Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity

Acquisition of C1 inhibitor by Bordetella pertussis virulence associated gene 8 results in C2 and C4 consumption away from the bacterial surface

(2017) Elise S. Hovingh et al.   PLoS Pathogens

Bordetella parapertussis Circumvents Neutrophil Extracellular Bactericidal Mechanisms

(2017) Juan Gorgojo et al.   PLoS One

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

GTL001, A Therapeutic Vaccine for Women Infected with Human Papillomavirus 16 or 18 and Normal Cervical Cytology: Results of a Phase I Clinical Trial

(2016) P. Van Damme et al.   CLINICAL CANCER RESEARCH

Bordetella pertussis

(2016) Nicholas H. Carbonetti   CURRENT OPINION IN INFECTIOUS DISEASES

cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity

(2016) Ondrej Cerny et al.   JOURNAL OF IMMUNOLOGY

Pertussis leukocytosis: mechanisms, clinical relevance and treatment

(2016) Nicholas H. Carbonetti   Pathogens and Disease

cAMP signalling ofBordetellaadenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL-Bax pro-apoptotic cascade in phagocytes

(2015) Jawid Nazir Ahmad et al.   CELLULAR MICROBIOLOGY

Investigating pertussis toxin and its impact on vaccination

(2015) Loic Coutte et al.   Future Microbiology

Pore-formation by adenylate cyclase toxoid activates dendritic cells to prime CD8+ and CD4+ T cells

(2015) Martina Svedova et al.   IMMUNOLOGY AND CELL BIOLOGY

Bordetella pertussisAdenylate Cyclase Toxin Blocks Induction of Bactericidal Nitric Oxide in Macrophages through cAMP-Dependent Activation of the SHP-1 Phosphatase

(2015) Ondrej Cerny et al.   JOURNAL OF IMMUNOLOGY

Complement evasion by Bordetella pertussis: implications for improving current vaccines

(2015) Ilse Jongerius et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3

(2015) Radim Osicka et al.   eLife

Bordetellaadenylate cyclase toxin: a unique combination of a pore-forming moiety with a cell-invading adenylate cyclase enzyme

(2015) Jiri Masin et al.   Pathogens and Disease

Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines

(2014) Peter Sebo et al.   Expert Review of Vaccines

Cyclic AMP-Mediated Suppression of Neutrophil Extracellular Trap Formation and Apoptosis by the Bordetella pertussis Adenylate Cyclase Toxin

(2014) Joshua C. Eby et al.   INFECTION AND IMMUNITY

Adenylate Cyclase Toxin Subverts Phagocyte Function by RhoA Inhibition and Unproductive Ruffling

(2014) J. Kamanova et al.   JOURNAL OF IMMUNOLOGY

Lipopolysaccharides from Bordetella pertussis and Bordetella parapertussis Differently Modulate Human Dendritic Cell Functions Resulting in Divergent Prevalence of Th17-Polarized Responses

(2014) G. Fedele et al.   JOURNAL OF IMMUNOLOGY

Antigen Targeting to CD11b+Dendritic Cells in Association with TLR4/TRIF Signaling Promotes Strong CD8+T Cell Responses

(2014) Gilles Dadaglio et al.   JOURNAL OF IMMUNOLOGY

Bordetella pertussis pathogenesis: current and future challenges

(2014) Jeffrey A. Melvin et al.   NATURE REVIEWS MICROBIOLOGY

Bordetella Adenylate Cyclase Toxin Differentially Modulates Toll-Like Receptor-Stimulated Activation, Migration and T Cell Stimulatory Capacity of Dendritic Cells

(2014) Irena Adkins et al.   PLoS One

IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection

(2013) Hsing-Chuan Tsai et al.   Clinical & Developmental Immunology

Quantification of the Adenylate Cyclase Toxin of Bordetella pertussisIn Vitroand during Respiratory Infection

(2013) Joshua C. Eby et al.   INFECTION AND IMMUNITY

Bordetella pertussisentry into respiratory epithelial cells and intracellular survival

(2013) Yanina Lamberti et al.   Pathogens and Disease

BothCD4+andCD8+Lymphocytes Participate in the IFN-γ Response to Filamentous Hemagglutinin fromBordetella pertussisin Infants, Children, and Adults

(2012) Violette Dirix et al.   Clinical & Developmental Immunology

Bacteria and their Toxins Tamed for Immunotherapy

(2012) Irena Adkins et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Delivery of Large Heterologous Polypeptides across the Cytoplasmic Membrane of Antigen-Presenting Cells by the Bordetella RTX Hemolysin Moiety Lacking the Adenylyl Cyclase Domain

(2012) Jana Holubova et al.   INFECTION AND IMMUNITY

Contribution of Bordetella Filamentous Hemagglutinin and Adenylate Cyclase Toxin to Suppression and Evasion of Interleukin-17-Mediated Inflammation

(2012) Michael W. Henderson et al.   INFECTION AND IMMUNITY

Calcium Influx Rescues Adenylate Cyclase-Hemolysin from Rapid Cell Membrane Removal and Enables Phagocyte Permeabilization by Toxin Pores

(2012) Radovan Fiser et al.   PLoS Pathogens

Attenuated Bordetella pertussis Vaccine Candidate BPZE1 Promotes Human Dendritic Cell CCL21-Induced Migration and Drives a Th1/Th17 Response

(2011) G. Fedele et al.   JOURNAL OF IMMUNOLOGY

Intracellular Trafficking of Bordetella pertussis in Human Macrophages

(2010) Y. A. Lamberti et al.   INFECTION AND IMMUNITY

Inflammasome Activation by Adenylate Cyclase Toxin Directs Th17 Responses and Protection against Bordetella pertussis

(2010) A. Dunne et al.   JOURNAL OF IMMUNOLOGY

Bordetella pertussis Commits Human Dendritic Cells to Promote a Th1/Th17 Response through the Activity of Adenylate Cyclase Toxin and MAPK-Pathways

(2010) Giorgio Fedele et al.   PLoS One

T- and B-Cell-Mediated Protection Induced by Novel, Live Attenuated Pertussis Vaccine in Mice. Cross Protection against Parapertussis

(2010) Pascal Feunou Feunou et al.   PLoS One

Bordetella Adenylate Cyclase Toxin Mobilizes Its β2 Integrin Receptor into Lipid Rafts to Accomplish Translocation across Target Cell Membrane in Two Steps

(2010) Ladislav Bumba et al.   PLoS Pathogens

Bordetellaevades the host immune system by inducing IL-10 through a type III effector, BopN

(2009) Kanna Nagamatsu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis

(2009) Shinji Kagami et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pertussis Toxin Stimulates IL-17 Production in Response to Bordetella pertussis Infection in Mice

(2009) Charlotte Andreasen et al.   PLoS One

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

(2008) H. J. P. M. Koenen et al.   BLOOD

Tuning Microenvironments: Induction of Regulatory T Cells by Dendritic Cells

(2008) Yasmine Belkaid et al.   IMMUNITY

Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells

(2008) Fionnuala B. Hickey et al.   JOURNAL OF LEUKOCYTE BIOLOGY