Role of sugar osmolytes and their nano-counterparts as inhibitors in protein fibrillation

COVID-19 related outcomes among individuals with neurodegenerative diseases: a cohort analysis in the UK biobank

(2022) Yihan Hu et al.   BMC Neurology

Using Sugar-Derived Nanoparticles to Mitigate Amyloid Fibril Formation of Lysozyme

(2022) You-Ren Lai et al.   Journal of the Taiwan Institute of Chemical Engineers

Engineered Nanoparticle-Protein Interactions Influence Protein Structural Integrity and Biological Significance

(2022) Surabhi Jaiswal et al.   Nanomaterials

Protective Effect of Natural Products against Huntington’s Disease: An Overview of Scientific Evidence and Understanding Their Mechanism of Action

(2021) Pei Teng Lum et al.   ACS Chemical Neuroscience

Trehalose-based neuroprotective autophagy inducers

(2021) Giulia Assoni et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

(2021) Phuong H. Nguyen et al.   CHEMICAL REVIEWS

Effects of Surface Protein Adsorption on the Distribution and Retention of Intratumorally Administered Gold Nanoparticles

(2021) Rossana Terracciano et al.   Pharmaceutics

Trehalose Restrains the Fibril Load towards α-Lactalbumin Aggregation and Halts Fibrillation in a Concentration-Dependent Manner

(2021) Sania Bashir et al.   Biomolecules

Current Strategies for Modulating Aβ Aggregation with Multifunctional Agents

(2021) Zhi Du et al.   ACCOUNTS OF CHEMICAL RESEARCH

From Small Molecules to Synthesized Polymers: Potential Role in Combating Amyloidogenic Disorders

(2021) Pooja Ghosh et al.   ACS Chemical Neuroscience

Amyloid-type Protein Aggregation and Prion-like Properties of Amyloids

(2021) Dieter Willbold et al.   CHEMICAL REVIEWS

Surface functionalization – The way for advanced applications of smart materials

(2021) Karolina Wieszczycka et al.   COORDINATION CHEMISTRY REVIEWS

Recent advances in anticancer and antimicrobial activity of silver nanoparticles synthesized using phytochemicals and organic polymers

(2021) Irshad A Wani et al.   NANOTECHNOLOGY

Biomarkers for neurodegenerative diseases

(2021) Oskar Hansson   NATURE MEDICINE

Nanoparticle Size Effects in Biomedical Applications

(2021) Jayanta Dolai et al.   ACS Applied Nano Materials

Trehalose Conjugated, Catechin Loaded Polylactide Nanoparticle for Improved Neuroprotection against Intracellular Polyglutamine Aggregate

(2020) Suman Mandal et al.   BIOMACROMOLECULES

Bifunctional carbon dots for cell imaging and inhibition of human insulin fibrillation in the whole aggregation process

(2020) Bei-Bei Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Effect of osmolytes on in-vitro aggregation properties of peptides derived from TGFBIp

(2020) Anandalakshmi Venkatraman et al.   Scientific Reports

Effect of metallic nanoparticles on amyloid fibrils and their influence to neural cell toxicity

(2020) Marianna Barbalinardo et al.   Nano Research

Biopolymer-coated gold nanoparticles inhibit human insulin amyloid fibrillation

(2020) Brahmaiah Meesaragandla et al.   Scientific Reports

Nanochaperones: Potential therapeutic approach for conformational diseases

(2020) Patrick Gamez et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multifunctional Efficacy of Environmentally Benign Silver Nanospheres for Organic Transformation, Photocatalysis, and Water Remediation

(2020) Farha Naaz et al.   ACS Omega

Biophysical Elucidation of Fibrillation Inhibition by Sugar Osmolytes in α-Lactalbumin: Multispectroscopic and Molecular Docking Approaches

(2020) Sania Bashir et al.   ACS Omega

Investigating the effect of sugar-terminated nanoparticles on amyloid fibrillogenesis of β-lactoglobulin

(2020) Chien-Yu Lin et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Natural Compounds as Inhibitors of Aβ Peptide Aggregation: Chemical Requirements and Molecular Mechanisms

(2020) Katiuscia Pagano et al.   Frontiers in Neuroscience

Motor Learning Deficits in Parkinson's Disease (PD) and Their Effect on Training Response in Gait and Balance: A Narrative Review

(2019) Markey Olson et al.   Frontiers in Neurology

Defective sarcomere assembly in smyd1a and smyd1b zebrafish mutants

(2019) Mengxin Cai et al.   FASEB JOURNAL

Small molecules as therapeutic drugs for Alzheimer's disease

(2019) Darryll M.A. Oliver et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Polyphenols Modulate Alzheimer’s Amyloid Beta Aggregation in a Structure-Dependent Manner

(2019) Huong Phan et al.   Nutrients

Nanoparticles With a Specific Size and Surface Charge Promote Disruption of the Secondary Structure and Amyloid-Like Fibrillation of Human Insulin Under Physiological Conditions

(2019) Alyona Sukhanova et al.   Frontiers in Chemistry

Fibrinogen alpha amyloidosis: insights from proteomics

(2019) Jessica Chapman et al.   Expert Review of Proteomics

Molecular and macromolecular crowding-induced stabilization of proteins: Effect of dextran and its building block alone and their mixtures on stability and structure of lysozyme

(2019) Shayamita Ghosh et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies

(2019) S.D. Voulgaropoulou et al.   BRAIN RESEARCH

Azadiradione Restores Protein Quality Control and Ameliorates the Disease Pathogenesis in a Mouse Model of Huntington’s Disease

(2018) Brijesh Kumar Singh et al.   MOLECULAR NEUROBIOLOGY

Monitoring ALS from speech articulation kinematics

(2018) Pedro Gómez et al.   NEURAL COMPUTING & APPLICATIONS

Functional amyloid materials at surfaces/interfaces

(2018) Chen Li et al.   Biomaterials Science

Examining the effects of dextran-based polymer-coated nanoparticles on amyloid fibrillogenesis of human insulin

(2018) Ning-Hui Lu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

A deep learning approach for Parkinson’s disease diagnosis from EEG signals

(2018) Shu Lih Oh et al.   NEURAL COMPUTING & APPLICATIONS

A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis

(2018) Marcel Maier et al.   Science Translational Medicine

Effect of mammalian kidney osmolytes on the folding pathway of sheep serum albumin

(2017) Mohammad Aasif Dar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The molecular mass of dextran used to modify magnetite nanoparticles affects insulin amyloid aggregation

(2017) Katarina Siposova et al.   JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

Trehalose-Functionalized Gold Nanoparticle for Inhibiting Intracellular Protein Aggregation

(2017) Suman Mandal et al.   LANGMUIR

Synthesis of a novel glucose capped gold nanoparticle as a better theranostic candidate

(2017) Saritha Suvarna et al.   PLoS One

Sucrose modulates insulin amyloid-like fibril formation: effect on the aggregation mechanism and fibril morphology

(2017) Carlotta Marasini et al.   RSC Advances

Modulating protein amyloid aggregation with nanomaterials

(2017) Bo Wang et al.   Environmental Science-Nano

Future Therapeutics in Alzheimer’s Disease: Development Status of BACE Inhibitors

(2016) Genevieve Evin   BIODRUGS

The pH Dependence of Saccharides' Influence on Thermal Denaturation of Two Model Proteins Supports an Excluded Volume Model for Stabilization Generalized to Allow for Intramolecular Electrostatic Interactions

(2016) Ilyas Beg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extension of in vivo half-life of biologically active molecules by XTEN protein polymers

(2016) Vladimir N. Podust et al.   JOURNAL OF CONTROLLED RELEASE

One of the possible mechanisms of amyloid fibrils formation based on the sizes of primary and secondary folding nuclei of Aβ40 and Aβ42

(2016) Nikita V. Dovidchenko et al.   JOURNAL OF STRUCTURAL BIOLOGY

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Vitamin k3 inhibits protein aggregation: Implication in the treatment of amyloid diseases

(2016) Parvez Alam et al.   Scientific Reports

Relationship between protein stability and functional activity in the presence of macromolecular crowding agents alone and in mixture: An insight into stability-activity trade-off

(2015) Sumra Shahid et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Thermal Stabilization of Proteins by Mono- and Oligosaccharides: Measurement and Analysis in the Context of an Excluded Volume Model

(2015) Ilyas Beg et al.   BIOCHEMISTRY

Functional and Clinical Consequences of Novel α-Galactosidase A Mutations in Fabry Disease

(2015) Jan Lukas et al.   HUMAN MUTATION

Chitosan Oligosaccharides Inhibit/Disaggregate Fibrils and Attenuate Amyloid β-Mediated Neurotoxicity

(2015) Xueling Dai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of dextran on the thermodynamic stability and structure of ribonuclease A

(2015) Moin Ishrat et al.   Journal of the Iranian Chemical Society

Lanosterol reverses protein aggregation in cataracts

(2015) Ling Zhao et al.   NATURE

Targeting protein aggregation for the treatment of degenerative diseases

(2015) Yvonne S. Eisele et al.   NATURE REVIEWS DRUG DISCOVERY

Unraveling Comparative Anti-Amyloidogenic Behavior of Pyrazinamide and D-Cycloserine: A Mechanistic Biophysical Insight

(2015) Sumit Kumar Chaturvedi et al.   PLoS One

Type 2 diabetes as a protein misfolding disease

(2015) Abhisek Mukherjee et al.   TRENDS IN MOLECULAR MEDICINE

Inhibition of insulin fibrillation by osmolytes: Mechanistic Insights

(2015) Sinjan Choudhary et al.   Scientific Reports

Rationally Designed Peptoids Modulate Aggregation of Amyloid-Beta 40

(2014) J. Phillip Turner et al.   ACS Chemical Neuroscience

Quantification of Transthyretin Kinetic Stability in Human Plasma Using Subunit Exchange

(2014) Irit Rappley et al.   BIOCHEMISTRY

How to Determine the Size of Folding Nuclei of Protofibrils from the Concentration Dependence of the Rate and Lag-Time of Aggregation. I. Modeling the Amyloid Protofibril Formation

(2014) Nikita V. Dovidchenko et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain

(2014) C. B. Cooley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer’s Disease: Pathophysiology and Applications of Magnetic Nanoparticles as MRI Theranostic Agents

(2013) Houshang Amiri et al.   ACS Chemical Neuroscience

Protein aggregation in amyotrophic lateral sclerosis

(2013) Anna M. Blokhuis et al.   ACTA NEUROPATHOLOGICA

Inhibition of Protein Misfolding/Aggregation Using Polyglutamine Binding Peptide QBP1 as a Therapy for the Polyglutamine Diseases

(2013) H. Akiko Popiel et al.   Neurotherapeutics

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism for retardation of amyloid fibril formation by sugars in Vλ6 protein

(2013) Masahiro Abe et al.   PROTEIN SCIENCE

Disulfide bonds in amyloidogenesis diseases related proteins

(2013) Yang Li et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Carbon Nanoparticle-based Fluorescent Bioimaging Probes

(2013) Susanta Kumar Bhunia et al.   Scientific Reports

Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle

(2013) Shruti R Saptarshi et al.   JOURNAL OF NANOBIOTECHNOLOGY

Carbohydrate-Derived Hydrothermal Carbons: A Thorough Characterization Study

(2012) Linghui Yu et al.   LANGMUIR

Nanoparticle-mediated photothermal therapy: A comparative study of heating for different particle types

(2012) Varun P. Pattani et al.   LASERS IN SURGERY AND MEDICINE

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

(2012) Adrienne M Wang et al.   Nature Chemical Biology

Long-term survival after liver transplantation in patients with familial amyloid polyneuropathy

(2012) T. Yamashita et al.   NEUROLOGY

A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo

(2012) Shubhangi Prabhudesai et al.   Neurotherapeutics

Why is Glycine not a Part of the Osmoticum in the Urea-rich Cells?

(2012) Sheeza Khan et al.   PROTEIN AND PEPTIDE LETTERS

Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with Proteins

(2011) Seong Il Yoo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Binding of the Molecular Chaperone αB-Crystallin to Aβ Amyloid Fibrils Inhibits Fibril Elongation

(2011) Sarah L. Shammas et al.   BIOPHYSICAL JOURNAL

γ-Secretase Inhibitors and Modulators for the Treatment of Alzheimer's Disease: Disappointments and Hopes

(2011) Bruno P. Imbimbo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Effect of Nanoparticles on Amyloid Aggregation Depends on the Protein Stability and Intrinsic Aggregation Rate

(2011) C. Cabaleiro-Lago et al.   LANGMUIR

Dual Effect of Amino Modified Polystyrene Nanoparticles on Amyloid β Protein Fibrillation

(2010) Celia Cabaleiro-Lago et al.   ACS Chemical Neuroscience

Mechanism of Hen Egg White Lysozyme Adsorption on a Charged Solid Surface

(2010) Karina Kubiak-Ossowska et al.   LANGMUIR

Effect of Fe3O4magnetic nanoparticles on lysozyme amyloid aggregation

(2010) Andrea Bellova et al.   NANOTECHNOLOGY

Chemical and Structural Properties of Carbonaceous Products Obtained by Hydrothermal Carbonization of Saccharides

(2009) Marta Sevilla et al.   CHEMISTRY-A EUROPEAN JOURNAL

Hyperhemolysis syndrome in sickle cell disease

(2009) Nay Win   Expert Review of Hematology

Diseases of protein aggregation and the hunt for potential pharmacological agents

(2007) Steven S.-S. Wang et al.   Biotechnology Journal