IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody

Role of IgG3 in Infectious Diseases

(2019) Timon Damelang et al.   TRENDS IN IMMUNOLOGY

The antibody response in HIV-1-infected donors

(2019) Simone I. Richardson et al.   Current Opinion in HIV and AIDS

HIV-specific Fc effector function early in infection predicts the development of broadly neutralizing antibodies

(2018) Simone I. Richardson et al.   PLoS Pathogens

IgG3 regulates tissue-like memory B cells in HIV-infected individuals

(2018) Lela Kardava et al.   NATURE IMMUNOLOGY

Importance of Fc-mediated functions of anti-HIV-1 broadly neutralizing antibodies

(2018) Matthew S. Parsons et al.   Retrovirology

The p.Arg435His Variation of IgG3 With High Affinity to FcRn Is Associated With Susceptibility for Pemphigus Vulgaris—Analysis of Four Different Ethnic Cohorts

(2018) Andreas Recke et al.   Frontiers in Immunology

Diversification of IgG effector functions

(2017) Stylianos Bournazos et al.   INTERNATIONAL IMMUNOLOGY

Monoclonal Antibodies Specific for the V2, V3, CD4-Binding Site, and gp41 of HIV-1 Mediate Phagocytosis in a Dose-Dependent Manner

(2017) Thomas Musich et al.   JOURNAL OF VIROLOGY

IgG Fc variant cross-reactivity between human and rhesus macaque FcγRs

(2017) Austin W. Boesch et al.   mAbs

V1V2-specific complement activating serum IgG as a correlate of reduced HIV-1 infection risk in RV144

(2017) Lautaro G. Perez et al.   PLoS One

Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge

(2017) Boris Julg et al.   Science Translational Medicine

Immunoglobulin G1 Allotype Influences Antibody Subclass Distribution in Response to HIV gp140 Vaccination

(2017) Sven Kratochvil et al.   Frontiers in Immunology

Immunologic Insights on the Membrane Proximal External Region: A Major Human Immunodeficiency Virus Type-1 Vaccine Target

(2017) Luis M. Molinos-Albert et al.   Frontiers in Immunology

Broadly neutralizing antibody specificities detected in the genital tract of HIV-1 infected women

(2016) Nonhlanhla N. Mkhize et al.   AIDS

Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and Potency

(2016) Stylianos Bournazos et al.   CELL

Human IgG1, IgG3, and IgG3 Hinge-Truncated Mutants Show Different Protection Capabilities against Meningococci Depending on the Target Antigen and Epitope Specificity

(2016) S. Giuntini et al.   Clinical and Vaccine Immunology

Broadly Neutralizing Antibodies Display Potential for Prevention of HIV-1 Infection of Mucosal Tissue Superior to That of Nonneutralizing Antibodies

(2016) Hannah M. Cheeseman et al.   JOURNAL OF VIROLOGY

Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies

(2016) M Sips et al.   Mucosal Immunology

Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo

(2016) C.-L. Lu et al.   SCIENCE

Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses

(2016) Matthew Zirui Tay et al.   PLoS Pathogens

Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control

(2016) Margaret E. Ackerman et al.   PLoS Pathogens

Ig Constant Region Effects on Variable Region Structure and Function

(2016) Alena Janda et al.   Frontiers in Microbiology

Neutralization Takes Precedence Over IgG or IgA Isotype-related Functions in Mucosal HIV-1 Antibody-mediated Protection

(2016) Rena D. Astronomo et al.   EBioMedicine

Enhancement of Immune Effector Functions by Modulating IgG’s Intrinsic Affinity for Target Antigen

(2016) Yariv Mazor et al.   PLoS One

Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology

(2015) Amy W. Chung et al.   CELL

Intra-Spike Crosslinking Overcomes Antibody Evasion by HIV-1

(2015) Rachel P. Galimidi et al.   CELL

New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency

(2015) Nicole A. Doria-Rose et al.   JOURNAL OF VIROLOGY

Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys

(2015) D. H. Barouch et al.   SCIENCE

Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques

(2015) Sampa Santra et al.   PLoS Pathogens

Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity

(2014) Stylianos Bournazos et al.   CELL

Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice

(2014) Ariel Halper-Stromberg et al.   CELL

Independent evolution of Fc- and Fab-mediated HIV-1-specific antiviral antibody activity following acute infection

(2014) Anne-Sophie Dugast et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dynamics of Inter-heavy Chain Interactions in Human Immunoglobulin G (IgG) Subclasses Studied by Kinetic Fab Arm Exchange

(2014) Theo Rispens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Vaccine-Induced C1 and V2 Env-Specific Antibodies Synergize for Increased Antiviral Activities

(2014) Justin Pollara et al.   JOURNAL OF VIROLOGY

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

(2014) Nicole A. Doria-Rose et al.   NATURE

Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines

(2014) A. W. Chung et al.   Science Translational Medicine

Vaccine-Induced Env V1-V2 IgG3 Correlates with Lower HIV-1 Infection Risk and Declines Soon After Vaccination

(2014) N. L. Yates et al.   Science Translational Medicine

Human immunoglobulin constant heavy G chain (IGHG) (Fcγ) (GM) genes, defining innate variants of IgG molecules and B cells, have impact on disease and therapy

(2013) Vivi-Anne Oxelius et al.   CLINICAL IMMUNOLOGY

Divergent Antibody Subclass and Specificity Profiles but Not Protective HLA-B Alleles Are Associated with Variable Antibody Effector Function among HIV-1 Controllers

(2013) J. I. Lai et al.   JOURNAL OF VIROLOGY

Protective effect of vaginal application of neutralizing and nonneutralizing inhibitory antibodies against vaginal SHIV challenge in macaques

(2013) C Moog et al.   Mucosal Immunology

A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

(2013) Rogier W. Sanders et al.   PLoS Pathogens

High-throughput, multiplexed IgG subclassing of antigen-specific antibodies from clinical samples

(2012) Eric P. Brown et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Disulfide bond structures of IgG molecules

(2012) Hongcheng Liu et al.   mAbs

Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody

(2012) D. Tudor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple HIV-1-specific IgG3 responses decline during acute HIV-1

(2011) Nicole L. Yates et al.   AIDS

High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses

(2011) Justin Pollara et al.   CYTOMETRY PART A

Isolation of a Monoclonal Antibody That Targets the Alpha-2 Helix of gp120 and Represents the Initial Autologous Neutralizing-Antibody Response in an HIV-1 Subtype C-Infected Individual

(2011) E. S. Gray et al.   JOURNAL OF VIROLOGY

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

(2011) J. F. Scheid et al.   SCIENCE

Decreased Fc receptor expression on innate immune cells is associated with impaired antibody-mediated cellular phagocytic activity in chronically HIV-1 infected individuals

(2011) Anne-Sophie Dugast et al.   VIROLOGY

Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential

(2011) Nigel M. Stapleton et al.   Nature Communications

A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples

(2010) Margaret E. Ackerman et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

(2010) Q. Abdool Karim et al.   SCIENCE

Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers

(2009) Olivier Lambotte et al.   AIDS

Utilization of Immunoglobulin G Fc Receptors by Human Immunodeficiency Virus Type 1: a Specific Role for Antibodies against the Membrane-Proximal External Region of gp41

(2009) L. G. Perez et al.   JOURNAL OF VIROLOGY

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

Engineered Antibodies of IgG1/IgG3 Mixed Isotype with Enhanced Cytotoxic Activities

(2008) A. Natsume et al.   CANCER RESEARCH

Establishing a Cohort at High Risk of HIV Infection in South Africa: Challenges and Experiences of the CAPRISA 002 Acute Infection Study

(2008) Francois van Loggerenberg et al.   PLoS One

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning

(2007) Thomas Tiller et al.   JOURNAL OF IMMUNOLOGICAL METHODS