Recent Advancement in Therapeutic Strategies for Alzheimer’s Disease: Insights from Clinical Trials

Comprehensive perspective towards the management of proteinopathies by elucidating protein misfolding and aggregation

(2023) Asimul Islam et al.   CNS & Neurological Disorders-Drug Targets

Aggregation of irisin and its prevention by trehalose: A biophysical approach

(2023) Rashid Waseem et al.   JOURNAL OF MOLECULAR STRUCTURE

Role of sugar osmolytes and their nano-counterparts as inhibitors in protein fibrillation

(2023) Danish Alam et al.   JOURNAL OF MOLECULAR LIQUIDS

FNDC5/Irisin: Physiology and Pathophysiology

(2022) Rashid Waseem et al.   MOLECULES

Unraveling the Binding Mechanism of Alzheimer’s Drugs with Irisin: Spectroscopic, Calorimetric, and Computational Approaches

(2022) Rashid Waseem et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Amyloid Cross-Seeding: Mechanism, Implication, and Inhibition

(2022) Sushma Subedi et al.   MOLECULES

Impact of Anti-amyloid-β Monoclonal Antibodies on the Pathology and Clinical Profile of Alzheimer’s Disease: A Focus on Aducanumab and Lecanemab

(2022) Mingchao Shi et al.   Frontiers in Aging Neuroscience

Immunotherapy for Alzheimer’s disease: targeting β-amyloid and beyond

(2022) Chenghuan Song et al.   Translational Neurodegeneration

Characterization of advanced glycation end products and aggregates of irisin: Multispectroscopic and microscopic approaches

(2022) Rashid Waseem et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Lecanemab for Alzheimer's disease: tempering hype and hope

(2022) The Lancet   LANCET

Lecanemab in Early Alzheimer’s Disease

(2022) Christopher H. van Dyck et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial Dysfunction: Pathophysiology and Mitochondria-Targeted Drug Delivery Approaches

(2022) Tanzeel Khan et al.   Pharmaceutics

An Insight Into Mitochondrial Dysfunction and its Implications in Neuro-logical Diseases

(2021) Asimul Islam et al.   CURRENT DRUG TARGETS

Absence of metabotropic glutamate receptor homolog(s) accelerates acetylcholine neurotransmission in Caenorhabditis elegans

(2021) Girish Sadananda et al.   NEUROSCIENCE LETTERS

Heparin Accelerates the Protein Aggregation via the Downhill Polymerization Mechanism: Multi-Spectroscopic Studies to Delineate the Implications on Proteinopathies

(2021) Ishfaq Ahmad Ahanger et al.   ACS Omega

Journey on Naphthoquinone and Anthraquinone Derivatives: New Insights in Alzheimer’s Disease

(2021) Marta Campora et al.   Pharmaceuticals

Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation

(2021) Shweta Kishor Sonawane et al.   Cell Communication and Signaling

The Cholinergic System, the Adrenergic System and the Neuropathology of Alzheimer’s Disease

(2021) Rola A. Bekdash   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Donanemab in Early Alzheimer’s Disease

(2021) Mark A. Mintun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lithium and Therapeutic Targeting of GSK-3

(2021) Melinda E. Snitow et al.   Cells

Multispectroscopic and Molecular Docking Insight into Elucidating the Interaction of Irisin with Rivastigmine Tartrate: A Combinational Therapy Approach to Fight Alzheimer’s Disease

(2021) Rashid Waseem et al.   ACS Omega

Cardiovascular brain impulses in Alzheimer's disease

(2021) Zalán Rajna et al.   BRAIN

Aducanumab: First Approval

(2021) Sohita Dhillon   DRUGS

Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity

(2021) Bin Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer’s disease

(2021) Xiao-ying Sun et al.   Journal of Neuroinflammation

The Fumarprotocetraric Acid Inhibits Tau Covalently, Avoiding Cytotoxicity of Aggregates in Cells

(2021) Camila González et al.   MOLECULES

Safety and efficacy of anti-tau monoclonal antibody gosuranemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial

(2021) Tien Dam et al.   NATURE MEDICINE

A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease

(2021) Stephen Salloway et al.   NATURE MEDICINE

Intracerebroventricular injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer’s disease dementia: a phase I clinical trial

(2021) Hee Jin Kim et al.   Alzheimers Research & Therapy

Neuroprotective Natural Products for Alzheimer’s Disease

(2021) Xin Chen et al.   Cells

MAP/Microtubule Affinity Regulating Kinase 4 Inhibitory Potential of Irisin: A New Therapeutic Strategy to Combat Cancer and Alzheimer’s Disease

(2021) Rashid Waseem et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nilotinib Effects on Safety, Tolerability, and Biomarkers in Alzheimer's Disease

(2020) Raymond S. Turner et al.   ANNALS OF NEUROLOGY

The combined effects of microglia activation and brain glucose hypometabolism in early-onset Alzheimer’s disease

(2020) Giacomo Tondo et al.   Alzheimers Research & Therapy

Passive immunotherapies targeting Aβ and tau in Alzheimer's disease

(2020) Steven S. Plotkin et al.   NEUROBIOLOGY OF DISEASE

Targeting Amyloidogenic Processing of APP in Alzheimer’s Disease

(2020) Jing Zhao et al.   Frontiers in Molecular Neuroscience

Microtubule Affinity Regulating Kinase 4 with an Alzheimer’s disease-related mutation promotes tau accumulation and exacerbates neurodegeneration

(2020) Toshiya Oba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biophysical Elucidation of Fibrillation Inhibition by Sugar Osmolytes in α-Lactalbumin: Multispectroscopic and Molecular Docking Approaches

(2020) Sania Bashir et al.   ACS Omega

Emerge and Engage topline results: Phase 3 studies of aducanumab in early Alzheimer’s disease

(2020) Samantha Budd Haeberlein et al.   Alzheimers & Dementia

Neuroprotection offered by mesenchymal stem cells in perinatal brain injury: Role of mitochondria, inflammation, and reactive oxygen species

(2020) Syam Nair et al.   JOURNAL OF NEUROCHEMISTRY

Human Pluripotent Stem Cells-Based Therapies for Neurodegenerative Diseases: Current Status and Challenges

(2020) Elizabeth Ford et al.   Cells

Amyloid-β Immunotherapy for Alzheimer's Disease - Is It Now A Long Shot…?

(2019) Francesco Panza et al.   ANNALS OF NEUROLOGY

A walk through tau therapeutic strategies

(2019) Santosh Jadhav et al.   Acta Neuropathologica Communications

Spectroscopic, calorimetric and molecular docking insight into the interaction of Alzheimer’s drug Donepezil with human transferrin: Implications of Alzheimer’s drug

(2019) Anas Shamsi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

A Close Look at BACE1 Inhibitors for Alzheimer’s Disease Treatment

(2019) Brati Das et al.   CNS DRUGS

Single cell‐derived clonally expanded mesenchymal progenitor cells from somatic cell nuclear transfer‐derived pluripotent stem cells ameliorate the endometrial function in the uterus of a murine model with Asherman’s syndrome

(2019) Sung‐Min Jun et al.   CELL PROLIFERATION

Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer’s disease-like symptoms in animal model

(2019) Guru Krishnakumar Viswanathan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Unraveling Binding Mechanism of Alzheimer’s Drug Rivastigmine Tartrate with Human Transferrin: Molecular Docking and Multi-Spectroscopic Approach towards Neurodegenerative Diseases

(2019) Anas Shamsi et al.   Biomolecules

Nanobiocatalyst facilitated aglycosidic quercetin as a potent inhibitor of tau protein aggregation

(2019) Sanjay Kumar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome

(2019) Richard M. Tsai et al.   JAMA Neurology

Usnic acid derivatives as tau-aggregation and neuroinflammation inhibitors

(2019) Cun-Jian Shi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer’s disease: a PET substudy interim analysis

(2019) Gregory Klein et al.   Alzheimers Research & Therapy

Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise

(2018) Christopher H. van Dyck   BIOLOGICAL PSYCHIATRY

Fibre-specific white matter reductions in Alzheimer’s disease and mild cognitive impairment

(2018) Remika Mito et al.   BRAIN

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease

(2018) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease

(2018) Lawrence S. Honig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β

(2018) Joseph W. Arndt et al.   Scientific Reports

Gantenerumab: A Novel Human Anti-Aβ Antibody Demonstrates Sustained Cerebral Amyloid-β Binding and Elicits Cell-Mediated Removal of Human Amyloid-β

(2018) Bernd Bohrmann et al.   JOURNAL OF ALZHEIMERS DISEASE

Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models

(2018) Era Taoufik et al.   Open Biology

Advances in developing novel therapeutic strategies for Alzheimer’s disease

(2018) Jiqing Cao et al.   Molecular Neurodegeneration

Clinical PET Imaging of Microglial Activation: Implications for Microglial Therapeutics in Alzheimer’s Disease

(2018) Zhiwei Shen et al.   Frontiers in Aging Neuroscience

Emerging treatments for Alzheimer’s disease for non-amyloid and non-tau targets

(2017) Ayesha Khan et al.   Expert Review of Neurotherapeutics

Nerve growth factor-loaded heparinized cationic solid lipid nanoparticles for regulating membrane charge of induced pluripotent stem cells during differentiation

(2017) Yung-Chih Kuo et al.   Materials Science & Engineering C-Materials for Biological Applications

Pancreatic differentiation of induced pluripotent stem cells in activin A-grafted gelatin-poly(lactide- co -glycolide) nanoparticle scaffolds with induction of LY294002 and retinoic acid

(2017) Yung-Chih Kuo et al.   Materials Science & Engineering C-Materials for Biological Applications

Tau-based therapies in neurodegeneration: opportunities and challenges

(2017) Chuanzhou Li et al.   NATURE REVIEWS DRUG DISCOVERY

Semagacestat Is a Pseudo-Inhibitor of γ-Secretase

(2017) Shinji Tagami et al.   Cell Reports

Emerging treatments for Alzheimer’s disease for non-amyloid and non-tau targets

(2017) Ayesha Khan et al.   Expert Review of Neurotherapeutics

Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms

(2017) Andrew Kneynsberg et al.   Frontiers in Neuroscience

Modified Immunotherapies Against Alzheimer's Disease: Toward Safer and Effective Amyloid-β Clearance

(2017) Yan-Jiang Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Deposition of amyloid β in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy

(2016) Abby Keable et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Dynamic relationships between age, amyloid-β deposition, and glucose metabolism link to the regional vulnerability to Alzheimer’s disease

(2016) Hwamee Oh et al.   BRAIN

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

(2016) Serge Gauthier et al.   LANCET

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Effect of systemic transplantation of bone marrow-derived mesenchymal stem cells on neuropathology markers in APP/PS1 Alzheimer mice

(2016) Y. Naaldijk et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease

(2016) Joana S. Cristóvão et al.   Oxidative Medicine and Cellular Longevity

Mutated tau, amyloid and neuroinflammation in Alzheimer disease—A brief review

(2016) A.S.M. Hung et al.   PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY

Drug development in Alzheimer’s disease: the path to 2025

(2016) Jeffrey Cummings et al.   Alzheimers Research & Therapy

Human Neural Stem Cell Transplantation Rescues Cognitive Defects in APP/PS1 Model of Alzheimer’s Disease by Enhancing Neuronal Connectivity and Metabolic Activity

(2016) Xueyuan Li et al.   Frontiers in Aging Neuroscience

Nilotinib Effects in Parkinson’s disease and Dementia with Lewy bodies

(2016) Fernando Pagan et al.   Journal of Parkinsons Disease

Protein-Induced Pluripotent Stem Cells Ameliorate Cognitive Dysfunction and Reduce Aβ Deposition in a Mouse Model of Alzheimer's Disease

(2016) Moon-Yong Cha et al.   Stem Cells Translational Medicine

Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer’s Disease

(2016) Francesco Panza et al.   Biomed Research International

Pluripotent Stem Cells: Current Understanding and Future Directions

(2016) Antonio Romito et al.   Stem Cells International

Azaphilones Inhibit Tau Aggregation and Dissolve Tau Aggregates in Vitro

(2015) Smita R. Paranjape et al.   ACS Chemical Neuroscience

Human Umbilical Cord Mesenchymal Stem Cells: A New Era for Stem Cell Therapy

(2015) Dah-Ching Ding et al.   CELL TRANSPLANTATION

Transplantation of placenta-derived mesenchymal stem cells reduces hypoxic-ischemic brain damage in rats by ameliorating the inflammatory response

(2015) Hongfang Ding et al.   Cellular & Molecular Immunology

Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease

(2015) Robert Baranello et al.   Current Alzheimer Research

Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss

(2015) Rahasson R. Ager et al.   HIPPOCAMPUS

Neural stem cell transplantation decreases neuroinflammation in a transgenic mouse model of Alzheimer's disease

(2015) Qi Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

The Role of Cdk5 in Alzheimer’s Disease

(2015) Shu-Lei Liu et al.   MOLECULAR NEUROBIOLOGY

Human neural stem cells alleviate Alzheimer-like pathology in a mouse model

(2015) Il-Shin Lee et al.   Molecular Neurodegeneration

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

A review on Alzheimer's disease pathophysiology and its management: an update

(2015) Anil Kumar et al.   Pharmacological Reports

GDF-15 Secreted from Human Umbilical Cord Blood Mesenchymal Stem Cells Delivered Through the Cerebrospinal Fluid Promotes Hippocampal Neurogenesis and Synaptic Activity in an Alzheimer's Disease Model

(2015) Dong Hyun Kim et al.   STEM CELLS AND DEVELOPMENT

A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer’s disease

(2015) Haakon B Nygaard et al.   Alzheimers Research & Therapy

Targeting Prodromal Alzheimer Disease With Avagacestat

(2015) Vladimir Coric et al.   JAMA Neurology

Neural Stem Cell Transplant-Induced Effect on Neurogenesis and Cognition in Alzheimer Tg2576 Mice Is Inhibited by Concomitant Treatment with Amyloid-Lowering or Cholinergicα7 Nicotinic Receptor Drugs

(2015) Anna M. Lilja et al.   NEURAL PLASTICITY

Progress toward the development of in vitro model system for chemical-induced developmental neurotoxicity: potential applicability of stem cells

(2014) V. Kumar et al.   ARCHIVES OF TOXICOLOGY

Characterization of New Specific Copper Chelators as Potential Drugs for the Treatment of Alzheimer’s Disease

(2014) Michel Nguyen et al.   CHEMISTRY-A EUROPEAN JOURNAL

The green tea polyphenol (−)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios

(2014) Heike J. Wobst et al.   FEBS LETTERS

OGlcNAcylation and Phosphorylation Have Opposing Structural Effects in tau: Phosphothreonine Induces Particular Conformational Order

(2014) Michael A. Brister et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting the β secretase BACE1 for Alzheimer's disease therapy

(2014) Riqiang Yan et al.   LANCET NEUROLOGY

Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies

(2014) Pradip K. Kamat et al.   MOLECULAR NEUROBIOLOGY

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxidative Stress in Alzheimer’s Disease: Why Did Antioxidant Therapy Fail?

(2014) Torbjörn Persson et al.   Oxidative Medicine and Cellular Longevity

Inhibition of Tau Aggregation by Three Aspergillus nidulans Secondary Metabolites: 2,ω-Dihydroxyemodin, Asperthecin, and Asperbenzaldehyde

(2014) Smita Paranjape et al.   PLANTA MEDICA

Degradation of amyloid beta by human induced pluripotent stem cell-derived macrophages expressing Neprilysin-2

(2014) Koutaro Takamatsu et al.   Stem Cell Research

Drug-like chelating agents: a potential lead for Alzheimer's disease

(2014) Wenhai Huang et al.   RSC Advances

Fyn kinase inhibition as a novel therapy for Alzheimer’s disease

(2014) Haakon B Nygaard et al.   Alzheimers Research & Therapy

First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model

(2014) Eva Kontsekova et al.   Alzheimers Research & Therapy

Therapeutic effects of the transplantation of VEGF overexpressing bone marrow mesenchymal stem cells in the hippocampus of murine model of Alzheimer’s disease

(2014) Karina O. Garcia et al.   Frontiers in Aging Neuroscience

Fetal stem cell transplantation: Past, present, and future

(2014) Tetsuya Ishii   World Journal of Stem Cells

Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease

(2013) Masha G. Savelieff et al.   ACS Chemical Biology

Mesenchymal stem cells: a new trend for cell therapy

(2013) Xin Wei et al.   ACTA PHARMACOLOGICA SINICA

Molecular Hairpin: A Possible Model for Inhibition of Tau Aggregation by Tannic Acid

(2013) Junliang Yao et al.   BIOCHEMISTRY

In vivo characterization of the early states of the amyloid-beta network

(2013) Jorge Sepulcre et al.   BRAIN

Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery

(2013) Daniel Tornero et al.   BRAIN

Microtubule Affinity-Regulating Kinase 4: Structure, Function, and Regulation

(2013) Farha Naz et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Alzheimer’s Disease and Antioxidant Therapy: How Long How Far?

(2013) J. Teixeira et al.   CURRENT MEDICINAL CHEMISTRY

Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons

(2013) Elisa M. Ramser et al.   MOLECULAR BIOLOGY OF THE CELL

Restoration of spatial memory dysfunction of human APP transgenic mice by transplantation of neuronal precursors derived from human iPS cells

(2013) Naruyoshi Fujiwara et al.   NEUROSCIENCE LETTERS

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Totipotency: What It Is and What It Is Not

(2013) Maureen L. Condic   STEM CELLS AND DEVELOPMENT

Placenta-derived mesenchymal stem cells improve memory dysfunction in an Aβ1–42-infused mouse model of Alzheimer’s disease

(2013) H-M Yun et al.   Cell Death & Disease

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Are Tau Aggregates Toxic or Protective in Tauopathies?

(2013) Catherine M. Cowan et al.   Frontiers in Neurology

BMS-708,163 Targets Presenilin and Lacks Notch-Sparing Activity

(2012) Christina J. Crump et al.   BIOCHEMISTRY

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Multicenter, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending Dose Study of the Oral γ-Secretase Inhibitor BMS-708163 (Avagacestat): Tolerability Profile, Pharmacokinetic Parameters, and Pharmacodynamic Markers

(2012) Gary Tong et al.   CLINICAL THERAPEUTICS

Roles of Glycogen Synthase Kinase 3 in Alzheimer’s Disease

(2012) Zhiyou Cai et al.   Current Alzheimer Research

Self-Renewal and Differentiation of Reactive Astrocyte-Derived Neural Stem/Progenitor Cells Isolated from the Cortical Peri-Infarct Area after Stroke

(2012) I. S. Shimada et al.   JOURNAL OF NEUROSCIENCE

Embryonic stem cell trials for macular degeneration: a preliminary report

(2012) Steven D Schwartz et al.   LANCET

Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study

(2012) Bengt Winblad et al.   LANCET NEUROLOGY

Immunotherapy for Alzheimer disease—the challenge of adverse effects

(2012) Yu-Hui Liu et al.   Nature Reviews Neurology

The Novel BACE Inhibitor MK-8931 Dramatically Lowers CSF A  Peptides in Healthy Subjects: Results from a Rising Single Dose Study (PL02.004)

(2012) M. Forman et al.   NEUROLOGY

Intraspinal Stem Cell Transplantation in Amyotrophic Lateral Sclerosis

(2012) Jonathan Riley et al.   NEUROSURGERY

The Preventive and Therapeutic Effects of Intravenous Human Adipose-Derived Stem Cells in Alzheimer’s Disease Mice

(2012) Saeromi Kim et al.   PLoS One

Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models

(2011) Xiyun Chai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Naturally Occurring Autoantibodies against  -Amyloid: Investigating Their Role in Transgenic Animal and In Vitro Models of Alzheimer's Disease

(2011) R. Dodel et al.   JOURNAL OF NEUROSCIENCE

Robust Amyloid Clearance in a Mouse Model of Alzheimer's Disease Provides Novel Insights into the Mechanism of Amyloid-  Immunotherapy

(2011) A. Wang et al.   JOURNAL OF NEUROSCIENCE

Resveratrol Inhibits Cdk5 Activity through Regulation of p35 Expression

(2011) Elias Utreras et al.   Molecular Pain

Induction of human neuronal cells by defined transcription factors

(2011) Zhiping P. Pang et al.   NATURE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Rescue of neurons from undergoing hallmark tau-induced Alzheimer's disease cell pathologies by the antimitotic drug paclitaxel

(2011) Or A. Shemesh et al.   NEUROBIOLOGY OF DISEASE

Immunotherapy for Alzheimer’s disease

(2010) D. Morgan   JOURNAL OF INTERNAL MEDICINE

Generation and Therapeutic Efficacy of Highly Oligomer-Specific  -Amyloid Antibodies

(2010) H. Hillen et al.   JOURNAL OF NEUROSCIENCE

Nuclear reprogramming to a pluripotent state by three approaches

(2010) Shinya Yamanaka et al.   NATURE

The Genetics of Alzheimer Disease: Back to the Future

(2010) Lars Bertram et al.   NEURON

Tau protein and tau aggregation inhibitors

(2010) Bruno Bulic et al.   NEUROPHARMACOLOGY

Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy

(2010) Elina Zotova et al.   Alzheimers Research & Therapy

Calcium and cell death signaling in neurodegeneration and aging

(2009) Soraya Smaili et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

Transplantation of primed or unprimed mouse embryonic stem cell-derived neural precursor cells improves cognitive function in Alzheimerian rats

(2009) Farshad Homayouni Moghadam et al.   DIFFERENTIATION

A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis

(2009) G. Di Fede et al.   SCIENCE

Intracerebral Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta Deposition and Rescues Memory Deficits in Alzheimer's Disease Mice by Modulation of Immune Responses

(2009) Jong Kil Lee et al.   STEM CELLS

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Clearance mechanisms of Alzheimer's amyloid-β peptide: implications for therapeutic design and diagnostic tests

(2008) K A Bates et al.   MOLECULAR PSYCHIATRY

Embryonic stem cell-derived neural precursor cells improve memory dysfunction in Aβ(1–40) injured rats

(2008) Jun Tang et al.   NEUROSCIENCE RESEARCH

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

(2003) H. F. Dovey et al.   JOURNAL OF NEUROCHEMISTRY