Mitochondrial Dysfunction: Pathophysiology and Mitochondria-Targeted Drug Delivery Approaches

FNDC5/Irisin: Physiology and Pathophysiology

(2022) Rashid Waseem et al.   MOLECULES

Gold Nanoparticle-Decorated Drug Nanocrystals for Enhancing Anticancer Efficacy and Reversing Drug Resistance Through Chemo-/Photothermal Therapy

(2022) Jihui Wang et al.   MOLECULAR PHARMACEUTICS

Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System

(2022) Ildikó Szabó et al.   Pharmaceutics

Role of Impaired Mitochondrial Dynamics Processes in the Pathogenesis of Alzheimer’s Disease

(2022) Alexander V. Blagov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The use of fibroblasts as a valuable strategy for studying mitochondrial impairment in neurological disorders

(2022) Margrethe A. Olesen et al.   Translational Neurodegeneration

The Impact of Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis

(2022) Jiantao Zhao et al.   Cells

Endogenous Stimuli-Responsive Autonomous Separation of Dual-Targeting DNA Guided Missile from Nanospacecraft for Intelligent Targeted Cancer Therapy

(2022) Shujuan Sun et al.   ACS Applied Materials & Interfaces

Mitochondrial targeted hierarchical drug delivery system based on HA-modified liposomes for cancer therapy

(2022) Huiting Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment

(2021) Asieh Emami Nejad et al.   Cancer Cell International

An Insight Into Mitochondrial Dysfunction and its Implications in Neuro-logical Diseases

(2021) Asimul Islam et al.   CURRENT DRUG TARGETS

Multispectroscopic and Molecular Docking Insight into Elucidating the Interaction of Irisin with Rivastigmine Tartrate: A Combinational Therapy Approach to Fight Alzheimer’s Disease

(2021) Rashid Waseem et al.   ACS Omega

Modified Gold Nanoparticles for Efficient Delivery of Betulinic Acid to Cancer Cell Mitochondria

(2021) Olakunle Oladimeji et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Destination Amyotrophic Lateral Sclerosis

(2021) Matt Keon et al.   Frontiers in Neurology

MAP/Microtubule Affinity Regulating Kinase 4 Inhibitory Potential of Irisin: A New Therapeutic Strategy to Combat Cancer and Alzheimer’s Disease

(2021) Rashid Waseem et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress

(2021) Anamaria Jurcau   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?

(2020) Alexis Diaz-Vegas et al.   ENDOCRINE REVIEWS

Mitochondrial Delivery of an Anticancer Drug Via Systemic Administration Using a Mitochondrial Delivery System that Inhibits the Growth of Drug-Resistant Cancer Engrafted on Mice

(2020) Yuma Yamada et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

Omics Approach to Axonal Dysfunction of Motor Neurons in Amyotrophic Lateral Sclerosis (ALS)

(2020) Naoki Suzuki et al.   Frontiers in Neuroscience

Mitochondria-targeted drug delivery in cancers

(2020) Hana Cho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial Dysfunction, Neurogenesis, and Epigenetics: Putative Implications for Amyotrophic Lateral Sclerosis Neurodegeneration and Treatment

(2020) Michele Longoni Calió et al.   Frontiers in Neuroscience

Validation of Gene Therapy for Mutant Mitochondria by Delivering Mitochondrial RNA Using a MITO-Porter

(2020) Eriko Kawamura et al.   Molecular Therapy-Nucleic Acids

Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019

(2020) Haidong Wang et al.   LANCET

Mitochondrial Dysfunction and Alzheimer’s Disease: Role of Microglia

(2020) Ishan Agrawal et al.   Frontiers in Aging Neuroscience

The Role of Mitochondrial Calcium Homeostasis in Alzheimer’s and Related Diseases

(2020) Kerry C. Ryan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Silver nanoparticles functionalized Paclitaxel nanocrystals enhance overall anti-cancer effect on human cancer cells

(2020) Nazim Muhammad et al.   NANOTECHNOLOGY

Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy

(2020) Ana Belen Malpartida et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial Dysfunction in Neural Injury

(2019) Xiu-Yun Zhao et al.   Frontiers in Neuroscience

Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure

(2019) Yan Wang et al.   CNS Neuroscience & Therapeutics

LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10

(2019) Fieke Wauters et al.   Autophagy

Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy

(2019) Wenjia Zhang et al.   Nature Communications

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

(2019) Benjamin G. Trist et al.   AGING CELL

Mitochondria-targeted delocalized lipophilic cation complexed with human serum albumin for tumor cell imaging and treatment

(2019) Kun Qian et al.   Nanomedicine-Nanotechnology Biology and Medicine

Mitochondria as Potential Targets in Alzheimer Disease Therapy: An Update

(2019) Giovanna Cenini et al.   Frontiers in Pharmacology

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

Mitochondrial membrane potential

(2018) Ljubava D. Zorova et al.   ANALYTICAL BIOCHEMISTRY

Mitochondrial transcription and translation: overview

(2018) Aaron R. D’Souza et al.   Essays in Biochemistry

Dequalinium-based functional nanosomes show increased mitochondria targeting and anticancer effect

(2018) Yoonhee Bae et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease

(2018) Xian-Si Zeng et al.   Frontiers in Aging Neuroscience

Diagnostic Criteria for Parkinson’s Disease: From James Parkinson to the Concept of Prodromal Disease

(2018) Luca Marsili et al.   Frontiers in Neurology

Insights into the respiratory chain and oxidative stress

(2018) V. Larosa et al.   BIOSCIENCE REPORTS

Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson’s disease

(2018) Sandra Franco-Iborra et al.   Cell Death & Disease

Intracellular Ca 2+ Sensing: Its Role in Calcium Homeostasis and Signaling

(2017) Rafaela Bagur et al.   MOLECULAR CELL

Role of Oxidative Stress and Mitochondrial Dysfunction in Sepsis and Potential Therapies

(2017) Konstantinos Mantzarlis et al.   Oxidative Medicine and Cellular Longevity

Cell-Penetrating Peptides: From Basic Research to Clinics

(2017) Giulia Guidotti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Anticancer Effect of α-Tocopheryl Succinate Delivered by Mitochondria-Targeted Mesoporous Silica Nanoparticles

(2016) Qiuyu Qu et al.   ACS Applied Materials & Interfaces

Role of PGC-1α in Vascular RegulationHighlights

(2016) Andrew O. Kadlec et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitochondrial drug targets in neurodegenerative diseases

(2016) Jiyoun Lee   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Role of mitochondrial dysfunction in cancer progression

(2016) Chia-Chi Hsu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer’s Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons

(2016) Feng-li Zhao et al.   Oxidative Medicine and Cellular Longevity

AP39, A Mitochondrially Targeted Hydrogen Sulfide Donor, Exerts Protective Effects in Renal Epithelial Cells Subjected to Oxidative Stress in Vitro and in Acute Renal Injury in Vivo

(2016) Akbar Ahmad et al.   SHOCK

Mitochondrial dysfunction is an important cause of neurological deficits in an inflammatory model of multiple sclerosis

(2016) Mona Sadeghian et al.   Scientific Reports

Intracellular pH imaging in cancer cells in vitro and tumors in vivo using the new genetically encoded sensor SypHer2

(2015) Marina V. Shirmanova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Overcoming drug-resistant lung cancer by paclitaxel loaded dual-functional liposomes with mitochondria targeting and pH-response

(2015) Lei Jiang et al.   BIOMATERIALS

Structure and function of mitochondrial membrane protein complexes

(2015) Werner Kühlbrandt   BMC BIOLOGY

Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy

(2015) Anne Hamacher-Brady et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits

(2015) Vladimir P. Skulachev   Frontiers in Bioscience-Landmark

Mitochondrial delivery of Coenzyme Q 10 via systemic administration using a MITO-Porter prevents ischemia/reperfusion injury in the mouse liver

