Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex–mediated immune responses

Neonatal Fc receptor expression in macrophages is indispensable for IgG homeostasis

(2019) Dilip K. Challa et al.   mAbs

The Neonatal Fc Receptor (FcRn): A Misnomer?

(2019) Michal Pyzik et al.   Frontiers in Immunology

538 FcRn blockade with SYNT001 for the treatment of pemphigus

(2018) V.P. Werth et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice

(2018) Wolfgang F. Richter et al.   mAbs

Vascular access for therapeutic plasma exchange

(2018) Tina S. Ipe et al.   TRANSFUSION

A human endothelial cell-based recycling assay for screening of FcRn targeted molecules

(2018) Algirdas Grevys et al.   Nature Communications

Neonatal Fc receptor antagonist efgartigimod safely and sustainably reduces IgGs in humans

(2018) Peter Ulrichts et al.   JOURNAL OF CLINICAL INVESTIGATION

M281, an Anti-FcRn Antibody: Pharmacodynamics, Pharmacokinetics, and Safety Across the Full Range of IgG Reduction in a First-in-Human Study

(2018) Leona E. Ling et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody

(2017) Jon A. Kenniston et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin

(2017) Esben G. W. Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distribution of FcRn Across Species and Tissues

(2017) Sari Latvala et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury

(2017) Michal Pyzik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The FcRn inhibitor rozanolixizumab reduces human serum IgG concentration: A randomized phase 1 study

(2017) Peter Kiessling et al.   Science Translational Medicine

Mechanisms of Autoantibody-Induced Pathology

(2017) Ralf J. Ludwig et al.   Frontiers in Immunology

Structures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interface

(2016) Matthew C. Franklin et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity

(2015) Jolien Suurmond et al.   JOURNAL OF CLINICAL INVESTIGATION

Assessment and Reporting of the Clinical Immunogenicity of Therapeutic Proteins and Peptides—Harmonized Terminology and Tactical Recommendations

(2014) G. Shankar et al.   AAPS Journal

Dissection of the Neonatal Fc Receptor (FcRn)-Albumin Interface Using Mutagenesis and Anti-FcRn Albumin-blocking Antibodies

(2014) Kine Marita Knudsen Sand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the Neonatal Fc Receptor for Antigen Delivery Using Engineered Fc Fragments

(2014) W. Mi et al.   JOURNAL OF IMMUNOLOGY

Clearance Efficacy of Autoantibodies in Double Filtration Plasmapheresis for Pemphigus Foliaceus

(2013) A Kasuya et al.   ACTA DERMATO-VENEREOLOGICA

Neonatal Fc Receptor Expression in Dendritic Cells Mediates Protective Immunity against Colorectal Cancer

(2013) Kristi Baker et al.   IMMUNITY

Neonatal Fc Receptor Promotes Immune Complex-Mediated Glomerular Disease

(2013) F. Olaru et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands

(2012) Jonah Cheung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Monoclonal antibodies directed against human FcRn and their applications

(2012) Gregory J. Christianson et al.   mAbs

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Nonclassical major histocompatibility complex I–like Fc neonatal receptor (FcRn) expression in neonatal human tissues

(2011) Corina Cianga et al.   HUMAN IMMUNOLOGY

A randomized and controlled study comparing immunoadsorption and plasma exchange in myasthenic crisis

(2011) Wolfgang Köhler et al.   JOURNAL OF CLINICAL APHERESIS

Clinical chemistry of human FcRn transgenic mice

(2011) Carsten Stein et al.   MAMMALIAN GENOME

Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells

(2011) K. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Warm Autoimmune Hemolytic Anemia: Recent Progress in Understanding the Immunobiology and the Treatment

(2010) Melca M.O. Barros et al.   TRANSFUSION MEDICINE REVIEWS

An FcRn-Dependent Role for Anti-flagellin Immunoglobulin G in Pathogenesis of Colitis in Mice

(2009) Kanna Kobayashi et al.   GASTROENTEROLOGY

Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice

(2009) Héctor Pérez Montoyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparing the Autoantibody Levels and Clinical Efficacy of Double Filtration Plasmapheresis, Immunoadsorption, and Intravenous Immunoglobulin for the Treatment of Late-onset Myasthenia Gravis

(2009) Jun-Feng Liu et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Analyses of the Recycling Receptor, FcRn, in Live Cells Reveal Novel Pathways for Lysosomal Delivery

(2009) Zhuo Gan et al.   TRAFFIC

Neonatal Fc receptor deficiency protects from tissue injury in experimental epidermolysis bullosa acquisita

(2008) Alina Sesarman et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn

(2008) A. R. Mezo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dependence of antibody-mediated presentation of antigen on FcRn

(2008) S.-W. Qiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA