- Home
- Publications
- Publication Search
- Publication Details
Title
Outsmarting Pathogens with Antibody Engineering
Authors
Keywords
-
Journal
Annual Review of Chemical and Biomolecular Engineering
Volume 14, Issue 1, Pages 217-241
Publisher
Annual Reviews
Online
2023-03-15
DOI
10.1146/annurev-chembioeng-101121-084508
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Synergistic Protection against Secondary Pneumococcal Infection by Human Monoclonal Antibodies Targeting Distinct Epitopes
- (2023) Aaron D. Gingerich et al. JOURNAL OF IMMUNOLOGY
- Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies
- (2022) Yunlong Cao et al. NATURE
- An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies
- (2022) Laura A. VanBlargan et al. NATURE MEDICINE
- Engineered human antibodies for the opsonization and killing of Staphylococcus aureus
- (2022) Xinhai Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Improving Antibody Therapeutics by Manipulating the Fc Domain: Immunological and Structural Considerations
- (2022) George Delidakis et al. Annual Review of Biomedical Engineering
- Kinetic Studies of the Activation of Bordetella pertussis Adenylate Cyclase by Calmodulin
- (2022) Ross L. Stein BIOCHEMISTRY
- Biophysical Characterization and Stability of Modified IgG1 Antibodies with Different Hexamerization Propensities
- (2022) Muriel D. van Kampen et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants
- (2022) Jessica Hong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Natural Human Immunity Against Staphylococcal Protein A Relies on Effector Functions Triggered by IgG3
- (2022) Elena Boero et al. Frontiers in Immunology
- A Molecular Analysis of Memory B Cell and Antibody Responses Against Plasmodium falciparum Merozoite Surface Protein 1 in Children and Adults From Uganda
- (2022) S. Jake Gonzales et al. Frontiers in Immunology
- Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models
- (2022) Alexander A. Cohen et al. SCIENCE
- Blockade of the Adenylate Cyclase Toxin Synergizes with Opsonizing Antibodies to Protect Mice against Bordetella pertussis
- (2022) Andrea M. DiVenere et al. mBio
- Superimmunity by pan-sarbecovirus nanobodies
- (2022) Yufei Xiang et al. Cell Reports
- Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin
- (2022) Jory A. Goldsmith et al. Cell Reports
- Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes
- (2022) Chengcheng Fan et al. IMMUNITY
- Evolution of the vls Antigenic Variability Locus of the Lyme Disease Pathogen and Development of Recombinant Monoclonal Antibodies Targeting Conserved VlsE Epitopes
- (2022) Li Li et al. Microbiology Spectrum
- Antibodies to watch in 2023
- (2022) Hélène Kaplon et al. mAbs
- Prospective mapping of viral mutations that escape antibodies used to treat COVID-19
- (2021) Tyler N. Starr et al. SCIENCE
- Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors
- (2021) Simon Leiris et al. ACS Medicinal Chemistry Letters
- Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis
- (2021) Avia Watson et al. Nature Communications
- Efficacy of Margetuximab vs Trastuzumab in Patients With Pretreated ERBB2-Positive Advanced Breast Cancer
- (2021) Hope S. Rugo et al. JAMA Oncology
- Pseudomonas aeruginosa elastase (LasB) as a therapeutic target
- (2021) Martin J Everett et al. DRUG DISCOVERY TODAY
- Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus
- (2021) Virginia-Maria Vlahava et al. JOURNAL OF CLINICAL INVESTIGATION
- Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation
- (2021) Ana Rita Cruz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Broadly Reactive Human Monoclonal Antibodies Targeting the Pneumococcal Histidine Triad Protein Protect against Fatal Pneumococcal Infection
- (2021) Jiachen Huang et al. INFECTION AND IMMUNITY
- Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE): a multicentre, randomised, double-blind, placebo-controlled, parallel-group, phase 2 pilot trial
- (2021) Bruno François et al. LANCET INFECTIOUS DISEASES
- An intracellular nanobody targeting T4SS effector inhibits Ehrlichia infection
- (2021) Wenqing Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human cytomegalovirus antagonizes activation of Fcγ receptors by distinct and synergizing modes of IgG manipulation
- (2021) Philipp Kolb et al. eLife
- Monoclonal antibodies opsonise Burkholderia and reduce intracellular actin tail formation in a macrophage infection assay.
- (2021) A. Taylor et al. JOURNAL OF BACTERIOLOGY
- SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape
- (2021) Tyler N. Starr et al. NATURE
- Predicting in vivo escape dynamics of HIV-1 from a broadly neutralizing antibody
- (2021) Matthijs Meijers et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A protein A based Staphylococcus aureus vaccine with improved safety
- (2021) Miaomiao Shi et al. VACCINE
- Potent Killing of Pseudomonas aeruginosa by an Antibody-Antibiotic Conjugate
- (2021) Kimberly K. Kajihara et al. mBio
- A Structural Model for the Ligand Binding of Pneumococcal Serotype 3 Capsular Polysaccharide-Specific Protective Antibodies
- (2021) Ahmet Ozdilek et al. mBio
- Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies
- (2021) Claudia A. Jette et al. Cell Reports
- Structural basis for antibody binding to adenylate cyclase toxin reveals RTX linkers as neutralization-sensitive epitopes
- (2021) Jory A. Goldsmith et al. PLoS Pathogens
- Human Single-Chain Antibodies That Neutralize Elastolytic Activity of Pseudomonas aeruginosa LasB
- (2021) Sirijan Santajit et al. Pathogens
- Breakthrough therapy designation of nirsevimab for the prevention of lower respiratory tract illness caused by respiratory syncytial virus infections (RSV)
- (2021) Harrison C. Bergeron et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Broadly neutralizing antibodies target a haemagglutinin anchor epitope
- (2021) Jenna J. Guthmiller et al. NATURE
- SARS-CoV-2 evolution in animals suggests mechanisms for rapid variant selection
- (2021) Laura Bashor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Single B cell technologies for monoclonal antibody discovery
- (2021) Alessandro Pedrioli et al. TRENDS IN IMMUNOLOGY
- Stabilized coronavirus spike stem elicits a broadly protective antibody
- (2021) Ching-Lin Hsieh et al. Cell Reports
- Two Distinct Lysosomal Targeting Strategies Afford Trojan Horse Antibodies With Pan-Filovirus Activity
- (2021) Ariel S. Wirchnianski et al. Frontiers in Immunology
- Further Insight into the Mechanism of Human PMN Lysis following Phagocytosis of Staphylococcus aureus
- (2021) Viktoria Rungelrath et al. Microbiology Spectrum
- Atomistic Simulations and In Silico Mutational Profiling of Protein Stability and Binding in the SARS-CoV-2 Spike Protein Complexes with Nanobodies: Molecular Determinants of Mutational Escape Mechanisms
- (2021) Gennady M. Verkhivker et al. ACS Omega
- A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
- (2020) Meng Yuan et al. SCIENCE
- Intracellular neutralisation of rotavirus by VP6-specific IgG
- (2020) Sarah L. Caddy et al. PLoS Pathogens
- Protease Inhibition Mechanism of Camelid-like Synthetic Human Antibodies
- (2020) Dong Hyun Nam et al. BIOCHEMISTRY
- Four-component Meningococcal Serogroup B Vaccine Induces Antibodies With Bactericidal Activity Against Diverse Outbreak Strains in Adolescents
- (2020) Alessia Biolchi et al. PEDIATRIC INFECTIOUS DISEASE JOURNAL
- Antibody-Dependent Enhancement: A Challenge for Developing a Safe Dengue Vaccine
- (2020) Rahul Shukla et al. Frontiers in Cellular and Infection Microbiology
- Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual
- (2019) Shelly J. Krebs et al. IMMUNITY
- Penetration of a Monoclonal Antibody Combination (ASN100) Targeting S. aureus Cytotoxins in Lung Epithelial Lining Fluid: A Randomized, Double-blind, Placebo-controlled, Single Ascending Dose Study in Healthy Volunteers.
- (2019) Zoltan Magyarics et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Defining the core essential genome of Pseudomonas aeruginosa
- (2019) Bradley E. Poulsen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Novel correlates of protection against pandemic H1N1 influenza A virus infection
- (2019) Sophia Ng et al. NATURE MEDICINE
- Multimeric Epitope-Scaffold HIV Vaccines Target V1V2 and Differentially Tune Polyfunctional Antibody Responses
- (2019) Ann J. Hessell et al. Cell Reports
- Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody
- (2019) Sunita Gulati et al. PLOS BIOLOGY
- Massive antibody discovery used to probe structure–function relationships of the essential outer membrane protein LptD
- (2019) Kelly M Storek et al. eLife
- The Roles of Host and Viral Antibody Fc Receptors in Herpes Simplex Virus (HSV) and Human Cytomegalovirus (HCMV) Infections and Immunity
- (2019) Jennifer A. Jenks et al. Frontiers in Immunology
- Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01
- (2019) Dora Pinto et al. Cell Host & Microbe
- High-Throughput Mapping of B Cell Receptor Sequences to Antigen Specificity
- (2019) Ian Setliff et al. CELL
- Intracellular delivery of therapeutic antibodies into specific cells using antibody-peptide fusions
- (2019) Julie Gaston et al. Scientific Reports
- IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody
- (2019) Simone I. Richardson et al. PLoS Pathogens
- Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex–mediated immune responses
- (2019) L. J. Blumberg et al. Science Advances
- Safety and tolerability of a single administration of AR-301, a human monoclonal antibody, in ICU patients with severe pneumonia caused by Staphylococcus aureus: first-in-human trial
- (2018) Bruno François et al. INTENSIVE CARE MEDICINE
- Structural basis for antibody targeting of the broadly expressed microbial polysaccharide poly-N-acetylglucosamine
- (2018) Caroline Soliman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Diversion of complement-mediated killing by Bordetella
- (2018) Anaïs Thiriard et al. MICROBES AND INFECTION
- A natural human monoclonal antibody targeting Staphylococcus Protein A protects against Staphylococcus aureus bacteremia
- (2018) Avanish K. Varshney et al. PLoS One
- Monoclonal antibody targeting the β-barrel assembly machine ofEscherichia coliis bactericidal
- (2018) Kelly M. Storek et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge
- (2018) Navid Madani et al. Nature Communications
- How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin
- (2018) Michael B. Doud et al. Nature Communications
- Phase 1 study of MEDI3902, an investigational anti–Pseudomonas aeruginosa PcrV and Psl bispecific human monoclonal antibody, in healthy adults
- (2018) S.O. Ali et al. CLINICAL MICROBIOLOGY AND INFECTION
- Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants
- (2018) Juhye M. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bispecific antibody targets multiple Pseudomonas aeruginosa evasion mechanisms in the lung vasculature
- (2017) Ajitha Thanabalasuriar et al. JOURNAL OF CLINICAL INVESTIGATION
- IgG antibodies to dengue enhanced for FcγRIIIA binding determine disease severity
- (2017) Taia T. Wang et al. SCIENCE
- A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants
- (2017) Qing Zhu et al. Science Translational Medicine
- Disarming Staphylococcus aureus from destroying human cells by simultaneously neutralizing six cytotoxins with two human monoclonal antibodies
- (2017) Harald Rouha et al. Virulence
- Endotoxin neutralization by an O-antigen specific monoclonal antibody: A potential novel therapeutic approach against Klebsiella pneumoniae ST258
- (2017) Valéria Szijártó et al. Virulence
- Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity
- (2017) Giorgio Fedele et al. Toxins
- A peptide immunization approach to counteract a Staphylococcus aureus protease defense against host immunity
- (2016) Robert E. Jordan et al. IMMUNOLOGY LETTERS
- Characterization of Antibody Bipolar Bridging Mediated by the Human Cytomegalovirus Fc Receptor gp68
- (2016) Blaise Ndjamen et al. JOURNAL OF VIROLOGY
- Pharmacokinetics and pharmacodynamics of DSTA4637A: A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus in mice
- (2016) Chenguang Zhou et al. mAbs
- Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody–drug conjugates
- (2016) Leanna R. Staben et al. Nature Chemistry
- Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined
- (2016) Massimiliano Biagini et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A “Trojan horse” bispecific-antibody strategy for broad protection against ebolaviruses
- (2016) Anna Z. Wec et al. SCIENCE
- Fc-Binding Ligands of Immunoglobulin G: An Overview of High Affinity Proteins and Peptides
- (2016) Weonu Choe et al. Materials
- Lessons from the RV144 Thai Phase III HIV-1 Vaccine Trial and the Search for Correlates of Protection
- (2015) Jerome H. Kim et al. Annual Review of Medicine
- Novel antibody–antibiotic conjugate eliminates intracellular S. aureus
- (2015) Sophie M. Lehar et al. NATURE
- Prefusion F–specific antibodies determine the magnitude of RSV neutralizing activity in human sera
- (2015) Joan O. Ngwuta et al. Science Translational Medicine
- Protein A-neutralizing monoclonal antibody protects neonatal mice against Staphylococcus aureus
- (2015) Vilasack Thammavongsa et al. VACCINE
- Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity
- (2014) Stylianos Bournazos et al. CELL
- Pertactin-Negative Bordetella pertussis Strains: Evidence for a Possible Selective Advantage
- (2014) S. W. Martin et al. CLINICAL INFECTIOUS DISEASES
- Human Anti-IgG1 Hinge Autoantibodies Reconstitute the Effector Functions of Proteolytically Inactivated IgGs
- (2014) R. J. Brezski et al. JOURNAL OF IMMUNOLOGY
- The HIV-1 gp120 CD4-Bound Conformation Is Preferentially Targeted by Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies in Sera from HIV-1-Infected Individuals
- (2014) Maxime Veillette et al. JOURNAL OF VIROLOGY
- Five birds, one stone: Neutralization of α-hemolysin and 4 bi-component leukocidins ofStaphylococcus aureuswith a single human monoclonal antibody
- (2014) Harald Rouha et al. mAbs
- Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
- (2014) Nicole A. Doria-Rose et al. NATURE
- Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo
- (2014) David J DiLillo et al. NATURE MEDICINE
- Complement Is Activated by IgG Hexamers Assembled at the Cell Surface
- (2014) C. A. Diebolder et al. SCIENCE
- Human Cytomegalovirus Fcγ Binding Proteins gp34 and gp68 Antagonize Fcγ Receptors I, II and III
- (2014) Eugenia Corrales-Aguilar et al. PLoS Pathogens
- IgG Subclasses and Allotypes: From Structure to Effector Functions
- (2014) Gestur Vidarsson et al. Frontiers in Immunology
- Staphylococcus aureus Elaborates Leukocidin AB To Mediate Escape from within Human Neutrophils
- (2013) Ashley L. DuMont et al. INFECTION AND IMMUNITY
- Engineered Protease-resistant Antibodies with Selectable Cell-killing Functions
- (2013) Michelle Kinder et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pseudomonas aeruginosa Utilizes the Type III Secreted Toxin ExoS to Avoid Acidified Compartments within Epithelial Cells
- (2013) Susan R. Heimer et al. PLoS One
- Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens
- (2013) C. Cywes-Bentley et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody
- (2013) J. S. McLellan et al. SCIENCE
- Results of a Phase 1 Study of AME-133v (LY2469298), an Fc-Engineered Humanized Monoclonal Anti-CD20 Antibody, in FcγRIIIa-Genotyped Patients with Previously Treated Follicular Lymphoma
- (2012) Andres Forero-Torres et al. CLINICAL CANCER RESEARCH
- Protein A-Specific Monoclonal Antibodies and Prevention of Staphylococcus aureus Disease in Mice
- (2012) Hwan Keun Kim et al. INFECTION AND IMMUNITY
- Identification of broadly protective human antibodies toPseudomonas aeruginosaexopolysaccharide Psl by phenotypic screening
- (2012) Antonio DiGiandomenico et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge
- (2012) Randall J. Brezski et al. mAbs
- Human Cytomegalovirus Escapes a Naturally Occurring Neutralizing Antibody by Incorporating It into Assembling Virions
- (2011) Kate Manley et al. Cell Host & Microbe
- The Sbi Protein Is a Multifunctional Immune Evasion Factor of Staphylococcus aureus
- (2011) Emma Jane Smith et al. INFECTION AND IMMUNITY
- Complement-Mediated Bactericidal Activity of Anti-Factor H Binding Protein Monoclonal Antibodies against the Meningococcus Relies upon Blocking Factor H Binding
- (2011) Serena Giuntini et al. INFECTION AND IMMUNITY
- Protease inhibitors decrease IgG shedding from Staphylococcus aureus, increasing complement activation and phagocytosis efficiency
- (2011) M. F. Fernandez Falcon et al. JOURNAL OF MEDICAL MICROBIOLOGY
- The Herpes Simplex Virus 1 IgG Fc Receptor Blocks Antibody-Mediated Complement Activation and Antibody-Dependent Cellular Cytotoxicity In Vivo
- (2011) J. M. Lubinski et al. JOURNAL OF VIROLOGY
- Are bloodstream leukocytes Trojan Horses for the metastasis of Staphylococcus aureus?
- (2011) Guy E. Thwaites et al. NATURE REVIEWS MICROBIOLOGY
- Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport
- (2011) Y. Bai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Preclinical In Vitro and In Vivo Characterization of the Fully Human Monoclonal IgM Antibody KBPA101 Specific for Pseudomonas aeruginosa Serotype IATS-O11
- (2010) M. P. Horn et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Cell cycle arrest induced by the bacterial adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis
- (2010) Mary C. Gray et al. CELLULAR MICROBIOLOGY
- Cleavage of IgGs by proteases associated with invasive diseases
- (2010) Randall J. Brezski et al. mAbs
- Antibodies protect against intracellular bacteria by Fc receptor-mediated lysosomal targeting
- (2010) N. Joller et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HIV-1 and influenza antibodies: seeing antigens in new ways
- (2009) Peter D Kwong et al. NATURE IMMUNOLOGY
- Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge
- (2009) R. J. Brezski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Human Cytomegalovirus Fc Receptor gp68 Binds the Fc CH2-CH3 Interface of Immunoglobulin G
- (2008) E. R. Sprague et al. JOURNAL OF VIROLOGY
- Microbial complement inhibitors as vaccines
- (2008) Seppo Meri et al. VACCINE
- Proteolysis of purified IgGs by human and bacterial enzymes in vitro and the detection of specific proteolytic fragments of endogenous IgG in rheumatoid synovial fluid
- (2007) Mary H. Ryan et al. MOLECULAR IMMUNOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started