Broadly Reactive Human Monoclonal Antibodies Targeting the Pneumococcal Histidine Triad Protein Protect against Fatal Pneumococcal Infection

Immunization with PhtD truncated fragments reduces nasopharyngeal colonization by Streptococcus pneumoniae

(2020) Greiciely O. André et al.   VACCINE

A New Pneumococcal Capsule Type, 10D, is the 100th Serotype and Has a Large cps Fragment from an Oral Streptococcus

(2020) Feroze Ganaie et al.   mBio

Co-infection with respiratory pathogens among COVID-2019 cases

(2020) Xiaojuan Zhu et al.   VIRUS RESEARCH

Antibody recognition of the Pneumovirus fusion protein trimer interface

(2020) Jiachen Huang et al.   PLoS Pathogens

Invasive pneumococcal disease in relation to vaccine type serotypes

(2019) Paeton L. Wantuch et al.   Human Vaccines & Immunotherapeutics

Opsonophagocytic Killing Assay to Assess Immunological Responses Against Bacterial Pathogens

(2019) Amy V. Paschall et al.   Jove-Journal of Visualized Experiments

A potent neutralizing site III-specific human antibody neutralizes human metapneumovirus in vivo

(2019) Yael Bar-Peled et al.   JOURNAL OF VIROLOGY

Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an international whole-genome sequencing study

(2019) Stephanie W Lo et al.   LANCET INFECTIOUS DISEASES

Prevalence of Various Vaccine Candidate Proteins in Clinical Isolates of Streptococcus pneumoniae: Characterization of the Novel Pht Fusion Proteins PhtA/B and PhtA/D

(2019) Kawaguchiya et al.   Pathogens

Efficacy, safety and immunogenicity of a pneumococcal protein-based vaccine co-administered with 13-valent pneumococcal conjugate vaccine against acute otitis media in young children: A phase IIb randomized study

(2019) Laura L. Hammitt et al.   VACCINE

Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae

(2018) Zhenyao Luo et al.   FEBS LETTERS

Enzymatic Hydrolysis of Pneumococcal Capsular Polysaccharide Renders the Bacterium Vulnerable to Host Defense

(2018) Dustin R. Middleton et al.   INFECTION AND IMMUNITY

Current status and future directions of invasive pneumococcal diseases and prophylactic approaches to control them

(2018) Paeton L. Wantuch et al.   Human Vaccines & Immunotherapeutics

Human monoclonal antibodies isolated from a primary pneumococcal conjugate Vaccinee demonstrates the expansion of an antigen-driven Hypermutated memory B cell response

(2018) Zhifeng Chen et al.   BMC INFECTIOUS DISEASES

Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection

(2017) Mark H. Wilcox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antibodies to PcpA and PhtD protect mice against Streptococcus pneumoniae by a macrophage- and complement-dependent mechanism

(2017) Lucian Visan et al.   Human Vaccines & Immunotherapeutics

Naturally Acquired Human Immunity to Pneumococcus Is Dependent on Antibody to Protein Antigens

(2017) Robert Wilson et al.   PLoS Pathogens

Towards Identifying Protective B-Cell Epitopes: The PspA Story

(2017) Naeem Khan et al.   Frontiers in Microbiology

Reduction of Streptococcus pneumoniae Colonization and Dissemination by a Nonopsonic Capsular Polysaccharide Antibody

(2016) Christopher R. Doyle et al.   mBio

Nonencapsulated Streptococcus pneumoniae : Emergence and Pathogenesis

(2016) Lance E. Keller et al.   mBio

Pneumococcal Capsules and Their Types: Past, Present, and Future

(2015) K. Aaron Geno et al.   CLINICAL MICROBIOLOGY REVIEWS

The First Histidine Triad Motif of PhtD Is Critical for Zinc Homeostasis inStreptococcus pneumoniae

(2015) Bart A. Eijkelkamp et al.   INFECTION AND IMMUNITY

Discovery of Immunodominant B Cell Epitopes within Surface Pneumococcal Virulence Proteins in Pediatric Patients with Invasive Pneumococcal Disease

(2015) Theano Lagousi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques

(2015) Y Fukuyama et al.   Mucosal Immunology

Diversity of Pneumolysin and Pneumococcal Histidine Triad Protein D of Streptococcus pneumoniae Isolated from Invasive Diseases in Korean Children

(2015) Ki Wook Yun et al.   PLoS One

Pneumococcal disease prevention among adults: Strategies for the use of pneumococcal vaccines

(2015) Tamara Pilishvili et al.   VACCINE

Passive protection of mice againstStreptococcus pneumoniaechallenge by naturally occurring and vaccine-induced human anti-PhtD antibodies

(2015) Roger H Brookes et al.   Human Vaccines & Immunotherapeutics

Virulence Factors of Streptococcus pneumoniae. Comparison between African and French Invasive Isolates and Implication for Future Vaccines

(2015) Sophie Blumental et al.   PLoS One

Role of Pht Proteins in Attachment of Streptococcus pneumoniae to Respiratory Epithelial Cells

(2014) Anna Kallio et al.   INFECTION AND IMMUNITY

Human Antibodies to PhtD, PcpA, and Ply Reduce Adherence to Human Lung Epithelial Cells and Murine Nasopharyngeal Colonization by Streptococcus pneumoniae

(2014) Ravinder Kaur et al.   INFECTION AND IMMUNITY

Protective properties of a fusion pneumococcal surface protein A (PspA) vaccine against pneumococcal challenge by five different PspA clades in mice

(2014) Zhenyu Piao et al.   VACCINE

Serum antibody responses to pneumococcal colonization in the first 2 years of life: results from an SE Asian longitudinal cohort study

(2013) P. Turner et al.   CLINICAL MICROBIOLOGY AND INFECTION

Surface Association of Pht Proteins of Streptococcus pneumoniae

(2013) Charles D. Plumptre et al.   INFECTION AND IMMUNITY

Nanogel-Based PspA Intranasal Vaccine Prevents Invasive Disease and Nasal Colonization by Streptococcus pneumoniae

(2013) Il Gyu Kong et al.   INFECTION AND IMMUNITY

Vaccination against Streptococcus pneumoniae Using Truncated Derivatives of Polyhistidine Triad Protein D

(2013) Charles D. Plumptre et al.   PLoS One

New Insights into Histidine Triad Proteins: Solution Structure of a Streptococcus pneumoniae PhtD Domain and Zinc Transfer to AdcAII

(2013) Beate Bersch et al.   PLoS One

Identifying the Interaction Between Influenza and Pneumococcal Pneumonia Using Incidence Data

(2013) S. Shrestha et al.   Science Translational Medicine

Experimental Human Pneumococcal Carriage Augments IL-17A-dependent T-cell Defence of the Lung

(2013) Adam K. A. Wright et al.   PLoS Pathogens

Development of a Fourfold Multiplexed Opsonophagocytosis Assay for Pneumococcal Antibodies against Additional Serotypes and Discovery of Serological Subtypes in Streptococcus pneumoniae Serotype 20

(2012) Robert L. Burton et al.   Clinical and Vaccine Immunology

The fundamental link between pneumococcal carriage and disease

(2012) Birgit Simell et al.   Expert Review of Vaccines

Nasopharyngeal Colonization Elicits Antibody Responses to Staphylococcal and Pneumococcal Proteins That Are Not Associated with a Reduced Risk of Subsequent Carriage

(2012) Sabine M. P. J. Prevaes et al.   INFECTION AND IMMUNITY

A new flow-cytometry-based opsonophagocytosis assay for the rapid measurement of functional antibody levels against Group B Streptococcus

(2012) Monica Fabbrini et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Pneumococcal Surface Protein A Inhibits Complement Deposition on the Pneumococcal Surface by Competing with the Binding of C-Reactive Protein to Cell-Surface Phosphocholine

(2012) R. Mukerji et al.   JOURNAL OF IMMUNOLOGY

Vaccine candidates PhtD and PhtE of Streptococcus pneumoniae are adhesins that elicit functional antibodies in humans

(2012) M. Nadeem Khan et al.   VACCINE

A protein-based pneumococcal vaccine protects rhesus macaques from pneumonia after experimental infection with Streptococcus pneumoniae

(2011) Philippe Denoël et al.   VACCINE

Preclinical Evaluation of the Pht Proteins as Potential Cross-Protective Pneumococcal Vaccine Antigens

(2010) Fabrice Godfroid et al.   INFECTION AND IMMUNITY

Transcriptional regulation, occurrence and putative role of the Pht family of Streptococcus pneumoniae

(2010) S. Rioux et al.   MICROBIOLOGY-SGM

Efficacy of Opsonic and Nonopsonic Serotype 3 Pneumococcal Capsular Polysaccharide-Specific Monoclonal Antibodies against Intranasal Challenge with Streptococcus pneumoniae in Mice

(2009) H. Tian et al.   INFECTION AND IMMUNITY

T Cell Memory Response to Pneumococcal Protein Antigens in an Area of High Pneumococcal Carriage and Disease

(2009) Marianne W. Mureithi et al.   JOURNAL OF INFECTIOUS DISEASES

Pathogenesis, treatment, and prevention of pneumococcal pneumonia

(2009) Tom van der Poll et al.   LANCET

Pneumococcal carriage and acute otitis media induce serum antibodies to pneumococcal surface proteins CbpA and PhtD in children

(2009) Birgit Simell et al.   VACCINE

Effects of Ageing and Gender on Naturally Acquired Antibodies to Pneumococcal Capsular Polysaccharides and Virulence-Associated Proteins

(2008) B. Simell et al.   Clinical and Vaccine Immunology

Epidemiologic Evidence for Serotype‐Specific Acquired Immunity to Pneumococcal Carriage

(2008) Daniel M. Weinberger et al.   JOURNAL OF INFECTIOUS DISEASES

Prevalence and risk factors for nasopharyngeal carriage of Streptococcus pneumoniae among adolescents

(2008) D. M. Cardozo et al.   JOURNAL OF MEDICAL MICROBIOLOGY

IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis

(2008) X. Brochet et al.   NUCLEIC ACIDS RESEARCH