(2015) Yuma Yamada et al.   JOURNAL OF CONTROLLED RELEASE

Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants

(2015) Victoria J.A. Jameson et al.   TETRAHEDRON

Liposomal nanohybrid cerasomes for mitochondria-targeted drug delivery

(2015) Yanfang Wang et al.   Journal of Materials Chemistry B

Molecular Vehicles for Mitochondrial Chemical Biology and Drug Delivery

(2014) Sae Rin Jean et al.   ACS Chemical Biology

Serendipity and the Discovery of Novel Compounds That Restore Mitochondrial Plasticity

(2014) H H Szeto et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Design and Development of Novel Mitochondrial Targeted Nanocarriers, DQAsomes for Curcumin Inhalation

(2014) Špela Zupančič et al.   MOLECULAR PHARMACEUTICS

AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro

(2014) Bartosz Szczesny et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Editorial (Thematic Issue: Controlled Release and Drug Delivery in Diseases)

(2014) Yusuf Tutar   PROTEIN AND PEPTIDE LETTERS

Targeted nanoparticles in mitochondrial medicine

(2014) Rakesh K. Pathak et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes

(2013) Huajun Jin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death

(2013) Gang Cheng et al.   BMC CANCER

Mitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target?

(2013) H Muyderman et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

(2013) Xinyuan Li et al.   Journal of Hematology & Oncology

Mitochondrial dysfunction contributes to neurodegeneration in multiple sclerosis

(2013) Maarten E. Witte et al.   TRENDS IN MOLECULAR MEDICINE

Parkinson's Disease and Parkinsonism: Neuropathology

(2013) D. W. Dickson   Cold Spring Harbor Perspectives in Medicine

Liposome: classification, preparation, and applications

(2013) Abolfazl Akbarzadeh et al.   Nanoscale Research Letters

Mitochondrial dysfunction and neurodegeneration in multiple sclerosis

(2013) Kimmy Su et al.   Frontiers in Physiology

Emerging Paradigms for Complex Iron-Sulfur Cofactor Assembly and Insertion

(2012) John W. Peters et al.   Annual Review of Biochemistry

A Mitochondria-Targeted Macrocyclic Mn(II) Superoxide Dismutase Mimetic

(2012) Geoffrey F. Kelso et al.   CHEMISTRY & BIOLOGY

Targeting Mitochondria in Fighting Cancer

(2012) Vladimir Gogvadze   CURRENT PHARMACEUTICAL DESIGN

Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease

(2012) T. A. Rouault   Disease Models & Mechanisms

Liposomes loaded with paclitaxel and modified with novel triphenylphosphonium-PEG-PE conjugate possess low toxicity, target mitochondria and demonstrate enhanced antitumor effects in vitro and in vivo

(2012) Swati Biswas et al.   JOURNAL OF CONTROLLED RELEASE

Mitochondria: master regulators of danger signalling

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondria-Specific Accumulation of Amyloid β Induces Mitochondrial Dysfunction Leading to Apoptotic Cell Death

(2012) Moon-Yong Cha et al.   PLoS One

Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice

(2012) J. Momb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model

(2012) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics

(2012) S. Marrache et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Fatal Mitochondrial Disease Is Associated with Defective NFU1 Function in the Maturation of a Subset of Mitochondrial Fe-S Proteins

(2011) Aleix Navarro-Sastre et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The use of mitochondrial targeting resveratrol liposomes modified with a dequalinium polyethylene glycol-distearoylphosphatidyl ethanolamine conjugate to induce apoptosis in resistant lung cancer cells

(2011) Xiao-Xing Wang et al.   BIOMATERIALS

Mitochondrial targeting topotecan-loaded liposomes for treating drug-resistant breast cancer and inhibiting invasive metastases of melanoma

(2011) Yang Yu et al.   BIOMATERIALS

A novel pH-responsive polysaccharidic ionic complex for proapoptotic d-(KLAKLAK)2 peptide delivery

(2011) Bo Reum Lee et al.   CHEMICAL COMMUNICATIONS

Inactivation and Reactivation of the Mitochondrial α-Ketoglutarate Dehydrogenase Complex

(2011) Qingli Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Derivatives of Rhodamine 19 as Mild Mitochondria-targeted Cationic Uncouplers

(2011) Yuri N. Antonenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Surface modification of liposomes with rhodamine-123-conjugated polymer results in enhanced mitochondrial targeting

(2011) Swati Biswas et al.   JOURNAL OF DRUG TARGETING

Mitochondrial dysfunction in epilepsy

(2011) Jaroslava Folbergrová et al.   MITOCHONDRION

Dual Function MITO-Porter, a Nano Carrier Integrating Both Efficient Cytoplasmic Delivery and Mitochondrial Macromolecule Delivery

(2011) Yuma Yamada et al.   MOLECULAR THERAPY

Novel Therapies Targeting Inner Mitochondrial Membrane—From Discovery to Clinical Development

(2011) Hazel H. Szeto et al.   PHARMACEUTICAL RESEARCH

Therapeutic Action of the Mitochondria-Targeted Antioxidant SkQ1 on Retinopathy in OXYS Rats Linked with Improvement of VEGF and PEDF Gene Expression

(2011) Anton M. Markovets et al.   PLoS One

Mitochondrial matrix delivery using MITO-Porter, a liposome-based carrier that specifies fusion with mitochondrial membranes

(2010) Yukari Yasuzaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial control of caspase-dependent and -independent cell death

(2010) Ludivine A. Pradelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Get With The Guidelines-Stroke Performance Indicators: Surveillance of Stroke Care in the Taiwan Stroke Registry

(2010) Fang-I Hsieh et al.   CIRCULATION

Activation of calcium/calmodulin-dependent protein kinase IV and peroxisome proliferator-activated receptor γ coactivator-1α signaling pathway protects against neuronal injury and promotes mitochondrial biogenesis in the hippocampal CA1 subfield after tra

(2010) Shang-Der Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Iron–sulfur proteins in health and disease

(2010) Alex Sheftel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

Potential Therapeutic Benefits of Strategies Directed to Mitochondria

(2009) Amadou K.S. Camara et al.   ANTIOXIDANTS & REDOX SIGNALING

Leucine-Rich Repeat Kinase 2 Mutations and Parkinson's Disease: Three Questions

(2009) Elisa Greggio et al.   ASN Neuro

Cationic amphiphilic polyproline helix P11LRR targets intracellular mitochondria

(2009) Li Li et al.   JOURNAL OF CONTROLLED RELEASE

Energetics, epigenetics, mitochondrial genetics

(2009) Douglas C. Wallace et al.   MITOCHONDRION

Mitochondrial gateways to cancer

(2009) Lorenzo Galluzzi et al.   MOLECULAR ASPECTS OF MEDICINE

Function and biogenesis of iron–sulphur proteins

(2009) Roland Lill   NATURE

Vulnerability of glial cells to hydrogen peroxide in cultured hippocampal slices

(2008) Chris J. Feeney et al.   BRAIN RESEARCH

Mitochondria-Penetrating Peptides

(2008) Kristin L. Horton et al.   CHEMISTRY & BIOLOGY

Get With the Guidelines–Stroke Is Associated With Sustained Improvement in Care for Patients Hospitalized With Acute Stroke or Transient Ischemic Attack

(2008) Lee H. Schwamm et al.   CIRCULATION

Antioxidant properties of MitoTEMPOL and its hydroxylamine

(2008) Jan Trnka et al.   FREE RADICAL RESEARCH

Nanocarrier-assisted sub-cellular targeting to the site of mitochondria improves the pro-apoptotic activity of paclitaxel

(2008) Gerard GM D'Souza et al.   JOURNAL OF DRUG TARGETING

Organelle-Targeted Nanocarriers: Specific Delivery of Liposomal Ceramide to Mitochondria Enhances Its Cytotoxicity in Vitro and in Vivo

(2008) Sarathi V. Boddapati et al.   NANO LETTERS

Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia

(2008) A RAMI et al.   PROGRESS IN NEUROBIOLOGY

MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion

(2007) Yuma Yamada et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES