Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management

Plasma levels of advanced glycation end products are associated with haemolysis-related organ complications in sickle cell patients

(2010) Erfan Nur et al.   BRITISH JOURNAL OF HAEMATOLOGY

Comparison of Clinically Used and Experimental Iron Chelators for Protection against Oxidative Stress-Induced Cellular Injury

(2010) Petra Bendova et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Effect of Oral Arginine Supplementation on Exhaled Nitric Oxide Concentration in Sickle Cell Anemia and Acute Chest Syndrome

(2010) Kevin Joseph Sullivan et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

The systems biology-based argument for taking a bold step in chemoprophylaxis of sickle vasculopathy

(2009) Robert P. Hebbel*   AMERICAN JOURNAL OF HEMATOLOGY

Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions

(2009) Gregory J. Kato et al.   AMERICAN JOURNAL OF HEMATOLOGY

The cost of health care for children and adults with sickle cell disease

(2009) Teresa L. Kauf et al.   AMERICAN JOURNAL OF HEMATOLOGY

Antisickling property of fetal hemoglobin enhances nitric oxide bioavailability and ameliorates organ oxidative stress in transgenic-knockout sickle mice

(2009) Trisha Dasgupta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Hydroxyurea-Induced Expression of Glutathione Peroxidase 1 in Red Blood Cells of Individuals with Sickle Cell Anemia

(2009) Chun-Seok Cho et al.   ANTIOXIDANTS & REDOX SIGNALING

Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death

(2009) Gregory J. Kato et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hematologic, biochemical, and cardiopulmonary effects of l-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy

(2009) Jane A. Little et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Circulating erythrocyte-derived microparticles are associated with coagulation activation in sickle cell disease

(2009) E. J. van Beers et al.   HAEMATOLOGICA

The proverbial chicken or the egg? Dissection of the role of cell-free hemoglobin versus reactive oxygen species in sickle cell pathophysiology

(2008) Megan L. Krajewski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress

(2008) Dhananjay K. Kaul et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Red blood cells induce hypoxic lung inflammation

(2008) R. Kiefmann et al.   BLOOD

Heme degradation and oxidative stress in murine models for hemoglobinopathies: Thalassemia, sickle cell disease and hemoglobin C disease

(2008) Enika Nagababu et al.   BLOOD CELLS MOLECULES AND DISEASES

Hypercoagulability in Sickle Cell Disease and Beta-Thalassemia

(2008) Sylvia Singer et al.   CURRENT MOLECULAR MEDICINE

Association of asymmetric dimethylarginine with sickle cell disease-related pulmonary hypertension

(2008) P. P. Landburg et al.   HAEMATOLOGICA

Sickle cell disease-related organ damage occurs irrespective of pain rate: implications for clinical practice

(2008) E. J. van Beers et al.   HAEMATOLOGICA

Fermented papaya preparation as redox regulator in blood cells ofβ-thalassemic mice and patients

(2008) Johnny Amer et al.   PHYTOTHERAPY RESEARCH

Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in sickle cell disease patients

(2008) Bin Bao et al.   Translational Research

N-acetylcysteine amide (AD4) attenuates oxidative stress in beta-thalassemia blood cells

(2007) Johnny Amer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS