Antibody-Dependent Enhancement: A Challenge for Developing a Safe Dengue Vaccine

A Review on Dengue Vaccine Development

(2020) Sheng-Qun Deng et al.   Vaccines

Safety and immunogenicity of a tetravalent dengue vaccine in children aged 2–17 years: a randomised, placebo-controlled, phase 2 trial

(2020) Vianney Tricou et al.   LANCET

Non-Human Primate Models of Dengue Virus Infection: A Comparison of Viremia Levels and Antibody Responses during Primary and Secondary Infection among Old World and New World Monkeys

(2020) Nor Azila Muhammad Azami et al.   Pathogens

Dimerization of dengue virus E-subunits impacts antibody function and domain focus.

(2020) Ashlie Thomas et al.   JOURNAL OF VIROLOGY

Zika virus infection enhances future risk of severe dengue disease

(2020) Leah C. Katzelnick et al.   SCIENCE

Dengue and Zika virus infections are enhanced by live attenuated dengue vaccine but not by recombinant DSV4 vaccine candidate in mouse models

(2020) Rahul Shukla et al.   EBioMedicine

Dengue vaccine development: Global and Indian scenarios

(2019) Sathyamangalam Swaminathan et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy

(2019) Julia A. Brown et al.   IMMUNITY

Production and Biomedical Application of Flavivirus-like Particles

(2019) Ewelina Krol et al.   TRENDS IN BIOTECHNOLOGY

Molecular Simulations Reveal the Role of Antibody Fine Specificity and Viral Maturation State on Antibody-Dependent Enhancement of Infection in Dengue Virus

(2019) Daniel R. Ripoll et al.   Frontiers in Cellular and Infection Microbiology

A protective Zika virus E-dimer-based subunit vaccine engineered to abrogate antibody-dependent enhancement of dengue infection

(2019) Jose Luis Slon-Campos et al.   NATURE IMMUNOLOGY

Human T Cell Response to Dengue Virus Infection

(2019) Yuan Tian et al.   Frontiers in Immunology

A review of Dengvaxia®: development to deployment

(2019) Stephen J. Thomas et al.   Human Vaccines & Immunotherapeutics

Four-year safety follow-up of the tetravalent dengue vaccine efficacy randomized controlled trials in Asia and Latin America

(2018) J.L. Arredondo-García et al.   CLINICAL MICROBIOLOGY AND INFECTION

Development of vaccines against Zika virus

(2018) Gregory A Poland et al.   LANCET INFECTIOUS DISEASES

Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys

(2018) Peter Abbink et al.   NATURE MEDICINE

Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy

(2018) Saranya Sridhar et al.   NEW ENGLAND JOURNAL OF MEDICINE

A tetravalent virus-like particle vaccine designed to display domain III of dengue envelope proteins induces multi-serotype neutralizing antibodies in mice and macaques which confer protection against antibody dependent enhancement in AG129 mice

(2018) Viswanathan Ramasamy et al.   PLoS Neglected Tropical Diseases

Reconstruction of antibody dynamics and infection histories to evaluate dengue risk

(2018) Henrik Salje et al.   NATURE

Next generation designer virus-like particle vaccines for dengue

(2018) Rahul Shukla et al.   Expert Review of Vaccines

The immune response against flaviviruses

(2018) Jose Luis Slon Campos et al.   NATURE IMMUNOLOGY

Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity

(2017) Susana V. Bardina et al.   SCIENCE

Antibody-dependent enhancement of severe dengue disease in humans

(2017) Leah C. Katzelnick et al.   SCIENCE

Dengvaxia sensitizes seronegatives to vaccine enhanced disease regardless of age

(2017) Scott B. Halstead   VACCINE

Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination?

(2017) Aravinda M. de Silva et al.   Cold Spring Harbor Perspectives in Biology

Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination?

(2017) Gavin Screaton et al.   Cold Spring Harbor Perspectives in Biology

Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope

(2017) Alexander Rouvinski et al.   Nature Communications

Dissecting antibodies induced by a chimeric yellow fever-dengue, live-attenuated, tetravalent dengue vaccine (CYD-TDV) in naïve and dengue exposed individuals

(2016) Sandra Henein et al.   JOURNAL OF INFECTIOUS DISEASES

Functional properties of DENV EDIII-reactive antibodies in human DENV-1-infected sera and rabbit antiserum to EDIII

(2016) Jing Chen et al.   Molecular Medicine Reports

Structural basis of potent Zika–dengue virus antibody cross-neutralization

(2016) Giovanna Barba-Spaeth et al.   NATURE

Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus

(2016) Wanwisa Dejnirattisai et al.   NATURE IMMUNOLOGY

Assessing the global threat from Zika virus

(2016) J. Lessler et al.   SCIENCE

Dengue Virus Envelope Dimer Epitope Monoclonal Antibodies Isolated from Dengue Patients Are Protective against Zika Virus

(2016) J. A. Swanstrom et al.   mBio

Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability

(2016) Henry Puerta-Guardo et al.   PLoS Pathogens

Protective Role of Cross-Reactive CD8 T Cells Against Dengue Virus Infection

(2016) Annie Elong Ngono et al.   EBioMedicine

Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope

(2015) Luke N. Robinson et al.   CELL

Key concepts, strategies, and challenges in dengue vaccine development: an opportunity for sub-unit candidates?

(2015) Jian Hang Lam et al.   Expert Review of Vaccines

Dengue Virus Nonstructural Protein 1–Induced Antibodies Cross-React with Human Plasminogen and Enhance Its Activation

(2015) Yung-Chun Chuang et al.   JOURNAL OF IMMUNOLOGY

Dengue Virus Infection with Highly Neutralizing Levels of Cross-Reactive Antibodies Causes Acute Lethal Small Intestinal Pathology without a High Level of Viremia in Mice

(2015) Satoru Watanabe et al.   JOURNAL OF VIROLOGY

Complexity of Neutralizing Antibodies against Multiple Dengue Virus Serotypes after Heterotypic Immunization and Secondary Infection Revealed by In-Depth Analysis of Cross-Reactive Antibodies

(2015) Wen-Yang Tsai et al.   JOURNAL OF VIROLOGY

CD8+T Cells Can Mediate Short-Term Protection against Heterotypic Dengue Virus Reinfection in Mice

(2015) Raphaël M. Zellweger et al.   JOURNAL OF VIROLOGY

Zika virus: following the path of dengue and chikungunya?

(2015) Didier Musso et al.   LANCET

Recognition determinants of broadly neutralizing human antibodies against dengue viruses

(2015) Alexander Rouvinski et al.   NATURE

Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease

(2015) Sri Rezeki Hadinegoro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of a Tetravalent Dengue Vaccine in Children in Latin America

(2015) Luis Villar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers

(2015) G. Fibriansah et al.   SCIENCE

Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination

(2015) P. Robert Beatty et al.   Science Translational Medicine

Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity

(2015) Naphak Modhiran et al.   Science Translational Medicine

Next generation dengue vaccines: A review of the preclinical development pipeline

(2015) Kirsten S. Vannice et al.   VACCINE

Shake, rattle, and roll: Impact of the dynamics of flavivirus particles on their interactions with the host

(2015) Richard J. Kuhn et al.   VIROLOGY

A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins

(2015) Guntur Fibriansah et al.   Nature Communications

A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface

(2014) Guntur Fibriansah et al.   EMBO Molecular Medicine

Isolation of Dengue Virus-Specific Memory B Cells with Live Virus Antigen from Human Subjects following Natural Infection Reveals the Presence of Diverse Novel Functional Groups of Antibody Clones

(2014) S. A. Smith et al.   JOURNAL OF VIROLOGY

The Human CD8+T Cell Responses Induced by a Live Attenuated Tetravalent Dengue Vaccine Are Directed against Highly Conserved Epitopes

(2014) Daniela Weiskopf et al.   JOURNAL OF VIROLOGY

Combined Effects of the Structural Heterogeneity and Dynamics of Flaviviruses on Antibody Recognition

(2014) K. A. Dowd et al.   JOURNAL OF VIROLOGY

Molecular Mimicry between Dengue Virus and Coagulation Factors Induces Antibodies To Inhibit Thrombin Activity and Enhance Fibrinolysis

(2014) Y.-C. Chuang et al.   JOURNAL OF VIROLOGY

Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial

(2014) Maria Rosario Capeding et al.   LANCET

A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus

(2014) Wanwisa Dejnirattisai et al.   NATURE IMMUNOLOGY

Relating structure to evolution in class II viral membrane fusion proteins

(2014) Yorgo Modis   Current Opinion in Virology

Structural Changes in Dengue Virus When Exposed to a Temperature of 37 C

(2013) G. Fibriansah et al.   JOURNAL OF VIROLOGY

Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells

(2013) D. Weiskopf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Patterns of Intrahuman Dengue Virus Diversity Reveal Associations with Viral Phylogenetic Clade and Interhost Diversity

(2012) Poornima Parameswaran et al.   JOURNAL OF VIROLOGY

Protective efficacy of the recombinant, live-attenuated, CYD tetravalent dengue vaccine in Thai schoolchildren: a randomised, controlled phase 2b trial

(2012) Arunee Sabchareon et al.   LANCET

Dengue

(2012) Cameron P. Simmons et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Structural Basis for Serotype-Specific Neutralization of Dengue Virus by a Human Antibody

(2012) E. P. Teoh et al.   Science Translational Medicine

Capturing a Virus while It Catches Its Breath

(2012) Theodore C. Pierson et al.   STRUCTURE

Mechanism of Dengue Virus Broad Cross-Neutralization by a Monoclonal Antibody

(2012) Joseph J.B. Cockburn et al.   STRUCTURE

Unique challenges faced by the clinical evaluation of dengue vaccines

(2011) Robert Edelman   Expert Review of Vaccines

Persistence of Circulating Memory B Cell Clones with Potential for Dengue Virus Disease Enhancement for Decades following Infection

(2011) S. A. Smith et al.   JOURNAL OF VIROLOGY

Ligation of Fc gamma receptor IIB inhibits antibody-dependent enhancement of dengue virus infection

(2011) K. R. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-Reactivity and Expansion of Dengue-Specific T cells During Acute Primary and Secondary Infections in Humans

(2011) Heather Friberg et al.   Scientific Reports

The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity

(2010) Martina Beltramello et al.   Cell Host & Microbe

Influence of pr-M Cleavage on the Heterogeneity of Extracellular Dengue Virus Particles

(2010) J. Junjhon et al.   JOURNAL OF VIROLOGY

Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes

(2010) Scott B Halstead et al.   LANCET INFECTIOUS DISEASES

Cross-Reacting Antibodies Enhance Dengue Virus Infection in Humans

(2010) W. Dejnirattisai et al.   SCIENCE

Immature Dengue Virus: A Veiled Pathogen?

(2010) Izabela A. Rodenhuis-Zybert et al.   PLoS Pathogens

A Protective Role for Dengue Virus-Specific CD8+ T Cells

(2009) L. E. Yauch et al.   JOURNAL OF IMMUNOLOGY

Dengue virus neutralization by human immune sera: Role of envelope protein domain III-reactive antibody

(2009) W.M.P.B. Wahala et al.   VIROLOGY

Understanding the contribution of cellular immunity to dengue disease pathogenesis

(2008) Anuja Mathew et al.   IMMUNOLOGICAL REVIEWS

Cross‐Reactive Memory CD8+T Cells Alter the Immune Response to Heterologous Secondary Dengue Virus Infections in Mice in a Sequence‐Specific Manner

(2008) Coreen M. Beaumier et al.   JOURNAL OF INFECTIOUS DISEASES

Characterization of Dengue Virus Complex-Specific Neutralizing Epitopes on Envelope Protein Domain III of Dengue 2 Virus

(2008) G. D. Gromowski et al.   JOURNAL OF VIROLOGY

Differential Modulation of prM Cleavage, Extracellular Particle Distribution, and Virus Infectivity by Conserved Residues at Nonfurin Consensus Positions of the Dengue Virus pr-M Junction

(2008) J. Junjhon et al.   JOURNAL OF VIROLOGY

Characterization of the interaction of domain III of the envelope protein of dengue virus with putative receptors from CHO cells

(2008) Vivian Huerta et al.   VIRUS RESEARCH