Unraveling the Binding Mechanism of Alzheimer’s Drugs with Irisin: Spectroscopic, Calorimetric, and Computational Approaches

FNDC5/Irisin: Physiology and Pathophysiology

(2022) Rashid Waseem et al.   MOLECULES

Implications of tempol in pyruvate dehydrogenase kinase 3 targeted anticancer therapeutics: Computational, spectroscopic, and calorimetric studies

(2022) Saleha Anwar et al.   JOURNAL OF MOLECULAR LIQUIDS

Elucidating the Interactions of Fluoxetine with Human Transferrin Employing Spectroscopic, Calorimetric, and In Silico Approaches: Implications of a Potent Alzheimer’s Drug

(2022) Mohd Shahnawaz Khan et al.   ACS Omega

An Insight Into Mitochondrial Dysfunction and its Implications in Neuro-logical Diseases

(2021) Asimul Islam et al.   CURRENT DRUG TARGETS

Multispectroscopic and Molecular Docking Insight into Elucidating the Interaction of Irisin with Rivastigmine Tartrate: A Combinational Therapy Approach to Fight Alzheimer’s Disease

(2021) Rashid Waseem et al.   ACS Omega

Targeting cyclin‐dependent kinase 6 by vanillin inhibits proliferation of breast and lung cancer cells: Combined computational and biochemical studies

(2021) Mohd Yousuf et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Exploring the molecular interactions of Galantamine with human Transferrin: In-silico and in vitro insight

(2021) Mohd Shahnawaz Khan et al.   JOURNAL OF MOLECULAR LIQUIDS

MAP/Microtubule Affinity Regulating Kinase 4 Inhibitory Potential of Irisin: A New Therapeutic Strategy to Combat Cancer and Alzheimer’s Disease

(2021) Rashid Waseem et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Probing the interaction of memantine, an important Alzheimer's drug, with human serum albumin: In silico and in vitro approach

(2021) Fahad A. Alhumaydhi et al.   JOURNAL OF MOLECULAR LIQUIDS

Effect of pH on the structure and stability of irisin, a multifunctional protein: Multispectroscopic and molecular dynamics simulation approach

(2021) Rashid Waseem et al.   JOURNAL OF MOLECULAR STRUCTURE

Probing the interaction of Rivastigmine Tartrate, an important Alzheimer's drug, with serum albumin: Attempting treatment of Alzheimer's disease

(2020) Anas Shamsi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Rosmarinic Acid Exhibits Anticancer Effects via MARK4 Inhibition

(2020) Saleha Anwar et al.   Scientific Reports

Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease

(2020) Gabriella Marucci et al.   NEUROPHARMACOLOGY

Treatment Combinations for Alzheimer’s Disease: Current And Future Pharmacotherapy Options

(2019) Jeffrey L. Cummings et al.   JOURNAL OF ALZHEIMERS DISEASE

Spectroscopic, calorimetric and molecular docking insight into the interaction of Alzheimer’s drug Donepezil with human transferrin: Implications of Alzheimer’s drug

(2019) Anas Shamsi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Unraveling Binding Mechanism of Alzheimer’s Drug Rivastigmine Tartrate with Human Transferrin: Molecular Docking and Multi-Spectroscopic Approach towards Neurodegenerative Diseases

(2019) Anas Shamsi et al.   Biomolecules

Multifactorial Hypothesis and Multi-Targets for Alzheimer’s Disease

(2018) Cheng-Xin Gong et al.   JOURNAL OF ALZHEIMERS DISEASE

New approaches for the treatment of Alzheimer’s disease

(2018) Paul V. Fish et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

(2018) Mychael V. Lourenco et al.   NATURE MEDICINE

Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid β production in Alzheimer’s disease

(2018) Yasuha Noda et al.   Molecular Brain

Probing the interaction of anticancer drug temsirolimus with human serum albumin: molecular docking and spectroscopic insight

(2017) Anas Shamsi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Irisin protects against neuronal injury induced by oxygen-glucose deprivation in part depends on the inhibition of ROS-NLRP3 inflammatory signaling pathway

(2017) Juan Peng et al.   MOLECULAR IMMUNOLOGY

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

(2016) Dinh Ha et al.   Acta Pharmaceutica Sinica B

Microstructured dextran hydrogels for burst-free sustained release of PEGylated protein drugs

(2015) Ki Hyun Bae et al.   BIOMATERIALS

Efficacy and adverse effects of memantine treatment for Alzheimer’s disease from randomized controlled trials

(2015) Jue Jiang et al.   NEUROLOGICAL SCIENCES

Development of a novel drug delivery system: chitosan nanoparticles entrapped in alginate microparticles

(2014) Ghislain Garrait et al.   JOURNAL OF MICROENCAPSULATION

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Transferrin as a drug carrier: Cytotoxicity, cellular uptake and transport kinetics of doxorubicin transferrin conjugate in the human leukemia cells

(2013) Marzena Szwed et al.   TOXICOLOGY IN VITRO

Nanomaterials for Drug Delivery

(2012) J. A. Hubbell et al.   SCIENCE

Accessible High-Throughput Virtual Screening Molecular Docking Software for Students and Educators

(2012) Reed B. Jacob et al.   PLoS Computational Biology

Clinical impact of serum proteins on drug delivery

(2011) Felix Kratz et al.   JOURNAL OF CONTROLLED RELEASE

Bio-inspired, bioengineered and biomimetic drug delivery carriers

(2011) Jin-Wook Yoo et al.   NATURE REVIEWS DRUG DISCOVERY

Phenotypic Characterization of the Binding of Tetracycline to Human Serum Albumin

(2010) Zhenxing Chi et al.   BIOMACROMOLECULES

Silk fibroin as a vehicle for drug delivery applications

(2010) Esther Wenk et al.   JOURNAL OF CONTROLLED RELEASE

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY