Absence of hydroxyurea‐induced mutational effects supports higher utilisation for the treatment of sickle cell anaemia

Current management strategies for polycythemia vera and essential thrombocythemia

(2020) Paola Guglielmelli et al.   BLOOD REVIEWS

Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage

(2019) Kelvin W. Pond et al.   PLoS Genetics

Predictions of genotoxic potential, mode of action, molecular targets, and potency via a tiered multiflow® assay data analysis strategy

(2019) Stephen D. Dertinger et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Pig‐a gene mutation database

(2019) Jennifer M. Shemansky et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

3Rs friendly study designs facilitate rat liver and blood micronucleus assays and Pig‐a gene mutation assessments: Proof‐of‐concept with 13 reference chemicals

(2019) Stephen D. Dertinger et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Treatment Patterns and Blood Counts in Patients With Polycythemia Vera Treated With Hydroxyurea in the United States: An Analysis From the REVEAL Study

(2019) Michael R. Grunwald et al.   Clinical Lymphoma Myeloma & Leukemia

The mutagenesis moonshot: The propitious beginnings of the environmental mutagenesis and genomics society

(2019) David M. DeMarini   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Genetic toxicology in silico protocol

(2019) Catrin Hasselgren et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Second cancers in MPN: Survival analysis from an international study

(2019) Monia Marchetti et al.   AMERICAN JOURNAL OF HEMATOLOGY

Guidelines for the use of hydroxycarbamide in children and adults with sickle cell disease

(2018) Amrana Qureshi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hydroxyurea (hydroxycarbamide) genotoxicity in pediatric patients with sickle cell disease

(2018) Anar Rodriguez et al.   PEDIATRIC BLOOD & CANCER

Glycosylphosphatidylinositol (GPI) anchored protein deficiency serves as a reliable reporter of Pig-a gene Mutation: Support from an in vitro assay based on L5178Y/Tk +/− cells and the CD90.2 antigen

(2017) Jeffrey C. Bemis et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Sickle cell disease

(2017) Russell E Ware et al.   LANCET

Investigating the Generalizability of the MultiFlow ® DNA Damage Assay and Several Companion Machine Learning Models With a Set of 103 Diverse Test Chemicals

(2017) Steven M Bryce et al.   TOXICOLOGICAL SCIENCES

Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach

(2016) Steven M. Bryce et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Risk of individual malignant neoplasms in patients with sickle cell disease: English national record linkage study

(2016) Olena O Seminog et al.   JOURNAL OF THE ROYAL SOCIETY OF MEDICINE

Frequency and prognostic value of resistance/intolerance to hydroxycarbamide in 890 patients with polycythaemia vera

(2015) Alberto Alvarez-Larrán et al.   BRITISH JOURNAL OF HAEMATOLOGY

Mutation analysis with random DNA identifiers (MARDI) catalogsPig-amutations in heterogeneous pools of CD48-deficient T cells derived from DMBA-treated rats

(2015) Javier R. Revollo et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Empirical analysis of BMD metrics in genetic toxicology part I:in vitroanalyses to provide robust potency rankings and support MOA determinations

(2015) John W. Wills et al.   MUTAGENESIS

Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats

(2015) Javier Revollo et al.   MUTAGENESIS

The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup

(2015) B. Bhaskar Gollapudi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Targeted single molecule mutation detection with massively parallel sequencing

(2015) Mark T. Gregory et al.   NUCLEIC ACIDS RESEARCH

Increased incidence of another cancer in myeloproliferative neoplasms patients at the time of diagnosis

(2014) Helna Pettersson et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Management of Sickle Cell Disease

(2014) Barbara P. Yawn et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Survival and prognosis among 1545 patients with contemporary polycythemia vera: an international study

(2013) A Tefferi et al.   LEUKEMIA

Detection of ultra-rare mutations by next-generation sequencing

(2012) M. W. Schmitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Monitoring of In Vivo Pig-a Gene Mutation and Chromosomal Damage: Summary of 7 Published Studies and Results From 11 New Reference Compounds

(2012) Stephen D. Dertinger et al.   TOXICOLOGICAL SCIENCES

Chronic myeloproliferative neoplasms and subsequent cancer risk: a Danish population-based cohort study

(2011) H. Frederiksen et al.   BLOOD

Chromosome damage and repair in children with sickle cell anaemia and long-term hydroxycarbamide exposure

(2011) Patrick T. McGann et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Integration of Pig-a, micronucleus, chromosome aberration, and comet assay endpoints in a 28-day rodent toxicity study with 4-nitroquinoline-1-oxide

(2011) Leon F. Stankowski et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Need and potential value of the Pig-ain vivo mutation assay-A hesi perspective

(2011) Maik Schuler et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Treatment-Related Risk Factors for Transformation to Acute Myeloid Leukemia and Myelodysplastic Syndromes in Myeloproliferative Neoplasms

(2011) Magnus Björkholm et al.   JOURNAL OF CLINICAL ONCOLOGY

Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)

(2011) Winfred C Wang et al.   LANCET

When pigs fly: Immunomagnetic separation facilitates rapid determination of Pig-a mutant frequency by flow cytometric analysis

(2011) Stephen D. Dertinger et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Genotoxicity associated with hydroxyurea exposure in infants with sickle cell anemia: Results from the BABY-HUG phase III clinical trial

(2011) Patrick T. McGann et al.   PEDIATRIC BLOOD & CANCER

The ToxTracker Assay: Novel GFP Reporter Systems that Provide Mechanistic Insight into the Genotoxic Properties of Chemicals

(2011) Giel Hendriks et al.   TOXICOLOGICAL SCIENCES

Reflections on the origins and evolution of genetic toxicology and the environmental mutagen society

(2010) John S. Wassom et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

In vitro genotoxicity testing using the micronucleus assay in cell lines, human lymphocytes and 3D human skin models

(2010) M. Kirsch-Volders et al.   MUTAGENESIS

Assessment of genotoxicity associated with hydroxyurea therapy in children with sickle cell anemia

(2010) Jonathan M. Flanagan et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies

(2010) Andreas Rothfuss et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities—Report from an ECVAM workshop

(2009) Stefan Pfuhler et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

DNA damage in blood leukocytes of individuals with sickle cell disease treated with hydroxyurea

(2007) João Ricardo Friedrisch et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS