflammatory cytokines through the NF-KB and type I interferon pathways. This finding provides new insights for therapeutic approaches targeting the HbS-TLR4 interaction in SCD.
Article
Biochemistry & Molecular Biology
Wenyao Su, Qiying Nong, Jie Wu, Ruihong Fan, Yuanting Liang, Anyi Hu, Zhongxiang Gao, Weihui Liang, Qifei Deng, Hailan Wang, Lihua Xia, Yongshun Huang, Yiru Qin, Na Zhao
Summary: This study found that bone marrow mesenchymal stem cells (BMSCs) attenuate silica-induced acute pulmonary inflammation by inhibiting NLRP3 inflammasome pathways in lung macrophages. Additionally, the study identified tumor necrosis factor-stimulated gene 6 (TSG-6) as a key paracrine secretion factor released from BMSCs, which exerts a protective effect by regulating the activation of inflammasome in macrophages. Treatment with exogenous recombinant mouse TSG-6 also showed similar effects in attenuating silica-induced inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
